메뉴 건너뛰기




Volumn 17, Issue 3, 2016, Pages 757-766

Kolliphor® HS 15 Micelles for the Delivery of Coenzyme Q10: Preparation, Characterization, and Stability

Author keywords

coenzyme Q10; Kolliphor HS 15; micelles; preparation; stability

Indexed keywords

UBIDECARENONE; KOLLIPHOR HS 15; MACROGOL DERIVATIVE; MICELLE; STEARIC ACID DERIVATIVE; UBIQUINONE;

EID: 84940826162     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-015-0399-5     Document Type: Article
Times cited : (31)

References (47)
  • 2
    • 0033626607 scopus 로고    scopus 로고
    • Ubiquinone (coenzyme Q10) and complex I in mitochondrial oxidative disorder of Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD3cXns1Grtbs%3D, PID: 11056957
    • Ebadi M, Muralikrishnan D, Pellett LJ, et al. Ubiquinone (coenzyme Q10) and complex I in mitochondrial oxidative disorder of Parkinson’s disease. Proc West Pharmacol Soc. 2000;43:55–63.
    • (2000) Proc West Pharmacol Soc , vol.43 , pp. 55-63
    • Ebadi, M.1    Muralikrishnan, D.2    Pellett, L.J.3
  • 3
    • 0031982317 scopus 로고    scopus 로고
    • Gemfibrozil-induced decrease in serum ubiquinone and α- and γ-tocopherol levels in men with combined hyperlipidaemia
    • COI: 1:CAS:528:DyaK1cXisFOrurk%3D
    • Aberg F, Appelkvist EL, Broijersen A, et al. Gemfibrozil-induced decrease in serum ubiquinone and α- and γ-tocopherol levels in men with combined hyperlipidaemia. Eur J Clin Investig. 1998;28:235–42.
    • (1998) Eur J Clin Investig , vol.28 , pp. 235-242
    • Aberg, F.1    Appelkvist, E.L.2    Broijersen, A.3
  • 4
    • 77958615761 scopus 로고    scopus 로고
    • Differential trafficking of oxidized LDL and oxidized LDL immune complexes in macrophages: impact on oxidative stress
    • Al Gadban MM, Smith KJ, Soodavar F, et al. Differential trafficking of oxidized LDL and oxidized LDL immune complexes in macrophages: impact on oxidative stress. PLoS One. 2010;5:1–10.
    • (2010) PLoS One , vol.5 , pp. 1-10
    • Al Gadban, M.M.1    Smith, K.J.2    Soodavar, F.3
  • 5
    • 1642287689 scopus 로고    scopus 로고
    • Metabolism and function of coenzyme Q
    • Turunen M, Olsson J, Dallner G. Metabolism and function of coenzyme Q. BBA-Biomembr. 2004;1600:171–99.
    • (2004) BBA-Biomembr , vol.1600 , pp. 171-199
    • Turunen, M.1    Olsson, J.2    Dallner, G.3
  • 6
    • 23144437239 scopus 로고    scopus 로고
    • Preparation and characterization of novel coenzyme Q10 Nanoparticles engineered from microemulsion precursors
    • Hsu CH, Cui ZR, et al. Preparation and characterization of novel coenzyme Q10 Nanoparticles engineered from microemulsion precursors. AAPS PharmSciTech. 2003;4:1–12.
    • (2003) AAPS PharmSciTech , vol.4 , pp. 1-12
    • Hsu, C.H.1    Cui, Z.R.2
  • 7
    • 69249217678 scopus 로고    scopus 로고
    • Assembly of Coenzyme Q10 nanostructure resembling nascent discoidal high density lipoprotein particle
    • COI: 1:CAS:528:DC%2BD1MXhtVOisrrM, PID: 19646960
    • Shin JY, Shin JI, Kim JS, et al. Assembly of Coenzyme Q10 nanostructure resembling nascent discoidal high density lipoprotein particle. Biochem Biophys Res Commun. 2009;388:217–21.
    • (2009) Biochem Biophys Res Commun , vol.388 , pp. 217-221
    • Shin, J.Y.1    Shin, J.I.2    Kim, J.S.3
  • 8
    • 34249983625 scopus 로고    scopus 로고
    • Preparation, characterization and evaluation of coenzyme Q10 binary solid dispersions for enhanced solubility and dissolution
    • COI: 1:CAS:528:DC%2BD2sXotFarsbg%3D, PID: 17541177
    • Bhandari KH, Newa M, Kim JA, et al. Preparation, characterization and evaluation of coenzyme Q10 binary solid dispersions for enhanced solubility and dissolution. Biol Pharm Bull. 2007;30:1171–6.
