Strategies to interfere with PDZ-mediated interactions in neurons: What we can learn from the rabies virus

Progress in Biophysics and Molecular Biology

Volumn 119, Issue 1, 2015, Pages 53-59

  Caillet Saguy, Célia ^a   Maisonneuve, Pierre ^a   Delhommel, Florent ^a,b   Terrien, Elouan ^a   Babault, Nicolas ^a   Lafon, Monique ^a   Cordier, Florence ^a   Wolff, Nicolas ^a  

^a INSTITUT PASTEUR   (France)

^b SORBONNE UNIVERSITÉ   (France)

Author keywords

Enzymatic regulation; Neuronal signaling; Neurons; PDZ domain; Phosphorylation; Rabies virus

Indexed keywords

NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 4; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE;

AMINO ACID SEQUENCE; ANIMAL; CYTOLOGY; ENZYMOLOGY; HUMAN; METABOLISM; MOLECULAR GENETICS; NERVE CELL; PDZ DOMAIN; PHYSIOLOGY; RABIES VIRUS; VIROLOGY;

AMINO ACID SEQUENCE; ANIMALS; HUMANS; MOLECULAR SEQUENCE DATA; NEURONS; PDZ DOMAINS; PROTEIN BINDING; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 4; PROTEIN-SERINE-THREONINE KINASES; RABIES VIRUS;

EID: 84940895214     PISSN: 00796107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbiomolbio.2015.02.007     Document Type: Review

References (36)

