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Volumn 4, Issue 1, 2008, Pages 2-11

Structure-function relationships in anti-DNA and anti-phospholipid antibodies and their relevance to the pathogenesis of disease

Author keywords

Anti DNA antibodies; Antiphospholipid antibodies; Antiphospholipid syndrome; Expression systems; Systemic lupus erythematosus

Indexed keywords

ALPHA ACTININ; ARGININE; ASPARAGINE; AUTOANTIBODY; BETA2 GLYCOPROTEIN 1; DNA ANTIBODY; DOUBLE STRANDED DNA; DOUBLE STRANDED DNA ANTIBODY; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN G; LYSINE; MONOCLONAL ANTIBODY; NUCLEOSOME ANTIBODY; PHOSPHOLIPID; PHOSPHOLIPID ANTIBODY;

EID: 39449099703     PISSN: 15733971     EISSN: None     Source Type: Journal    
DOI: 10.2174/157339708783497991     Document Type: Review
Times cited : (2)

References (79)
  • 1
    • 0025374697 scopus 로고
    • Measurement of increases in anti-double-stranded DNA antibody levels as a predictor of disease exacerbation in systemic lupus erythematosus. A long-term, prospective study
    • ter Borg EJ, Horst G, Hummel EJ, Limburg PC, Kallenberg CG. Measurement of increases in anti-double-stranded DNA antibody levels as a predictor of disease exacerbation in systemic lupus erythematosus. A long-term, prospective study. Arthritis Rheum 1990; 33(5): 634-43.
    • (1990) Arthritis Rheum , vol.33 , Issue.5 , pp. 634-643
    • ter Borg, E.J.1    Horst, G.2    Hummel, E.J.3    Limburg, P.C.4    Kallenberg, C.G.5
  • 3
    • 33845477908 scopus 로고    scopus 로고
    • Association of anti-nucleosome antibodies with disease flare in serologically active clinically quiescent patients with systemic lupus erythematosus
    • Ng KP, Manson JJ, Rahman A, Isenberg DA. Association of anti-nucleosome antibodies with disease flare in serologically active clinically quiescent patients with systemic lupus erythematosus. Arthritis Rheum 2006; 55(6): 900-4.
    • (2006) Arthritis Rheum , vol.55 , Issue.6 , pp. 900-904
    • Ng, K.P.1    Manson, J.J.2    Rahman, A.3    Isenberg, D.A.4
  • 4
    • 33947660078 scopus 로고    scopus 로고
    • Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis
    • Kalaaji M, Fenton KA, Mortensen ES, et al. Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis. Kidney Int 2007; 71(7): 664-72.
    • (2007) Kidney Int , vol.71 , Issue.7 , pp. 664-672
    • Kalaaji, M.1    Fenton, K.A.2    Mortensen, E.S.3
  • 5
    • 0038328802 scopus 로고    scopus 로고
    • Deposition of nucleosomal antigens (histones and DNA) in the epidermal basement membrane in human lupus nephritis
    • Grootscholten C, van Bruggen MC, van der Pijl JW, et al. Deposition of nucleosomal antigens (histones and DNA) in the epidermal basement membrane in human lupus nephritis. Arthritis Rheum 2003; 48(5): 1355-62.
    • (2003) Arthritis Rheum , vol.48 , Issue.5 , pp. 1355-1362
    • Grootscholten, C.1    van Bruggen, M.C.2    van der Pijl, J.W.3
  • 6
    • 33845893222 scopus 로고    scopus 로고
    • Human hipus autoantibodies against NMDA receptors mediate cognitive impairment
    • Kowal C, Degiorgio LA, Lee J-Y, et al. Human hipus autoantibodies against NMDA receptors mediate cognitive impairment. Proc Natl Acad Sci USA 2006; 103(52): 19854-9.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.52 , pp. 19854-19859
    • Kowal, C.1    Degiorgio, L.A.2    Lee, J.-Y.3
  • 7
    • 0023277281 scopus 로고
    • Murine monoclonal anti-DNA anti-bodies bind directly to glomerular antigens and form immune deposits
    • Madaio MP, Carlson J, Cataldo J, Ucci A, Migliorini P, Pankewycz O. Murine monoclonal anti-DNA anti-bodies bind directly to glomerular antigens and form immune deposits. J Immunol 1987; 138(9): 2883-9.
    • (1987) J Immunol , vol.138 , Issue.9 , pp. 2883-2889
    • Madaio, M.P.1    Carlson, J.2    Cataldo, J.3    Ucci, A.4    Migliorini, P.5    Pankewycz, O.6
  • 8
    • 0029086996 scopus 로고
    • Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice
    • Ehrenstein MR, Katz DR, Griffiths ME, et al. Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice. Kidney Int 1995; 48(3): 705-11.
