메뉴 건너뛰기




Volumn 37, Issue 8, 2015, Pages 1837-1850

The Pathophysiology and Treatment of Osteoporosis

Author keywords

bisphosphonate; bone; bone mineral density; Key words aging; menopause; osteoporosis

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; DENOSUMAB; ESTROGEN; FOLLITROPIN; IBANDRONIC ACID; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE[1-34]; RISEDRONIC ACID; SELECTIVE ESTROGEN RECEPTOR MODULATOR; VITAMIN D; ZOLEDRONIC ACID; BONE DENSITY CONSERVATION AGENT;

EID: 84940719700     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2015.06.006     Document Type: Review
Times cited : (211)

References (89)
  • 1
    • 0000664911 scopus 로고    scopus 로고
    • NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy
    • NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy JAMA 285 2001 785 795
    • (2001) JAMA , vol.285 , pp. 785-795
  • 2
    • 84967614664 scopus 로고    scopus 로고
    • Sex steroids and the construction and conservation of the adult skeleton
    • B.L. Riggs, S. Khosla, and L.J. Melton 3rd Sex steroids and the construction and conservation of the adult skeleton Endocr Rev 23 2002 279 302
    • (2002) Endocr Rev , vol.23 , pp. 279-302
    • Riggs, B.L.1    Khosla, S.2    Melton, L.J.3
  • 3
    • 84857439516 scopus 로고    scopus 로고
    • The potential impact of the National Osteoporosis Foundation guidance on treatment eligibility in the USA: An update in NHANES 2005-2008
    • B. Dawson-Hughes, A.C. Looker, A.N. Tosteson, and et al. The potential impact of the National Osteoporosis Foundation guidance on treatment eligibility in the USA: an update in NHANES 2005-2008 Osteoporos Int 23 2012 811 820
    • (2012) Osteoporos Int , vol.23 , pp. 811-820
    • Dawson-Hughes, B.1    Looker, A.C.2    Tosteson, A.N.3
  • 4
    • 0037129560 scopus 로고    scopus 로고
    • Epidemiology and outcomes of osteoporotic fractures
    • S.R. Cummings, and L.J. Melton Epidemiology and outcomes of osteoporotic fractures Lancet 359 2002 1761 1767
    • (2002) Lancet , vol.359 , pp. 1761-1767
    • Cummings, S.R.1    Melton, L.J.2
  • 5
    • 34247194211 scopus 로고    scopus 로고
    • Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025
    • R. Burge, B. Dawson-Hughes, D.H. Solomon, and et al. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025 J Bone Miner Res 22 2007 465 475
    • (2007) J Bone Miner Res , vol.22 , pp. 465-475
    • Burge, R.1    Dawson-Hughes, B.2    Solomon, D.H.3
  • 6
    • 44649157879 scopus 로고    scopus 로고
    • Implications of absolute fracture risk assessment for osteoporosis practice guidelines in the USA
    • B. Dawson-Hughes, A.N. Tosteson, L.J. Melton 3rd, et al. National Osteoporosis Goundation Guide Committee Implications of absolute fracture risk assessment for osteoporosis practice guidelines in the USA Osteoporos Int 19 2008 449 458
    • (2008) Osteoporos Int , vol.19 , pp. 449-458
    • Dawson-Hughes, B.1    Tosteson, A.N.2    Melton, L.J.3
  • 7
    • 20244381352 scopus 로고    scopus 로고
    • Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites
    • B.L. Riggs, L.J. Melton 3rd, R.A. Robb, and et al. Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites J Bone Miner Res 19 2004 1945 1954
    • (2004) J Bone Miner Res , vol.19 , pp. 1945-1954
    • Riggs, B.L.1    Melton, L.J.2    Robb, R.A.3
  • 8
    • 27944480412 scopus 로고    scopus 로고
    • Pathophysiology of age-related bone loss and osteoporosis
    • S. Khosla, and B.L. Riggs Pathophysiology of age-related bone loss and osteoporosis Endocrinol Metab Clin North Am 34 2005 1015 1030
    • (2005) Endocrinol Metab Clin North Am , vol.34 , pp. 1015-1030
    • Khosla, S.1    Riggs, B.L.2
  • 9
    • 33744750875 scopus 로고    scopus 로고
    • Bone strength: Current concepts
    • C.H. Turner Bone strength: current concepts Ann N Y Acad Sci 1068 2006 429 446
    • (2006) Ann N y Acad Sci , vol.1068 , pp. 429-446
    • Turner, C.H.1
  • 11
    • 0030969826 scopus 로고    scopus 로고
    • Effects of age and estrogen status on serum parathyroid hormone levels and biochemical markers of bone turnover in women: A population-based study
    • S. Khosla, E.J. Atkinson, L.J. Melton 3rd, and B.L. Riggs Effects of age and estrogen status on serum parathyroid hormone levels and biochemical markers of bone turnover in women: a population-based study J Clin Endocrinol Metab 82 1997 1522 1527
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1522-1527
    • Khosla, S.1    Atkinson, E.J.2    Melton, L.J.3    Riggs, B.L.4
  • 12
    • 0029798819 scopus 로고    scopus 로고
    • Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta
    • D.E. Hughes, A. Dai, J.C. Tiffee, and et al. Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta Nat Med 2 1996 1132 1136
    • (1996) Nat Med , vol.2 , pp. 1132-1136
    • Hughes, D.E.1    Dai, A.2    Tiffee, J.C.3
  • 13
    • 0034455103 scopus 로고    scopus 로고
    • Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
    • S.C. Manolagas Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis Endocr Rev 21 2000 115 137
    • (2000) Endocr Rev , vol.21 , pp. 115-137
    • Manolagas, S.C.1
  • 14
    • 0029928837 scopus 로고    scopus 로고
    • Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis
    • P. Garnero, E. Sornay-Rendu, M.C. Chapuy, and P.D. Delmas Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis J Bone Miner Res 11 1996 337 349
    • (1996) J Bone Miner Res , vol.11 , pp. 337-349
    • Garnero, P.1    Sornay-Rendu, E.2    Chapuy, M.C.3    Delmas, P.D.4
  • 15
    • 0015262035 scopus 로고
    • Effects of artificial menopause on plasma and urine calcium and phosphate
    • J.C. Gallagher, M.M. Young, and B.E. Nordin Effects of artificial menopause on plasma and urine calcium and phosphate Clin Endocrinol 1 1972 57 64
    • (1972) Clin Endocrinol , vol.1 , pp. 57-64
    • Gallagher, J.C.1    Young, M.M.2    Nordin, B.E.3
  • 16
    • 0025185276 scopus 로고
    • Estrogen preserves a normal intestinal responsiveness to 1,25-dihydroxyvitamin D3 in oophorectomized women
    • C. Gennari, D. Agnusdei, P. Nardi, and R. Civitelli Estrogen preserves a normal intestinal responsiveness to 1,25-dihydroxyvitamin D3 in oophorectomized women J Clin Endocrinol Metab 71 1990 1288 1293
    • (1990) J Clin Endocrinol Metab , vol.71 , pp. 1288-1293
    • Gennari, C.1    Agnusdei, D.2    Nardi, P.3    Civitelli, R.4
  • 17
    • 79951839091 scopus 로고    scopus 로고
    • The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: Is a revision needed?
    • S. Khosla, L.J. Melton 3rd, and B.L. Riggs The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: is a revision needed? J Bone Miner Res 26 2011 441 451
    • (2011) J Bone Miner Res , vol.26 , pp. 441-451
    • Khosla, S.1    Melton, L.J.2    Riggs, B.L.3
  • 18
    • 0028841891 scopus 로고
    • Mechanism of renal calcium conservation with estrogen replacement therapy in women in early postmenopause - A clinical research center study
    • W.R. McKane, S. Khosla, M.F. Burritt, and et al. Mechanism of renal calcium conservation with estrogen replacement therapy in women in early postmenopause - a clinical research center study J Clin Endocrinol Metab 80 1995 3458 3464
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 3458-3464
    • McKane, W.R.1    Khosla, S.2    Burritt, M.F.3
  • 19
    • 84930211948 scopus 로고    scopus 로고
    • Estrogen and bone health in men and women
    • J.A. Cauley Estrogen and bone health in men and women Steroids 99 2015 11 15
    • (2015) Steroids , vol.99 , pp. 11-15
    • Cauley, J.A.1
  • 20
    • 0037398261 scopus 로고    scopus 로고
    • Role of RANK ligand in mediating increased bone resorption in early postmenopausal women
    • G. Eghbali-Fatourechi, S. Khosla, A. Sanyal, and et al. Role of RANK ligand in mediating increased bone resorption in early postmenopausal women J Clin Invest 111 2003 1221 1230
    • (2003) J Clin Invest , vol.111 , pp. 1221-1230
    • Eghbali-Fatourechi, G.1    Khosla, S.2    Sanyal, A.3
  • 21
    • 0033304632 scopus 로고    scopus 로고
    • Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells
    • L.C. Hofbauer, S. Khosla, C.R. Dunstan, and et al. Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells Endocrinology 140 1999 4367 4370
    • (1999) Endocrinology , vol.140 , pp. 4367-4370
    • Hofbauer, L.C.1    Khosla, S.2    Dunstan, C.R.3
  • 22
    • 0027473329 scopus 로고
    • Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors
    • S. Tanaka, N. Takahashi, N. Udagawa, and et al. Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors J Clin Invest 91 1993 257 263
    • (1993) J Clin Invest , vol.91 , pp. 257-263
    • Tanaka, S.1    Takahashi, N.2    Udagawa, N.3
  • 23
    • 0026777433 scopus 로고
    • Increased osteoclast development after estrogen loss: Mediation by interleukin-6
    • R.L. Jilka, G. Hangoc, G. Girasole, and et al. Increased osteoclast development after estrogen loss: mediation by interleukin-6 Science 257 1992 88 91
    • (1992) Science , vol.257 , pp. 88-91
    • Jilka, R.L.1    Hangoc, G.2    Girasole, G.3
  • 24
    • 0030950131 scopus 로고    scopus 로고
    • Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency
    • P. Ammann, R. Rizzoli, J.P. Bonjour, and et al. Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency J Clin Invest 99 1997 1699 1703
    • (1997) J Clin Invest , vol.99 , pp. 1699-1703
    • Ammann, P.1    Rizzoli, R.2    Bonjour, J.P.3
  • 25
    • 0029113851 scopus 로고
    • Ovariectomy enhances and estrogen replacement inhibits the activity of bone marrow factors that stimulate prostaglandin production in cultured mouse calvariae
    • H. Kawaguchi, C.C. Pilbeam, S.J. Vargas, and et al. Ovariectomy enhances and estrogen replacement inhibits the activity of bone marrow factors that stimulate prostaglandin production in cultured mouse calvariae J Clin Invest 96 1995 539 548
    • (1995) J Clin Invest , vol.96 , pp. 539-548
    • Kawaguchi, H.1    Pilbeam, C.C.2    Vargas, S.J.3
  • 26
    • 34447303828 scopus 로고    scopus 로고
    • Effect of blockade of TNF-alpha and interleukin-1 action on bone resorption in early postmenopausal women
    • N. Charatcharoenwitthaya, S. Khosla, E.J. Atkinson, and et al. Effect of blockade of TNF-alpha and interleukin-1 action on bone resorption in early postmenopausal women J Bone Miner Res 22 2007 724 729
    • (2007) J Bone Miner Res , vol.22 , pp. 724-729
    • Charatcharoenwitthaya, N.1    Khosla, S.2    Atkinson, E.J.3
  • 27
    • 0034608813 scopus 로고    scopus 로고
    • Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression
    • N.K. Shevde, A.C. Bendixen, K.M. Dienger, and J.W. Pike Estrogens suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression Proc Natl Acad Sci U S A 97 2000 7829 7834
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 7829-7834
    • Shevde, N.K.1    Bendixen, A.C.2    Dienger, K.M.3    Pike, J.W.4
  • 28
    • 0035937747 scopus 로고    scopus 로고
    • Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kappa B ligand (RANKL)-induced JNK activation
    • S. Srivastava, G. Toraldo, M.N. Weitzmann, and et al. Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kappa B ligand (RANKL)-induced JNK activation J Biol Chem 276 2001 8836 8840
    • (2001) J Biol Chem , vol.276 , pp. 8836-8840
    • Srivastava, S.1    Toraldo, G.2    Weitzmann, M.N.3
  • 29
    • 78650955673 scopus 로고    scopus 로고
    • Regulation of circulating sclerostin levels by sex steroids in women and in men
    • U.I. Modder, J.A. Clowes, K. Hoey, and et al. Regulation of circulating sclerostin levels by sex steroids in women and in men J Bone Miner Res 26 2011 27 34
    • (2011) J Bone Miner Res , vol.26 , pp. 27-34
    • Modder, U.I.1    Clowes, J.A.2    Hoey, K.3
  • 30
    • 84890912443 scopus 로고    scopus 로고
    • Clinical utility of serum sclerostin measurements
    • B.L. Clarke, and M.T. Drake Clinical utility of serum sclerostin measurements Bonekey Rep 2 2013 361
    • (2013) Bonekey Rep , vol.2 , pp. 361
    • Clarke, B.L.1    Drake, M.T.2
  • 31
    • 33646041942 scopus 로고    scopus 로고
    • Hormone predictors of bone mineral density changes during the menopausal transition
    • M.R. Sowers, M. Jannausch, D. McConnell, and et al. Hormone predictors of bone mineral density changes during the menopausal transition J Clin Endocrinol Metab 91 2006 1261 1267
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1261-1267
    • Sowers, M.R.1    Jannausch, M.2    McConnell, D.3
  • 32
    • 0029794732 scopus 로고    scopus 로고
    • Bone turnover markers and bone density across the menopausal transition
    • P.R. Ebeling, L.M. Atley, J.R. Guthrie, and et al. Bone turnover markers and bone density across the menopausal transition J Clin Endocrinol Metab 81 1996 3366 3371
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3366-3371
    • Ebeling, P.R.1    Atley, L.M.2    Guthrie, J.R.3
  • 33
    • 33646036678 scopus 로고    scopus 로고
    • FSH directly regulates bone mass
    • L. Sun, Y. Peng, A.C. Sharrow, and et al. FSH directly regulates bone mass Cell 125 2006 247 260
    • (2006) Cell , vol.125 , pp. 247-260
    • Sun, L.1    Peng, Y.2    Sharrow, A.C.3
  • 34
    • 77958081869 scopus 로고    scopus 로고
    • Effects of suppression of follicle-stimulating hormone secretion on bone resorption markers in postmenopausal women
    • M.T. Drake, L.K. McCready, K.A. Hoey, and et al. Effects of suppression of follicle-stimulating hormone secretion on bone resorption markers in postmenopausal women J Clin Endocrinol Metab 95 2010 5063 5068
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 5063-5068
    • Drake, M.T.1    McCready, L.K.2    Hoey, K.A.3