1. Babault N., Cordier F., Lafage M., Cockburn J., Haouz A., Prehaud C., Rey F.A., Delepierre M., Buc H., Lafon M., Wolff N. Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death. Structure 2011, 19:1518-1524.
2. Bard L., Groc L. Glutamate receptor dynamics and protein interaction: lessons from the NMDA receptor. Mol. Cell. Neurosci. 2011, 48:298-307.
3. Boerkoel C.F., Takashima H., Bacino C.A., Daentl D., Lupski J.R. EGR2 mutation R359W causes a spectrum of Dejerine-Sottas neuropathy. Neurogenetics 2001, 3:153-157.
4. Bunney T.D., Katan M. Phosphoinositide signalling in cancer: beyond PI3K and PTEN. Nat. Rev. Cancer 2010, 10:342-352.
5. Chang N., El-Hayek Y.H., Gomez E., Wan Q. Phosphatase PTEN in neuronal injury and brain disorders. Trends Neurosci. 2007, 30:581-586.
6. Cho K.O., Hunt C.A., Kennedy M.B. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron 1992, 9:929-942.
7. Cordier F., Chaffotte A., Terrien E., Prehaud C., Theillet F.X., Delepierre M., Lafon M., Buc H., Wolff N. Ordered phosphorylation events in two independent cascades of the PTEN C-tail revealed by NMR. J. Am. Chem. Soc. 2012, 134:20533-20543.
8. Cordier F., Chaffotte A., Wolff N. Quantitative and dynamic analysis of PTEN phosphorylation by NMR. Methods 2014, 10.1016/j.ymeth.2014.10.007.
9. Davey N.E., Trave G., Gibson T.J. How viruses hijack cell regulation. Trends Biochem. Sci. 2011, 36:159-169.
10. Doyle D.A., Lee A., Lewis J., Kim E., Sheng M., MacKinnon R. Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell 1996, 85:1067-1076.
11. Feng W., Zhang M. Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density. Nat. Rev. Neurosci. 2009, 10:87-99.
12. Garland L.L., Rankin C., Gandara D.R., Rivkin S.E., Scott K.M., Nagle R.B., Klein-Szanto A.J., Testa J.R., Altomare D.A., Borden E.C. Phase II study of erlotinib in patients with malignant pleural mesothelioma: a southwest oncology group study. J. Clin. Oncol. 2007, 25:2406-2413.
13. Griffin R.J., Moloney A., Kelliher M., Johnston J.A., Ravid R., Dockery P., O'Connor R., O'Neill C. Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J. Neurochem. 2005, 93:105-117.
14. Hou S.W., Zhi H.Y., Pohl N., Loesch M., Qi X.M., Li R.S., Basir Z., Chen G. PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction. Cancer Res. 2010, 70:2901-2910.
15. Javier R.T., Rice A.P. Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses. J. Virol. 2011, 85:11544-11556.
16. Khan Z., Lafon M. PDZ domain-mediated protein interactions: therapeutic targets in neurological disorders. Curr. Med. Chem. 2014, 21:2632-2641.
17. Kim E., Sheng M. PDZ domain proteins of synapses. Nat. Rev. Neurosci. 2004, 5:771-781.
18. Lafon M. Evasive strategies in rabies virus infection. Adv. Virus Res. 2011, 79:33-53.
19. Leslie N.R., Maccario H., Spinelli L., Davidson L. The significance of PTEN's protein phosphatase activity. Adv. Enzyme Regul. 2009, 49:190-196.
20. Li J., Yen C., Liaw D., Podsypanina K., Bose S., Wang S.I., Puc J., Miliaresis C., Rodgers L., McCombie R., Bigner S.H., Giovanella B.C., Ittmann M., Tycko B., Hibshoosh H., Wigler M.H., Parsons R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997, 275:1943-1947.
21. Loh S.H., Francescut L., Lingor P., Bahr M., Nicotera P. Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen. Cell. Death Differ. 2008, 15:283-298.
22. Maisonneuve P., Caillet-Saguy C., Raynal B., Gilquin B., Chaffotte A., Perez J., Zinn-Justin S., Delepierre M., Buc H., Cordier F., Wolff N. Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain. FEBS J. 2014, 281:4852-4865.
23. Nourry C., Grant S.G., Borg J.P. PDZ domain proteins: plug and play!. Sci. STKE 2003, 2003:RE7.
24. Prehaud C., Lay S., Dietzschold B., Lafon M. Glycoprotein of nonpathogenic rabies viruses is a key determinant of human cell apoptosis. J. Virol. 2003, 77:10537-10547.
25. Prehaud C., Wolff N., Terrien E., Lafage M., Megret F., Babault N., Cordier F., Tan G.S., Maitrepierre E., Menager P., Chopy D., Hoos S., England P., Delepierre M., Schnell M.J., Buc H., Lafon M. Attenuation of rabies virulence: takeover by the cytoplasmic domain of its envelope protein. Sci. Signal. 2010, 3:ra5.
26. Rahdar M., Inoue T., Meyer T., Zhang J., Vazquez F., Devreotes P.N. A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:480-485.
27. Steck P.A., Pershouse M.A., Jasser S.A., Yung W.K., Lin H., Ligon A.H., Langford L.A., Baumgard M.L., Hattier T., Davis T., Frye C., Hu R., Swedlund B., Teng D.H., Tavtigian S.V. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet. 1997, 15:356-362.
28. Terrien E., Chaffotte A., Lafage M., Khan Z., Prehaud C., Cordier F., Simenel C., Delepierre M., Buc H., Lafon M., Wolff N. Interference with the PTEN-MAST2 interaction by a viral protein leads to cellular relocalization of PTEN. Sci. Signal. 2012, 5:ra58.
29. Thoulouze M.I., Lafage M., Schachner M., Hartmann U., Cremer H., Lafon M. The neural cell adhesion molecule is a receptor for rabies virus. J. Virol. 1998, 72:7181-7190.
30. Valiente M., Andres-Pons A., Gomar B., Torres J., Gil A., Tapparel C., Antonarakis S.E., Pulido R. Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases. J. Biol. Chem. 2005, 280:28936-28943.
31. Vazquez F., Grossman S.R., Takahashi Y., Rokas M.V., Nakamura N., Sellers W.R. Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex. J. Biol. Chem. 2001, 276:48627-48630.
32. Vazquez F., Ramaswamy S., Nakamura N., Sellers W.R. Phosphorylation of the PTEN tail regulates protein stability and function. Mol. Cell. Biol. 2000, 20:5010-5018.
33. Ventruti A., Kazdoba T.M., Niu S., D'Arcangelo G. Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. Neuroscience 2011, 189:32-42.
34. Verpy E., Leibovici M., Zwaenepoel I., Liu X.Z., Gal A., Salem N., Mansour A., Blanchard S., Kobayashi I., Keats B.J., Slim R., Petit C. A defect in harmonin, a PDZ domain-containing protein expressed in the inner ear sensory hair cells, underlies Usher syndrome type 1C. Nat. Genet. 2000, 26:51-55.
35. Wang C.K., Pan L., Chen J., Zhang M. Extensions of PDZ domains as important structural and functional elements. Protein Cell. 2010, 1:737-751.
36. Weatheritt R.J., Luck K., Petsalaki E., Davey N.E., Gibson T.J. The identification of short linear motif-mediated interfaces within the human interactome. Bioinformatics 2012, 28:976-982.