    • (2007) Biol Pharm Bull , vol.30 , pp. 1171-1176
    • Bhandari, K.H.1    Newa, M.2    Kim, J.A.3
  • 9
    • 37249049215 scopus 로고    scopus 로고
    • Purified and surfactant-free coenzyme Q10-loaded biodegradable nanoparticles
    • COI: 1:CAS:528:DC%2BD2sXhsVGlurvP, PID: 17692482
    • Nehilla BJ, Bergkvist M, Popat KC, et al. Purified and surfactant-free coenzyme Q10-loaded biodegradable nanoparticles. Int J Pharm. 2008;348:107–14.
    • (2008) Int J Pharm , vol.348 , pp. 107-114
    • Nehilla, B.J.1    Bergkvist, M.2    Popat, K.C.3
  • 10
    • 79960556005 scopus 로고    scopus 로고
    • Oral bioava ilability, therapeutic efficacy and reactive oxygen species scavenging properties of coenzyme Q10-loaded polymeric nanoparticles
    • COI: 1:CAS:528:DC%2BC3MXpt1artLc%3D, PID: 21704368
    • Swarnakar NK, Jain AK, Singh RP, et al. Oral bioava ilability, therapeutic efficacy and reactive oxygen species scavenging properties of coenzyme Q10-loaded polymeric nanoparticles. Biomaterials. 2011;32:6860–74.
    • (2011) Biomaterials , vol.32 , pp. 6860-6874
    • Swarnakar, N.K.1    Jain, A.K.2    Singh, R.P.3
  • 11
    • 0037121041 scopus 로고    scopus 로고
    • Preparation and characterization of coenzyme Q10-loaded PMMA nanoparticles by a new emulsification process based on microfluidization
    • COI: 1:CAS:528:DC%2BD38XntF2ktLc%3D
    • Kwon SS, Nam YS, Lee JS, et al. Preparation and characterization of coenzyme Q10-loaded PMMA nanoparticles by a new emulsification process based on microfluidization. Colloid Surf A. 2002;210:95–104.
    • (2002) Colloid Surf A , vol.210 , pp. 95-104
    • Kwon, S.S.1    Nam, Y.S.2    Lee, J.S.3
  • 13
    • 0034193310 scopus 로고    scopus 로고
    • Therapeutic applications of colloidal drug carriers
    • COI: 1:CAS:528:DC%2BD3cXjtVCitbg%3D, PID: 10785658
    • Barratt GM. Therapeutic applications of colloidal drug carriers. Pharm Sci Technol Today. 2000;3:163–71.
    • (2000) Pharm Sci Technol Today , vol.3 , pp. 163-171
    • Barratt, G.M.1
  • 14
    • 84857923604 scopus 로고    scopus 로고
    • Polymeric micelle stability
    • COI: 1:CAS:528:DC%2BC38Xjt1Omtbk%3D
    • Owen SC, Chan D, Shoichet MS. Polymeric micelle stability. Nano Today. 2012;7:53–65.
    • (2012) Nano Today , vol.7 , pp. 53-65
    • Owen, S.C.1    Chan, D.2    Shoichet, M.S.3
  • 15
    • 0041703019 scopus 로고    scopus 로고
    • Pharmacological effects of formulation vehicles: implications for cancer chemotherapy
    • PID: 12844327
    • Ten Tije AJ, Verweij J, Loos WJ, et al. Pharmacological effects of formulation vehicles: implications for cancer chemotherapy. Clin Pharmacokinet. 2003;42:665–85.
    • (2003) Clin Pharmacokinet , vol.42 , pp. 665-685
    • Ten Tije, A.J.1    Verweij, J.2    Loos, W.J.3
  • 16
    • 0026101562 scopus 로고
    • Solutol HS15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance
    • COI: 1:CAS:528:DyaK3MXhtlGltbw%3D, PID: 1988130
    • Coon JS, Knudson W, Clodfelter K, et al. Solutol HS15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid, reverses multidrug resistance. Cancer Res. 1991;51:897–902.
