메뉴 건너뛰기




Volumn 10, Issue 3, 2015, Pages 311-324

Treatment of advanced thyroid cancer: role of molecularly targeted therapies

Author keywords

Molecularly targeted therapies; Multi kinase inhibitors; Thyroid cancer

Indexed keywords

AXITINIB; BORTEZOMIB; CABOZANTINIB; CARBOPLATIN; CISPLATIN; COMBRETASTATIN A4 PHOSPHATE; CROLIBULIN; EVEROLIMUS; IMATINIB; LENVATINIB; LIVER ENZYME; MITOGEN ACTIVATED PROTEIN KINASE; MOTESANIB; PACLITAXEL; PAZOPANIB; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PROTEIN RET; PROTEIN TYROSINE KINASE INHIBITOR; RADIOACTIVE IODINE; SELUMETINIB; SORAFENIB; SUNITINIB; TIPIFARNIB; VANDETANIB; VASCULOTROPIN; ANILIDE; ANTINEOPLASTIC AGENT; CARBANILAMIDE DERIVATIVE; IMETELSTAT; IMIDAZOLE DERIVATIVE; INDAZOLE DERIVATIVE; INDOLE DERIVATIVE; N-(4-BROMO-2-FLUOROPHENYL)-6-METHOXY-7-((1-METHYLPIPERIDIN-4-YL)METHOXY)QUINAZOLIN-4-AMINE; NICOTINAMIDE; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE; QUINAZOLINE DERIVATIVE; QUINOLINE DERIVATIVE; RET PROTEIN, HUMAN; SULFONAMIDE; VASCULOTROPIN A;

EID: 84940894311     PISSN: 17762596     EISSN: 1776260X     Source Type: Journal    
DOI: 10.1007/s11523-014-0331-z     Document Type: Review
Times cited : (19)

References (79)
  • 1
    • 84892805731 scopus 로고    scopus 로고
    • Cancer statistics, 2014
    • PID: 24399786
    • Siegel R, Ma J, Zou Z, Jemal A (2014) Cancer statistics, 2014. CA Cancer J Clin 64(1):9–29. doi:10.3322/caac.21208
    • (2014) CA Cancer J Clin , vol.64 , Issue.1 , pp. 9-29
    • Siegel, R.1    Ma, J.2    Zou, Z.3    Jemal, A.4
  • 3
    • 78649946814 scopus 로고    scopus 로고
    • Analysis of the rising incidence of thyroid cancer using the Surveillance, Epidemiology and End Results national cancer data registry
    • PID: 21134545, discussion 1152-1143
    • Cramer JD, Fu P, Harth KC, Margevicius S, Wilhelm SM (2010) Analysis of the rising incidence of thyroid cancer using the Surveillance, Epidemiology and End Results national cancer data registry. Surgery 148(6):1147–1152. doi:10.1016/j.surg.2010.10.016, discussion 1152-1143
    • (2010) Surgery , vol.148 , Issue.6 , pp. 1147-1152
    • Cramer, J.D.1    Fu, P.2    Harth, K.C.3    Margevicius, S.4    Wilhelm, S.M.5
  • 7
    • 0032535770 scopus 로고    scopus 로고
    • A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995 [see comments]
    • COI: 1:STN:280:DyaK1M%2FovFylug%3D%3D, PID: 9874472
    • Hundahl SA, Fleming ID, Fremgen AM, Menck HR (1998) A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995 [see comments]. Cancer 83(12):2638–2648
    • (1998) Cancer , vol.83 , Issue.12 , pp. 2638-2648
    • Hundahl, S.A.1    Fleming, I.D.2    Fremgen, A.M.3    Menck, H.R.4
  • 8
    • 0037425748 scopus 로고    scopus 로고
    • Thyroid carcinoma
    • PID: 12583960
    • Sherman SI (2003) Thyroid carcinoma. Lancet 361(9356):501–511
    • (2003) Lancet , vol.361 , Issue.9356 , pp. 501-511
    • Sherman, S.I.1
  • 10
    • 33645307434 scopus 로고    scopus 로고
    • Pathogenetic mechanisms in thyroid follicular-cell neoplasia
    • COI: 1:CAS:528:DC%2BD28XivVyqsbg%3D, PID: 16557281
    • Kondo T, Ezzat S, Asa SL (2006) Pathogenetic mechanisms in thyroid follicular-cell neoplasia. Nat Rev Cancer 6(4):292–306. doi:10.1038/nrc1836
