Notochord to Nucleus Pulposus Transition

Current Osteoporosis Reports

Volumn 13, Issue 5, 2015, Pages 336-341

  Lawson, Lisa ^a,b   Harfe, Brian D ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Chordoma; Intervertebral disc; Notochord; Nucleus pulposus

Indexed keywords

CELL PROTEIN; EPH PROTEIN; EPHRIN; ROUNDABOUT RECEPTOR; SLIT PROTEIN; UNCLASSIFIED DRUG;

ANNULUS FIBROSUS; BIOLOGICAL MODEL; CANCER RISK; CELL COUNT; CELL DEATH; CELL FATE; CELL MIGRATION; CHORDOMA; CONFORMATIONAL TRANSITION; EMBRYO CELL; EMBRYO PATTERN FORMATION; GENE; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE LOCUS; GENE MUTATION; HISTOLOGY; HUMAN; NONHUMAN; NOTOCHORD; NUCLEUS PULPOSUS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; REVIEW; ROBO GENE; SIGNAL TRANSDUCTION; SLIT GENE; T BRACHYURY; EMBRYOLOGY; INTERVERTEBRAL DISK; PHYSIOLOGY;

CHORDOMA; HUMANS; INTERVERTEBRAL DISC; NOTOCHORD;

EID: 84941022059     PISSN: 15441873     EISSN: 15442241     Source Type: Journal    
DOI: 10.1007/s11914-015-0284-x     Document Type: Review

References (52)