    • (1995) Kidney Int , vol.48 , Issue.3 , pp. 705-711
    • Ehrenstein, M.R.1    Katz, D.R.2    Griffiths, M.E.3
  • 9
    • 0031964947 scopus 로고    scopus 로고
    • Genetic, structural and functional properties of an IgG DNA-binding monoclonal anti-body from a lupus patient with nephritis
    • Ravirajan CT, Rahman MA, Papadaki L, et al. Genetic, structural and functional properties of an IgG DNA-binding monoclonal anti-body from a lupus patient with nephritis. Eur J Immunol 1998; 29(1): 339-50.
    • (1998) Eur J Immunol , vol.29 , Issue.1 , pp. 339-350
    • Ravirajan, C.T.1    Rahman, M.A.2    Papadaki, L.3
  • 10
    • 0035060979 scopus 로고    scopus 로고
    • Lupus anti-DNA autoantibodies cross-react with a glomerular structural protein: A case for tissue injury by molecular mimicry
    • Mostoslavsky G, Fischel R, Yachimovich N, et al. Lupus anti-DNA autoantibodies cross-react with a glomerular structural protein: a case for tissue injury by molecular mimicry. Eur J Immunol 2001; 31(4): 1221-7.
    • (2001) Eur J Immunol , vol.31 , Issue.4 , pp. 1221-1227
    • Mostoslavsky, G.1    Fischel, R.2    Yachimovich, N.3
  • 11
    • 0028074657 scopus 로고
    • Mutational analysis of an autoantibody: Differential binding and pathogenicity
    • Katz JB, Limpanasithikul W, Diamond B. Mutational analysis of an autoantibody: differential binding and pathogenicity. J Exp Med 1994; 180(3): 925-32.
    • (1994) J Exp Med , vol.180 , Issue.3 , pp. 925-932
    • Katz, J.B.1    Limpanasithikul, W.2    Diamond, B.3
  • 12
    • 0023841089 scopus 로고
    • Circulating DNA and lupus nephritis
    • Fournie GJ. Circulating DNA and lupus nephritis. Kidney Int 1988; 33(2): 487-97.
    • (1988) Kidney Int , vol.33 , Issue.2 , pp. 487-497
    • Fournie, G.J.1
  • 13
    • 1442274798 scopus 로고    scopus 로고
    • Anti-DNA antibody subpopulations and hipus nephritis
    • Rekvig OP, Kalaaji M, Nossent H. Anti-DNA antibody subpopulations and hipus nephritis. Autoimmun Rev 2004; 3(2): 1-6.
    • (2004) Autoimmun Rev , vol.3 , Issue.2 , pp. 1-6
    • Rekvig, O.P.1    Kalaaji, M.2    Nossent, H.3
  • 14
    • 0029899083 scopus 로고    scopus 로고
    • Nephritogenic autoantibodies in lupus: Current concepts and continuing controversies
    • Lefkowith JB, Gilkeson GS. Nephritogenic autoantibodies in lupus: current concepts and continuing controversies. Arthritis Rheum 1996; 39(6): 894-903.
    • (1996) Arthritis Rheum , vol.39 , Issue.6 , pp. 894-903
    • Lefkowith, J.B.1    Gilkeson, G.S.2
  • 15
    • 0028015572 scopus 로고
    • Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo
    • Kramers C, Hylkema MN, van Bruggen MC, et al. Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo. J Clin Invest 1994; 94(2): 568-77.
    • (1994) J Clin Invest , vol.94 , Issue.2 , pp. 568-577
    • Kramers, C.1    Hylkema, M.N.2    van Bruggen, M.C.3
  • 16
    • 0030971352 scopus 로고    scopus 로고
    • Antigen specificity of anti-nuclear antibodies complexed to nucleosomes determines glomerular basement membrane binding in vivo
    • van Bruggen MC, Walgreen B, Rijke TP, et al. Antigen specificity of anti-nuclear antibodies complexed to nucleosomes determines glomerular basement membrane binding in vivo. Eur J Immunol 1997; 27(6): 1564-9.
    • (1997) Eur J Immunol , vol.27 , Issue.6 , pp. 1564-1569
    • van Bruggen, M.C.1    Walgreen, B.2    Rijke, T.P.3
  • 17
    • 33744756400 scopus 로고    scopus 로고
    • Nephritogenic lupus antibodies recognize glomerular basement membrane-associated chromatin fragments released from apoptotic intraglomerular cells
    • Kalaaji M, Mortensen E, Jorgensen L, Olsen R, Rekvig OP. Nephritogenic lupus antibodies recognize glomerular basement membrane-associated chromatin fragments released from apoptotic intraglomerular cells. Am J Pathol 2006; 168(6): 1779-92.
    • (2006) Am J Pathol , vol.168 , Issue.6 , pp. 1779-1792
    • Kalaaji, M.1    Mortensen, E.2    Jorgensen, L.3    Olsen, R.4    Rekvig, O.P.5
  • 18
    • 26844529249 scopus 로고    scopus 로고
    • Treatment with a laminin-derived peptide suppresses lupus nephritis
    • Amital H, Heilweil M, Ulmansky R, et al. Treatment with a laminin-derived peptide suppresses lupus nephritis. J Immunol 2005; 175(8): 5516-23.
