Galectin-3 is a negative regulator of lipopolysaccharide-mediated inflammation

Journal of Immunology

Volumn 181, Issue 4, 2008, Pages 2781-2789

  Li, Yubin ^a   Komai Koma, Mousa ^a   Gilchrist, Derek S ^a   Hsu, Daniel K ^b   Liu, Fu Tong ^b   Springall, Tabitha ^a   Xu, Damo ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CYTOKINE; GALECTIN 3; INTERLEUKIN 12; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRIC OXIDE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; LIPID A; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALMONELLOSIS; SEPTIC SHOCK; WILD TYPE; ANIMAL; ANIMAL SALMONELLOSIS; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; DOWN REGULATION; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ANTIGENS, CD14; CELLS, CULTURED; DOWN-REGULATION; FEMALE; GALECTIN 3; GENE EXPRESSION REGULATION; IMMUNITY, NATURAL; INFLAMMATION MEDIATORS; LIPID A; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SALMONELLA INFECTIONS, ANIMAL; SHOCK, SEPTIC; TOLL-LIKE RECEPTOR 4;

EID: 53149147450     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.4.2781     Document Type: Article

References (47)

1. Ulevitch, R. J., and P. S. Tobias. 1995. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu. Rev. Immunol. 13: 437-457.
2. Raetz, C. R. H. 1996. Bacterial lipopolysaccharides: a remarkable family of bioactive macroamphiphiles. In Escherichia coli and Salmonella. F. C. Neidhardt, ed. American Society for Microbiology, Washington, D.C., pp. 1035-1063.
3. Jiang, Z., P. Georgel, X. Du, L. Shamel, S. Sovath, S. Mudd, M. Huber, C. Kalis, S. Keck, C. Galanos, et al. 2005. CD14 is required for MyD88-independent LPS signaling. Nat. Immunol. 6: 565-570.
4. Takeda, K., T. Kaisho, and S. Akira. 2003. Toll-like receptors. Annu. Rev. Immunol. 21: 335-376.
5. Miller, S. I., R. K. Ernst, and M. W. Bader. 2005. LPS, TLR4 and infectious disease diversity. Nat. Rev. Microbiol. 3: 36-46.
6. Liew, F. Y., D. Xu, E. K. Brint, and L. A. O'Neill. 2005. Negative regulation of Toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 5: 446-458.
7. Ho, M. K., and T. A. Springer. 1982. Mac-2, a novel 32,000 Mr mouse macrophage subpopulation-specific antigen defined by monoclonal antibodies. J. Immunol. 128: 1221-1228.
8. Brewer, C. F., M. C. Miceli, and L. G. Baum. 2002. Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions. Curr. Opin. Struct. Biol. 12: 616-623.
9. Liu, F. T. 2005. Regulatory roles of galectins in the immune response. Int. Arch. Allergy Immunol. 136: 385-400.
10. Rabinovich, G. A., L. G. Baum, N. Tinari, R. Paganelli, C. Natoli, F. T. Liu, and S. Iacobelli. 2002. Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response? Trends Immunol. 23: 313-320.
11. Hughes, R. C. 1999. Secretion of the galectin family of mammalian carbohydratebinding proteins. Biochim. Biophys. Acta 1473: 172-185.
12. Cherayil, B. J., S. J. Weiner, and S. Pillai. 1989. The Mac-2 antigen is a galactose-specific lectin that binds IgE. J. Exp. Med. 170: 1959-1972.
13. Sano, H., D. K. Hsu, L. Yu, J. R. Apgar, I. Kuwabara, T. Yamanaka, M. Hirashima, and F. T. Liu. 2000. Human galectin-3 is a novel chemoattractant for monocytes and macrophages. J. Immunol. 165: 2156-2164.
14. Henderson, N. C., A. C. Mackinnon, S. L. Farnworth, F. Poirier, F. P. Russo, J. P. Iredale, C. Haslett, K. J. Simpson, and T. Sethi. 2006. Galectin-3 regulates myofibroblast activation and hepatic fibrosis. Proc. Natl. Acad. Sci. USA 103:5060-5065.