    • (2006) Nat Rev Cancer , vol.6 , Issue.4 , pp. 292-306
    • Kondo, T.1    Ezzat, S.2    Asa, S.L.3
  • 11
    • 77954762933 scopus 로고    scopus 로고
    • Cytotoxic chemotherapy for differentiated thyroid carcinoma
    • COI: 1:STN:280:DC%2BC3cnovFehtw%3D%3D
    • Sherman SI (2010) Cytotoxic chemotherapy for differentiated thyroid carcinoma. Clin Oncol 22(6):464–468. doi:10.1016/j.clon.2010.03.014
    • (2010) Clin Oncol , vol.22 , Issue.6 , pp. 464-468
    • Sherman, S.I.1
  • 12
    • 56649105350 scopus 로고    scopus 로고
    • Molecular pathology of thyroid cancer: diagnostic and clinical implications
    • COI: 1:CAS:528:DC%2BD1cXhsVeksrbL, PID: 19041825
    • Fagin JA, Mitsiades N (2008) Molecular pathology of thyroid cancer: diagnostic and clinical implications. Best Pract Res Clin Endocrinol Metab 22(6):955–969. doi:10.1016/j.beem.2008.09.017
    • (2008) Best Pract Res Clin Endocrinol Metab , vol.22 , Issue.6 , pp. 955-969
    • Fagin, J.A.1    Mitsiades, N.2
  • 13
    • 0024208663 scopus 로고
    • Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains
    • COI: 1:CAS:528:DyaL1MXlt1Oqsbs%3D, PID: 3078962
    • Takahashi M, Buma Y, Iwamoto T, Inaguma Y, Ikeda H, Hiai H (1988) Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene 3(5):571–578
    • (1988) Oncogene , vol.3 , Issue.5 , pp. 571-578
    • Takahashi, M.1    Buma, Y.2    Iwamoto, T.3    Inaguma, Y.4    Ikeda, H.5    Hiai, H.6
  • 14
    • 36448947662 scopus 로고    scopus 로고
    • Neurotrophic factor receptor RET: structure, cell biology, and inherited diseases
    • COI: 1:CAS:528:DC%2BD2sXhtlCltrzN, PID: 17934909
    • Runeberg-Roos P, Saarma M (2007) Neurotrophic factor receptor RET: structure, cell biology, and inherited diseases. Ann Med 39(8):572–580. doi:10.1080/07853890701646256
    • (2007) Ann Med , vol.39 , Issue.8 , pp. 572-580
    • Runeberg-Roos, P.1    Saarma, M.2
  • 17
    • 67349168712 scopus 로고    scopus 로고
    • Correlation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas
    • COI: 1:CAS:528:DC%2BD1MXmsVChtbk%3D, PID: 19401695
    • Moura MM, Cavaco BM, Pinto AE, Domingues R, Santos JR, Cid MO, Bugalho MJ, Leite V (2009) Correlation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas. Br J Cancer 100(11):1777–1783. doi:10.1038/sj.bjc.6605056
    • (2009) Br J Cancer , vol.100 , Issue.11 , pp. 1777-1783
    • Moura, M.M.1    Cavaco, B.M.2    Pinto, A.E.3    Domingues, R.4    Santos, J.R.5    Cid, M.O.6    Bugalho, M.J.7    Leite, V.8
  • 18
    • 0037379904 scopus 로고    scopus 로고
    • High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
    • COI: 1:CAS:528:DC%2BD3sXisFaisLs%3D, PID: 12670889
    • Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA (2003) High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res 63(7):1454–1457
    • (2003) Cancer Res , vol.63 , Issue.7 , pp. 1454-1457
    • Kimura, E.T.1    Nikiforova, M.N.2    Zhu, Z.3    Knauf, J.A.4    Nikiforov, Y.E.5    Fagin, J.A.6
  • 19
    • 27244459732 scopus 로고    scopus 로고
    • Biology of Ras in thyroid cells
    • PID: 16209042
    • Meinkoth JL (2004) Biology of Ras in thyroid cells. Cancer Treat Res 122:131–148
    • (2004) Cancer Treat Res , vol.122 , pp. 131-148