    • (2005) J Immunol , vol.175 , Issue.8 , pp. 5516-5523
    • Amital, H.1    Heilweil, M.2    Ulmansky, R.3
  • 19
    • 0037087262 scopus 로고    scopus 로고
    • Alpha-actinin is a cross-reactive renal target for pathogenic anti-DNA antibodies
    • Deocharan B, Qing Y, Lichauco J. Putterman C. Alpha-actinin is a cross-reactive renal target for pathogenic anti-DNA antibodies. J Immunol 2002; 168(6): 3072-8.
    • (2002) J Immunol , vol.168 , Issue.6 , pp. 3072-3078
    • Deocharan, B.1    Qing, Y.2    Lichauco, J.3    Putterman, C.4
  • 20
    • 0024559855 scopus 로고
    • A murine nephritogenic monoclonal anti-DNA autoantibody binds directly to mouse laminin, the major non-collagenous protein component of the glomerular basement membrane
    • Sabbaga J, Line SR, Potocnjak P, Madaio MP. A murine nephritogenic monoclonal anti-DNA autoantibody binds directly to mouse laminin, the major non-collagenous protein component of the glomerular basement membrane. Eur J Immunol 1989; 19(1): 137-43.
    • (1989) Eur J Immunol , vol.19 , Issue.1 , pp. 137-143
    • Sabbaga, J.1    Line, S.R.2    Potocnjak, P.3    Madaio, M.P.4
  • 21
    • 33344458573 scopus 로고    scopus 로고
    • International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
    • Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4(2): 295-306.
    • (2006) J Thromb Haemost , vol.4 , Issue.2 , pp. 295-306
    • Miyakis, S.1    Lockshin, M.D.2    Atsumi, T.3
  • 22
    • 0024427029 scopus 로고
    • Antiphospholipid antibodies and the antiphospholipid syndrome in systemic lupus erythematosus. A prospective analysis of 500 consecutive patients
    • Alarcon-Segovia D, Deleze M. Oria CV, et al. Antiphospholipid antibodies and the antiphospholipid syndrome in systemic lupus erythematosus. A prospective analysis of 500 consecutive patients. Medicine (Baltimore) 1989; 68(6): 353-65.
    • (1989) Medicine (Baltimore) , vol.68 , Issue.6 , pp. 353-365
    • Alarcon-Segovia, D.1    Deleze, M.2    Oria, C.V.3
  • 23
    • 8944227500 scopus 로고    scopus 로고
    • Libman-Sacks endocarditis in the antiphospholipid syndrome: Immunopathologic findings in deformed heart valves
    • Ziporen L, Goldberg I, Arad M, et al. Libman-Sacks endocarditis in the antiphospholipid syndrome: immunopathologic findings in deformed heart valves. Lupus 1996; 5(3): 196-205.
    • (1996) Lupus , vol.5 , Issue.3 , pp. 196-205
    • Ziporen, L.1    Goldberg, I.2    Arad, M.3
  • 24
    • 0033060155 scopus 로고    scopus 로고
    • Valvular deposition of antiphospholipid antibodies in the antiphospholipid syndrome: A clue to the origin of the disease
    • Amital H, Langevitz P, Levy Y, et al. Valvular deposition of antiphospholipid antibodies in the antiphospholipid syndrome: a clue to the origin of the disease. Clin Exp Rheumatol 1999; 17(1): 99-102.
    • (1999) Clin Exp Rheumatol , vol.17 , Issue.1 , pp. 99-102
    • Amital, H.1    Langevitz, P.2    Levy, Y.3
  • 26
    • 0033832202 scopus 로고    scopus 로고
    • Functional analyses of patient-derived IgG monoclonal anticardiolipin antibodies using in vivo thrombosis and in vivo microcirculation models
    • Pierangeli SS, Liu X, Espinola R, et al. Functional analyses of patient-derived IgG monoclonal anticardiolipin antibodies using in vivo thrombosis and in vivo microcirculation models. Thromb Haemost 2000; 84(3): 388-95.
    • (2000) Thromb Haemost , vol.84 , Issue.3 , pp. 388-395
    • Pierangeli, S.S.1    Liu, X.2    Espinola, R.3
  • 27
    • 9144243607 scopus 로고    scopus 로고
    • Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation
    • Girardi G, Redecha P, Salmon JE. Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation. Nat Med 2004; 10(11): 1222-6.
    • (2004) Nat Med , vol.10 , Issue.11 , pp. 1222-1226
    • Girardi, G.1    Redecha, P.2    Salmon, J.E.3
  • 28
    • 0346969977 scopus 로고    scopus 로고
    • Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome
    • Girardi G, Berman J, Redecha P, et al. Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome. J Clin Invest 2003; 112(11): 1644-54.