15. Pugliese, G., F. Pricci, C. Iacobini, G. Leto, L. Amadio, P. Barsotti, L. Frigeri, D. K. Hsu, H. Vlassara, et al. 2001. Accelerated diabetic glomerulopathy in galectin-3/AGE receptor 3 knockout mice. FASEB J. 15: 2471-2479.
16. Zuberi, R. I., D. K. Hsu, O. Kalayci, H. Y. Chen, H. K. Sheldon, L. Yu, J. R. Apgar, T. Kawakami, C. M. Lilly, and F. T. Liu. 2004. Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma. Am. J. Pathol. 165: 2045-2053.
17. Bernardes, E. S., N. M. Silva, L. P. Ruas, J. R. Mineo, A. M. Loyola, D. K. Hsu, F. T. Liu, R. Chammas, and M. C. Roque-Barreira. 2006. Toxoplasma gondii infection reveals a novel regulatory role for galectin-3 in the interface of innate and adaptive immunity. Am. J. Pathol. 168: 1910-1920.
18. Nomoto, K., K. Tsuneyama, H. O. Abdel Aziz, H. Takahashi, Y. Murai, Z. G. Cui, M. Fujimoto, I. Kato, K. Hiraga, D. K. Hsu, et al. 2006. Disrupted galectin-3 causes non-alcoholic fatty liver disease in male mice. J. Pathol. 210:469-477.
19. Mandrell, R. E., M. A. Apicella, R. Lindstedt, and H. Leffler. 1994. Possible interaction between animal lectins and bacterial carbohydrates. Methods Enzymol. 236: 231-254.
20. Gupta, S. K., S. Masinick, M. Garrett, and L. D. Hazlett. 1997. Pseudomonas aeruginosa lipopolysaccharide binds galectin-3 and other human corneal epithelial proteins. Infect. Immun. 65: 2747-2753.
21. Pelletier, I., and S. Sato. 2002. Specific recognition and cleavage of galectin-3 by Leishmania major through species-specific polygalactose epitope. J. Biol. Chem. 277: 17663-17670.
22. van den Berg, T. K., H. Honing, N. Franke, A. van Remoortere, W. E. Schiphorst, F. T. Liu, A. M. Deelder, R. D. Cummings, C. H. Hokke, and I. van Die. 2004. LacdiNAc-glycans constitute a parasite pattern for galectin-3-mediated immune recognition. J. Immunol. 173: 1902-1907.
23. Kohatsu, L., D. K. Hsu, A. G. Jegalian, F. T. Liu, and L. G. Baum. 2006. Galectin-3 induces death of Candida species expressing specific β-1,2-linked mannans. J. Immunol. 177: 4718-4726.
24. Fradin, C., D. Poulain, and T. Jouault. 2000. β-1,2-linked oligomannosides from Candida albicans bind to a 32-kilodalton macrophage membrane protein homologous to the mammalian lectin galectin-3. Infect. Immun. 68: 4391-4398.
25. Mey, A., H. Leffler, Z. Hmama, G. Normier, and J. P. Revillard. 1996. The animal lectin galectin-3 interacts with bacterial lipopolysaccharides via two independent sites. J. Immunol. 156: 1572-1577.
26. Sweet, M. J., B. P. Leung, D. Kang, M. Sogaard, K. Schulz, V. Trajkovic, C. C. Campbell, D. Xu, and F. Y. Liew. 2001. A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression. J. Immunol. 166: 6633-6639.
27. Xu, D., S. J. McSorley, L. Tetley, S. Chatfield, G. Dougan, W. L. Chan, A. Satoskar, J. R. David, and F. Y. Liew. 1998. Protective effect on Leishmania major infection of migration inhibitory factor, TNF-α, and IFN-γ administered orally via attenuated Salmonella typhimurium. J. Immunol. 160: 1285-1289.
28. -). Immunology 85: 1-7.
29. Ruberto, F., F. Pugliese, A. D'Alio, S. Martelli, K. Bruno, V. Marcellino, S. Perrella, A. Cappannoli, V. Mazzarino, A. Tosi, et al. 2007. Clinical effects of use of polymyxin B fixed on fibers in liver transplant patients with severe sepsis or septic shock. Transplant. Proc. 39: 1953-1955.
30. MacMicking, J. D., C. Nathan, G. Hom, N. Chartrain, D. S. Fletcher, M. Trumbauer, K. Stevens, Q. W. Xie, K. Sokol, N. Hutchinson, et al. 1995. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 81: 641-650.