  • 36
    • 0031756218 scopus 로고    scopus 로고
    • Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen
    • S. Khosla, L.J. Melton 3rd, E.J. Atkinson, and et al. Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen J Clin Endocrinol Metab 83 1998 2266 2274
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2266-2274
    • Khosla, S.1    Melton, L.J.2    Atkinson, E.J.3
  • 37
    • 0030931083 scopus 로고    scopus 로고
    • Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens
    • C.W. Slemenda, C. Longcope, L. Zhou, and et al. Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens J Clin Invest 100 1997 1755 1759
    • (1997) J Clin Invest , vol.100 , pp. 1755-1759
    • Slemenda, C.W.1    Longcope, C.2    Zhou, L.3
  • 38
    • 0030685090 scopus 로고    scopus 로고
    • Endogenous sex steroids and bone mineral density in older women and men: The Rancho Bernardo Study
    • G.A. Greendale, S. Edelstein, and E. Barrett-Connor Endogenous sex steroids and bone mineral density in older women and men: the Rancho Bernardo Study J Bone Miner Res 12 1997 1833 1843
    • (1997) J Bone Miner Res , vol.12 , pp. 1833-1843
    • Greendale, G.A.1    Edelstein, S.2    Barrett-Connor, E.3
  • 39
    • 0033304569 scopus 로고    scopus 로고
    • Hormonal and biochemical parameters in the determination of osteoporosis in elderly men
    • J.R. Center, T.V. Nguyen, P.N. Sambrook, and J.A. Eisman Hormonal and biochemical parameters in the determination of osteoporosis in elderly men J Clin Endocrinol Metab 84 1999 3626 3635
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3626-3635
    • Center, J.R.1    Nguyen, T.V.2    Sambrook, P.N.3    Eisman, J.A.4
  • 40
    • 0034687826 scopus 로고    scopus 로고
    • Association of hypogonadism and estradiol levels with bone mineral density in elderly men from the Framingham study
    • S. Amin, Y. Zhang, C.T. Sawin, and et al. Association of hypogonadism and estradiol levels with bone mineral density in elderly men from the Framingham study Ann Intern Med 133 2000 951 963
    • (2000) Ann Intern Med , vol.133 , pp. 951-963
    • Amin, S.1    Zhang, Y.2    Sawin, C.T.3
  • 41
    • 0034890081 scopus 로고    scopus 로고
    • Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men
    • S. Khosla, L.J. Melton 3rd, E.J. Atkinson, and W.M. 'oFallon Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men J Clin Endocrinol Metab 86 2001 3555 3561
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3555-3561
    • Khosla, S.1    Melton, L.J.2    Atkinson, E.J.3    'oFallon, W.M.4
  • 42
    • 17644366424 scopus 로고    scopus 로고
    • Relationship of volumetric BMD and structural parameters at different skeletal sites to sex steroid levels in men
    • S. Khosla, L.J. Melton 3rd, R.A. Robb, and et al. Relationship of volumetric BMD and structural parameters at different skeletal sites to sex steroid levels in men J Bone Miner Res 20 2005 730 740
    • (2005) J Bone Miner Res , vol.20 , pp. 730-740
    • Khosla, S.1    Melton, L.J.2    Robb, R.A.3
  • 43
    • 0034521393 scopus 로고    scopus 로고
    • Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men
    • A. Falahati-Nini, B.L. Riggs, E.J. Atkinson, and et al. Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men J Clin Invest 106 2000 1553 1560
    • (2000) J Clin Invest , vol.106 , pp. 1553-1560
    • Falahati-Nini, A.1    Riggs, B.L.2    Atkinson, E.J.3
  • 44
    • 0025884279 scopus 로고
    • Androgen treatment prevents loss of cancellous bone in the orchidectomized rat
    • G.K. Wakley, H.D. Schutte Jr., K.S. Hannon, and R.T. Turner Androgen treatment prevents loss of cancellous bone in the orchidectomized rat J Bone Miner Res 6 1991 325 330
    • (1991) J Bone Miner Res , vol.6 , pp. 325-330
    • Wakley, G.K.1    Schutte, H.D.2    Hannon, K.S.3    Turner, R.T.4
  • 45
    • 0023098492 scopus 로고
    • Effects of sex and age on the 24-hour profile of growth hormone secretion in man: Importance of endogenous estradiol concentrations
    • K.Y. Ho, W.S. Evans, R.M. Blizzard, and et al. Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations J Clin Endocrinol Metab 64 1987 51 58
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 51-58
    • Ho, K.Y.1    Evans, W.S.2    Blizzard, R.M.3
  • 47
    • 0033378714 scopus 로고    scopus 로고
    • Down-regulation of the serum stimulatory components of the insulin-like growth factor (IGF) system (IGF-I, IGF-II, IGF binding protein [BP]-3, and IGFBP-5) in age-related (type II) femoral neck osteoporosis