    • (2003) J Clin Invest , vol.112 , Issue.11 , pp. 1644-1654
    • Girardi, G.1    Berman, J.2    Redecha, P.3
  • 29
    • 0036839070 scopus 로고    scopus 로고
    • Complement activation as a mediator of antiphospholipid antibody induced pregnancy loss and thrombosis
    • ii46-50
    • Salmon JE, Girardi G, Holers VM. Complement activation as a mediator of antiphospholipid antibody induced pregnancy loss and thrombosis. Ann Rheum Dis 2002; 61 Suppl 2: ii46-50.
    • (2002) Ann Rheum Dis , vol.61 , Issue.SUPPL. 2
    • Salmon, J.E.1    Girardi, G.2    Holers, V.M.3
  • 30
    • 0037528699 scopus 로고    scopus 로고
    • Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies
    • Raschi E, Testoni C, Bosisio D, et al. Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies. Blood 2003; 101(9): 3495-500.
    • (2003) Blood , vol.101 , Issue.9 , pp. 3495-3500
    • Raschi, E.1    Testoni, C.2    Bosisio, D.3
  • 31
    • 33746741718 scopus 로고    scopus 로고
    • Antiphosphohpid antibodies and the antiphospholipid syndrome: An update on treatment and pathogenic mechanisms
    • Pierangeli SS, Chen PP, Gonzalez EB. Antiphosphohpid antibodies and the antiphospholipid syndrome: an update on treatment and pathogenic mechanisms. Curr Opin Hematol 2006; 13(5): 366-75.
    • (2006) Curr Opin Hematol , vol.13 , Issue.5 , pp. 366-375
    • Pierangeli, S.S.1    Chen, P.P.2    Gonzalez, E.B.3
  • 32
    • 33846243719 scopus 로고    scopus 로고
    • Current concepts on the pathogenesis of the antiphospholipid syndrome
    • Giannakopoulos B, Passam F, Rahgozar S, Krilis SA. Current concepts on the pathogenesis of the antiphospholipid syndrome. Blood 2007; 109(2): 422-30.
    • (2007) Blood , vol.109 , Issue.2 , pp. 422-430
    • Giannakopoulos, B.1    Passam, F.2    Rahgozar, S.3    Krilis, S.A.4
  • 33
    • 0025905663 scopus 로고
    • Natural autoantibodies: From 'horror autotoxicus' to 'gnothi seauton'
    • Avrameas S. Natural autoantibodies: from 'horror autotoxicus' to 'gnothi seauton'. Immunol Today 1991; 12(5): 154-9.
    • (1991) Immunol Today , vol.12 , Issue.5 , pp. 154-159
    • Avrameas, S.1
  • 34
    • 0034599499 scopus 로고    scopus 로고
    • Deficiency in serum immunoglobutin (Ig)M predisposes to development of IgG autoantibodies
    • Ehrenstein MR, Cook HT, Neuberger MS. Deficiency in serum immunoglobutin (Ig)M predisposes to development of IgG autoantibodies. J Exp Med 2000; 191(7): 1253-8.
    • (2000) J Exp Med , vol.191 , Issue.7 , pp. 1253-1258
    • Ehrenstein, M.R.1    Cook, H.T.2    Neuberger, M.S.3
  • 35
    • 0021885638 scopus 로고
    • Detection of cross-reactive anti-DNA antibody idiotypes in the semin of systemic lupus erythematosus patients and of their relatives
    • Isenberg DA, Shoenfeld Y, Walport M, et al. Detection of cross-reactive anti-DNA antibody idiotypes in the semin of systemic lupus erythematosus patients and of their relatives. Arthritis Rheum 1985; 28(9): 999-1007.
    • (1985) Arthritis Rheum , vol.28 , Issue.9 , pp. 999-1007
    • Isenberg, D.A.1    Shoenfeld, Y.2    Walport, M.3
  • 36
    • 0027463332 scopus 로고
    • Significance of enzyme linked immunosorbent assay (ELISA) for antibodies to double stranded and single stranded DNA in patients with lupus nephritis: Correlation with severity of renal histology
    • Okamura. M, Kanayama Y, Amastu K, et al. Significance of enzyme linked immunosorbent assay (ELISA) for antibodies to double stranded and single stranded DNA in patients with lupus nephritis: correlation with severity of renal histology. Ann Rheum Dis 1993; 52(1): 14-20.
    • (1993) Ann Rheum Dis , vol.52 , Issue.1 , pp. 14-20
    • Okamura, M.1    Kanayama, Y.2    Amastu, K.3
  • 37
    • 0027422315 scopus 로고
    • Anticardiolipin antibodies and dependence of a serum cofactor. A mechanism of thrombosis
    • Ordi J, Selva A, Monegal F, Porcel JM, Martinez-Costa X, Vilardell M. Anticardiolipin antibodies and dependence of a serum cofactor. A mechanism of thrombosis. J Rheumatol 1993; 20(8): 1321-4.
