Oxidative damage: The biochemical mechanism of cellular injury and necrosis in choline deficiency

Experimental and Molecular Pathology

Volumn 88, Issue 1, 2010, Pages 143-149

  Repetto, Marisa G ^a   Ossani, Georgina ^b   Monserrat, Alberto J ^b   Boveris, Alberto ^a  

^a Laboratory of Free Radical Biology   (Argentina)

^b School of Medicine   (Argentina)

Author keywords

Choline deficiency; Lipid peroxidation; Necrosis; Oxidative damage

Indexed keywords

ALPHA TOCOPHEROL; CHOLINE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN NECROSIS; CONTROLLED STUDY; FATTY LIVER; HEART MUSCLE INJURY; HEART MUSCLE NECROSIS; HISTOPATHOLOGY; INFLAMMATION; KIDNEY INJURY; KIDNEY NECROSIS; LIPID PEROXIDATION; LIVER CELL DAMAGE; LIVER NECROSIS; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; VITAMIN DEFICIENCY;

ANIMALS; ANTIOXIDANTS; BRAIN; CHOLINE DEFICIENCY; DISEASE MODELS, ANIMAL; FATTY LIVER; KIDNEY GLOMERULUS; KIDNEY TUBULES; LIPID PEROXIDATION; LIVER; MALE; MYOCARDIUM; NECROSIS; OXIDATIVE STRESS; RATS; RATS, WISTAR; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

RATTUS;

EID: 74749096179     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2009.11.002     Document Type: Article

References (36)

