The NADPH oxidase inhibitor DPI can abolish hypoxia-induced apoptosis of human kidney proximal tubular epithelial cells through Bcl2 up-regulation via ERK activation without ROS reduction

Life Sciences

Volumn 126, Issue , 2015, Pages 69-75

  Song, Hyunkeun ^a   Han, Il Yong ^a   Kim, Yeonye ^a   Kim, Young Hwan ^a   Choi, Il Whan ^a   Seo, Su Kil ^a   Jung, So Young ^a   Park, SaeGwang ^a   Kang, Mi Seon ^a  

^a Inje University   (South Korea)

Author keywords

Antioxidant; Apoptosis; Cell viability; Human renal proximal tubular epithelial cells; NADPH oxidase inhibitor; Reactive oxygen species; Renal ischemia reperfusion injury

Indexed keywords

3,3' DIINDOLYLMETHANE; ACETYLCYSTEINE; CAFFEIC ACID PHENETHYL ESTER; DIPHENYLIODONIUM SALT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; OXIDOREDUCTASE INHIBITOR; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; YCG 063; ANTIMUTAGENIC AGENT; BAX PROTEIN, HUMAN; BCL2 PROTEIN, HUMAN; CATION; COBALT; COBALT CHLORIDE; PROTEIN BAX; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

APOPTOSIS; ARTICLE; CELL VIABILITY; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; EXPERIMENTAL HYPOXIA; HUMAN; HUMAN CELL; ISCHEMIA; KIDNEY EPITHELIUM; KIDNEY PROXIMAL TUBULE; PROTEIN EXPRESSION; REPERFUSION INJURY; UPREGULATION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL HYPOXIA; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; ENZYME ACTIVATION; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ANTIMUTAGENIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL HYPOXIA; CELL LINE; CELL SURVIVAL; COBALT; ENZYME ACTIVATION; EPITHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; KIDNEY TUBULES, PROXIMAL; MAP KINASE SIGNALING SYSTEM; NADPH OXIDASE; ONIUM COMPOUNDS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; UP-REGULATION;

EID: 84924290361     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2015.02.004     Document Type: Article

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