A proportion of mutations fixed in the genomes of in vitro selected isogenic drug-resistant Mycobacterium tuberculosis mutants can be detected as minority variants in the parent culture

FEMS Microbiology Letters

Volumn 362, Issue 2, 2015, Pages

  Bergval, Indra ^a   Coll, Francesc ^b   Schuitema, Anja ^a   de Ronde, Hans ^a   Mallard, Kim ^b   Pain, Arnab ^c   McNerney, Ruth ^b   Clark, Taane G ^b   Anthony, Richard M ^a  

^a ROYAL TROPICAL INSTITUTE   (Netherlands)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Saudi Arabia)

Author keywords

drug resistance; Evolution; MDR TB; mutation; Tuberculosis; whole genome sequencing

Indexed keywords

BACTERIAL DNA; TUBERCULOSTATIC AGENT;

ALLELE; ARTICLE; BACTERIAL GENOME; BACTERIAL MUTATION; BACTERIAL STRAIN; BACTERIUM CULTURE; BACTERIUM MUTANT; DNA ISOLATION; DNA SEQUENCE; GENE LOCUS; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC STABILITY; GENETIC VARIABILITY; IN VITRO STUDY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; DRUG EFFECTS; GENETIC VARIATION; GENETICS; HIGH THROUGHPUT SEQUENCING; MULTIDRUG RESISTANCE; MUTATION; PHYLOGENY;

ALLELES; ANTITUBERCULAR AGENTS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENETIC VARIATION; GENOME, BACTERIAL; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PHYLOGENY; SEQUENCE ANALYSIS, DNA;

EID: 84940727075     PISSN: 03781097     EISSN: 15746968     Source Type: Journal    
DOI: 10.1093/femsle/fnu037     Document Type: Article

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