Protective effects of quercetin and taraxasterol against H2O2-induced human umbilical vein endothelial cell injury in vitro

Experimental and Therapeutic Medicine

Volumn 10, Issue 4, 2015, Pages 1253-1260

  Yang, Dongwei ^a   Liu, Xinye ^a   Liu, Min ^a   Chi, Hao ^a   Liu, Jirong ^b   Han, Huamin ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b NORTH CHINA ELECTRIC POWER UNIVERSITY   (China)

Author keywords

Anti inflammatory; Atherosclerosis; Human umbilical vein endothelial cells; Quercetin; Taraxasterol

Indexed keywords

B7 ANTIGEN; HYDROGEN PEROXIDE; QUERCETIN; TARAXASTEROL; VASCULAR CELL ADHESION MOLECULE 1;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; INFLAMMATION; PROTEIN EXPRESSION; TUNEL ASSAY; UMBILICAL VEIN ENDOTHELIAL CELL;

EID: 84940526713     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2015.2713     Document Type: Article

References (51)

1. Versari D, Daghini E, Virdis A, Ghiadoni L and Taddei S: Endothelial dysfunction as a target for prevention of cardiovascular disease. Diabetes Care 32 Suppl 2: S314-S321, 2009.
2. Savoia C, Sada L, Zezza L, et al: Vascular inflammation and endothelial dysfunction in experimental hypertension. Int J Hypertens 2011: 281240, 2011.
3. Thompson AM, Zhang Y, Tong W, et al: Association of inflammation and endothelial dysfunction with metabolic syndrome, prediabetes and diabetes in adults from Inner Mongolia, China. BMC Endocr Disord 11: 16, 2011.
4. Wannamethee SG, Tchernova J, Whincup P, et al: Plasma leptin: associations with metabolic, inflammatory and haemostatic risk factors for cardiovascular disease. Atherosclerosis 191: 418-426, 2007.
5. Spagnoli LG, Bonanno E, Sangiorgi G and Mauriello A: Role of inflammation in atherosclerosis. J Nucl Med 48: 1800-1815, 2007.
6. Lawson C and Wolf S: ICAM-1 signaling in endothelial cells. Pharmacol Rep 61: 22-32, 2009.
7. Hwang SJ, Ballantyne CM, Sharrett AR, et al: Circulatingadhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) study. Circulation 96: 4219-4225, 1997.
8. Rubio-Guerra AF, Vargas-Robles H, Serrano AM, et al: Correlation between the levels of circulating adhesion molecules and atherosclerosis in hypertensive type-2 diabetic patients. Clin Exp Hypertens 32: 308-310, 2010.
9. Ellison S, Gabunia K, Kelemen SE, et al: Attenuation of experimental atherosclerosis by interleukin-19. Arterioscler Thromb Vasc Biol 33: 2316-2324, 2013.
10. McLaren JE, Michael DR, Salter RC, et al: IL-33 reduces macrophage foam cell formation. J Immunol 185: 1222-1229, 2010.
11. Miller AM, Xu D, Asquith DL, et al: IL-33 reduces the development of atherosclerosis. J Exp Med 205: 339-346, 2008.
12. Ridker PM, Rifai N, Clearfield M, et al; Air Force/Texas Coronary Atherosclerosis Prevention Study Investigators: Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events. N Engl J Med 344: 1959-1965, 2001.
13. Kleemann R, Verschuren L, de Rooij BJ, et al: Evidence for anti-inflammatory activity of statins and PPARalpha activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro. Blood 103: 4188-4194, 2004.
14. Mirjanic-Azaric B, Rizzo M, Sormaz L, et al: Atorvastatin in stable angina patients lowers CCL2 and ICAM1 expression: pleiotropic evidence from plasma mRNA analyses. Clin Biochem 46: 1526-1531, 2013.
15. Colucci R, Fornai M, Duranti E, et al: Rosuvastatin prevents angiotensin II-induced vascular changes by inhibition of NAD(P)H oxidase and COX-1. Br J Pharmacol 169: 554-566, 2013.
16. Nie P, Li D, Hu L, et al: Atorvastatin improves plaque stability in ApoE-knockout mice by regulating chemokines and chemokine receptors. PLoS One 9: e97009, 2014.
17. Berman JP, Farkouh ME and Rosenson RS: Emerging anti-inflammatory drugs for atherosclerosis. Expert Opin Emerg Drugs 18: 193-205, 2013.
18. Larson AJ, Symons JD and Jalili T: Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms. Adv Nutr 3: 39-46, 2012.
19. Egert S, Bosy-Westphal A, Seiberl J, et al: Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. Br J Nutr 102: 1065-1074, 2009.
20. Galindo P, Rodriguez-Gómez I, González-Manzano S, et al: Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation. PLoS One 7: e32673, 2012.
