Iron oxide nanoparticles induce oxidative stress, DNA damage, and caspase activation in the human breast cancer cell line

Biological Trace Element Research

Volumn 159, Issue 1-3, 2014, Pages 416-424

  Alarifi, Saud ^a   Ali, Daoud ^a   Alkahtani, Saad ^a   Alhader, M S ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY   (Saudi Arabia)

Author keywords

Apoptosis; DNA damage; Iron oxide nanoparticles; MCF 7 cells; Oxidative stress

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4',6 DIAMIDINO 2 PHENYLINDOLE; CASPASE; GLUTATHIONE; LACTATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE; CASPASE 3; FERRIC ION; FERRIC OXIDE; INDOLE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL SHAPE; CELL VIABILITY; CHROMOSOME CONDENSATION; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; DNA STRAND BREAKAGE; DOSE TIME EFFECT RELATION; DRUG CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME RELEASE; FLUORESCENCE MICROSCOPY; GENOTOXICITY; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MCF 7 CELL LINE; MEMBRANE DAMAGE; OXIDATIVE STRESS; PROTEIN DEPLETION; STAINING; TRANSMISSION ELECTRON MICROSCOPY; DRUG EFFECTS; METABOLISM;

CASPASE 3; DNA DAMAGE; FERRIC COMPOUNDS; GLUTATHIONE; HUMANS; INDOLES; MCF-7 CELLS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84902544027     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-014-9972-0     Document Type: Article

References (38)

