Biodistribution and translational pharmacokinetic modeling of a human recombinant alkaline phosphatase

International Journal of Pharmaceutics

Volumn 495, Issue 1, 2015, Pages 122-131

  Peters, Esther ^a   Stevens, Jasper ^b   Arend, Jacques ^c   Guan, Zheng ^b   Raaben, Willem ^c   Laverman, Peter ^a   Elsas, Andrea Van ^c   Masereeuw, Rosalinde ^a,d   Pickkers, Peter ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b CENTRE FOR HUMAN DRUG RESEARCH   (Netherlands)

^c AM Pharma   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Acute kidney injury; Alkaline phosphatase; Biodistribution; NONMEM; Pharmacokinetics; Sepsis

Indexed keywords

IODINE 125; RECOMBINANT CHIMERIC ALKALINE PHOSPHATASE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; ALKALINE PHOSPHATASE; LIPOPOLYSACCHARIDE; RADIOACTIVE IODINE; RECOMBINANT PROTEIN;

ACUTE KIDNEY FAILURE; ALLOMETRY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; COLORIMETRY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; ENDOTOXEMIA; ENZYME ACTIVITY; HUMAN; ISOTOPE LABELING; LIMIT OF QUANTITATION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; REPEATED DRUG DOSE; SINGLE DRUG DOSE; THIN LAYER CHROMATOGRAPHY; TIME TO MAXIMUM PLASMA CONCENTRATION; TISSUE DISTRIBUTION; TREATMENT DURATION; VOLUME OF DISTRIBUTION; VOLUME OF DISTRIBUTION AT STEADY-STATE; ANIMAL; BIOLOGICAL MODEL; BLOOD; CHEMICALLY INDUCED; DIAGNOSTIC IMAGING; DOSE RESPONSE; MINIPIG; PIG; SCINTISCANNING;

ACUTE KIDNEY INJURY; ALKALINE PHOSPHATASE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IODINE RADIOISOTOPES; LIPOPOLYSACCHARIDES; MODELS, BIOLOGICAL; RADIONUCLIDE IMAGING; RATS; RECOMBINANT PROTEINS; SWINE; SWINE, MINIATURE; TISSUE DISTRIBUTION;

EID: 84940948168     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.08.090     Document Type: Article

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