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Volumn 7, Issue 9, 2015, Pages 3497-3511

Mass spectrometric detection of bacterial protein toxins and their enzymatic activity

Author keywords

Anthrax; Anthrax lethal factor; Botulinum neurotoxin; Botulism; Mass spectrometry

Indexed keywords

BACTERIAL TOXIN; BOTULINUM TOXIN; SYNTAXIN 1A; ANTHRAX TOXIN; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; BOTULINUM TOXIN A; NEUROTOXIN;

EID: 84940871804     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins7093497     Document Type: Article
Times cited : (27)

References (50)
  • 1
    • 0000114030 scopus 로고
    • Identification of Bacteria Using Mass Spectrometry
    • Anhalt, J.P.; Fenselau, C. Identification of Bacteria Using Mass Spectrometry. Anal. Chem. 1975, 47, 219-225.
    • (1975) Anal. Chem , vol.47 , pp. 219-225
    • Anhalt, J.P.1    Fenselau, C.2
  • 4
    • 4444267311 scopus 로고    scopus 로고
    • Structure of heptameric protective antigen bound to an anthrax toxin receptor: A role for receptor in pH-dependent pore formation
    • Lacy, D.B.; Wigelsworth, D.J.; Melnyk, R.A.; Harrison, S.C.; Collier, R.J. Structure of heptameric protective antigen bound to an anthrax toxin receptor: A role for receptor in pH-dependent pore formation. Proc. Natl. Acad. Sci. USA 2004, 101, 13147-13151.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 13147-13151
    • Lacy, D.B.1    Wigelsworth, D.J.2    Melnyk, R.A.3    Harrison, S.C.4    Collier, R.J.5
  • 6
    • 0034672216 scopus 로고    scopus 로고
    • Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor
    • Vitale, G.; Bernardi, L.; Napolitani, G.; Mock, M.; Montecucco, C. Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor. Biochem. J. 2000, 352, 739-745.
    • (2000) Biochem. J , vol.352 , pp. 739-745
    • Vitale, G.1    Bernardi, L.2    Napolitani, G.3    Mock, M.4    Montecucco, C.5
  • 7
    • 0000947082 scopus 로고
    • Anthrax Toxin Edema Factor-A Bacterial Adenylate-Cyclase that Increases Cyclic-Amp Concentrations in Eukaryotic Cells
    • Leppla, S.H. Anthrax Toxin Edema Factor-A Bacterial Adenylate-Cyclase that Increases Cyclic-Amp Concentrations in Eukaryotic Cells. Proc. Natl. Acad. Sci. USA 1982, 79, 3162-3166.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 3162-3166
    • Leppla, S.H.1
  • 9
    • 0037238128 scopus 로고    scopus 로고
    • Anthrax toxins and the host: A story of intimacy
    • Mock, M.; Mignot, T. Anthrax toxins and the host: A story of intimacy. Cell. Microbiol. 2003, 5, 15-23.
    • (2003) Cell. Microbiol , vol.5 , pp. 15-23
    • Mock, M.1    Mignot, T.2
  • 13
    • 0029874232 scopus 로고    scopus 로고
    • Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: Correlation with its blockade of catecholamine release
    • Foran, P.; Lawrence, G.W.; Shone, C.C.; Foster, K.A.; Dolly, J.O. Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilized chromaffin cells: Correlation with its blockade of catecholamine release. Biochemistry 1996, 35, 2630-2636.
    • (1996) Biochemistry , vol.35 , pp. 2630-2636
    • Foran, P.1    Lawrence, G.W.2    Shone, C.C.3    Foster, K.A.4    Dolly, J.O.5
  • 16
    • 0029980484 scopus 로고    scopus 로고
    • Clostridial neurotoxins and substrate proteolysis in intact neurons: Botulinum neurotoxin C acts on synaptosomal-associated protein of 25 kDa
    • Williamson, L.C.; Halpern, J.L.; Montecucco, C.; Brown, J.E.; Neale, E.A. Clostridial neurotoxins and substrate proteolysis in intact neurons: Botulinum neurotoxin C acts on synaptosomal-associated protein of 25 kDa. J. Biol. Chem. 1996, 271, 7694-7699.
