Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage

Molecular Neurobiology

Volumn 52, Issue 2, 2015, Pages 913-926

  Imam, Syed Z ^a   Lantz McPeak, Susan M ^a   Cuevas, Elvis ^a   Rosas Hernandez, Hector ^a   Liachenko, Serguei ^a   Zhang, Yongbin ^a   Sarkar, Sumit ^a   Ramu, Jaivijay ^a   Robinson, Bonnie L ^a   Jones, Yvonne ^a   Gough, Bobby ^a   Paule, Merle G ^a   Ali, Syed F ^a   Binienda, Zbigniew K ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Dopamine; Fe NPs; Iron oxide nanoparticles; Magnetic resonance imaging; Mitochondria; Neuroblastoma cells; Neurotoxicity

Indexed keywords

ABELSON KINASE; ALPHA SYNUCLEIN; DOPAMINE; METAL NANOPARTICLE; REACTIVE OXYGEN METABOLITE; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE; CASPASE; CATECHOLAMINE; MAGNETITE NANOPARTICLE; NANOSPHERE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN CAPILLARY ENDOTHELIAL CELL; BRAIN VENTRICLE; CELL PROLIFERATION; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE BRAIN LEVEL; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOCHONDRION; NERVE CELL CULTURE; NERVE CELL LESION; NERVE CELL NECROSIS; NERVE ENDING; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTICLE SIZE; PERIKARYON; PROTEIN EXPRESSION; RAT; ANIMAL; APOPTOSIS; CELL DIVISION; CHEMISTRY; DRUG EFFECTS; METABOLISM; NEUROBLASTOMA; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATIVE STRESS; PATHOLOGY; PERMEABILITY; SPECTROMETRY; SPRAGUE DAWLEY RAT; TUMOR CELL LINE; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; BLOOD-BRAIN BARRIER; CASPASES; CATECHOLAMINES; CELL DIVISION; CELL LINE, TUMOR; CORPUS STRIATUM; DOPAMINERGIC NEURONS; ENZYME ACTIVATION; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MAGNETITE NANOPARTICLES; MALE; MITOCHONDRIA; NANOSPHERES; NEUROBLASTOMA; OXIDATIVE STRESS; PARTICLE SIZE; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SPECTROMETRY, X-RAY EMISSION;

EID: 84940787361     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9259-2     Document Type: Article

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