    • (1993) J Rheumatol , vol.20 , Issue.8 , pp. 1321-1324
    • Ordi, J.1    Selva, A.2    Monegal, F.3    Porcel, J.M.4    Martinez-Costa, X.5    Vilardell, M.6
  • 38
    • 0025302635 scopus 로고
    • Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor
    • Calli M, Comfurius P, Maassen C, et al. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet 1990; 335(8705): 1544-7.
    • (1990) Lancet , vol.335 , Issue.8705 , pp. 1544-1547
    • Calli, M.1    Comfurius, P.2    Maassen, C.3
  • 39
    • 0025332717 scopus 로고
    • Antiphospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: Beta 2-glycoprotein I (apolipoprotein H)
    • McNeil HP, Simpson RJ, Chesterman CN, Krilis SA. Antiphospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H). Proc Natl Acad Sci USA 1990; 87(11): 4120-4.
    • (1990) Proc Natl Acad Sci USA , vol.87 , Issue.11 , pp. 4120-4124
    • McNeil, H.P.1    Simpson, R.J.2    Chesterman, C.N.3    Krilis, S.A.4
  • 40
    • 0037386632 scopus 로고    scopus 로고
    • Specificities, properties, and clinical significance of antiprothrombin antibodies
    • Amengual O, Atsumi T, Koike T. Specificities, properties, and clinical significance of antiprothrombin antibodies. Arthritis Rheum 2003; 48(4): 886-95.
    • (2003) Arthritis Rheum , vol.48 , Issue.4 , pp. 886-895
    • Amengual, O.1    Atsumi, T.2    Koike, T.3
  • 41
    • 0035893021 scopus 로고    scopus 로고
    • Identification of anti-thrombin intibodies in the antiphospholipid syndrome that interfere with the inactivation pf thrombin by antithrombin
    • Hwang KK, Grossman JM, Visvanathan S, et al. Identification of anti-thrombin intibodies in the antiphospholipid syndrome that interfere with the inactivation pf thrombin by antithrombin. J Immunol 2001; 167(12): 7192-8.
    • (2001) J Immunol , vol.167 , Issue.12 , pp. 7192-7198
    • Hwang, K.K.1    Grossman, J.M.2    Visvanathan, S.3
  • 42
    • 0033711669 scopus 로고    scopus 로고
    • Association of autoantibodies against the phosphatidylserine-prothrombia complex with manifestations of the antiphospholipid syndrome and with the presence of lupus anticoagulant
    • Atsumi T, Ieko M, Bertolaccini ML, et al. Association of autoantibodies against the phosphatidylserine-prothrombia complex with manifestations of the antiphospholipid syndrome and with the presence of lupus anticoagulant. Arthritis Rheum 2000; 43(9): 1982-93.
    • (2000) Arthritis Rheum , vol.43 , Issue.9 , pp. 1982-1993
    • Atsumi, T.1    Ieko, M.2    Bertolaccini, M.L.3
  • 43
    • 0032217240 scopus 로고    scopus 로고
    • Anti-beta2 glycoprotein I (beta2GPI) autoantibodies recognize an epitope on the first domain of beta2GPI
    • Iverson GM, Victoria EJ, Marquis DM. Anti-beta2 glycoprotein I (beta2GPI) autoantibodies recognize an epitope on the first domain of beta2GPI. Proc Natl Acad Sci USA 1998; 95(26): 15542-6.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.26 , pp. 15542-15546
    • Iverson, G.M.1    Victoria, E.J.2    Marquis, D.M.3
  • 44
    • 0037114142 scopus 로고    scopus 로고
    • Use of single point mutations in domain I of beta 2-glycoprotein I to determine fine antigenic specificity of antiphospholipid autoantibodies
    • Iverson GM, Reddel S, Victoria EJ, et al. Use of single point mutations in domain I of beta 2-glycoprotein I to determine fine antigenic specificity of antiphospholipid autoantibodies. J Immunol 2002; 169(12): 7097-103.
    • (2002) J Immunol , vol.169 , Issue.12 , pp. 7097-7103
    • Iverson, G.M.1    Reddel, S.2    Victoria, E.J.3
  • 45
    • 33344456904 scopus 로고    scopus 로고
    • Pathogenic anti-beta2-glycoprotein I antibodies recognize domain I of beta2-glycoprotein I only after a conformational change
    • de Laat B, Derksen RH, van Lummel M, Pennings MT, de Groot PG. Pathogenic anti-beta2-glycoprotein I antibodies recognize domain I of beta2-glycoprotein I only after a conformational change. Blood 2006; 107(5): 1916-24.