    • (1996) J. Biol. Chem , vol.271 , pp. 7694-7699
    • Williamson, L.C.1    Halpern, J.L.2    Montecucco, C.3    Brown, J.E.4    Neale, E.A.5
  • 20
    • 0027241009 scopus 로고
    • Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin
    • Schiavo, G.; Shone, C.C.; Rossetto, O.; Alexander, F.C.; Montecucco, C. Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin. J. Biol. Chem. 1993, 268, 11516-11519.
    • (1993) J. Biol. Chem , vol.268 , pp. 11516-11519
    • Schiavo, G.1    Shone, C.C.2    Rossetto, O.3    Alexander, F.C.4    Montecucco, C.5
  • 23
    • 0037073091 scopus 로고    scopus 로고
    • Characterisation of botulinum toxins type A and B, by matrix-assisted laser desorption ionisation and electrospray mass spectrometry
    • Van Baar, B.L.; Hulst, A.G.; de Jong, A.L.; Wils, E.R. Characterisation of botulinum toxins type A and B, by matrix-assisted laser desorption ionisation and electrospray mass spectrometry. J. Chromatogr. A 2002, 970, 95-115.
    • (2002) J. Chromatogr. A , vol.970 , pp. 95-115
    • Van Baar, B.L.1    Hulst, A.G.2    de Jong, A.L.3    Wils, E.R.4
  • 24
    • 1842555530 scopus 로고    scopus 로고
    • Characterisation of botulinum toxins type C, D, E, and F by matrix-assisted laser desorption ionisation and electrospray mass spectrometry
    • Van Baar, B.L.; Hulst, A.G.; de Jong, A.L.; Wils, E.R. Characterisation of botulinum toxins type C, D, E, and F by matrix-assisted laser desorption ionisation and electrospray mass spectrometry. J. Chromatogr. A 2004, 1035, 97-114.
    • (2004) J. Chromatogr. A , vol.1035 , pp. 97-114
    • Van Baar, B.L.1    Hulst, A.G.2    de Jong, A.L.3    Wils, E.R.4
  • 25
    • 63249104816 scopus 로고    scopus 로고
    • Determination of botulinum toxins after peptic sample pre-treatment by multidimensional nanoscale liquid chromatography and nano-electrospray ion-trap mass spectrometry
    • Klaubert, B.; Vujtovic-Ockenga, N.; Wermter, R.; Schad, K.; von Meyer, L. Determination of botulinum toxins after peptic sample pre-treatment by multidimensional nanoscale liquid chromatography and nano-electrospray ion-trap mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2009, 877, 1084-1092.
    • (2009) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci , vol.877 , pp. 1084-1092
    • Klaubert, B.1    Vujtovic-Ockenga, N.2    Wermter, R.3    Schad, K.4    von Meyer, L.5
  • 26
    • 26444605032 scopus 로고    scopus 로고
    • Detection of botulinum neurotoxin A in a spiked milk sample with subtype identification through toxin proteomics
    • Kalb, S.R.; Goodnough, M.C.; Malizio, C.J.; Pirkle, J.L.; Barr, J.R. Detection of botulinum neurotoxin A in a spiked milk sample with subtype identification through toxin proteomics. Anal. Chem. 2005, 77, 6140-6146.
    • (2005) Anal. Chem , vol.77 , pp. 6140-6146
    • Kalb, S.R.1    Goodnough, M.C.2    Malizio, C.J.3    Pirkle, J.L.4    Barr, J.R.5
  • 27
    • 77950398578 scopus 로고    scopus 로고
    • Multiplex detection of microbial and plant toxins by immunoaffinity enrichment and matrix-assisted laser desorption/ionization mass spectrometry
    • Kull, S.; Pauly, D.; Stormann, B.; Kirchner, S.; Stammler, M.; Dorner, M.B.; Lasch, P.; Naumann, D.; Dorner, B.G. Multiplex detection of microbial and plant toxins by immunoaffinity enrichment and matrix-assisted laser desorption/ionization mass spectrometry. Anal. Chem. 2010, 82, 2916-2924.
    • (2010) Anal. Chem , vol.82 , pp. 2916-2924