1. Ariente de Garcia I., Perazzo J., and Monserrat A.J. Necrosis cardíaca y deficiencia de factores lipotrópicos. Medicina 41 (1981) 556-564
2. Boveris A., and Cadenas E. Mitochondrial production of hydrogen peroxide regulation by nitric oxide and the role of ubisemiquinone. IUBMB Life 50 (2000) 245-250
3. Boveris A., and Navarro A. Brain mitochondrial dysfunction in aging. IUBMB Life 60 (2008) 308-314
4. Boveris A., Repetto M., Bustamante J., Boveris A.D., and Valdez L. The concept of oxidative stress in pathology. In: Alvarez S., Evelson P., and Boveris A. (Eds). Free Radical Pathophysiology (2008), Research Signpost, Kerala, India 1-17
5. Bustamante J., Di Libero E., Fernandez-Cobo M., Monti N., Cadenas E., and Boveris A. Kinetic analysis of thapsigargin-induced thymocyte apoptosis. Free Radic. Biol. Med. 37 (2004) 1490-1498
6. Carter A., and Frenkel R. The relationship of choline and carnitine in the choline deficient rat. J. Nutr. 108 (1978) 1748-1754
7. Esterbauer H., Gebicki J., Puhl H., and Jurgens G. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radic. Biol. Med. 13 (1992) 341-390
8. Esterbauer H. Cytotoxicity and genotoxicity of lipid-oxidation products. Am. J. Clin. Nutr. 57 (1993) 779-785
9. Farber E., and Sarma D. Biology of disease: hepatocarcinogenesis: a dynamic cellular perspective. Lab. Invest. 56 (1987) 4-22
10. Floyd R., Kotake Y., Hensley K., Nakae D., and Konishi Y. Reactive oxygen species in choline deficiency induced carcinogenesis and nitrone inhibition. Mol. Cell Biochem. 234 (2002) 195-203
11. Fraga C., Llesuy S., and Boveris A. Increased carbon tetrachloride-stimulated chemiluminescence in the in situ liver of barbital-treated mice. Acta Physiol. Pharmacol. Latinoam. 34 (1984) 143-152
12. Fraga C., Leibovitz B., and Tappel A. Lipid peroxidation measured as thiobarbituric acid-reactive substances in tissue slices: characterization and comparison with homogenates and microsomes. Free Radic. Biol. Med 4 (1988) 155-161
13. Ghoshal A., and Farber E. Choline deficiency, lipotrope deficiency and the development of liver disease including liver cancer: a new perspective. Lab. Invest. 68 (1993) 255-260
14. Gonzalez Flecha B., Llesuy S., and Boveris A. Hydroperoxide-initiated chemiluminescence: an assay for oxidative stress in biopsies of heart, liver, and muscle. Free Radic. Biol. Med. 10 (1991) 93-100
15. Guo W., Pye Q., Williamson K., Stewart C., Hensley K., Kotake Y., Floyd R., and Broyles R. Mitochondrial dysfunction in choline deficiency-induced apoptosis in cultured rat hepatocytes. Free Radic. Biol. Med. 39 (2005) 641-650
16. Handler P. Factors affecting the occurrence of hemorrhagic kidneys due to choline deficiency. J. Nutr. 31 (1946) 621-633
17. 2 generation in liver mitochondria. Carcinogenesis 21 (2000) 983-989
18. Holmes-McNary M., Loy R., Mar M., Albright C., and Zeisel S. Apoptosis is induced by choline deficiency in fetal brain and in PC12 cells. Brain Res. Dev. 101 (1997) 9-16
19. Holmes-McNary M., Baldwin A., and Zeisel S. Opposing regulation of choline deficiency-induced apoptosis by p53 and nuclear factor kappa-B. J. Biol. Chem. 276 (2001) 41197-41204
20. Kroemer G., Dallaporta B., and Resche-Rigon M. The mitochondrial death/life regulators in apoptosis and necrosis. Annu. Rev. Physiol. 60 (1998) 619-642
21. Lissi E., Pascual C., and Del Castillo M. Luminol luminescence induced by 2, 2′-Azo-bis(2-amidinopropane) thermolysis. Free Radic. Res. Comm. 17 (1992) 299-311
22. Lowry O., Rosebroughi A., Farr A., and Randall R. Protein measurement with Folin phenol reagent. J Biol. Chem. 193 (1951) 265-275
23. Matoso M., Descalzo A., Fariña S., Porta E.A., and Monserrat A.J. Rat hepatocytic apoptosis in early choline deficiency. FASEB J. 12 (1998) A779 (Abstract)
24. Monserrat A.J., Ghoshal A., Hartroft W., and Porta E. Lipoperoxidation in the pathogenesis of renal necrosis in choline deficient rats. Am. J. Pathol. 55 (1969) 163-190
25. Navarro A., and Boveris A. The mitochondrial energy transduction system and the aging process. Am. J. Physiol. Cell Physiol. 292 (2007) C670-C686
26. Ossani G., Dalghi M., and Repetto M. Oxidative damage and lipid peroxidation in the kidney of choline deficient rats. Front. Biosci. 12 (2007) 1174-1183
27. Sanders L., and Zeisel S. Dietary requirements and role in brain development. Nutr. Today 42 (2007) 181-186
28. Sarri E., García Dorado D., Abellan A., and Soler J. Effects of hypoxia, glucose deprivation and acidosis on phosphatidylcholine synthesis in HL-1 cardiomyocytes. CTP: phosphocholine cytidylyltransferase activity correlates with sarcolemmal disruption. Biochem. J. 394 (2006) 325-334
29. Sies H. Oxidative stress: from basic research to clinical application. Am. J. Med. 91 (1991) 31-38
30. Woodard J.C. Effects of deficiencies in labile methyl groups on the growth and development of fetal rats. J. Nutr. 100 (1970) 1215-1226
31. Zeisel S. Choline: an important nutrient in brain development, liver function and carcinogenesis. J. Am. Coll. Nutr. 11 (1992) 473-481
32. Zeisel S. Choline. A nutrient that is involved in the regulation of cell proliferation, cell death, and cell transformation. Adv. Exp. Med. Biol. 399 (1996) 131-141
33. Zeisel S. Choline: Needed for normal development of memory. J. Am. Coll. Nutr. 19 (2000) 528-531
34. Zeisel S. Nutritional importance of choline for brain development. J. Am. Coll. Nutr. 23 (2004) 621-626
35. Zeisel S. Choline: Critical role during fetal development and dietary requirements in adults. Annu. Rev. Nutr. 26 (2006) 229-250
36. Zeisel S., and Niculescu M. Perinatal choline influences brain structure and function. Nutr. Rev. 64 (2006) 197-203