    • S. Boonen, S. Mohan, J. Dequeker, and et al. Down-regulation of the serum stimulatory components of the insulin-like growth factor (IGF) system (IGF-I, IGF-II, IGF binding protein [BP]-3, and IGFBP-5) in age-related (type II) femoral neck osteoporosis J Bone Miner Res 14 1999 2150 2158
    • (1999) J Bone Miner Res , vol.14 , pp. 2150-2158
    • Boonen, S.1    Mohan, S.2    Dequeker, J.3
  • 48
    • 14844301968 scopus 로고    scopus 로고
    • A potentially deleterious role of IGFBP-2 on bone density in aging men and women
    • S. Amin, B.L. Riggs, E.J. Atkinson, and et al. A potentially deleterious role of IGFBP-2 on bone density in aging men and women J Bone Miner Res 19 2004 1075 1083
    • (2004) J Bone Miner Res , vol.19 , pp. 1075-1083
    • Amin, S.1    Riggs, B.L.2    Atkinson, E.J.3
  • 49
    • 84901254305 scopus 로고    scopus 로고
    • Bone cell senescence: Mechanisms and perspectives
    • P.J. Marie Bone cell senescence: mechanisms and perspectives J Bone Miner Res 29 2014 1311 1321
    • (2014) J Bone Miner Res , vol.29 , pp. 1311-1321
    • Marie, P.J.1
  • 50
    • 84897904635 scopus 로고    scopus 로고
    • In vivo assessment of bone quality in postmenopausal women with type 2 diabetes
    • J.N. Farr, M.T. Drake, S. Amin, and et al. In vivo assessment of bone quality in postmenopausal women with type 2 diabetes J Bone Miner Res 29 2014 787 795
    • (2014) J Bone Miner Res , vol.29 , pp. 787-795
    • Farr, J.N.1    Drake, M.T.2    Amin, S.3
  • 52
    • 84919343070 scopus 로고    scopus 로고
    • Management of osteoporosis of the oldest old
    • R. Rizzoli, J. Branco, M.L. Brandi, and et al. Management of osteoporosis of the oldest old Osteoporos Int 25 2014 2507 2529
    • (2014) Osteoporos Int , vol.25 , pp. 2507-2529
    • Rizzoli, R.1    Branco, J.2    Brandi, M.L.3
  • 53
    • 0035143147 scopus 로고    scopus 로고
    • Anabolic effect of estrogen replacement on bone in postmenopausal women with osteoporosis: Histomorphometric evidence in a longitudinal study
    • G. Khastgir, J. Studd, N. Holland, and et al. Anabolic effect of estrogen replacement on bone in postmenopausal women with osteoporosis: histomorphometric evidence in a longitudinal study J Clin Endocrinol Metab 86 2001 289 295
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 289-295
    • Khastgir, G.1    Studd, J.2    Holland, N.3
  • 54
    • 0036677998 scopus 로고    scopus 로고
    • Meta-analyses of therapies for postmenopausal osteoporosis. V. Meta-analysis of the efficacy of hormone replacement therapy in treating and preventing osteoporosis in postmenopausal women
    • G. Wells, P. Tugwell, B. Shea, et al. Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group Meta-analyses of therapies for postmenopausal osteoporosis. V. Meta-analysis of the efficacy of hormone replacement therapy in treating and preventing osteoporosis in postmenopausal women Endocr Rev 23 2002 529 539
    • (2002) Endocr Rev , vol.23 , pp. 529-539
    • Wells, G.1    Tugwell, P.2    Shea, B.3
  • 55
    • 0345183982 scopus 로고    scopus 로고
    • Hormone replacement therapy and prevention of vertebral fractures: A meta-analysis of randomised trials
    • D.J. Torgerson, and S.E. Bell-Syer Hormone replacement therapy and prevention of vertebral fractures: a meta-analysis of randomised trials BMC Musculoskelet Disord 2 2001 7
    • (2001) BMC Musculoskelet Disord , vol.2 , pp. 7
    • Torgerson, D.J.1    Bell-Syer, S.E.2
  • 56
    • 0141705375 scopus 로고    scopus 로고
    • Women's Health Initiative Investigators. Effects of estrogen plus progestin on risk of fracture and bone mineral density: The Womens Health Initiative randomized trial
    • J.A. Cauley, J. Robbins, Z. Chen, and et al. Women's Health Initiative Investigators. Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women trial JAMA 290 2003 1729 1738
    • (2003) JAMA , vol.290 , pp. 1729-1738
    • Cauley, J.A.1    Robbins, J.2    Chen, Z.3
  • 57
    • 0037125379 scopus 로고    scopus 로고
    • Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women controlled trial
    • J.E. Rossouw, G.L. Anderson, R.L. Prentice, and et al. Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women controlled trial JAMA 288 2002 321 333
    • (2002) JAMA , vol.288 , pp. 321-333
    • Rossouw, J.E.1    Anderson, G.L.2    Prentice, R.L.3
  • 58
    • 84899896223 scopus 로고    scopus 로고
    • Use of SERMs for treatment in postmenopausal women
    • J.V. Pinkerton, and S. Thomas Use of SERMs for treatment in postmenopausal women J Steroid Biochem Mol Biol 142 2014 142 154