31. Beutler, B., I. W. Milsark, and A. C. Cerami. 1985. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 229: 869-871.
32. Vazquez-Torres, A., B. A. Vallance, M. A. Bergman, B. B. Finlay, B. T. Cookson, J. Jones-Carson, and F. C. Fang. 2004. Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: importance of the Kupffer cell network. J. Immunol. 172: 6202-6208.
33. Mastroeni, P., A. Vazquez-Torres, F. C. Fang, Y. Xu, S. Khan, C. E. Hormaeche, and G. Dougan. 2000. Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis: II. Effects on microbial proliferation and host survival in vivo. J. Exp. Med. 192: 237-248.
34. Shiloh, M. U., J. D. MacMicking, S. Nicholson, J. E. Brause, S. Potter, M. Marino, F. Fang, M. Dinauer, and C. Nathan. 1999. Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity 10: 29-38.
35. Lehmann, J., S. Bellmann, C. Werner, R. Schroder, N. Schutze, and G. Alber. 2001. IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis. J. Immunol. 167: 5304-5315.
36. Vazquez-Torres, A., G. Fantuzzi, C. K. Edwards III, C. A. Dinarello, and F. C. Fang. 2001. Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages. Proc. Natl. Acad. Sci. USA 98: 2561-2565.
37. Mackinnon, A. C., S. L. Farnworth, P. S. Hodkinson, N. C. Henderson, K. M. Atkinson, H. Leffler, U. J. Nilsson, C. Haslett, S. J. Forbes, and T. Sethi. 2008. Regulation of alternative macrophage activation by galectin-3. J. Immunol. 180: 2650-2658.
38. Mina-Osorio, P., I. Soto-Cruz, and E. Ortega. 2007. A role for galectin-3 in CD13-mediated homotypic aggregation of monocytes. Biochem. Biophys. Res. Commun. 353: 605-610.
39. Hsu, Y. W., K. H. Chi, W. C. Huang, and W. W. Lin. 2001. Ceramide inhibits lipopolysaccharide-mediated nitric oxide synthase and cyclooxygenase-2 induction in macrophages: effects on protein kinases and transcription factors. J. Immunol. 166: 5388-5397.
40. Uto, T., M. Fujii, and D. X. Hou. 2005. 6-(Methylsulfinyl)hexyl isothiocyanate suppresses inducible nitric oxide synthase expression through the inhibition of Janus kinase 2-mediated JNK pathway in lipopolysaccharide- activated murine macrophages. Biochem. Pharmacol. 70: 1211-1221.
41. Lin, M. W., L. T. Tsao, L. C. Chang, Y. L. Chen, L. J. Huang, S. C. Kuo, C. C. Tzeng, M. R. Lee, and J. P. Wang. 2007. Inhibition of lipopolysaccharide- stimulated NO production by a novel synthetic compound CYL-4d in RAW 264.7 macrophages involving the blockade of MEK4/JNK/AP-1 pathway. Biochem. Pharmacol. 73: 1796-1806.
42. Trinchieri, G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3: 133-146.
43. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260: 547-549.
44. Galan, J. E., and H. Wolf-Watz. 2006. Protein delivery into eukaryotic cells by type III secretion machines. Nature 444: 567-573.
45. Waterman, S. R., and D. W. Holden. 2003. Functions and effectors of the Salmonella pathogenicity island 2 type III secretion system. Cell. Microbiol. 5: 501-511.
46. O'Brien, G. C., J. H. Wang, and H. P. Redmond. 2005. Bacterial lipoprotein induces resistance to Gram-negative sepsis in TLR4-deficient mice via enhanced bacterial clearance. J. Immunol. 174: 1020-1026.
47. Quintela, J. C., M. A. de Pedro, P. Zollner, G. Allmaier, and F. Garcia-del Portillo. 1997. Peptidoglycan structure of Salmonella typhimurium growing within cultured mammalian cells. Mol. Microbiol. 23: 693-704.