    • (2006) Blood , vol.107 , Issue.5 , pp. 1916-1924
    • de Laat, B.1    Derksen, R.H.2    van Lummel, M.3    Pennings, M.T.4    de Groot, P.G.5
  • 46
    • 33846236309 scopus 로고    scopus 로고
    • Binding of antiphospholipid antibodies to discontinuous epitopes on domain I of human beta(2)-glycoprotein I: Mutation studies including residues R39 to R43
    • Ioannou Y, Pericleous C, Giles I, Latchman DS, Isenberg DA, Rahman A. Binding of antiphospholipid antibodies to discontinuous epitopes on domain I of human beta(2)-glycoprotein I: mutation studies including residues R39 to R43. Arthritis Rheum 2007; 56(1): 280-90.
    • (2007) Arthritis Rheum , vol.56 , Issue.1 , pp. 280-290
    • Ioannou, Y.1    Pericleous, C.2    Giles, I.3    Latchman, D.S.4    Isenberg, D.A.5    Rahman, A.6
  • 47
    • 0042574000 scopus 로고    scopus 로고
    • How do antiphospholipid antibodies bind beta2-glycoprotein I?
    • Giles IP, Isenberg DA, Latchman DS, Rahman A. How do antiphospholipid antibodies bind beta2-glycoprotein I? Arthritis Rheum 2003; 48(8): 2111-21.
    • (2003) Arthritis Rheum , vol.48 , Issue.8 , pp. 2111-2121
    • Giles, I.P.1    Isenberg, D.A.2    Latchman, D.S.3    Rahman, A.4
  • 48
    • 0004750551 scopus 로고    scopus 로고
    • Guidelines on the Investigation and management of the antiphospholipid syndrome
    • Greaves M, Cohen H, MacHin SJ, Mackie I. Guidelines on the Investigation and management of the antiphospholipid syndrome. Br J Haematol 2000; 109(4): 704-15.
    • (2000) Br J Haematol , vol.109 , Issue.4 , pp. 704-715
    • Greaves, M.1    Cohen, H.2    MacHin, S.J.3    Mackie, I.4
  • 49
    • 0016245886 scopus 로고
    • The three dimensional structure of a combining region-ligand complex of immunoglobulin NEW at 3.5-A resolution
    • Amzel LM, Poljak RJ, Saul F, Varga JM, Richards FF. The three dimensional structure of a combining region-ligand complex of immunoglobulin NEW at 3.5-A resolution. Proc Natl Acad Sci USA 1974; 71(4): 1427-30.
    • (1974) Proc Natl Acad Sci USA , vol.71 , Issue.4 , pp. 1427-1430
    • Amzel, L.M.1    Poljak, R.J.2    Saul, F.3    Varga, J.M.4    Richards, F.F.5
  • 50
    • 0014828908 scopus 로고
    • An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity
    • Wu TT, Kabat EA. An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity. J Exp Med 1970; 132(2): 211-50.
    • (1970) J Exp Med , vol.132 , Issue.2 , pp. 211-250
    • Wu, T.T.1    Kabat, E.A.2
  • 51
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa S. Somatic generation of antibody diversity. Nature 1983; 302(5909): 575-81.
    • (1983) Nature , vol.302 , Issue.5909 , pp. 575-581
    • Tonegawa, S.1
  • 52
    • 33748491516 scopus 로고    scopus 로고
    • Structure and function of autoantibodies and their role in autoimmune diseases
    • Rahman A, Giles I. Structure and function of autoantibodies and their role in autoimmune diseases. Expert Rev Clin Immunol 2006; 2: 225-236.
    • (2006) Expert Rev Clin Immunol , vol.2 , pp. 225-236
    • Rahman, A.1    Giles, I.2
  • 56
    • 0028292951 scopus 로고
    • Genetic and structural evidence for antigen selection of anti-DNA antibodies
    • Radic MZ, Weigert M. Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu Rev Immunol 1994; 12: 487-520.
    • (1994) Annu Rev Immunol , vol.12 , pp. 487-520
    • Radic, M.Z.1    Weigert, M.2
  • 57
    • 0036954862 scopus 로고    scopus 로고
    • Systematic analysis of sequences of anti-DNA antibodies-relevance to theories of origin and pathogenicity
    • Rahman A, Giles I, Haley J, Isenberg D. Systematic analysis of sequences of anti-DNA antibodies-relevance to theories of origin and pathogenicity. Lupus 2002; 11(12): 807-23.
    • (2002) Lupus , vol.11 , Issue.12 , pp. 807-823
    • Rahman, A.1    Giles, I.2    Haley, J.3    Isenberg, D.4
  • 59
    • 0027787933 scopus 로고
    • Utilization of the VH4-21 gene segment by anti-DNA antibodies from patients with systemic lupus erythematosus
    • Stevenson FK, Longhurst C, Chapman CJ, et al. Utilization of the VH4-21 gene segment by anti-DNA antibodies from patients with systemic lupus erythematosus. J Autoimmun 1993; 6(6): 809-25.