    • Meinkoth, J.L.1
  • 20
    • 65549128212 scopus 로고    scopus 로고
    • Anaplastic thyroid cancer: molecular pathogenesis and emerging therapies
    • COI: 1:CAS:528:DC%2BD1MXptlOiu7o%3D, PID: 18987168
    • Smallridge RC, Marlow LA, Copland JA (2009) Anaplastic thyroid cancer: molecular pathogenesis and emerging therapies. Endocr Relat Cancer 16(1):17–44. doi:10.1677/ERC-08-0154
    • (2009) Endocr Relat Cancer , vol.16 , Issue.1 , pp. 17-44
    • Smallridge, R.C.1    Marlow, L.A.2    Copland, J.A.3
  • 21
    • 33847072340 scopus 로고    scopus 로고
    • RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis
    • COI: 1:CAS:528:DC%2BD2sXitlWgu7Y%3D, PID: 16946010
    • Ciampi R, Nikiforov YE (2007) RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis. Endocrinology 148(3):936–941. doi:10.1210/en.2006-0921
    • (2007) Endocrinology , vol.148 , Issue.3 , pp. 936-941
    • Ciampi, R.1    Nikiforov, Y.E.2
  • 22
    • 34548192281 scopus 로고    scopus 로고
    • The prevalence and prognostic value of BRAF mutation in thyroid cancer
    • PID: 17717450, discussion 470-461
    • Kebebew E, Weng J, Bauer J, Ranvier G, Clark OH, Duh QY, Shibru D, Bastian B, Griffin A (2007) The prevalence and prognostic value of BRAF mutation in thyroid cancer. Ann Surg 246(3):466–470. doi:10.1097/SLA.0b013e318148563d, discussion 470-461
    • (2007) Ann Surg , vol.246 , Issue.3 , pp. 466-470
    • Kebebew, E.1    Weng, J.2    Bauer, J.3    Ranvier, G.4    Clark, O.H.5    Duh, Q.Y.6    Shibru, D.7    Bastian, B.8    Griffin, A.9
  • 23
    • 21244457181 scopus 로고    scopus 로고
    • BRAF mutation in thyroid cancer
    • COI: 1:CAS:528:DC%2BD2MXnsl2ntLw%3D, PID: 15947100
    • Xing M (2005) BRAF mutation in thyroid cancer. Endocr Relat Cancer 12(2):245–262. doi:10.1677/erc.1.0978
    • (2005) Endocr Relat Cancer , vol.12 , Issue.2 , pp. 245-262
    • Xing, M.1
  • 24
    • 53749086690 scopus 로고    scopus 로고
    • BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study
    • COI: 1:CAS:528:DC%2BD1cXht1Gmur3O, PID: 18682506
    • Elisei R, Ugolini C, Viola D, Lupi C, Biagini A, Giannini R, Romei C, Miccoli P, Pinchera A, Basolo F (2008) BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study. J Clin Endocrinol Metab 93(10):3943–3949. doi:10.1210/jc.2008-0607
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.10 , pp. 3943-3949
    • Elisei, R.1    Ugolini, C.2    Viola, D.3    Lupi, C.4    Biagini, A.5    Giannini, R.6    Romei, C.7    Miccoli, P.8    Pinchera, A.9    Basolo, F.10
  • 26
    • 77950921126 scopus 로고    scopus 로고
    • The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors
    • COI: 1:CAS:528:DC%2BC3cXksVamurY%3D, PID: 19897009
    • Saji M, Ringel MD (2010) The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors. Mol Cell Endocrinol 321(1):20–28. doi:10.1016/j.mce.2009.10.016
    • (2010) Mol Cell Endocrinol , vol.321 , Issue.1 , pp. 20-28
    • Saji, M.1    Ringel, M.D.2
  • 27
    • 66349098309 scopus 로고    scopus 로고
    • Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1
    • COI: 1:CAS:528:DC%2BD1MXmsFGksrg%3D, PID: 19487299