    • (1991) Cancer Res , vol.51 , pp. 897-902
    • Coon, J.S.1    Knudson, W.2    Clodfelter, K.3
  • 17
    • 84897973277 scopus 로고    scopus 로고
    • Solutol HS15 as a novel excipient
    • Solutol HS15 as a novel excipient
    • Ku S, Velagaleti R. Solutol HS15 as a novel excipient, Pharm Technol. 2010. Solutol HS15 as a novel excipient, Pharm Technol. Accessed 2 Nov 2010.
    • (2010) Pharm Technol
    • Ku, S.1    Velagaleti, R.2
  • 18
    • 77955121385 scopus 로고    scopus 로고
    • The effect of novel surfactants and solutol® HS15 on paclitaxel aqueous solubility and permeability across a caco-2 monolayer
    • COI: 1:STN:280:DC%2BC3crpslKhtQ%3D%3D, PID: 20198687
    • Alani Adam WG, Rao DA, Seidel R, et al. The effect of novel surfactants and solutol® HS15 on paclitaxel aqueous solubility and permeability across a caco-2 monolayer. J Pharm Sci. 2010;99:3473–85.
    • (2010) J Pharm Sci , vol.99 , pp. 3473-3485
    • Alani Adam, W.G.1    Rao, D.A.2    Seidel, R.3
  • 19
    • 84856974148 scopus 로고    scopus 로고
    • Preparation and pharmacokinetic evaluation of curcumin solid dispersion using Solutol® HS15 as a carrier
    • COI: 1:CAS:528:DC%2BC38XhvFOit78%3D, PID: 22226878
    • Seo SW, Han HK, Chun MK, et al. Preparation and pharmacokinetic evaluation of curcumin solid dispersion using Solutol® HS15 as a carrier. Int J Pharm. 2012;424:18–25.
    • (2012) Int J Pharm , vol.424 , pp. 18-25
    • Seo, S.W.1    Han, H.K.2    Chun, M.K.3
  • 20
    • 84898793152 scopus 로고    scopus 로고
    • Effect of oil and co-surfactant on the formation of Solutol HS15 based colloidal drug carrier by Box–Behnken statistical design
    • COI: 1:CAS:528:DC%2BC2cXot1SjtLs%3D
    • Ahmad J, Mir SR, Kohli K, et al. Effect of oil and co-surfactant on the formation of Solutol HS15 based colloidal drug carrier by Box–Behnken statistical design. Colloid Surf A. 2014;453:68–77.
    • (2014) Colloid Surf A , vol.453 , pp. 68-77
    • Ahmad, J.1    Mir, S.R.2    Kohli, K.3
  • 21
    • 0037687293 scopus 로고    scopus 로고
    • Impact of Solutol HS15 on the pharmacokinetic behaviour of colchicine upon intravenous administration to male wistar rats
    • COI: 1:CAS:528:DC%2BD3sXkt1Ohu7Y%3D, PID: 12698501
    • Bittner B, Gonzalez RCB, Walter I, et al. Impact of Solutol HS15 on the pharmacokinetic behaviour of colchicine upon intravenous administration to male wistar rats. Biopharm Drug Dispos. 2003;24:173–81.
    • (2003) Biopharm Drug Dispos , vol.24 , pp. 173-181
    • Bittner, B.1    Gonzalez, R.C.B.2    Walter, I.3
  • 22
    • 2442671307 scopus 로고    scopus 로고
    • Impact of excipients on the absorption of P- glycoprotein substrates in vitro and in vivo
    • Cornaire G, Woodley J, Hermann P, et al. Impact of excipients on the absorption of P- glycoprotein substrates in vitro and in vivo. Int J Pharm. 2004;278:119–31.
    • (2004) Int J Pharm , vol.278 , pp. 119-131
    • Cornaire, G.1    Woodley, J.2    Hermann, P.3
  • 23
    • 77954312806 scopus 로고    scopus 로고
    • Solubilization of poorly water-soluble drugs by mixed micelles based on hydrogenated phosphatidylcholine
    • COI: 1:CAS:528:DC%2BC3cXosF2it7g%3D, PID: 20580793
    • Rupp C, Steckel H, Mueller BW. Solubilization of poorly water-soluble drugs by mixed micelles based on hydrogenated phosphatidylcholine. Int J Pharm. 2010;395:272–80.
