Promoting brain remodeling to aid in stroke recovery

Trends in Molecular Medicine

Volumn 21, Issue 9, 2015, Pages 543-548

  Zhang, Zheng Gang ^a   Chopp, Michael ^a,b  

^a HENRY FORD HOSPITAL   (United States)

^b OAKLAND UNIVERSITY   (United States)

Author keywords

Exosomes; MiRNAs; Neurorestorative therapy; Stroke recovery

Indexed keywords

HISTONE DEACETYLASE; MICRORNA;

ANGIOGENESIS; BRAIN; BRAIN DISEASE; BRAIN REMODELING; CEREBROVASCULAR ACCIDENT; CONVALESCENCE; CYTOCHEMISTRY; EXOSOME; HUMAN; MOLECULAR BIOLOGY; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; OLIGODENDROGENESIS; OLIGODENDROGLIA; REVIEW; ANIMAL; GENETICS; METABOLISM; PATHOPHYSIOLOGY; STROKE;

ANIMALS; BRAIN; HUMANS; MICRORNAS; RECOVERY OF FUNCTION; STROKE;

EID: 84940609087     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2015.07.005     Document Type: Review

References (80)

1. Lackland D.T., et al. Factors influencing the decline in stroke mortality: a statement from the American Heart Association/American Stroke Association. Stroke 2014, 45:315-353.
2. Moskowitz M.A., et al. The science of stroke: mechanisms in search of treatments. Neuron 2010, 67:181-198.
3. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N. Engl. J. Med. 1995, 333:1581-1587. NINDS.
4. Hacke W., et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N. Engl. J. Med. 2008, 359:1317-1329.
5. Goyal M., et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N. Engl. J. Med. 2015, 372:1019-1030.
6. Campbell B.C., et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N. Engl. J. Med. 2015, 372:1009-1018.
7. Berkhemer O.A., et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N. Engl. J. Med. 2015, 372:11-20.
8. Verheyden G., et al. Time course of trunk, arm, leg, and functional recovery after ischemic stroke. Neurorehabil. Neural. Repair 2008, 22:173-179.
9. Zhang Z.G., Chopp M. Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurol. 2009, 8:491-500.
10. Li Y., et al. The role of astrocytes in mediating exogenous cell-based restorative therapy for stroke. Glia 2014, 62:1-16.
11. Bartel D.P. MicroRNAs: target recognition and regulatory functions. Cell 2009, 136:215-233.
12. Nam J.W., et al. Global analyses of the effect of different cellular contexts on microRNA targeting. Mol. Cell 2014, 53:1031-1043.
13. Xin H., et al. Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J. Cereb. Blood Flow Metab. 2013, 33:1711-1715.
14. Xin H., et al. Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth. Stem Cells 2012, 30:1556-1564.
15. Kassis H., et al. Histone deacetylase expression in white matter oligodendrocytes after stroke. Neurochem. Int. 2014, 77:17-23.
16. Anand S. A brief primer on microRNAs and their roles in angiogenesis. Vasc. Cell 2013, 5:2.
17. Yin K.J., et al. Angiogenesis-regulating microRNAs and ischemic stroke. Curr. Vasc. Pharmacol. 2015, 13:352-365.
18. Zeng L., et al. MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain. Gene Ther. 2014, 21:37-43.
19. Teng H., et al. Stroke alters expression of miRNAs and ROCK signaling in cerebral endothelial cells. Neuroscience 2013, 337. 21/U6.
20. Alvarez-Buylla A., et al. The subventricular zone: source of neuronal precursors for brain repair. Prog. Brain Res. 2000, 127:1-11.
21. Gage F.H., et al. Isolation, characterization, and use of stem cells from the CNS. Annu. Rev. Neurosci. 1995, 18:159-192.
22. Liu X.S., et al. MicroRNAs in cerebral ischemia-induced neurogenesis. J. Neuropathol. Exp. Neurol. 2013, 72:718-722.
23. Huttner H.B., et al. The age and genomic integrity of neurons after cortical stroke in humans. Nat. Neurosci. 2014, 17:801-803.
24. Wang X., et al. Conditional depletion of neurogenesis inhibits long-term recovery after experimental stroke in mice. PLoS ONE 2012, 7:e38932.