    • Ricarte-Filho JC, Ryder M, Chitale DA, Rivera M, Heguy A, Ladanyi M, Janakiraman M, Solit D, Knauf JA, Tuttle RM, Ghossein RA, Fagin JA (2009) Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1. Cancer Res 69(11):4885–4893. doi:10.1158/0008-5472.CAN-09-0727
    • (2009) Cancer Res , vol.69 , Issue.11 , pp. 4885-4893
    • Ricarte-Filho, J.C.1    Ryder, M.2    Chitale, D.A.3    Rivera, M.4    Heguy, A.5    Ladanyi, M.6    Janakiraman, M.7    Solit, D.8    Knauf, J.A.9    Tuttle, R.M.10    Ghossein, R.A.11    Fagin, J.A.12
  • 28
    • 0034729805 scopus 로고    scopus 로고
    • PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1
    • COI: 1:CAS:528:DC%2BD3cXlt1Wisr0%3D, PID: 10918569
    • Bruni P, Boccia A, Baldassarre G, Trapasso F, Santoro M, Chiappetta G, Fusco A, Viglietto G (2000) PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1. Oncogene 19(28):3146–3155. doi:10.1038/sj.onc.1203633
    • (2000) Oncogene , vol.19 , Issue.28 , pp. 3146-3155
    • Bruni, P.1    Boccia, A.2    Baldassarre, G.3    Trapasso, F.4    Santoro, M.5    Chiappetta, G.6    Fusco, A.7    Viglietto, G.8
  • 30
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • COI: 1:CAS:528:DC%2BD2MXhtlSksrnI, PID: 16355214
    • Ferrara N, Kerbel RS (2005) Angiogenesis as a therapeutic target. Nature 438(7070):967–974. doi:10.1038/nature04483
    • (2005) Nature , vol.438 , Issue.7070 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 31
    • 33846227109 scopus 로고    scopus 로고
    • Targeting BRAF in thyroid cancer
    • COI: 1:CAS:528:DC%2BD2sXis1KgtA%3D%3D, PID: 17179987
    • Espinosa AV, Porchia L, Ringel MD (2007) Targeting BRAF in thyroid cancer. Br J Cancer 96(1):16–20. doi:10.1038/sj.bjc.6603520
    • (2007) Br J Cancer , vol.96 , Issue.1 , pp. 16-20
    • Espinosa, A.V.1    Porchia, L.2    Ringel, M.D.3
  • 32
    • 30744455269 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in thyroid cancers
    • COI: 1:CAS:528:DC%2BD28XkvFyqsA%3D%3D, PID: 16398617
    • Lin JD, Chao TC (2005) Vascular endothelial growth factor in thyroid cancers. Cancer Biother Radiopharm 20(6):648–661. doi:10.1089/cbr.2005.20.648
    • (2005) Cancer Biother Radiopharm , vol.20 , Issue.6 , pp. 648-661
    • Lin, J.D.1    Chao, T.C.2
  • 33
    • 77955298957 scopus 로고    scopus 로고
    • Increased expression of vascular endothelial growth factor and its receptors, VEGFR-1 and VEGFR-2, in medullary thyroid carcinoma
    • COI: 1:CAS:528:DC%2BC3cXpsF2gs7o%3D
    • Capp C, Wajner SM, Siqueira DR, Brasil BA, Meurer L, Maia AL (2010) Increased expression of vascular endothelial growth factor and its receptors, VEGFR-1 and VEGFR-2, in medullary thyroid carcinoma. Thyroid Off J Am Thyroid Assoc 20(8):863–871. doi:10.1089/thy.2009.0417
    • (2010) Thyroid Off J Am Thyroid Assoc , vol.20 , Issue.8 , pp. 863-871
    • Capp, C.1    Wajner, S.M.2    Siqueira, D.R.3    Brasil, B.A.4    Meurer, L.5    Maia, A.L.6
  • 34
    • 0028868639 scopus 로고
    • Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PlGF) associated with malignancy in human thyroid tumors and cell lines
    • COI: 1:CAS:528:DyaK2MXptVymt7Y%3D, PID: 7478581
    • Viglietto G, Maglione D, Rambaldi M, Cerutti J, Romano A, Trapasso F, Fedele M, Ippolito P, Chiappetta G, Botti G et al (1995) Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PlGF) associated with malignancy in human thyroid tumors and cell lines. Oncogene 11(8):1569–1579
