Systemic treatment with a 5HT1a agonist induces anti-oxidant protection and preserves the retina from mitochondrial oxidative stress

Experimental Eye Research

Volumn 140, Issue , 2015, Pages 94-105

  Biswal, Manas R ^a   Ahmed, Chulbul M ^a   Ildefonso, Cristhian J ^a   Han, Pingyang ^a   Li, Hong ^a   Jivanji, Hiral ^a   Mao, Haoyu ^a   Lewin, Alfred S ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

5 hydroxy tryptamine 1a receptor; Age related macular degeneration; Drug therapy; Mitochondria; Mouse model; Oxidative stress; Retinal pigment epithelium; Superoxide dismutase

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; MANGANESE SUPEROXIDE DISMUTASE; SEROTONIN 1A AGONIST; METALLOTHIONEIN; OXIDOREDUCTASE; REACTIVE OXYGEN METABOLITE; SEROTONIN 1A RECEPTOR; SEROTONIN AGONIST; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DOSE INCREASE; ELECTRORETINOGRAM; GENE EXPRESSION; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; SYSTEMIC THERAPY; UPREGULATION; VISION; VISUAL ACUITY; ANIMAL; C57BL MOUSE; CELL LINE; DRUG EFFECTS; ELECTRORETINOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE DELETION; GENETICS; INDIRECT FLUORESCENT ANTIBODY TECHNIQUE; KNOCKOUT MOUSE; METABOLISM; OPTICAL COHERENCE TOMOGRAPHY; PATHOPHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; RETINA; RETINAL PIGMENT EPITHELIUM;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; CELL LINE; ELECTRORETINOGRAPHY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE DELETION; METALLOTHIONEIN; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; OXIDATIVE STRESS; OXIDOREDUCTASES; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, SEROTONIN, 5-HT1A; RETINA; RETINAL PIGMENT EPITHELIUM; SEROTONIN RECEPTOR AGONISTS; SUPEROXIDE DISMUTASE; TOMOGRAPHY, OPTICAL COHERENCE; VISUAL ACUITY;

EID: 84940538851     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2015.07.022     Document Type: Article

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