Apple polyphenols decrease atherosclerosis and hepatic steatosis in ApoE−/− mice through the ROS/MAPK/NF-κB Pathway

Nutrients

Volumn 7, Issue 8, 2015, Pages 7085-7105

  Xu, Zhe Rong ^a   Li, Jin You ^a   Dong, Xin Wei ^a   Tan, Zhong Ju ^a   Wu, Wei Zhen ^a   Xie, Qiang Min ^a,b   Yang, Yun Mei ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

ApoE mice; Apple polyphenols; Atherosclerosis; Atorvastatin; Hepatic steatosis; Oxidative stress; Vascular inflammation; Western type diet

Indexed keywords

ACYL COENZYME A DESATURASE; ADIPONECTIN; ATORVASTATIN; CATALASE; CD68 ANTIGEN; CHAPERONE; GLUTATHIONE PEROXIDASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; POLYPHENOL DERIVATIVE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; TRIACYLGLYCEROL; VASCULAR CELL ADHESION MOLECULE 1; CCL2 PROTEIN, MOUSE; CD68 PROTEIN, MOUSE; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN; LOW DENSITY LIPOPROTEIN; POLYPHENOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; AORTA ENDOTHELIUM; APPLE; ARTICLE; BODY WEIGHT; CELL ADHESION ASSAY; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FATTY LIVER; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; HYPERLIPIDEMIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFLAMMATORY INFILTRATE; INTRACELLULAR SIGNALING; LIPID METABOLISM; MALE; MONOCYTE; MOUSE; MTT ASSAY; NONHUMAN; OXIDATIVE STRESS; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WESTERN DIET; ANIMAL; ATHEROSCLEROSIS; BLOOD; C57BL MOUSE; CELL ADHESION; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; ENDOTHELIUM CELL; GENETICS; KNOCKOUT MOUSE; LIVER; MALUS; METABOLISM; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; ATHEROSCLEROSIS; CELL ADHESION; CELL LINE; CELL SURVIVAL; CHEMOKINE CCL2; ENDOTHELIAL CELLS; FATTY LIVER; INTERCELLULAR ADHESION MOLECULE-1; LIPOPROTEINS, LDL; LIVER; MALE; MALONDIALDEHYDE; MALUS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OXIDATIVE STRESS; POLYPHENOLS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84940827346     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu7085324     Document Type: Article

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