    • Kull, S.1    Pauly, D.2    Stormann, B.3    Kirchner, S.4    Stammler, M.5    Dorner, M.B.6    Lasch, P.7    Naumann, D.8    Dorner, B.G.9
  • 28
    • 84861888481 scopus 로고    scopus 로고
    • Subtyping botulinum neurotoxins by sequential multiple endoproteases in-gel digestion coupled with mass spectrometry
    • Wang, D.; Baudys, J.; Rees, J.; Marshall, K.M.; Kalb, S.R.; Parks, B.A.; Nowaczyk, L., II; Pirkle, J.L.; Barr, J.R. Subtyping botulinum neurotoxins by sequential multiple endoproteases in-gel digestion coupled with mass spectrometry. Anal. Chem. 2012, 84, 4652-4658.
    • (2012) Anal. Chem , vol.84 , pp. 4652-4658
    • Wang, D.1    Baudys, J.2    Rees, J.3    Marshall, K.M.4    Kalb, S.R.5    Parks, B.A.6    Nowaczyk, L.7    Pirkle, J.L.8    Barr, J.R.9
  • 29
    • 85027938825 scopus 로고    scopus 로고
    • Characterization of botulinum neurotoxin type A subtypes by immunocapture enrichment and liquid chromatography-tandem mass spectrometry
    • Morineaux, V.; Mazuet, C.; Hilaire, D.; Enche, J.; Popoff, M.R. Characterization of botulinum neurotoxin type A subtypes by immunocapture enrichment and liquid chromatography-tandem mass spectrometry. Anal. Bioanal. Chem. 2015, 407, 5559-5570.
    • (2015) Anal. Bioanal. Chem , vol.407 , pp. 5559-5570
    • Morineaux, V.1    Mazuet, C.2    Hilaire, D.3    Enche, J.4    Popoff, M.R.5
  • 31
    • 77957876488 scopus 로고    scopus 로고
    • Extraction of BoNT/A, /B, /E, and /F with a single, high affinity monoclonal antibody for detection of botulinum neurotoxin by Endopep-MS
    • Kalb, S.R.; Garcia-Rodriguez, C.; Lou, J.; Baudys, J.; Smith, T.J.; Marks, J.D.; Smith, L.A.; Pirkle, J.L.; Barr, J.R. Extraction of BoNT/A, /B, /E, and /F with a single, high affinity monoclonal antibody for detection of botulinum neurotoxin by Endopep-MS. PLoS ONE 2010, 5, e12237.
    • (2010) PLoS ONE , vol.5
    • Kalb, S.R.1    Garcia-Rodriguez, C.2    Lou, J.3    Baudys, J.4    Smith, T.J.5    Marks, J.D.6    Smith, L.A.7    Pirkle, J.L.8    Barr, J.R.9
  • 33
    • 21644452600 scopus 로고    scopus 로고
    • From the mouse to the mass spectrometer: Detection and differentiation of the endoproteinase activities of botulinum neurotoxins A-G by mass spectrometry
    • Boyer, A.E.; Moura, H.; Woolfitt, A.R.; Kalb, S.R.; McWilliams, L.G.; Pavlopoulos, A.; Schmidt, J.G.; Ashley, D.L.; Barr, J.R. From the mouse to the mass spectrometer: Detection and differentiation of the endoproteinase activities of botulinum neurotoxins A-G by mass spectrometry. Anal. Chem. 2005, 77, 3916-3924.
    • (2005) Anal. Chem , vol.77 , pp. 3916-3924
    • Boyer, A.E.1    Moura, H.2    Woolfitt, A.R.3    Kalb, S.R.4    McWilliams, L.G.5    Pavlopoulos, A.6    Schmidt, J.G.7    Ashley, D.L.8    Barr, J.R.9
  • 34
    • 33644933631 scopus 로고    scopus 로고
    • The use of Endopep-MS for the detection of botulinum toxins A, B, E, and F in serum and stool samples
    • Kalb, S.R.; Moura, H.; Boyer, A.E.; McWilliams, L.G.; Pirkle, J.L.; Barr, J.R. The use of Endopep-MS for the detection of botulinum toxins A, B, E, and F in serum and stool samples. Anal. Biochem. 2006, 351, 84-92.
    • (2006) Anal. Biochem , vol.351 , pp. 84-92
    • Kalb, S.R.1    Moura, H.2    Boyer, A.E.3    McWilliams, L.G.4    Pirkle, J.L.5    Barr, J.R.6
  • 35
    • 79952442264 scopus 로고    scopus 로고
    • Improved detection of botulinum neurotoxin type A in stool by mass spectrometry
    • Wang, D.; Baudys, J.; Kalb, S.R.; Barr, J.R. Improved detection of botulinum neurotoxin type A in stool by mass spectrometry. Anal. Biochem. 2011, 412, 67-73.