    • (2010) Int J Pharm , vol.395 , pp. 272-280
    • Rupp, C.1    Steckel, H.2    Mueller, B.W.3
  • 24
    • 84907272782 scopus 로고    scopus 로고
    • Enhanced effect of pH -sensitive mixed copolymer micelles for overcoming multidrug resistance of doxorubicin
    • COI: 1:CAS:528:DC%2BC2cXhtlKru77I, PID: 25201738
    • Qiu LP, Qiao MX, et al. Enhanced effect of pH -sensitive mixed copolymer micelles for overcoming multidrug resistance of doxorubicin. Biomaterials. 2014;35:9877–87.
    • (2014) Biomaterials , vol.35 , pp. 9877-9887
    • Qiu, L.P.1    Qiao, M.X.2
  • 25
    • 84971246961 scopus 로고    scopus 로고
    • Preparation and evaluation of lipid nanoparticles for loading enzyme subtilisin FS3
    • Wang CT, Ji BQ, Cao YP, et al. Preparation and evaluation of lipid nanoparticles for loading enzyme subtilisin FS3. Food Sci. 2008;29:158–61.
    • (2008) Food Sci , vol.29 , pp. 158-161
    • Wang, C.T.1    Ji, B.Q.2    Cao, Y.P.3
  • 26
    • 84899979223 scopus 로고    scopus 로고
    • Preparation and characterization of creatine phosphate sodium
    • Yang M, Liu L, Su QJ, et al. Preparation and characterization of creatine phosphate sodium. Lat Am J Pharm. 2014;33:658–65.
    • (2014) Lat Am J Pharm , vol.33 , pp. 658-665
    • Yang, M.1    Liu, L.2    Su, Q.J.3
  • 27
    • 33750041061 scopus 로고    scopus 로고
    • Preparation and characterization of polymeric micelles for solubilization of poorly soluble anticancer drugs
    • COI: 1:CAS:528:DC%2BD28XhtFSrurzL, PID: 16884896
    • Sezgin Z, Yuksel N, Baykara T. Preparation and characterization of polymeric micelles for solubilization of poorly soluble anticancer drugs. Eur J Pharm Biopharm. 2006;64:261–8.
    • (2006) Eur J Pharm Biopharm , vol.64 , pp. 261-268
    • Sezgin, Z.1    Yuksel, N.2    Baykara, T.3
  • 28
    • 84876706816 scopus 로고    scopus 로고
    • Preparation and in vitro evaluation of apigenin-loaded polymeric micelles
    • Zhai YG, Guo SS, Liu CH, et al. Preparation and in vitro evaluation of apigenin-loaded polymeric micelles. Colloid Surf A. 2013;429:24–30.
    • (2013) Colloid Surf A , vol.429 , pp. 24-30
    • Zhai, Y.G.1    Guo, S.S.2    Liu, C.H.3
  • 29
    • 84887201583 scopus 로고    scopus 로고
    • Paclitaxel-loaded polymeric microparticles: quantitative relationships between in vitro drug release rate and in vivo pharmacodynamics
    • Tsai M, Lu Z, Wientjes MG, et al. Paclitaxel-loaded polymeric microparticles: quantitative relationships between in vitro drug release rate and in vivo pharmacodynamics. J Control Release. 2013;172:737–44.
    • (2013) J Control Release , vol.172 , pp. 737-744
    • Tsai, M.1    Lu, Z.2    Wientjes, M.G.3
  • 30
    • 0031041732 scopus 로고    scopus 로고
    • Dissolution media for in vitro testing of water-insoluble drugs: effect of surfactant purity and electrolyte on in vitro dissolution of carbamazepine in aqueous solutions of sodium lauryl sulfate
    • Crison JR, Weiner ND, Amidon GL. Dissolution media for in vitro testing of water-insoluble drugs: effect of surfactant purity and electrolyte on in vitro dissolution of carbamazepine in aqueous solutions of sodium lauryl sulfate. J Pharm Sci. 1997;86:384–8.
    • (1997) J Pharm Sci , vol.86 , pp. 384-388
    • Crison, J.R.1    Weiner, N.D.2    Amidon, G.L.3
  • 31
    • 53049088424 scopus 로고    scopus 로고
    • Stability studies of anticancer agent bis (4-fluorobenzyl) trisulfide and synthesis of related substances
    • COI: 1:CAS:528:DC%2BD1cXht1yms7fO
    • Bao YM, Mo XP, Xu XY. Stability studies of anticancer agent bis (4-fluorobenzyl) trisulfide and synthesis of related substances. J Pharm Biomed. 2008;48:664–71.
