Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain

FEBS Journal

Volumn 281, Issue 21, 2014, Pages 4852-4865

  Maisonneuve, Pierre ^a,b   Caillet Saguy, Célia ^a   Raynal, Bertrand ^a   Gilquin, Bernard ^c   Chaffotte, Alain ^a   Pérez, Javier ^d   Zinn Justin, Sophie ^c   Delepierre, Muriel ^a   Buc, Henri ^a   Cordier, Florence ^a   Wolff, Nicolas ^a  

^a INSTITUT PASTEUR   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c Laboratoire de Biologie Structurale et Radiobiologie   (France)

^d SYNCHROTRON SOLEIL   (France)

Author keywords

Enzymology; Intramolecular regulation; PDZ domain; Protein dynamics; Protein tyrosine phosphatase

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 12; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 4; HYBRID PROTEIN; LIGAND; PEPTIDE FRAGMENT; PROTEIN BINDING; PTPN4 PROTEIN, HUMAN; SOLUTION AND SOLUBILITY;

ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; MICHAELIS MENTEN KINETICS; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR WEIGHT; NITROGEN NUCLEAR MAGNETIC RESONANCE; PDZ DOMAIN; PHOSPHATASE DOMAIN; PROTEIN DEPHOSPHORYLATION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ULTRACENTRIFUGATION; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; KINETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE; PROTEIN CONFORMATION; SMALL ANGLE SCATTERING; SOLUTION AND SOLUBILITY; X RAY DIFFRACTION;

CATALYSIS; HUMANS; KINETICS; LIGANDS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PDZ DOMAINS; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 4; RECOMBINANT FUSION PROTEINS; SCATTERING, SMALL ANGLE; SIGNAL TRANSDUCTION; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; X-RAY DIFFRACTION;

EID: 84915759490     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.13024     Document Type: Article

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