    • (2011) Anal. Biochem , vol.412 , pp. 67-73
    • Wang, D.1    Baudys, J.2    Kalb, S.R.3    Barr, J.R.4
  • 36
    • 84868708344 scopus 로고    scopus 로고
    • Improved detection of botulinum neurotoxin serotype A by Endopep-MS through peptide substrate modification
    • Wang, D.; Baudys, J.; Ye, Y.M.; Rees, J.C.; Barr, J.R.; Pirkle, J.L.; Kalb, S.R. Improved detection of botulinum neurotoxin serotype A by Endopep-MS through peptide substrate modification. Anal. Biochem. 2013, 432, 115-123.
    • (2013) Anal. Biochem , vol.432 , pp. 115-123
    • Wang, D.1    Baudys, J.2    Ye, Y.M.3    Rees, J.C.4    Barr, J.R.5    Pirkle, J.L.6    Kalb, S.R.7
  • 37
    • 84921483351 scopus 로고    scopus 로고
    • A new peptide substrate for enhanced BoNT/B detection by Endopep-LC-MS-MS/MRM assay
    • Rosen, O.; Feldberg, L.; Gura, S.; Zichel, R. A new peptide substrate for enhanced BoNT/B detection by Endopep-LC-MS-MS/MRM assay. Anal. Biochem. 2015, 473, 7-10.
    • (2015) Anal. Biochem , vol.473 , pp. 7-10
    • Rosen, O.1    Feldberg, L.2    Gura, S.3    Zichel, R.4
  • 38
    • 84937391073 scopus 로고    scopus 로고
    • Enhanced detection of type C botulinum neurotoxin by the Endopep-MS assay through optimization of peptide substrates
    • Wang, D.; Krilich, J.; Baudys, J.; Barr, J.R.; Kalb, S.R. Enhanced detection of type C botulinum neurotoxin by the Endopep-MS assay through optimization of peptide substrates. Bioorg. Med. Chem. 2015, 23, 3667-3673.
    • (2015) Bioorg. Med. Chem , vol.23 , pp. 3667-3673
    • Wang, D.1    Krilich, J.2    Baudys, J.3    Barr, J.R.4    Kalb, S.R.5
  • 39
    • 84908462523 scopus 로고    scopus 로고
    • Optimization of peptide substrates for botulinum neurotoxin E improves detection sensitivity in the Endopep-MS assay
    • Wang, D.; Krilich, J.; Baudys, J.; Barr, J.R.; Kalb, S.R. Optimization of peptide substrates for botulinum neurotoxin E improves detection sensitivity in the Endopep-MS assay. Anal. Biochem. 2015, 468, 15-21.
    • (2015) Anal. Biochem , vol.468 , pp. 15-21
    • Wang, D.1    Krilich, J.2    Baudys, J.3    Barr, J.R.4    Kalb, S.R.5
  • 40
    • 79953111292 scopus 로고    scopus 로고
    • Different substrate recognition requirements for cleavage of synaptobrevin-2 by Clostridium baratii and Clostridium botulinum type F neurotoxins
    • Kalb, S.R.; Baudys, J.; Egan, C.; Smith, T.J.; Smith, L.A.; Pirkle, J.L.; Barr, J.R. Different substrate recognition requirements for cleavage of synaptobrevin-2 by Clostridium baratii and Clostridium botulinum type F neurotoxins. Appl. Environ. Microbiol. 2011, 77, 1301-1318.
    • (2011) Appl. Environ. Microbiol , vol.77 , pp. 1301-1318
    • Kalb, S.R.1    Baudys, J.2    Egan, C.3    Smith, T.J.4    Smith, L.A.5    Pirkle, J.L.6    Barr, J.R.7
  • 46
    • 79952163192 scopus 로고    scopus 로고
    • Comparison of MALDI-TOF-MS and HPLC-ESI-MS/MS for Endopeptidase Activity-Based Quantification of Anthrax Lethal Factor in Serum
    • Kuklenyik, Z.; Boyer, A.E.; Lins, R.; Quinn, C.P.; Gallegos-Candela, M.; Woolfitt, A.; Pirkle, J.L.; Barr, J.R. Comparison of MALDI-TOF-MS and HPLC-ESI-MS/MS for Endopeptidase Activity-Based Quantification of Anthrax Lethal Factor in Serum. Anal. Chem. 2011, 83, 1760-1765.
    • (2011) Anal. Chem , vol.83 , pp. 1760-1765
    • Kuklenyik, Z.1    Boyer, A.E.2    Lins, R.3    Quinn, C.P.4    Gallegos-Candela, M.5    Woolfitt, A.6    Pirkle, J.L.7    Barr, J.R.8


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