Nanoparticle modulation of the tumor microenvironment enhances therapeutic efficacy of cisplatin

Journal of Controlled Release

Volumn 217, Issue , 2015, Pages 27-41

  Miao, Lei ^a   Wang, Yuhua ^a   Lin, C Michael ^a   Xiong, Yang ^a,b   Chen, Naihan ^a   Zhang, Lu ^a   Kim, William Y ^c   Huang, Leaf ^a  

^a UNC Hamner Institute for Drug Safety Sciences   (United States)

^b ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Cisplatin; Nanoparticle; Tumor associated fibroblast; Tumor microenvironment; Wnt16

Indexed keywords

CELL CULTURE; CHEMOTHERAPY; DRUG DOSAGE; FIBROBLASTS; NANOPARTICLES; PHYSIOLOGY; PLATINUM COMPOUNDS;

CIS-PLATIN; MULTIDRUG RESISTANTS; NANOPARTICLE (NPS); PARACRINE MANNERS; THERAPEUTIC EFFICACY; THERAPEUTIC OUTCOMES; TUMOR MICROENVIRONMENT; WNT16;

TUMORS;

CISPLATIN; NANOPARTICLE; UNCLASSIFIED DRUG; WNT PROTEIN; WNT16 PROTEIN; ANTINEOPLASTIC AGENT; SMALL INTERFERING RNA; WNT16 PROTEIN, HUMAN; WNT16 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CANCER CELL LINE; CANCER INHIBITION; CANCER RESISTANCE; CELL PROLIFERATION; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG EFFICACY; EMBRYO; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; IC50; LONG TERM EXPOSURE; MOUSE; NEOPLASM; NONHUMAN; PARACRINE SIGNALING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; STROMA CELL; TUMOR CELL; TUMOR INVASION; TUMOR MICROENVIRONMENT; UPREGULATION; 3T3 CELL LINE; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; COCULTURE; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; METABOLISM; NUDE MOUSE; PATHOLOGY; TREATMENT OUTCOME; TUMOR CELL LINE; TUMOR VOLUME; UMBILICAL VEIN ENDOTHELIAL CELL; URINARY BLADDER NEOPLASMS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELLS, CULTURED; CISPLATIN; COCULTURE TECHNIQUES; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NANOPARTICLES; NIH 3T3 CELLS; RNA, SMALL INTERFERING; TREATMENT OUTCOME; TUMOR BURDEN; TUMOR MICROENVIRONMENT; URINARY BLADDER NEOPLASMS; WNT PROTEINS;

EID: 84940526908     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.08.027     Document Type: Article

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