    • (2014) J Steroid Biochem Mol Biol , vol.142 , pp. 142-154
    • Pinkerton, J.V.1    Thomas, S.2
  • 59
    • 84896738949 scopus 로고    scopus 로고
    • Effects of bazedoxifene/conjugated estrogens on the endometrium and bone: A randomized trial
    • J.V. Pinkerton, J.A. Harvey, R. Lindsay, and et al. Effects of bazedoxifene/conjugated estrogens on the endometrium and bone: a randomized trial J Clin Endocrinol Metab 99 2014 E189 E198
    • (2014) J Clin Endocrinol Metab , vol.99 , pp. E189-E198
    • Pinkerton, J.V.1    Harvey, J.A.2    Lindsay, R.3
  • 60
    • 77953517352 scopus 로고    scopus 로고
    • Bisphosphonate therapeutics in bone disease: The hard and soft data on osteoclast inhibition
    • M.T. Drake, and S.C. Cremers Bisphosphonate therapeutics in bone disease: the hard and soft data on osteoclast inhibition Mol Interv 10 2010 141 152
    • (2010) Mol Interv , vol.10 , pp. 141-152
    • Drake, M.T.1    Cremers, S.C.2
  • 61
    • 51349163043 scopus 로고    scopus 로고
    • Bisphosphonates: Mechanism of action and role in clinical practice
    • M.T. Drake, B.L. Clarke, and S. Khosla Bisphosphonates: mechanism of action and role in clinical practice Mayo Clin Proc 83 2008 1032 1045
    • (2008) Mayo Clin Proc , vol.83 , pp. 1032-1045
    • Drake, M.T.1    Clarke, B.L.2    Khosla, S.3
  • 62
    • 0035146537 scopus 로고    scopus 로고
    • Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates
    • J.E. Dunford, K. Thompson, F.P. Coxon, and et al. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates J Pharmacol Exp Ther 296 2001 235 242
    • (2001) J Pharmacol Exp Ther , vol.296 , pp. 235-242
    • Dunford, J.E.1    Thompson, K.2    Coxon, F.P.3
  • 63
    • 33646725498 scopus 로고    scopus 로고
    • The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs
    • K.L. Kavanagh, K. Guo, J.E. Dunford, and et al. The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs Proc Natl Acad Sci U S A 103 2006 7829 7834
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 7829-7834
    • Kavanagh, K.L.1    Guo, K.2    Dunford, J.E.3
  • 64
    • 0030766092 scopus 로고    scopus 로고
    • Elimination and biochemical responses to intravenous alendronate in postmenopausal osteoporosis
    • S.A. Khan, J.A. Kanis, S. Vasikaran, and et al. Elimination and biochemical responses to intravenous alendronate in postmenopausal osteoporosis J Bone Miner Res 12 1997 1700 1707
    • (1997) J Bone Miner Res , vol.12 , pp. 1700-1707
    • Khan, S.A.1    Kanis, J.A.2    Vasikaran, S.3
  • 65
    • 0004851872 scopus 로고    scopus 로고
    • Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group
    • D.M. Black, S.R. Cummings, D.B. Karpf, and et al. Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group Lancet 348 1996 1535 1541
    • (1996) Lancet , vol.348 , pp. 1535-1541
    • Black, D.M.1    Cummings, S.R.2    Karpf, D.B.3
  • 66
    • 33845890326 scopus 로고    scopus 로고
    • Effects of continuing or stopping alendronate after 5 years of treatment: The Fracture Intervention Trial Long-term Extension (FLEX): A randomized trial
    • D.M. Black, A.V. Schwartz, K.E. Ensrud, et al. FLEX Research Group Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial JAMA 296 2006 2927 2938
    • (2006) JAMA , vol.296 , pp. 2927-2938
    • Black, D.M.1    Schwartz, A.V.2    Ensrud, K.E.3
  • 67
    • 77952331323 scopus 로고    scopus 로고
    • Efficacy of continued alendronate for fractures in women with and without prevalent vertebral fracture: The FLEX trial
    • A.V. Schwartz, D.C. Bauer, S.R. Cummings, et al. FLEX Research Group Efficacy of continued alendronate for fractures in women with and without prevalent vertebral fracture: the FLEX trial J Bone Miner Res 25 2010 976 982
    • (2010) J Bone Miner Res , vol.25 , pp. 976-982
    • Schwartz, A.V.1    Bauer, D.C.2    Cummings, S.R.3
  • 68
    • 0033552255 scopus 로고    scopus 로고
    • Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: A randomized controlled trial. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group
    • S.T. Harris, N.B. Watts, H.K. Genant, and et al. Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group JAMA 282 1999 1344 1352
    • (1999) JAMA , vol.282 , pp. 1344-1352
    • Harris, S.T.1    Watts, N.B.2    Genant, H.K.3
  • 69
    • 12944291524 scopus 로고    scopus 로고
    • Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group
    • J. Reginster, H.W. Minne, O.H. Sorensen, and et al. Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group Osteoporos Int 11 2000 83 91
    • (2000) Osteoporos Int , vol.11 , pp. 83-91
