-
1
-
-
79957920754
-
Inflammatory links between obesity and metabolic disease
-
Lumeng CN, Saltiel AR. (2011) Inflammatory links between obesity and metabolic disease. J. Clin. Invest. 121:2011–7
-
(2011)
J. Clin. Invest
, vol.121
, pp. 2011-2017
-
-
Lumeng, C.N.1
Saltiel, A.R.2
-
2
-
-
84861543083
-
The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
-
Chalasani N, et al. (2012) The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 55:2005–23
-
(2012)
Hepatology
, vol.55
, pp. 2005-2023
-
-
Chalasani, N.1
-
3
-
-
0031947715
-
Steatohepatitis: A tale of two “hits”?
-
Day CP, James OF. (1998) Steatohepatitis: a tale of two “hits”? Gastroenterology. 114:842–5
-
(1998)
Gastroenterology
, vol.114
, pp. 842-845
-
-
Day, C.P.1
James, O.F.2
-
4
-
-
77955472579
-
Evolving challenges in hepatic fibrosis
-
Friedman, S.L. (2010) Evolving challenges in hepatic fibrosis. Nat. Rev. Gastroenterol. Hepatol. 7:425–36
-
(2010)
Nat. Rev. Gastroenterol. Hepatol
, vol.7
, pp. 425-436
-
-
Friedman, S.L.1
-
5
-
-
33745006606
-
Galectin-3: An open-ended story. Biochim. Biophys
-
Dumic J, et al. (2006) Galectin-3: an open-ended story. Biochim. Biophys. Acta. 1760:616–35
-
(2006)
Acta
, vol.1760
, pp. 616-635
-
-
Dumic, J.1
-
6
-
-
18244404848
-
Regulatory roles of galectins in the immune response
-
Liu FT. (2005) Regulatory roles of galectins in the immune response. Int. Arch. Allergy. Immunol. 136:385–400
-
(2005)
Int. Arch. Allergy. Immunol
, vol.136
, pp. 385-400
-
-
Liu, F.T.1
-
7
-
-
67649831425
-
The regulation of inflammation by galectin-3. Immunol
-
Henderson NC, et al. (2009) The regulation of inflammation by galectin-3. Immunol. Rev. 230:160–71
-
(2009)
Rev
, vol.230
, pp. 160-171
-
-
Henderson, N.C.1
-
8
-
-
84859893633
-
The roles of Galectin-3 in autoimmunity and tumor progression. Immunol
-
Radosavljevic G, et al. (2010) The roles of Galectin-3 in autoimmunity and tumor progression. Immunol. Res. 52:100–10
-
(2010)
Res
, vol.52
, pp. 100-110
-
-
Radosavljevic, G.1
-
9
-
-
53149147450
-
Galectin-3 is a negative regulator of lipopolysaccharide-mediated inflammation
-
Li Y, et al. (2008) Galectin-3 is a negative regulator of lipopolysaccharide-mediated inflammation. J. Immunol. 181:2781–9
-
(2008)
J. Immunol
, vol.181
, pp. 2781-2789
-
-
Li, Y.1
-
10
-
-
84874329045
-
Increased adiposity, dysregulated glucose metabolism and systemic inflammation in galectin-3 KO mice
-
Pang J, et al. (2013) Increased adiposity, dysregulated glucose metabolism and systemic inflammation in galectin-3 KO mice. PLoS One. 8:e57915
-
(2013)
Plos One
, vol.8
-
-
Pang, J.1
-
11
-
-
84878239208
-
Galectin-3 deficiency accelerates high-fat diet-induced obesity and amplifies inflammation in adipose tissue and pancreatic islets
-
Pejnovic NN, et al. (2013) Galectin-3 deficiency accelerates high-fat diet-induced obesity and amplifies inflammation in adipose tissue and pancreatic islets. Diabetes. 62:1932–44
-
(2013)
Diabetes
, vol.62
, pp. 1932-1944
-
-
Pejnovic, N.N.1
-
12
-
-
66349127163
-
Accelerated lipid-induced atherogenesis in galectin-3 deficient mice: Role of lipoxidation via receptor-mediated mechanisms