    • (1995) Oncogene , vol.11 , Issue.8 , pp. 1569-1579
    • Viglietto, G.1    Maglione, D.2    Rambaldi, M.3    Cerutti, J.4    Romano, A.5    Trapasso, F.6    Fedele, M.7    Ippolito, P.8    Chiappetta, G.9    Botti, G.10
  • 38
    • 84867527699 scopus 로고    scopus 로고
    • Long-term analysis of the efficacy and tolerability of sorafenib in advanced radio-iodine refractory differentiated thyroid carcinoma: final results of a phase II trial
    • COI: 1:CAS:528:DC%2BC38XhslSmsLnE
    • Schneider TC, Abdulrahman RM, Corssmit EP, Morreau H, Smit JW, Kapiteijn E (2012) Long-term analysis of the efficacy and tolerability of sorafenib in advanced radio-iodine refractory differentiated thyroid carcinoma: final results of a phase II trial. Eur J Endocrinol Eur Fed Endocr Soc 167(5):643–650. doi:10.1530/EJE-12-0405
    • (2012) Eur J Endocrinol Eur Fed Endocr Soc , vol.167 , Issue.5 , pp. 643-650
    • Schneider, T.C.1    Abdulrahman, R.M.2    Corssmit, E.P.3    Morreau, H.4    Smit, J.W.5    Kapiteijn, E.6
  • 42
    • 78049462514 scopus 로고    scopus 로고
    • Phase II study of daily sunitinib in FDG-PET-positive, iodine-refractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlation
    • COI: 1:CAS:528:DC%2BC3cXhtl2rsLrF
    • Carr LL, Mankoff DA, Goulart BH, Eaton KD, Capell PT, Kell EM, Bauman JE, Martins RG (2010) Phase II study of daily sunitinib in FDG-PET-positive, iodine-refractory differentiated thyroid cancer and metastatic medullary carcinoma of the thyroid with functional imaging correlation. Clin Cancer Res Off J Am Assoc Cancer Res 16(21):5260–5268. doi:10.1158/1078-0432.CCR-10-0994
    • (2010) Clin Cancer Res Off J Am Assoc Cancer Res , vol.16 , Issue.21 , pp. 5260-5268
    • Carr, L.L.1    Mankoff, D.A.2    Goulart, B.H.3    Eaton, K.D.4    Capell, P.T.5    Kell, E.M.6    Bauman, J.E.7    Martins, R.G.8
  • 54
    • 65249127575 scopus 로고    scopus 로고
    • Cutaneous squamous cell carcinoma and inflammation of actinic keratoses associated with sorafenib
    • COI: 1:CAS:528:DC%2BD1MXjslKqs7w%3D, PID: 19213663
    • Dubauskas Z, Kunishige J, Prieto VG, Jonasch E, Hwu P, Tannir NM (2009) Cutaneous squamous cell carcinoma and inflammation of actinic keratoses associated with sorafenib. Clin Genitourin Cancer 7(1):20–23. doi:10.3816/CGC.2009.n.003
    • (2009) Clin Genitourin Cancer , vol.7 , Issue.1 , pp. 20-23
    • Dubauskas, Z.1    Kunishige, J.2    Prieto, V.G.3    Jonasch, E.4    Hwu, P.5    Tannir, N.M.6
  • 56
    • 84883811272 scopus 로고    scopus 로고
    • Antitumor activities of the targeted multi-tyrosine kinase inhibitor lenvatinib (E7080) against RET gene fusion-driven tumor models
    • COI: 1:CAS:528:DC%2BC3sXhtFygtb7M, PID: 23856031
    • Okamoto K, Kodama K, Takase K, Sugi NH, Yamamoto Y, Iwata M, Tsuruoka A (2013) Antitumor activities of the targeted multi-tyrosine kinase inhibitor lenvatinib (E7080) against RET gene fusion-driven tumor models. Cancer Lett 340(1):97–103. doi:10.1016/j.canlet.2013.07.007
    • (2013) Cancer Lett , vol.340 , Issue.1 , pp. 97-103
