A TIM-3/Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid Leukemia Stem Cells and Leukemic Progression

Cell Stem Cell

Volumn 17, Issue 3, 2015, Pages 341-352

  Kikushige, Yoshikane ^a,b,c   Miyamoto, Toshihiro ^a   Yuda, Junichiro ^a   Jabbarzadeh Tabrizi, Siamak ^a   Shima, Takahiro ^a   Takayanagi, Shin Ichiro ^d   Niiro, Hiroaki ^a   Yurino, Ayano ^a   Miyawaki, Kohta ^a   Takenaka, Katsuto ^b   Iwasaki, Hiromi ^b   Akashi, Koichi ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY HOSPITAL   (Japan)

^c JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^d KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTHROMBIN COMPLEX; BETA CATENIN; ECALECTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN TYROSINE KINASE; CANCER ANTIBODY; CD34 ANTIGEN; GALECTIN; HAVCR2 PROTEIN, HUMAN; LGALS9 PROTEIN, HUMAN; LIGAND; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BINDING; PROTEIN KINASE B;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOCRINE EFFECT; CANCER GROWTH; CANCER STEM CELL; CELL RENEWAL; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOUSE; MYELODYSPLASTIC SYNDROME; MYELOID LEUKEMIA; MYELOPROLIFERATIVE NEOPLASM; NONHODGKIN LYMPHOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; TUMOR XENOGRAFT; UPREGULATION; WESTERN BLOTTING; ACUTE MYELOBLASTIC LEUKEMIA; ADULT; ANIMAL; BIOLOGICAL MODEL; BLAST CELL CRISIS; BLOOD; CELL NUCLEUS; CELL PROLIFERATION; DISEASE COURSE; DRUG SCREENING; IMMUNOLOGY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROTEIN TRANSPORT; TRANSFORMED CELL LINE; TUMOR VOLUME;

ADULT; ANIMALS; ANTIBODIES, NEOPLASM; ANTIGENS, CD34; AUTOCRINE COMMUNICATION; BETA CATENIN; BLAST CRISIS; CELL LINE, TRANSFORMED; CELL NUCLEUS; CELL PROLIFERATION; DISEASE PROGRESSION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GALECTINS; HUMANS; LEUKEMIA, MYELOID, ACUTE; LIGANDS; MEMBRANE PROTEINS; MICE; MODELS, BIOLOGICAL; NEOPLASTIC STEM CELLS; NF-KAPPA B; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84941023046     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2015.07.011     Document Type: Article

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