1. Alghamdi IG, Hussain II, Alghamdi MS, El-Sheemy MA (2013) The incidence rate of female breast cancer in Saudi Arabia: an observational descriptive epidemiological analysis of data from Saudi Cancer Registry 2001-2008. Breast Cancer Targets Ther 5:103-109
2. Jain TK, Reddy MK, Morales MA, Leslie-Pelecky DL, Labhasetwar V (2008) Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats. Mol Pharm 5(2):316-327 (Pubitemid 351579134)
3. Lee KJ, An JH, Shin JS, Kim DH (2012) Synthesis and characterization of bicalutamide-loaded magnetic nanoparticles as anti-tumor drug carriers. J Nanosci Nanotechnol 12(2):1611-1615
4. Maeng JH, Lee DH, Jung KH, Bae YH, Park IS, Jeong S, Jeon YS, Shim CK, Kim W, Kim J, Lee J, Lee YM, Kim JH, Kim WH, Hong SS (2010) Multi-functional doxorubicin-loaded super paramagnetic iron oxide nanoparticles for chemotherapy and magnetic resonance imaging in liver cancer. Biomaterials 31(18):4995-5006
5. Jia Y, Yuan M, Yuan H, Huang X, Sui X, Cui X, Tang F, Peng J, Chen J, Lu S, Xu W, Zhang L, Guo Q (2012) Co-encapsulation ofmagnetic Fe3O4 nanoparticles and doxorubicin into biodegradable PLGA nanocarriers for intratumoral drug delivery. Int J Nanomedicine 63:1697-1708
6. Li Y-F, Chen C (2011) Fate and toxicity of metallic and metal-containing nanoparticles for biomedical applications. Small 7:2965-2980
7. Singh N, Manshian B, Jenkins GJS, Griffiths SM, Williams PM, Maffeis TG, Wright CJ, Doak SH (2009) Nano genotoxicology: the DNA damaging potential of engineered nanomaterials. Biomaterials 30:3891-3914
8. Skocaj M, Filipic M, Petkovic J, Novak S (2011) Titanium dioxide in our everyday life; is it safe? Radiol Oncol 45:227-247
9. Wang Y, Aker WG, Hwang HM, Yedjou CGYH et al (2011) A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells. Sci Total Environ 409:4753-4762
10. van Maanen JM, Borm PJ, Knaapen A, van Herwijnen M, Schilderman PA, Smith KR, Aust AE, Tomatis M, Fubini B (1999) In vitro effects of coal fly ashes: hydroxyl radical generation, iron release, and DNA damage and toxicity in rat lung epithelial cells. Inhal Toxicol 11:1123-1141 (Pubitemid 30023325)
11. Borm PJ, Schins RP, Albrecht C (2004) Inhaled particles and lung cancer, part B: paradigms and risk assessment. Int J Cancer 110:3-14 (Pubitemid 38507198)
12. Naziroglu M, Simsek M, Kutlu M (2004) Moderate exercise with dietary vitamin C and E combination protects streptozotocin induced oxidative damage to the blood and improves fetal outcomes in pregnant rats. Clin Chem Lab Med 42:511-517 (Pubitemid 38779752)
13. Mossman T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63
14. Wroblewski F, LaDue JS (1955) Lactate dehydrogenase activity in blood. Proc Soc Exp Biol Med 90:210-213
15. Wang H, Joseph JA (1999) Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med 27:612-616 (Pubitemid 29408648)
16. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
17. Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358 (Pubitemid 9194347)
18. Ellman G (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70-77
19. Sinha AK (1972) Colorimetric assay of catalase. Anal Biochem 47:389-394
20. Alarifi S, Ali D, Verma A, Alakhtani S, Ali BA (2013) Cytotoxicity and genotoxicity of copper oxide nanoparticles in human skin keratinocytes cells. Int J Toxicol 32(4):296-307
21. Ali D, Ray RS, Hans RK (2010) UVA-induced cyototoxicity and DNA damaging potential of benz (e) acephenanthrylene in human skin cell line. Toxicol Lett 199(2):193-200
22. Monteiro-Riviere NA, Inman AO, Zhang LW (2009) Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line. Toxicol Appl Pharmacol 234(2):222-235
23. Xia T, Kovochich M, Liong M, Mädler L, Gilbert B, Shi H, Yeh JI, Zink JI, Nel AE (2008) Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano 2(10):2121-2134
24. Asha Rani PV, Mun GLK, Hande MP, Valiyaveettil S (2009) Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano 3(2):279-290
25. Srinivas A, Rao PJ, Selvam G, Murthy PB, Reddy PN (2011) Acute inhalation toxicity of cerium oxide nanoparticles in rats. Toxicol Lett 205:105-115
26. 2+-ATPase and the antioxidant redox system in rats. J. Membr Biol 231:57-64
27. Brooks C, Wei Q, Feng L, Dong G, Tao Y, Mei L, Xie ZJ, Dong Z (2007) Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins. Proc Nat Acad Sci USA 104:11649-11654 (Pubitemid 47175067)
28. Ostrovsky S, Kazimirsky G, Gedanken A, Brodie C (2009) Selective cytotoxic effect of ZnO nanoparticles on glioma cells. Nano Res 2:882-890
29. Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T et al (2006) Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett 6(8):1794-1807 (Pubitemid 44327550)
30. Ott M, Gogvadze V, Orrenius S, Zhivotovsky B (2007) Mitochondria, oxidative stress and cell death.Apoptosis 12:913-922 (Pubitemid 46653300)
31. Alarifi S, Ali D, Alakhtani S, Al-Suhaibani ES, Al-Qahtani AA (2014) Reactive oxygen species-mediated DNA damage and apoptosis in human skin epidermal cells after exposure to nickel nanoparticles. Biol Trace Elem Res 157:84-93
32. Nel A, Xia T, Madler L, Li N (2006) Toxic potential of materials at the nano level. Science 311:622-627 (Pubitemid 43191298)
33. Eom HJ, Choi J (2009) Oxidative stress of CeO2 nanoparticles via p38-Nrf-2 signaling pathway in human bronchial epithelial cell, BEAS-2B. Toxicol Lett 187:77-83
34. Park EJ, Park K (2007) Induction of reactive oxygen species and apoptosis in BEAS-2B cells by mercuric chloride. Toxicol in Vitro 21:789-794
35. Porter AG, Janicke RU (1999) Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6:99-104 (Pubitemid 29082297)
36. Chen M, Mikecz A (2005) Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles. Exp Cell Res 305(1):51-62 (Pubitemid 40380653)
37. Collins AR (2004) The comet assay for DNA damage and repair: principles, applications and limitations. Mol Biotechnol 26(3):249-261
38. Martinez GR, Loureiro AP, Marques SA, Miyamoto S, Yamaguchi LF, Onuki J, Almeida EA, Garcia CC, Barbosa LF, Medeiros MH, Di Mascio P (2003) Oxidative and alkylating damage in DNA. Mutat Res 544:115-127 (Pubitemid 37487655)