Polarized human embryonic stem cell-derived retinal pigment epithelial cell monolayers have higher resistance to oxidative stress-induced cell death than nonpolarized cultures

Stem Cells Translational Medicine

Volumn 4, Issue 1, 2014, Pages 10-20

  Hsiung, Jamie ^a   Zhu, Danhong ^a   Hinton, David R ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Age related macular degeneration; Apoptosis; Embryonic stem cells; Oxidative stress; Polarized retinal pigment epithelial cell; Retinal pigment epithelial cell

Indexed keywords

CASPASE 3; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; HYDROGEN PEROXIDE; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE; P21 ACTIVATED KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; OXIDIZING AGENT;

AGE RELATED MACULAR DEGENERATION; APOPTOSIS; ARTICLE; BLINDNESS; CELL DEATH; CELL DIFFERENTIATION; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CELL THERAPY; CONTROLLED STUDY; DENSITOMETRY; EMBRYONIC STEM CELL; ENZYME CHEMISTRY; HUMAN; HUMAN CELL; NICK END LABELING; OXIDATIVE STRESS; PIGMENT EPITHELIUM; POLARIZATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; CELL CULTURE; CELL CULTURE TECHNIQUE; CELL POLARITY; CYTOLOGY; DRUG EFFECTS; PHYSIOLOGY; PROCEDURES; REAL TIME POLYMERASE CHAIN REACTION; RETINAL PIGMENT EPITHELIUM; TISSUE ENGINEERING; TUNEL ASSAY;

APOPTOSIS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL POLARITY; CELLS, CULTURED; EMBRYONIC STEM CELLS; HUMANS; HYDROGEN PEROXIDE; IN SITU NICK-END LABELING; OXIDANTS; OXIDATIVE STRESS; REAL-TIME POLYMERASE CHAIN REACTION; RETINAL PIGMENT EPITHELIUM; TISSUE ENGINEERING;

EID: 84919785953     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2014-0205     Document Type: Article

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