    • (2008) J Pharm Biomed , vol.48 , pp. 664-671
    • Bao, Y.M.1    Mo, X.P.2    Xu, X.Y.3
  • 32
    • 23144457078 scopus 로고    scopus 로고
    • Preparation and physicochemical characterization of dioctyl sodium sulfosuccinate (Aerosol OT) microemul sion for oral drug delivery
    • El-Laithy HM. Preparation and physicochemical characterization of dioctyl sodium sulfosuccinate (Aerosol OT) microemul sion for oral drug delivery. AAPS PharmSciTech. 2003;4:1–10.
    • (2003) AAPS PharmSciTech , vol.4 , pp. 1-10
    • El-Laithy, H.M.1
  • 33
    • 73249132767 scopus 로고    scopus 로고
    • Properties of epigallocatechin-3-Gallate in Tween80 micelle
    • Liu TQ, Gao XG. Properties of epigallocatechin-3-Gallate in Tween80 micelle. Acta Phys -Chim Sin. 2010;26:66–72.
    • (2010) Acta Phys -Chim Sin , vol.26 , pp. 66-72
    • Liu, T.Q.1    Gao, X.G.2
  • 34
    • 84864722272 scopus 로고    scopus 로고
    • CriticalSorb™: a novel efficient nasal delivery system for human growth hormone based on Solutol HS15
    • COI: 1:CAS:528:DC%2BC38XhtFCltrjN, PID: 22709592
    • Illum L, Jordan F, Lewis AL. CriticalSorb™: a novel efficient nasal delivery system for human growth hormone based on Solutol HS15. J Control Release. 2012;162:194–200.
    • (2012) J Control Release , vol.162 , pp. 194-200
    • Illum, L.1    Jordan, F.2    Lewis, A.L.3
  • 35
    • 79953773205 scopus 로고    scopus 로고
    • Phospholipid-Tween 80 mixed micelles as an intravenous delivery carrier for paclitaxel
    • Jun LH, Xia YQ, Li D, Zhong LJ, et al. Phospholipid-Tween 80 mixed micelles as an intravenous delivery carrier for paclitaxel. Drug Dev Ind Pharm. 2011;37:597–605.
    • (2011) Drug Dev Ind Pharm , vol.37 , pp. 597-605
    • Jun, L.H.1    Xia, Y.Q.2    Li, D.3    Zhong, L.J.4
  • 36
    • 84971244241 scopus 로고    scopus 로고
    • Liu H, Ma XQ. Coenzyme Q10 intravenous infusion and its preparation method: China. 2006. CN200410022007X
    • Liu H, Ma XQ. Coenzyme Q10 intravenous infusion and its preparation method: China. 2006. CN200410022007X.
  • 37
    • 33646367645 scopus 로고    scopus 로고
    • Polyethylene glycol–phosphatidylethanolamine conjugate (PEG–PE)-based mixed micelles: some properties, loading with paclitaxel, and modulation of P-glycoprotein-mediated efflux
    • COI: 1:CAS:528:DC%2BD28XksFyhsr0%3D, PID: 16616818
    • Dabholkar RD, Sawant RM, Mongayt DA, et al. Polyethylene glycol–phosphatidylethanolamine conjugate (PEG–PE)-based mixed micelles: some properties, loading with paclitaxel, and modulation of P-glycoprotein-mediated efflux. Int J Pharm. 2006;315:148–57.
    • (2006) Int J Pharm , vol.315 , pp. 148-157
    • Dabholkar, R.D.1    Sawant, R.M.2    Mongayt, D.A.3
  • 38
    • 10044225776 scopus 로고    scopus 로고
    • Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs
    • COI: 1:CAS:528:DC%2BD2cXhtVChsrvP, PID: 15585275
    • Win KY, Feng SS. Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials. 2005;26:2713–22.
    • (2005) Biomaterials , vol.26 , pp. 2713-2722
    • Win, K.Y.1    Feng, S.S.2
  • 39
    • 79959739491 scopus 로고    scopus 로고
    • Lipid nanocarriers for dermal delivery of lutein: preparation, characterization, stability and performance
    • COI: 1:CAS:528:DC%2BC3MXnvFOkurw%3D, PID: 21596122
    • Mitri K, Shegokar R, Gohla S, et al. Lipid nanocarriers for dermal delivery of lutein: preparation, characterization, stability and performance. Int J Pharm. 2011;414:267–75.
