Allelic variants in Arhgef11 via the Rho-Rock pathway are linked to epithelial-mesenchymal transition and contributes to kidney injury in the Dahl salt-sensitive rat

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Jia, Zhen ^a   Johnson, Ashley C ^a   Wang, Xuexiang ^a   Guo, Zibiao ^a,b   Dreisbach, Albert W ^a   Lewin, Jack R ^a   Kyle, Patrick B ^a   Garrett, Michael R ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; GELATINASE B; NERVE CELL ADHESION MOLECULE; OSTEOGENIC PROTEIN 1; RHO FACTOR; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; VIMENTIN; ARHGEF11 PROTEIN, HUMAN; ARHGEF11 PROTEIN, RAT; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PLAKIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARHGEF11 GENE; ARTICLE; BMP7 GENE; CHRONIC KIDNEY DISEASE; COL1A3 GENE; CONTROLLED STUDY; DAHL SALT RESISTANT RAT; DISEASE MODEL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; EPITHELIAL MESENCHYMAL TRANSITION; GENE; GENE EXPRESSION; GENE SILENCING; GENETIC LINKAGE; GENETIC STABILITY; GENETIC VARIABILITY; HEK293 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTENSION; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CELL; KIDNEY FIBROSIS; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; MALE; MMP9 GENE; MOLECULAR PATHOLOGY; NONHUMAN; OCLN GENE; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; STRESS FIBER; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHRONIC KIDNEY FAILURE; CONGENIC STRAIN; DAHL RAT; GENETIC VARIATION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPONTANEOUSLY HYPERTENSIVE RAT;

ALLELES; ANIMALS; ANIMALS, CONGENIC; CELL LINE; DISEASE MODELS, ANIMAL; EPITHELIAL-MESENCHYMAL TRANSITION; GENE KNOCKDOWN TECHNIQUES; GENETIC VARIATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEK293 CELLS; HUMANS; KIDNEY TUBULES, PROXIMAL; MALE; PLAKINS; RATS; RATS, INBRED DAHL; RATS, INBRED SHR; RENAL INSUFFICIENCY, CHRONIC; RHO GTP-BINDING PROTEINS; RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION;

EID: 84940704429     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0132553     Document Type: Article

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