-
Iacobini C, et al. (2009) Accelerated lipid-induced atherogenesis in galectin-3 deficient mice: role of lipoxidation via receptor-mediated mechanisms. Arterioscler. Thromb. Vasc. Biol. 29:831–6
-
(2009)
Arterioscler. Thromb. Vasc. Biol
, vol.29
, pp. 831-836
-
-
Iacobini, C.1
-
13
-
-
33751529246
-
Disrupted galectin-3 causes non-alcoholic fatty liver disease in male mice
-
Nomoto K, et al. (2006) Disrupted galectin-3 causes non-alcoholic fatty liver disease in male mice. J. Pathol. 210:469–77
-
(2006)
J. Pathol
, vol.210
, pp. 469-477
-
-
Nomoto, K.1
-
14
-
-
55449125261
-
Nonalcoholic steatohepatitis and hepatocellular carcinoma in galectin-3 knockout mice
-
Nomoto K, et al. (2008) Nonalcoholic steatohepatitis and hepatocellular carcinoma in galectin-3 knockout mice. Hepatol. Res. 38:1241–51
-
(2008)
Hepatol. Res
, vol.38
, pp. 1241-1251
-
-
Nomoto, K.1
-
15
-
-
79954954319
-
Galectin-3 ablation protects mice from diet-induced NASH: A major scavenging role for galectin-3 in liver
-
Iacobini C, et al. (2011) Galectin-3 ablation protects mice from diet-induced NASH: A major scavenging role for galectin-3 in liver. J. Hepatol. 54:975–83
-
(2011)
J. Hepatol
, vol.54
, pp. 975-983
-
-
Iacobini, C.1
-
16
-
-
0032963712
-
Galectin 3 expression is induced in cirrhotic liver and hepatocellular carcinoma
-
Hsu DK, et al. (1999) Galectin 3 expression is induced in cirrhotic liver and hepatocellular carcinoma. Int. J. Cancer. 81:519–26
-
(1999)
Int. J. Cancer
, vol.81
, pp. 519-526
-
-
Hsu, D.K.1
-
17
-
-
84857055199
-
Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury
-
Baeck C, et al. (2012) Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Gut. 61:416–26
-
(2012)
Gut
, vol.61
, pp. 416-426
-
-
Baeck, C.1
-
18
-
-
84861872575
-
Hepatic recruitment of macro - phages promotes nonalcoholic steatohepatitis through CCR2
-
Miura K, Yang L, van Rooijen N, Ohnishi H, Seki E. (2012) Hepatic recruitment of macro - phages promotes nonalcoholic steatohepatitis through CCR2. Am. J. Physiol. Gastrointest. Liver. Physiol. 302:1310–21
-
(2012)
Am. J. Physiol. Gastrointest. Liver. Physiol
, vol.302
, pp. 1310-1321
-
-
Miura, K.1
Yang, L.2
Van Rooijen, N.3
Ohnishi, H.4
Seki, E.5
-
19
-
-
84898789996
-
Macrophage heterogeneity in liver injury and fibrosis
-
Tacke F, Zimmermann HW. (2014) Macrophage heterogeneity in liver injury and fibrosis. J. Hepatol. 60:1090–6
-
(2014)
J. Hepatol
, vol.60
, pp. 1090-1096
-
-
Tacke, F.1
Zimmermann, H.W.2
-
21
-
-
84896806249
-
Liver fibrosis and repair: Immune regulation of wound healing in a solid organ. Nat
-
Pellicoro A, Ramachandran P, Iredale JP, Fallowfield JA. (2014) Liver fibrosis and repair: immune regulation of wound healing in a solid organ. Nat. Rev. Immunol. 14:181–94
-
(2014)
Rev. Immunol
, vol.14
, pp. 181-194
-
-
Pellicoro, A.1
Ramachandran, P.2
Iredale, J.P.3
Fallowfield, J.A.4
-
22
-
-
33645533798
-
Galectin-3 regulates myofibroblast activation and hepatic fibrosis
-
Henderson NC, et al. (2006) Galectin-3 regulates myofibroblast activation and hepatic fibrosis. Proc. Natl. Acad. Sci. U.S.A. 103:5060–5
