Cell- and nuclear-penetrating anti-dsDNA autoantibodies have multiple arginines in CDR3 of VH and increase cellular level of pERK and Bcl-2 in mesangial cells

Molecular Immunology

Volumn 67, Issue 2, 2015, Pages 377-387

  Im, Sae Ran ^a   Im, Sun Woo ^a   Chung, Hee Yong ^b   Pravinsagar, Pavithra ^a   Jang, Young Ju ^a  

^a Ajou University School of Medicine   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Anti DNA autoantibody; Arginine; Bcl 2; CDR3 VH; ERK; Lupus nephritis; Nuclear penetrating; Pathogenesis; Recombinant scFv; Recombinant VH domain

Indexed keywords

ARGININE; CELL PROTEIN; DOUBLE STRANDED DNA ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; MONOCLONAL ANTIBODY; PROTEIN BCL 2; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; ANTINUCLEAR ANTIBODY; AUTOANTIBODY; COMPLEMENTARITY DETERMINING REGION; IMMUNOGLOBULIN VARIABLE REGION; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BINDING;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIBODY COMBINING SITE; ARTICLE; CELL NUCLEUS; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; LUPUS ERYTHEMATOSUS NEPHRITIS; MESANGIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; UPREGULATION; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; COMPLEMENTARITY DETERMINING REGION; FLOW CYTOMETRY; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, MONOCLONAL; ARGININE; AUTOANTIBODIES; BLOTTING, WESTERN; CELL LINE; CELL NUCLEUS; CELL SURVIVAL; COMPLEMENTARITY DETERMINING REGIONS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLOW CYTOMETRY; IMMUNOGLOBULIN VARIABLE REGION; MESANGIAL CELLS; MICE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2; SEQUENCE HOMOLOGY, AMINO ACID; SINGLE-CHAIN ANTIBODIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84940958631     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2015.06.025     Document Type: Article

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