    • Reginster, J.1    Minne, H.W.2    Sorensen, O.H.3
  • 70
    • 4344580653 scopus 로고    scopus 로고
    • Daily and intermittent oral ibandronate normalize bone turnover and provide significant reduction in vertebral fracture risk: Results from the BONE study
    • P.D. Delmas, R.R. Recker, C.H. Chesnut 3rd, and et al. Daily and intermittent oral ibandronate normalize bone turnover and provide significant reduction in vertebral fracture risk: results from the BONE study Osteoporos Int 15 2004 792 798
    • (2004) Osteoporos Int , vol.15 , pp. 792-798
    • Delmas, P.D.1    Recker, R.R.2    Chesnut, C.H.3
  • 71
    • 2342476583 scopus 로고    scopus 로고
    • Insufficiently dosed intravenous ibandronate injections are associated with suboptimal antifracture efficacy in postmenopausal osteoporosis
    • R. Recker, J.A. Stakkestad, C.H. Chesnut 3rd, and et al. Insufficiently dosed intravenous ibandronate injections are associated with suboptimal antifracture efficacy in postmenopausal osteoporosis Bone 34 2004 890 899
    • (2004) Bone , vol.34 , pp. 890-899
    • Recker, R.1    Stakkestad, J.A.2    Chesnut, C.H.3
  • 72
    • 34247866550 scopus 로고    scopus 로고
    • HORIZON Pivotal Fracture Trial. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis
    • D.M. Black, P.D. Delmas, R. Eastell, and et al. HORIZON Pivotal Fracture Trial. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis N Engl J Med 356 2007 1809 1822
    • (2007) N Engl J Med , vol.356 , pp. 1809-1822
    • Black, D.M.1    Delmas, P.D.2    Eastell, R.3
  • 73
    • 67650767002 scopus 로고    scopus 로고
    • Adverse effects of bisphosphonates: Implications for osteoporosis management
    • quiz 638
    • K.A. Kennel, and M.T. Drake Adverse effects of bisphosphonates: implications for osteoporosis management Mayo Clin Proc 84 2009 632 637 quiz 638
    • (2009) Mayo Clin Proc , vol.84 , pp. 632-637
    • Kennel, K.A.1    Drake, M.T.2
  • 74
    • 84919934170 scopus 로고    scopus 로고
    • International Task Force on Osteonecrosis of the Jaw. Diagnosis and management of osteonecrosis of the jaw: A systematic review and international consensus
    • A.A. Khan, A. Morrison, D.A. Hanley, and et al. International Task Force on Osteonecrosis of the Jaw. Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus J Bone Miner Res 30 2015;3 23
    • (2015) J Bone Miner Res , vol.30 , pp. 3-23
    • Khan, A.A.1    Morrison, A.2    Hanley, D.A.3
  • 75
    • 84891034178 scopus 로고    scopus 로고
    • Atypical subtrochanteric and diaphyseal femoral fractures: Second report of a task force of the American Society for Bone and Mineral Research
    • E. Shane, D. Burr, B. Abrahamsen, and et al. Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research J Bone Miner Res 29 2014 1 23
    • (2014) J Bone Miner Res , vol.29 , pp. 1-23
    • Shane, E.1    Burr, D.2    Abrahamsen, B.3
  • 76
    • 84887691042 scopus 로고    scopus 로고
    • Controversies in osteoporosis management: Concerns about bisphosphonates and when are "drug holidays " required?
    • M. McClung Controversies in osteoporosis management: concerns about bisphosphonates and when are "drug holidays " required? Clin Obstet Gynecol 56 2013 743 748
    • (2013) Clin Obstet Gynecol , vol.56 , pp. 743-748
    • McClung, M.1
  • 77
    • 69049083492 scopus 로고    scopus 로고
    • FREEDOM Trial. Denosumab for prevention of fractures in postmenopausal women with osteoporosis
    • S.R. Cummings, J. San Martin, M.R. McClung, and et al. FREEDOM Trial. Denosumab for prevention of fractures in postmenopausal women with osteoporosis N Engl J Med 361 2009 756 765
    • (2009) N Engl J Med , vol.361 , pp. 756-765
    • Cummings, S.R.1    San Martin, J.2    McClung, M.R.3
  • 78
    • 84887456516 scopus 로고    scopus 로고
    • The effect of three or six years of denosumab exposure in women with postmenopausal osteoporosis: Results from the FREEDOM extension
    • H.G. Bone, R. Chapurlat, M.L. Brandi, and et al. The effect of three or six years of denosumab exposure in women with postmenopausal osteoporosis: results from the FREEDOM extension J Clin Endocrinol Metab 98 2013 4483 4492
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 4483-4492
    • Bone, H.G.1    Chapurlat, R.2    Brandi, M.L.3
  • 79
    • 84869413759 scopus 로고    scopus 로고
    • The US postmarketing surveillance study of adult osteosarcoma and teriparatide: Study design and findings from the first 7 years