25. Liu X.S., et al. MicroRNA profiling in subventricular zone after stroke: miR-124a regulates proliferation of neural progenitor cells through Notch signaling pathway. PLoS ONE 2011, 6:e23461.
26. Gaiano N.F.G. The role of notch in promoting glial and neural stem cell fates. Annu. Rev. Neurosci. 2002, 25:471-490.
27. Wang L.C.M., et al. The Notch pathway mediates expansion of a progenitor pool and neuronal differentiation in adult neural progenitor cells after stroke. Neuroscience 2009, 158:1356-1363.
28. Xiao C., et al. Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nat. Immunol. 2008, 9:405-414.
29. de Pontual L., et al. Germline deletion of the miR-17 approximately 92 cluster causes skeletal and growth defects in humans. Nat. Genet. 2011, 43:1026-1030.
30. Liu X.S., et al. MicroRNA-17-92 cluster mediates the proliferation and survival of neural progenitor cells after stroke. J. Biol. Chem. 2013, 288:12478-12488.
31. Gregorian C., et al. Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. J. Neurosci. 2009, 29:1874-1886.
32. Groszer M., et al. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:111-116.
33. Groszer M., et al. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 2001, 294:2186-2189.
34. Li L., et al. PTEN regulation of neural development and CNS stem cells. J. Cell. Biochem. 2003, 88:24-28.
35. Li L., et al. PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation. Mol. Cell. Neurosci. 2002, 20:21-29.
36. Otaegi G., et al. Modulation of the PI 3-kinase-Akt signalling pathway by IGF-I and PTEN regulates the differentiation of neural stem/precursor cells. J. Cell Sci. 2006, 119:2739-2748.
37. Zheng H., et al. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature 2008, 455:1129-1133.
38. Marti E., Bovolenta P. Sonic hedgehog in CNS development: one signal, multiple outputs. Trends Neurosci. 2002, 25:89-96.
39. Wang L., et al. The Sonic hedgehog pathway mediates carbamylated erythropoietin-enhanced proliferation and differentiation of adult neural progenitor cells. J. Biol. Chem. 2007, 282:32462-32470.
40. Young K.M., et al. Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling. Neuron 2013, 77:873-885.
41. Fields R.D. White matter in learning, cognition and psychiatric disorders. Trends Neurosci. 2008, 31:361-370.
42. Zatorre R.J., et al. Plasticity in gray and white: neuroimaging changes in brain structure during learning. Nat. Neurosci. 2012, 15:528-536.
43. Pantoni L., et al. Cerebral white matter is highly vulnerable to ischemia. Stroke 1996, 27:1641-1646. discussion 1647.
44. Dewar D., et al. Oligodendrocytes and ischemic brain injury. J. Cereb. Blood Flow Metab. 2003, 23:263-274.
45. Zhang R.L., et al. Ascl1 lineage cells contribute to ischemia-induced neurogenesis and oligodendrogenesis. J. Cereb. Blood Flow Metab. 2011, 31:614-625.
46. Ueno Y., et al. Axonal outgrowth and dendritic plasticity in the cortical peri-infarct area after experimental stroke. Stroke 2012, 43:2221-2228.
47. Gregersen R., et al. Focal cerebral ischemia induces increased myelin basic protein and growth-associated protein-43 gene transcription in peri-infarct areas in the rat brain. Exp. Brain Res. 2001, 138:384-392.
48. He X., et al. Unwrapping myelination by microRNAs. Neuroscientist 2012, 18:45-55.
49. Zhao X., et al. MicroRNA-mediated control of oligodendrocyte differentiation. Neuron 2010, 65:612-626.
50. Dugas J.C., et al. Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination. Neuron 2010, 65:597-611.
51. Buller B., et al. Regulation of serum response factor by miRNA-200 and miRNA-9 modulates oligodendrocyte progenitor cell differentiation. Glia 2012, 60:1906-1914.
