Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans

Brain, Behavior, and Immunity

Volumn 51, Issue , 2016, Pages 223-229

  Carroll, Judith E ^a   Cole, Steven W ^a,b   Seeman, Teresa E ^b   Breen, Elizabeth C ^a   Witarama, Tuff ^a   Arevalo, Jesusa M G ^b   Ma, Jeffrey ^b   Irwin, Michael R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cellular aging; DNA damage; Gene expression; Inflammation; Older adults; Senescence; Sleep deprivation

Indexed keywords

CHECKPOINT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; NIBRIN; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1;

ADAPTATION; ADULT; AGED; AGING; ARTICLE; BIOACCUMULATION; BLOOD SAMPLING; CELL AGING; CELL CYCLE ARREST; COMMUNITY LIVING; CONTROLLED STUDY; DNA DAMAGE RESPONSE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN EXPERIMENT; LEUKOCYTE; MALE; MICROARRAY ANALYSIS; NORMAL HUMAN; PARTIAL SLEEP DEPRIVATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SENESCENCE; SENESCENCE ASSOCIATED SECRETORY PHENOTYPE; SLEEP DEPRIVATION; BLOOD; DNA DAMAGE; GENETICS; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; PHENOTYPE; TUMOR SUPPRESSOR GENE; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AGING; CELL AGING; DNA DAMAGE; FEMALE; GENES, P16; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PHENOTYPE; SLEEP DEPRIVATION;

EID: 84940871316     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2015.08.024     Document Type: Article

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