    • (1993) J Autoimmun , vol.6 , Issue.6 , pp. 809-825
    • Stevenson, F.K.1    Longhurst, C.2    Chapman, C.J.3
  • 60
    • 0029897521 scopus 로고    scopus 로고
    • Functional and modelling studies of the binding of human monoclonal anti-DNA antibodies to DNA
    • Kalsi JK, Martin AC, Hirabayashi Y, et al. Functional and modelling studies of the binding of human monoclonal anti-DNA antibodies to DNA. Mol Immunol 1996; 33(4-5): 471-83.
    • (1996) Mol Immunol , vol.33 , Issue.4-5 , pp. 471-483
    • Kalsi, J.K.1    Martin, A.C.2    Hirabayashi, Y.3
  • 61
    • 0036773056 scopus 로고    scopus 로고
    • Molecular and genetic characterizations of five pathogenic and two non-pathogenic monoclonal antiphospholipid antibodies
    • Chukwuocha RU, Zhu M, Cho CS, et al. Molecular and genetic characterizations of five pathogenic and two non-pathogenic monoclonal antiphospholipid antibodies. Mol Immunol 2002; 39(5-6): 299-311.
    • (2002) Mol Immunol , vol.39 , Issue.5-6 , pp. 299-311
    • Chukwuocha, R.U.1    Zhu, M.2    Cho, C.S.3
  • 62
    • 0043198210 scopus 로고    scopus 로고
    • Relative importance of different human aPL derived heavy and light chains in the binding of aPL to cardiolipin
    • Giles IP, Haley J, Nagl S, et al. Relative importance of different human aPL derived heavy and light chains in the binding of aPL to cardiolipin. Mol Immunol 2003; 40(1): 49-60.
    • (2003) Mol Immunol , vol.40 , Issue.1 , pp. 49-60
    • Giles, I.P.1    Haley, J.2    Nagl, S.3
  • 63
    • 0028797990 scopus 로고
    • DNA mimics a self-protein that may be a target for some anti-DNA antibodies in systemic lupus erythematosus
    • Zack DJ, Yamamoto K, Wong AL, Stempniak M, French C, Weisbart RH. DNA mimics a self-protein that may be a target for some anti-DNA antibodies in systemic lupus erythematosus. J Immunol 1995; 154(4): 1987-94.
    • (1995) J Immunol , vol.154 , Issue.4 , pp. 1987-1994
    • Zack, D.J.1    Yamamoto, K.2    Wong, A.L.3    Stempniak, M.4    French, C.5    Weisbart, R.H.6
  • 64
    • 33746210258 scopus 로고    scopus 로고
    • Arginine residues are important in determining the binding of human monoclonal antiphospholipid antibodies to clinically relevant antigens
    • Gilew I, Lambrianides N, Pattni N, et al. Arginine residues are important in determining the binding of human monoclonal antiphospholipid antibodies to clinically relevant antigens. J Immunol 2006; 177(3): 1729-36.
    • (2006) J Immunol , vol.177 , Issue.3 , pp. 1729-1736
    • Gilew, I.1    Lambrianides, N.2    Pattni, N.3
  • 65
    • 0345016363 scopus 로고    scopus 로고
    • Chromatin specificity of anti-double-stranded DNA antibodies and a role for Arg residues in the third complementarity-determining region of the heavy chain
    • Guth AM, Zhang X, Smith D, Detanico T, Wysocki LJ. Chromatin specificity of anti-double-stranded DNA antibodies and a role for Arg residues in the third complementarity-determining region of the heavy chain. J Immunol 2003; 171(11): 6260-6.
    • (2003) J Immunol , vol.171 , Issue.11 , pp. 6260-6266
    • Guth, A.M.1    Zhang, X.2    Smith, D.3    Detanico, T.4    Wysocki, L.J.5
  • 66
    • 0031038715 scopus 로고    scopus 로고
    • An integrated vector system for the eukaryotic expression of antibodies or their fragments after selection from phage display libraries
    • Persic L, Roberts A, Wilton J, Cattaneo A, Bradbury A, Hoogenboom HR. An integrated vector system for the eukaryotic expression of antibodies or their fragments after selection from phage display libraries. Gene 1997; 187(1): 9-18.
    • (1997) Gene , vol.187 , Issue.1 , pp. 9-18
    • Persic, L.1    Roberts, A.2    Wilton, J.3    Cattaneo, A.4    Bradbury, A.5    Hoogenboom, H.R.6
  • 67
    • 0036949846 scopus 로고    scopus 로고
    • Molecular expression systems for anti-DNA antibodies-1
    • Rahman A, Haley J, Batchman DS. Molecular expression systems for anti-DNA antibodies-1. Lupus 2002; 11(12): 824-32.
    • (2002) Lupus , vol.11 , Issue.12 , pp. 824-832
    • Rahman, A.1    Haley, J.2    Batchman, D.S.3
  • 69
    • 0035896020 scopus 로고    scopus 로고
    • The importance of somatic mutations in the V(lambda) gene 2a2 in human monoclonal anti-DNA antibodies
    • Rahman A, Haley J, Radway-Bright E, et al. The importance of somatic mutations in the V(lambda) gene 2a2 in human monoclonal anti-DNA antibodies. J Mol Biol 2001; 307(1): 149-60.