    • E.B. Andrews, A.W. Gilsenan, K. Midkiff, and et al. The US postmarketing surveillance study of adult osteosarcoma and teriparatide: study design and findings from the first 7 years J Bone Miner Res 27 2012 2429 2437
    • (2012) J Bone Miner Res , vol.27 , pp. 2429-2437
    • Andrews, E.B.1    Gilsenan, A.W.2    Midkiff, K.3
  • 80
    • 0035837553 scopus 로고    scopus 로고
    • Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis
    • R.M. Neer, C.D. Arnaud, J.R. Zanchetta, and et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis N Engl J Med 344 2001 1434 1441
    • (2001) N Engl J Med , vol.344 , pp. 1434-1441
    • Neer, R.M.1    Arnaud, C.D.2    Zanchetta, J.R.3
  • 81
    • 0030804947 scopus 로고    scopus 로고
    • Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis
    • R. Lindsay, J. Nieves, C. Formica, and et al. Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis Lancet 350 1997 550 555
    • (1997) Lancet , vol.350 , pp. 550-555
    • Lindsay, R.1    Nieves, J.2    Formica, C.3
  • 82
    • 77951644239 scopus 로고    scopus 로고
    • Effects of teriparatide, alendronate, or both in women with postmenopausal osteoporosis
    • J.S. Finkelstein, J.J. Wyland, H. Lee, and R.M. Neer Effects of teriparatide, alendronate, or both in women with postmenopausal osteoporosis J Clin Endocrinol Metab 95 2010 1838 1845
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1838-1845
    • Finkelstein, J.S.1    Wyland, J.J.2    Lee, H.3    Neer, R.M.4
  • 83
    • 78649412131 scopus 로고    scopus 로고
    • Effects of intravenous zoledronic acid plus subcutaneous teriparatide [rhPTH(1-34)] in postmenopausal osteoporosis
    • F. Cosman, E.F. Ericksen, C. Recknor, and et al. Effects of intravenous zoledronic acid plus subcutaneous teriparatide [rhPTH(1-34)] in postmenopausal osteoporosis J Bone Miner Res 26 2011 503 511
    • (2011) J Bone Miner Res , vol.26 , pp. 503-511
    • Cosman, F.1    Ericksen, E.F.2    Recknor, C.3
  • 84
    • 84879887680 scopus 로고    scopus 로고
    • Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: The DATA study randomised trial
    • J.N. Tsai, A.V. Uihlein, H. Lee, and et al. Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the DATA study randomised trial Lancet 382 2013 50 56
    • (2013) Lancet , vol.382 , pp. 50-56
    • Tsai, J.N.1    Uihlein, A.V.2    Lee, H.3
  • 85
    • 84899961372 scopus 로고    scopus 로고
    • Two years of Denosumab and teriparatide administration in postmenopausal women with osteoporosis (The DATA Extension Study): A randomized controlled trial
    • B.Z. Leder, J.N. Tsai, A.V. Uihlein, and et al. Two years of Denosumab and teriparatide administration in postmenopausal women with osteoporosis (The DATA Extension Study): a randomized controlled trial J Clin Endocrinol Metab 99 2014 1694 1700
    • (2014) J Clin Endocrinol Metab , vol.99 , pp. 1694-1700
    • Leder, B.Z.1    Tsai, J.N.2    Uihlein, A.V.3
  • 86
    • 84861973260 scopus 로고    scopus 로고
    • Endocrine Society. Osteoporosis in men: An Endocrine Society clinical practice guideline
    • N.B. Watts, R.A. Adler, J.P. Bilezikian, and et al. Endocrine Society. Osteoporosis in men: an Endocrine Society clinical practice guideline J Clin Endocrinol Metab 97 2012 1802 1822
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1802-1822
    • Watts, N.B.1    Adler, R.A.2    Bilezikian, J.P.3
  • 87
    • 84881539601 scopus 로고    scopus 로고
    • A unique collagenolytic cysteine peptidase
    • M. Novinec, B. Lenarcic, and K. Cathepsin a unique collagenolytic cysteine peptidase Biol Chem 394 2013 1163 1179
    • (2013) Biol Chem , vol.394 , pp. 1163-1179
    • Novinec, M.1    Lenarcic, B.2    Cathepsin, K.3
  • 88
    • 84867526082 scopus 로고    scopus 로고
    • Odanacatib in the treatment of postmenopausal women with low bone mineral density: Five years of continued therapy in a phase 2 study
    • B. Langdahl, N. Binkley, H. Bone, and et al. Odanacatib in the treatment of postmenopausal women with low bone mineral density: five years of continued therapy in a phase 2 study J Bone Miner Res 27 2012 2251 2258
    • (2012) J Bone Miner Res , vol.27 , pp. 2251-2258
    • Langdahl, B.1    Binkley, N.2    Bone, H.3
  • 89
    • 84893044528 scopus 로고    scopus 로고
    • Romosozumab in postmenopausal women with low bone mineral density
    • M.R. McClung, A. Grauer, S. Boonen, and et al. Romosozumab in postmenopausal women with low bone mineral density N Engl J Med 370 2014 412 420
    • (2014) N Engl J Med , vol.370 , pp. 412-420
    • McClung, M.R.1    Grauer, A.2    Boonen, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.