1. Sulik K, Dehart DB, Iangaki T, et al. Morphogenesis of the murine node and notochordal plate. Dev Dyn. 1994;201(3):260–78.
2. Beddington RS. Induction of a second neural axis by the mouse node. Development. 1994;120(3):613–20.
3. Fleming A, Kishida MG, Kimmel CB, Keynes RJ. Building the backbone: the development and evolution of vertebral patterning. Development. 2015;142(10):1733–44.
4. Yusuf F, Brand-Saberi B. The eventful somite: patterning, fate determination and cell division in the somite. Anat Embryol (Berl). 2006;211 Suppl 1:21–30.
5. Litingtung Y, Chiang C. Control of Shh activity and signaling in the neural tube. Dev Dyn. 2000;219(2):143–54.
6. Trout JJ, Buckwalter JA, Moore KC. Ultrastructure of the human intervertebral disc: II. Cells of the nucleus pulposus. Anat Rec. 1982;204(4):307–14.
7. Trout JJ, Buckwalter JA, Moore KC, Landas SK. Ultrastructure of the human intervertebral disc. I. Changes in notochordal cells with age. Tissue Cell. 1982;14(2):359–69.
8. Hadjipavlou AG, Tzermiadianos MN, Bogduk N, Zindrick MR. The pathophysiology of disc degeneration: a critical review. J Bone Joint Surg (Br). 2008;90(10):1261–70.
9. Gallucci M, Puglielli E, Splendiani A, Pistoia F, Spacca G. Degenerative disorders of the spine. Eur Radiol. 2005;15(3):591–8.
10. Katz JN. Lumbar disc disorders and low-back pain: socioeconomic factors and consequences. J Bone Joint Surg Am. 2006;88 Suppl 2:21–4.
11. Rubin DI. Epidemiology and risk factors for spine pain. Neurol Clin. 2007;25(2):353–71.
12. Walmsley R. The development and growth of the intervertebral disc. Edinb Med J. 1953;60(8):341–64.
13. Choi KS, Cohn MJ, Harfe BD. Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation. Dev Dyn. 2008;237(12):3953–8. First paper demonstrating that notochord cells form nuclei pulposi and that notochordal remnants are present in mice.
14. McCann MR, Tamplin OJ, Rossant J, Seguin CA. Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development. Dis Model Mech. 2011. Independent confirmation that mice contain notochordal remnants and that nuclei pulposi are formed from the embryonic notochord.
15. Smith LJ, Nerurkar NL, Choi KS, Harfe BD, Elliott DM. Degeneration and regeneration of the intervertebral disc: lessons from development. Dis Model Mech. 2011;4(1):31–41.
16. Bruggeman BJ, Maier JA, Mohiuddin YS, et al. Avian intervertebral disc arises from rostral sclerotome and lacks a nucleus pulposus: implications for evolution of the vertebrate disc. Dev Dyn. 2012;241(4):675–83.
17. Aszodi A, Chan D, Hunziker E, Bateman JF, Fassler R. Collagen II is essential for the removal of the notochord and the formation of intervertebral discs. J Cell Biol. 1998;143(5):1399–412.
18. Choi KS, Harfe BD. Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs. Proc Natl Acad Sci U S A. 2011;108(23):9484–9.
19. Cayuso J, Xu Q, Wilkinson DG. Mechanisms of boundary formation by Eph receptor and ephrin signaling. Dev Biol. 2015;401(1):122–31.
20. Lisabeth EM, Falivelli G, Pasquale EB. Eph receptor signaling and ephrins. Cold Spring Harb Perspect Biol. 2013;5(9). doi:10.1101/cshperspect.a009159
21. Fagotto F. The cellular basis of tissue separation. Development. 2014;141(17):3303–18.
22. Durbin L, Brennan C, Shiomi K, et al. Eph signaling is required for segmentation and differentiation of the somites. Genes Dev. 1998;12(19):3096–109.
23. Xu Q, Mellitzer G, Robinson V, Wilkinson DG. In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins. Nature. 1999;399(6733):267–71.
24. Xu Q, Alldus G, Holder N, Wilkinson DG. Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain. Development. 1995;121(12):4005–16.
25. Rohani N, Canty L, Luu O, Fagotto F, Winklbauer R. EphrinB/EphB signaling controls embryonic germ layer separation by contact-induced cell detachment. PLoS Biol. 2011;9(3), e1000597.
26. Rothberg JM, Hartley DA, Walther Z, Artavanis-Tsakonas S. Slit: an EGF-homologous locus of D. Melanogaster involved in the development of the embryonic central nervous system. Cell. 1988;55(6):1047–59.
27. Brose K, Bland KS, Wang KH, et al. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell. 1999;96(6):795–806.
28. Kidd T, Brose K, Mitchell KJ, et al. Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. Cell. 1998;92(2):205–15.
29. Ypsilanti AR, Zagar Y, Chedotal A. Moving away from the midline: new developments for Slit and Robo. Development. 2010;137(12):1939–52.
30. Domyan ET, Branchfield K, Gibson DA, et al. Roundabout receptors are critical for foregut separation from the body wall. Dev Cell. 2013;24(1):52–63.
31. Seeger M, Tear G, Ferres-Marco D, Goodman CS. Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron. 1993;10(3):409–26.
32. Rothberg JM, Jacobs JR, Goodman CS, Artavanis-Tsakonas S. Slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. Genes Dev. 1990;4(12A):2169–87.
33. Shiau CE, Lwigale PY, Das RM, Wilson SA, Bronner-Fraser M. Robo2-Slit1 dependent cell-cell interactions mediate assembly of the trigeminal ganglion. Nat Neurosci. 2008;11(3):269–76.
34. Howitt JA, Clout NJ, Hohenester E. Binding site for Robo receptors revealed by dissection of the leucine-rich repeat region of Slit. EMBO J. 2004;23(22):4406–12.
35. Liu Z, Patel K, Schmidt H, Andrews W, Pini A, Sundaresan V. Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding. Mol Cell Neurosci. 2004;26(2):232–40.
36. Gilthorpe JD, Papantoniou EK, Chedotal A, Lumsden A, Wingate RJ. The migration of cerebellar rhombic lip derivatives. Development. 2002;129(20):4719–28.
37. Causeret F, Hidalgo-Sanchez M, Fort P, et al. Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1. Development. 2004;131(12):2841–52.
38. Causeret F, Danne F, Ezan F, Sotelo C, Bloch-Gallego E. Slit antagonizes netrin-1 attractive effects during the migration of inferior olivary neurons. Dev Biol. 2002;246(2):429–40.
39. Hu H. Chemorepulsion of neuronal migration by Slit2 in the developing mammalian forebrain. Neuron. 1999;23(4):703–11.
40. Nguyen-Ba-Charvet KT, Picard-Riera N, Tessier-Lavigne M, Baron-Van Evercooren A, Sotelo C, Chedotal A. Multiple roles for slits in the control of cell migration in the rostral migratory stream. J Neurosci. 2004;24(6):1497–506.
41. Sawamoto K, Wichterle H, Gonzalez-Perez O, et al. New neurons follow the flow of cerebrospinal fluid in the adult brain. Science. 2006;311(5761):629–32.
42. Geisen MJ, Di Meglio T, Pasqualetti M, et al. Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling. PLoS Biol. 2008;6(6), e142.
43. Marillat V, Cases O, Nguyen-Ba-Charvet KT, Tessier-Lavigne M, Sotelo C, Chedotal A. Spatiotemporal expression patterns of slit and robo genes in the rat brain. J Comp Neurol. 2002;442(2):130–55.
44. McMaster ML, Goldstein AM, Bromley CM, Ishibe N, Parry DM. Chordoma: incidence and survival patterns in the United States, 1973–1995. Cancer Causes Control: CCC. 2001;12(1):1–11.
45. Sciubba DM, Chi JH, Rhines LD, Gokaslan ZL. Chordoma of the spinal column. Neurosurg Clin N Am. 2008;19(1):5–15.
46. Stacchiotti S, Sommer J. Chordoma Global Consensus G. Building a global consensus approach to chordoma: a position paper from the medical and patient community. Lancet Oncol. 2015;16(2):e71–83.
47. Yamaguchi T, Watanabe-Ishiiwa H, Suzuki S, Igarashi Y, Ueda Y. Incipient chordoma: a report of two cases of early-stage chordoma arising from benign notochordal cell tumors. Mod Pathol. 2005;18(7):1005–10.
48. Yamaguchi T, Yamato M, Saotome K. First histologically confirmed case of a classic chordoma arising in a precursor benign notochordal lesion: differential diagnosis of benign and malignant notochordal lesions. Skelet Radiol. 2002;31(7):413–8.
49. Yamaguchi T, Suzuki S, Ishiiwa H, Shimizu K, Ueda Y. Benign notochordal cell tumors: a comparative histological study of benign notochordal cell tumors, classic chordomas, and notochordal vestiges of fetal intervertebral discs. Am J Surg Pathol. 2004;28(6):756–61.
50. Yamaguchi T, Suzuki S, Ishiiwa H, Ueda Y. Intraosseous benign notochordal cell tumours: overlooked precursors of classic chordomas? Histopathology. 2004;44(6):597–602.
51. Yang XR, Ng D, Alcorta DA, et al. T (brachyury) gene duplication confers major susceptibility to familial chordoma. Nat Genet. 2009;41(11):1176–8. Key paper showing that T (brachyury) is duplicated in familial chordoma.
52. Vujovic S, Henderson S, Presneau N, et al. Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas. J Pathol. 2006;209(2):157–65.