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 5060-5065
-
-
Henderson, N.C.1
-
23
-
-
84908120931
-
Functions of galectin-3 and its role in fibrotic diseases
-
Li LC, Li J, Gao J. (2014) Functions of galectin-3 and its role in fibrotic diseases. J. Pharmacol. Exp. Ther. 351:336–43
-
(2014)
J. Pharmacol. Exp. Ther
, vol.351
, pp. 336-343
-
-
Li, L.C.1
Li, J.2
Gao, J.3
-
24
-
-
84875409549
-
Macrophages as IL-25/IL-33- responsive cells play an important role in the induction of type 2 immunity
-
Yang Z, et al. (2013) Macrophages as IL-25/IL-33- responsive cells play an important role in the induction of type 2 immunity. PLoS One. 8:e59441
-
(2013)
Plos One
, vol.8
-
-
Yang, Z.1
-
25
-
-
84882580383
-
Interleukin-33- dependent innate lymphoid cells mediate hepatic fibrosis
-
Mchedidze T, et al. (2013) Interleukin-33- dependent innate lymphoid cells mediate hepatic fibrosis. Immunity. 39:357–71
-
(2013)
Immunity
, vol.39
, pp. 357-371
-
-
McHedidze, T.1
-
26
-
-
79958086613
-
Interleukin-33 biology with potential insights into human diseases. Nat
-
Palmer G. and Gabay C. (2011) Interleukin-33 biology with potential insights into human diseases. Nat. Rev. Rheumatol. 7:321–9
-
(2011)
Rev. Rheumatol
, vol.7
, pp. 321-329
-
-
Palmer, G.1
Gabay, C.2
-
27
-
-
80052654374
-
IL-13 induces connective tissue growth factor in rat hepatic stellate cells via TGF- -independent Smad signaling
-
Liu Y, et al. (2011) IL-13 induces connective tissue growth factor in rat hepatic stellate cells via TGF- -independent Smad signaling. J. Immunol. 187:2814–23
-
(2011)
J. Immunol
, vol.187
, pp. 2814-2823
-
-
Liu, Y.1
-
28
-
-
0021813187
-
Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
-
Matthews DR, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28:412–9
-
(1985)
Diabetologia
, vol.28
, pp. 412-419
-
-
Matthews, D.R.1
-
29
-
-
20044374023
-
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
-
Kleiner DE, et al. (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 41:1313–21
-
(2005)
Hepatology
, vol.41
, pp. 1313-1321
-
-
Kleiner, D.E.1
-
30
-
-
84899490742
-
IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice
-
Harley IT, et al. (2014) IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice. Hepatology. 59:1830–9
-
(2014)
Hepatology
, vol.59
, pp. 1830-1839
-
-
Harley, I.T.1
-
31
-
-
84887650508
-
Digital image analysis approach for lipid droplet size quantitation of Oil Red Ostained cultured cells
-
Deutch MJ, Schriever SC, Roscher AA, Ensenauer R. (2014) Digital image analysis approach for lipid droplet size quantitation of Oil Red Ostained cultured cells. Anal. Biochem. 445:87–9
-
(2014)
Anal. Biochem
, vol.445
, pp. 87-89
-
-
Deutch, M.J.1
Schriever, S.C.2
Roscher, A.A.3
Ensenauer, R.4
-
32
-
-
79955654602
-
Rapid quantification of myocardial fibrosis: A new macro-based automated analysis
-
Hadi AM, et al. (2010) Rapid quantification of myocardial fibrosis: A new macro-based automated analysis. Anal. Cell. Pathol. (Amst). 33:257–69
-
(2010)
Anal. Cell. Pathol. (Amst).