    • Okamoto, K.1    Kodama, K.2    Takase, K.3    Sugi, N.H.4    Yamamoto, Y.5    Iwata, M.6    Tsuruoka, A.7
  • 57
    • 33749544080 scopus 로고    scopus 로고
    • An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases
    • COI: 1:CAS:528:DC%2BD28XhtFSjtbrN, PID: 16849418
    • Kim DW, Jo YS, Jung HS, Chung HK, Song JH, Park KC, Park SH, Hwang JH, Rha SY, Kweon GR, Lee SJ, Jo KW, Shong M (2006) An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases. J Clin Endocrinol Metab 91(10):4070–4076. doi:10.1210/jc.2005-2845
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.10 , pp. 4070-4076
    • Kim, D.W.1    Jo, Y.S.2    Jung, H.S.3    Chung, H.K.4    Song, J.H.5    Park, K.C.6    Park, S.H.7    Hwang, J.H.8    Rha, S.Y.9    Kweon, G.R.10    Lee, S.J.11    Jo, K.W.12    Shong, M.13
  • 64
    • 77954478933 scopus 로고    scopus 로고
    • Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • COI: 1:CAS:528:DC%2BC3cXnvVaks7o%3D, PID: 20371662
    • Robinson BG, Paz-Ares L, Krebs A, Vasselli J, Haddad R (2010) Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Endocrinol Metab 95(6):2664–2671. doi:10.1210/jc.2009-2461
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.6 , pp. 2664-2671
    • Robinson, B.G.1    Paz-Ares, L.2    Krebs, A.3    Vasselli, J.4    Haddad, R.5
  • 72
  • 73
    • 29644434934 scopus 로고    scopus 로고
    • Inhibition of ABL tyrosine kinase potentiates radiation-induced terminal growth arrest in anaplastic thyroid cancer cells
    • COI: 1:CAS:528:DC%2BD28XhsVOlsA%3D%3D, PID: 16392960
    • Podtcheko A, Ohtsuru A, Namba H, Saenko V, Starenki D, Palona I, Sedliarou I, Rogounovitch T, Yamashita S (2006) Inhibition of ABL tyrosine kinase potentiates radiation-induced terminal growth arrest in anaplastic thyroid cancer cells. Radiat Res 165(1):35–42
    • (2006) Radiat Res , vol.165 , Issue.1 , pp. 35-42
    • Podtcheko, A.1    Ohtsuru, A.2    Namba, H.3    Saenko, V.4    Starenki, D.5    Palona, I.6    Sedliarou, I.7    Rogounovitch, T.8    Yamashita, S.9
  • 78
    • 84890548123 scopus 로고    scopus 로고
    • Phase I/II trial of crolibulin and cisplatin in solid tumors with a focus on anaplastic thyroid cancer: phase I results
    • Gramza AW, Balasubramaniam S, Fojo AT, Ward J, Wells SA (2013) Phase I/II trial of crolibulin and cisplatin in solid tumors with a focus on anaplastic thyroid cancer: phase I results. ASCO Meet Abstr 31(15_suppl):6074
    • (2013) ASCO Meet Abstr , vol.31 , pp. 6074
    • Gramza, A.W.1    Balasubramaniam, S.2    Fojo, A.T.3    Ward, J.4    Wells, S.A.5
  • 79
    • 84891818247 scopus 로고    scopus 로고
    • Pretherapeutic drug evaluation by tumor xenografting in anaplastic thyroid cancer
    • COI: 1:CAS:528:DC%2BC3sXhtVOru7nF, PID: 23845866
    • Wunderlich A, Khoruzhyk M, Roth S, Ramaswamy A, Greene BH, Doll D, Bartsch DK, Hoffmann S (2013) Pretherapeutic drug evaluation by tumor xenografting in anaplastic thyroid cancer. J Surg Res 185(2):676–683. doi:10.1016/j.jss.2013.06.017
    • (2013) J Surg Res , vol.185 , Issue.2 , pp. 676-683
    • Wunderlich, A.1    Khoruzhyk, M.2    Roth, S.3    Ramaswamy, A.4    Greene, B.H.5    Doll, D.6    Bartsch, D.K.7    Hoffmann, S.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.