From the mouse to the mass spectrometer: Detection and differentiation of the endoproteinase activities of botulinum neurotoxins A-G by mass spectrometry

Analytical Chemistry

Volumn 77, Issue 13, 2005, Pages 3916-3924

  Boyer, Anne E ^a   Moura, Hercules ^a   Woolfitt, Adrian R ^a   Kalb, Suzanne R ^a   McWilliams, Lisa G ^b   Pavlopoulos, Antonis ^a   Schmidt, Jurgen G ^c   Ashley, David L ^a   Barr, John R ^a  

^a NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

^b BATTELLE MEMORIAL INSTITUTE   (United States)

^c LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DETECTION LIMITS; ELECTROSPRAY IONIZATION; MATRIX-ASSISTED LASER DEPOSITION/IONIZATION; NEURONAL TRANSMISSION;

DESORPTION; ENZYMES; IONIZATION; LIQUID CHROMATOGRAPHY; LIVING SYSTEMS STUDIES;

BIOASSAY;

BOTULINUM TOXIN; BOTULINUM TOXIN A; BOTULINUM TOXIN B; BOTULINUM TOXIN C; BOTULINUM TOXIN D; BOTULINUM TOXIN E; BOTULINUM TOXIN F; BOTULINUM TOXIN G; BUFFER; PEPTIDE; PROTEINASE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; DETECTION LIMIT; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SUBSTRATE; LD 50; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MULTIPLEX ASSAY; NEUROTRANSMISSION; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BOTULINUM TOXINS; ENDOPEPTIDASES; MICE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 21644452600     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac050485f     Document Type: Article

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