    • (2001) J Mol Biol , vol.307 , Issue.1 , pp. 149-160
    • Rahman, A.1    Haley, J.2    Radway-Bright, E.3
  • 70
    • 34547405325 scopus 로고    scopus 로고
    • Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome
    • Lambrianides A, Giles I, Ioannou Y, et al. Arginine mutation alters binding of a human monoclonal antibody to antigens linked to systemic lupus erythematosus and the antiphospholipid syndrome. Arthritis Rheum 2007; 56(7); 2392-2401.
    • (2007) Arthritis Rheum , vol.56 , Issue.7 , pp. 2392-2401
    • Lambrianides, A.1    Giles, I.2    Ioannou, Y.3
  • 71
    • 33645070833 scopus 로고    scopus 로고
    • The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin
    • Giles I, Lambrianides N, Latchman D, et al. The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin. Arthritis Res Ther 2005; 7(1): R47-56.
    • (2005) Arthritis Res Ther , vol.7 , Issue.1
    • Giles, I.1    Lambrianides, N.2    Latchman, D.3
  • 72
    • 33645743830 scopus 로고    scopus 로고
    • Stable expression of a recombinant human antinucleosome antibody to investigate relationships between antibody sequence, binding properties, and pathogenicity
    • Mason LJ, Lambrianides A, Haley JD, et al. Stable expression of a recombinant human antinucleosome antibody to investigate relationships between antibody sequence, binding properties, and pathogenicity. Arthritis Res Ther 2005; 7(5): R971-83.
    • (2005) Arthritis Res Ther , vol.7 , Issue.5
    • Mason, L.J.1    Lambrianides, A.2    Haley, J.D.3
  • 73
    • 39449119868 scopus 로고    scopus 로고
    • The light chain of a human monoclonal antiphospholipid antibody has a dramatic influence on its functional properties in an in vivo mouse model
    • Giles I, Liu X, M. N-W, et al. The light chain of a human monoclonal antiphospholipid antibody has a dramatic influence on its functional properties in an in vivo mouse model. Arthritis Rheum 2006; 54: S559.
    • (2006) Arthritis Rheum , vol.54
    • Giles, I.1    Liu, X.2    N-W, M.3
  • 74
    • 24144501267 scopus 로고    scopus 로고
    • SLE-a disease of clearance deficiency?
    • Munoz LE, Gaipl US, Franz S, et al. SLE-a disease of clearance deficiency? Rheumatology (Oxford) 2005; 44(9): 1101-7.
    • (2005) Rheumatology (Oxford) , vol.44 , Issue.9 , pp. 1101-1107
    • Munoz, L.E.1    Gaipl, U.S.2    Franz, S.3
  • 75
    • 0031838606 scopus 로고    scopus 로고
    • Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus
    • Herrmann M, Voll RE, Zoller OM, Hagenhofer M, Ponner BB, Kalden JR. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998; 41(7): 1241-50.
    • (1998) Arthritis Rheum , vol.41 , Issue.7 , pp. 1241-1250
    • Herrmann, M.1    Voll, R.E.2    Zoller, O.M.3    Hagenhofer, M.4    Ponner, B.B.5    Kalden, J.R.6
  • 76
    • 0028288510 scopus 로고
    • Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes
    • Casciola-Rosen LA, Anhalt G, Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994; 179(4): 1317-30.
    • (1994) J Exp Med , vol.179 , Issue.4 , pp. 1317-1330
    • Casciola-Rosen, L.A.1    Anhalt, G.2    Rosen, A.3
  • 77
    • 0036644073 scopus 로고    scopus 로고
    • Blebs and apoptotic bodies are B cell autoantigens
    • Cocca BA, Cline AM, Padic MZ. Blebs and apoptotic bodies are B cell autoantigens. J Immunol 2002; 169(1): 159-66.
    • (2002) J Immunol , vol.169 , Issue.1 , pp. 159-166
    • Cocca, B.A.1    Cline, A.M.2    Padic, M.Z.3
  • 78
    • 0035923534 scopus 로고    scopus 로고
    • Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells
    • Cocca BA, Seal SN, D'Agnillo P, et al. Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells. Proc Natl Acad Sci USA 2001; 98(24): 13826-31.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.24 , pp. 13826-13831
    • Cocca, B.A.1    Seal, S.N.2    D'Agnillo, P.3
  • 79
    • 33644951517 scopus 로고    scopus 로고
    • A novel expression system of domain I of human beta2 glycoprotein I in Escherichia coli
    • Ioannou Y, Giles I, Lambrianides A, et al. A novel expression system of domain I of human beta2 glycoprotein I in Escherichia coli. BMC Biotechnol 2006; 8.
    • (2006) BMC Biotechnol , pp. 8
    • Ioannou, Y.1    Giles, I.2    Lambrianides, A.3


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