Improved detection of botulinum neurotoxin serotype A by Endopep-MS through peptide substrate modification

Analytical Biochemistry

Volumn 432, Issue 2, 2013, Pages 115-123

  Wang, Dongxia ^a   Baudys, Jakub ^a   Ye, Yiming ^a   Rees, Jon C ^a   Barr, John R ^a   Pirkle, James L ^a   Kalb, Suzanne R ^a  

^a NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

Author keywords

Botulinum neurotoxin; Detection; Mass spectrometry; Peptide substrate

Indexed keywords

ACETYLATION; ANTIBODIES; ERROR DETECTION; MASS SPECTROMETRY; SUBSTRATES; TOXIC MATERIALS;

AMINO ACID RESIDUES; BIOLOGICAL MATRIXES; BOTULINUM NEUROTOXINS; MULTIPLE SUBSTITUTIONS; PEPTIDE SUBSTRATES; SENSITIVE DETECTION; SPECIFIC CLEAVAGES; SUBSTRATE PEPTIDES;

PEPTIDES;

BOTULINUM TOXIN A; BUFFER;

ACETYLATION; AMIDATION; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; ENDOPEP MASS SPECTROMETRY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN CLEAVAGE; PROTEIN MODIFICATION; SENSITIVITY ANALYSIS;

EID: 84868708344     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2012.09.021     Document Type: Article

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