, vol.33
, pp. 257-269
-
-
Hadi, A.M.1
-
33
-
-
83555160892
-
Protective role of IL- 33/ST2 axis in Con A-induced hepatitis
-
Volarevic V, et al. (2012) Protective role of IL- 33/ST2 axis in Con A-induced hepatitis. J. Hepatol. 56:26–33
-
(2012)
J. Hepatol
, vol.56
, pp. 26-33
-
-
Volarevic, V.1
-
35
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
-
Livak KJ and Schmittgen TD. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–8
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
36
-
-
79952698689
-
Inflammatory signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice
-
Stanton MC, et al. (2011) Inflammatory signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice. J. Inflamm. (Lond.). 8:8
-
(2011)
J. Inflamm. (Lond.).
, vol.8
-
-
Stanton, M.C.1
-
37
-
-
36849005372
-
A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Tolllike receptors 2 and 4 and JNK-dependent pathways
-
Nguyen MT, et al. (2007) A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Tolllike receptors 2 and 4 and JNK-dependent pathways. J. Biol. Chem. 282:35279–92
-
(2007)
J. Biol. Chem
, vol.282
, pp. 35279-35292
-
-
Nguyen, M.T.1
-
38
-
-
84907984443
-
Immune and inflammatory pathways in NASH
-
Ganz M, Szabo G. (2013) Immune and inflammatory pathways in NASH. Hepatol. Int. 7:771–81
-
(2013)
Hepatol. Int
, vol.7
, pp. 771-781
-
-
Ganz, M.1
Szabo, G.2
-
39
-
-
38649096259
-
Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPAR-
-
Jie Zhou, et al. (2008) hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPAR-gin promoting steatosis. Gastroenterology. 134:556–67
-
(2008)
Gastroenterology
, vol.134
, pp. 556-567
-
-
Zhou, J.1
-
40
-
-
52749092267
-
Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell
-
Patsouris D, et al. (2008) Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell. Metabolism. 8:301–9
-
(2008)
Metabolism
, vol.8
, pp. 301-309
-
-
Patsouris, D.1
-
41
-
-
84865460082
-
Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver
-
Stefanovic-Racic M, et al. (2012) Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver. Diabetes. 61:2330–9
-
(2012)
Diabetes
, vol.61
, pp. 2330-2339
-
-
Stefanovic-Racic, M.1
-
42
-
-
77951146612
-
C-c chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis
-
Obstfeld AE, et al. (2010) C-c chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes. 59:916–25
-
(2010)
Diabetes
, vol.59
, pp. 916-925
-
-
Obstfeld, A.E.1
-
43
-
-
79959573042
-
Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells
-
Csak T, et al. (2011) Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells. Hepatology. 54:133–44
-
(2011)
Hepatology
, vol.54
, pp. 133-144
-
-
Csak, T.1
-
44
-
-
77953891627
-
Toll-like receptor 9 promotes steatohepatitis by induction of interleukin- 1beta in mice
-
Miura K, et al. (2010) Toll-like receptor 9 promotes steatohepatitis by induction of interleukin- 1beta in mice. Gastroenterology. 139:323–34
-
(2010)
Gastroenterology
, vol.139
, pp. 323-334
-
-
Miura, K.1
-
45
-
-
84860280502
-
Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis. Lab
-
Dixon LJ, Berk M, Thapaliya S, Papouchado BG, Feldstein AE. (2012) Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis. Lab. Invest. 92:713–23
-
(2012)
Invest
, vol.92
, pp. 713-723
-
-
Dixon, L.J.1
Berk, M.2
Thapaliya, S.3
Papouchado, B.G.4
Feldstein, A.E.5
-
46
-
-
84921284050
-
Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection
-
Bléroit C, et al. (2015) Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection. Immunity. 42:145–58
-
(2015)
Immunity
, vol.42
, pp. 145-158
-
-
Bléroit, C.1
-
47
-
-
84886280379
-
Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals
-
Shan M, et al. (2013) Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science. 342:447–53
-
(2013)
Science
, vol.342
, pp. 447-453
-
-
Shan, M.1
-
48
-
-
84919866420
-
IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice
-
Li D, et al. (2014) IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice. J. Allergy. Clin. Immunol. 134:1422-32.e11
-
(2014)
J. Allergy. Clin. Immunol
, vol.134
, pp. 1422-1432
-
-
Li, D.1
-
49
-
-
84859917147
-
IL-33/ST2 axis in inflammation and immunopathology. Immunol
-
Milovanovic M, et al. (2012) IL-33/ST2 axis in inflammation and immunopathology. Immunol. Res. 52:89–99.
-
(2012)
Res
, vol.52
, pp. 89-99
-
-
Milovanovic, M.1
|