    • (2011) Int J Pharm , vol.414 , pp. 267-275
    • Mitri, K.1    Shegokar, R.2    Gohla, S.3
  • 40
    • 55049097442 scopus 로고    scopus 로고
    • Preparation of docetaxel loaded pH-sensitive block copolymer micelles
    • COI: 1:CAS:528:DC%2BD1cXhsVOrsb7L
    • Chen DW, Yan L, Qiao MX, et al. Preparation of docetaxel loaded pH-sensitive block copolymer micelles. Acta Pharm Sin. 2008;43:1066–70.
    • (2008) Acta Pharm Sin , vol.43 , pp. 1066-1070
    • Chen, D.W.1    Yan, L.2    Qiao, M.X.3
  • 41
    • 0037289662 scopus 로고    scopus 로고
    • On the determination of the critical micelle concentration by the pyrene 1:3 ratio method
    • COI: 1:CAS:528:DC%2BD3sXhtlGqtb0%3D
    • Aguiar J, Carpena P, Molina-Bolívar JA, et al. On the determination of the critical micelle concentration by the pyrene 1:3 ratio method. J Colloid Interface Sci. 2003;258:116–22.
    • (2003) J Colloid Interface Sci , vol.258 , pp. 116-122
    • Aguiar, J.1    Carpena, P.2    Molina-Bolívar, J.A.3
  • 42
    • 84861100250 scopus 로고    scopus 로고
    • Polymeric micelles of PEG-PE as carriers of all-trans retinoic acid for stability improvement
    • COI: 1:CAS:528:DC%2BC38XisFalurk%3D, PID: 22274760
    • Wichit A, Tangsumranjit A, et al. Polymeric micelles of PEG-PE as carriers of all-trans retinoic acid for stability improvement. AAPS PharmSciTech. 2012;13:336–43.
    • (2012) AAPS PharmSciTech , vol.13 , pp. 336-343
    • Wichit, A.1    Tangsumranjit, A.2
  • 43
    • 0034780776 scopus 로고    scopus 로고
    • Role of co-solute in biomolecular stability: glucose, urea and the water structure
    • Oro JRD. Role of co-solute in biomolecular stability: glucose, urea and the water structure. J Biol Phys. 2001;27:73–9.
    • (2001) J Biol Phys , vol.27 , pp. 73-79
    • Oro, J.R.D.1
  • 44
    • 84904792690 scopus 로고    scopus 로고
    • Albumin nanoparticles for the delivery of gabapentin: preparation, characterization and pharmacodynamic studies
    • COI: 1:CAS:528:DC%2BC2cXht1Chu7vL, PID: 24999053
    • Wilson B, Lavanya Y, Priyadarshini RAB, et al. Albumin nanoparticles for the delivery of gabapentin: preparation, characterization and pharmacodynamic studies. Int J Pharm. 2014;473:73–9.
    • (2014) Int J Pharm , vol.473 , pp. 73-79
    • Wilson, B.1    Lavanya, Y.2    Priyadarshini, R.A.B.3
  • 45
    • 1542611547 scopus 로고    scopus 로고
    • Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles
    • Venkateswarlu V, Manjunath K. Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles. J Control Release. 2004;95:627–38.
    • (2004) J Control Release , vol.95 , pp. 627-638
    • Venkateswarlu, V.1    Manjunath, K.2
  • 46
    • 0035850224 scopus 로고    scopus 로고
    • Structure and design of polymeric surfactant-based drug delivery systems
    • Torchilin PV. Structure and design of polymeric surfactant-based drug delivery systems. J Control Release. 2011;73:137–72.
    • (2011) J Control Release , vol.73 , pp. 137-172
    • Torchilin, P.V.1
  • 47
    • 52049098243 scopus 로고    scopus 로고
    • Stability issues of polymeric micelles
    • COI: 1:CAS:528:DC%2BD1cXhtFensLfL, PID: 18625275
    • Bae YH, Yin HQ. Stability issues of polymeric micelles. J Control Release. 2008;131:2–4.
    • (2008) J Control Release , vol.131 , pp. 2-4
    • Bae, Y.H.1    Yin, H.Q.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.