52. Rosenzweig S., Carmichael S.T. Age-dependent exacerbation of white matter stroke outcomes: a role for oxidative damage and inflammatory mediators. Stroke 2013, 44:2579-2586.
53. Gherardini L., et al. Perilesional treatment with chondroitinase ABC and motor training promote functional recovery after stroke in rats. Cereb. Cortex 2015, 25:202-212.
54. Iyer A.N., et al. microRNAs in axon guidance. Front. Cell Neurosci. 2014, 8:78.
55. Zhang Y., et al. MicroRNAs in the axon locally mediate the effects of chondroitin sulfate proteoglycans and cGMP on axonal growth. Dev. Neurobiol. 2015, Published online March 18, 2015. 10.1002/dneu.22292.
56. Zhang Y., et al. The MicroRNA-17-92 cluster enhances axonal outgrowth in embryonic cortical neurons. J. Neurosci. 2013, 33:6885-6894.
57. Kouzarides T. Chromatin modifications and their function. Cell 2007, 128:693-705.
58. Jenuwein T., Allis C.D. Translating the histone code. Science 2001, 293:1074-1080.
59. Qureshi I.A., Mehler M.F. The emerging role of epigenetics in stroke: II. RNA regulatory circuitry. Arch. Neurol. 2010, 67:1435-1441.
60. Felling R.J., Song H. Epigenetic mechanisms of neuroplasticity and the implications for stroke recovery. Exp. Neurol. 2015, 268:37-45.
61. Shen S., Casaccia-Bonnefil P. Post-translational modifications of nucleosomal histones in oligodendrocyte lineage cells in development and disease. J. Mol. Neurosci. 2008, 35:13-22.
62. Shen S., et al. Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency. Nat. Neurosci. 2008, 11:1024-1034.
63. Ye F., et al. HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat. Neurosci. 2009, 12:829-838.
64. Liu X.S., et al. Valproic acid increases white matter repair and neurogenesis after stroke. Neuroscience 2012, 220:313-321.
65. Grozinger C.M., Schreiber S.L. Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:7835-7840.
66. Kassis H., et al. Stroke induces nuclear shuttling of histone deacetylase 4. Stroke 2015, 46:1909-1915.
67. Ellis L., et al. Targeting tumor angiogenesis with histone deacetylase inhibitors. Cancer Lett. 2009, 280:145-153.
68. Urbich C., et al. HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells. Blood 2009, 113:5669-5679.
69. Lai C.P., Breakefield X.O. Role of exosomes/microvesicles in the nervous system and use in emerging therapies. Front. Physiol. 2012, 3:228.
70. Zhang Y., et al. Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury. J. Neurosurg. 2015, 122:856-867.
71. Jones E.V., Bouvier D.S. Astrocyte-secreted matricellular proteins in CNS remodelling during development and disease. Neural Plast. 2014, 2014:321209.
72. Xin H., et al. Exosomes/miRNAs as mediating cell-based therapy of stroke. Front. Cell Neurosci. 2014, 8:377.
73. Zhang Y., et al. Exosomes derived from mesenchymal stromal cells promote axonal outgrowth. Stroke 2015, 46:A67.
74. Fruhbeis C., et al. Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS Biol. 2013, 11:e1001604.
75. Bakhti M., et al. Inhibition of myelin membrane sheath formation by oligodendrocyte-derived exosome-like vesicles. J. Biol. Chem. 2011, 286:787-796.
76. Bhalala O.G., et al. The emerging roles of microRNAs in CNS injuries. Nat. Rev. Neurol. 2013, 9:328-339.
77. Zhang R., et al. Oligodendrogenesis after cerebral ischemia. Front. Cell Neurosci. 2013, 7:201.
78. Li Z., Rana T.M. Therapeutic targeting of microRNAs: current status and future challenges. Nat. Rev. Drug Discov. 2014, 13:622-638.
79. Barteneva N.S., et al. Microvesicles and intercellular communication in the context of parasitism. Front. Cell Infect. Microbiol. 2013, 3:49.
80. Alvarez-Erviti L., et al. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat. Biotechnol. 2011, 29:341-345.