21. Chopra M, Fitzsimons PE, Strain JJ, Thurnham DI and Howard AN: Nonalcoholic red wine extract and quercetin inhibit LDL oxidation without affecting plasma antioxidant vitamin and carotenoid concentrations. Clin Chem 46: 1162-1170, 2000.
22. Galindo P, González-Manzano S, Zarzuelo MJ, et al: Different cardiovascular protective effects of quercetin administered orally or intraperitoneally in spontaneously hypertensive rats. Food Funct 3: 643-650, 2012.
23. Hubbard GP, Wolffram S, de Vos R, et al: Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study. Br J Nutr 96: 482-488, 2006.
24. Zhang X, Xiong H and Liu L: Effects of taraxasterol on inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages. J Ethnopharmacol 141: 206-211, 2012.
25. Liu J, Xiong H, Cheng Y, et al: Effects of taraxasterol on ovalbumin-induced allergic asthma in mice. J Ethnopharmacol 148: 787-793, 2013.
26. Shen HM, Dai J, Chia SE, Lim A and Ong CN: Detection of apoptotic alterations in sperm in subfertile patients and their correlations with sperm quality. Hum Reprod 17: 1266-1273, 2002.
27. Kumar A, Sehgal N, Kumar P, Padi SS and Naidu PS: Protective effect of quercetin against ICV colchicine-induced cognitive dysfunctions and oxidative damage in rats. Phytother Res 22: 1563-1569, 2008.
28. Ishizawa K, Yoshizumi M, Kawai Y, et al: Pharmacology in health food: metabolism of quercetin in vivo and its protective effect against arteriosclerosis. J Pharmacol Sci 115: 466-470, 2011.
29. Nabavi SF, Nabavi SM, Mirzaei M and Moghaddam AH: Protective effect of quercetin against sodium fluoride induced oxidative stress in rat's heart. Food Funct 3: 437-441, 2012.
30. Matouk AI, Taye A, Heeba GH and El-Moselhy MA: Quercetin augments the protective effect of losartan against chronic doxorubicin cardiotoxicity in rats. Environ Toxicol Pharmacol 36: 443-450, 2013.
31. Chi Z and Melendez AJ: Role of cell adhesion molecules and immune-cell migration in the initiation, onset and development of atherosclerosis. Cell Adh Migr 1: 171-175, 2007.
32. Buono C, Pang H, Uchida Y, et al: B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice. Circulation 109: 2009-2015, 2004.
33. Prasad V, Lorenz JN, Miller ML, et al: Loss of NHE1 activity leads to reduced oxidative stress in heart and mitigates high-fat diet-induced myocardial stress. J Mol Cell Cardiol 65: 33-42, 2013.
34. Cooper MP: Interplay of mitochondrial biogenesis and oxidative stress in heart failure. Circulation 127: 1932-1934, 2013.
35. Paravicini TM and Touyz RM: NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Diabetes Care 31 Suppl 2: S170-S180, 2008.
36. Moukdar F, Robidoux J, Lyght O, et al: Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mice. J Lipid Res 50: 59-70, 2009.
37. Watanabe T, Pakala R, Katagiri T and Benedict CR: Oxidized low-density lipoproteins potentiate the mitogenic effect of 5-hydroxytryptamine on vascular smooth muscle cells. Jpn Heart J 43: 35-42, 2002.
38. Takasaki M, Konoshima T, Tokuda H, et al: Anti-carcinogenic activity of Taraxacum plant I. Biol Pharm Bull 22: 602-605, 1999.
39. Kook D, Wolf AH, Yu AL, et al: The protective effect of quercetin against oxidative stress in the human RPE in vitro. Invest Ophthalmol Vis Sci 49: 1712-1720, 2008.
40. Liu CL, Xie LX, Li M, et al: Salvianolic acid B inhibits hydrogen peroxide-induced endothelial cell apoptosis through regulating PI3K/Akt signaling. PLoS One 2: e1321, 2007.
41. 2-induced injury in primary human umbilical vein endothelial cells. J Ethnopharmacol 128: 438-445, 2010.
42. Alvarez A, Cerdá-Nicolas M, Naim Abu Nabah Y, et al: Direct evidence of leukocyte adhesion in arterioles by angiotensin II. Blood 104: 402-408, 2004.
43. Davies MJ, Gordon JL, Gearing AJ, et al: The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis. J Pathol 171: 223-229, 1993.
44. Rendig SV, Symons JD, Longhurst JC and Amsterdam EA: Effects of red wine, alcohol, and quercetin on coronary resistance and conductance arteries. J Cardiovasc Pharmacol 38: 219-227, 2001.
45. Ovesná Z, Vachálková A and Horváthová K: Taraxasterol and beta-sitosterol: new naturally compounds with chemoprotective/chemopreventive effects. Neoplasma 51: 407-414, 2004.
46. Villarreal ML, Alvarez L, Alonso D, et al: Cytotoxic and antimicrobial screening of selected terpenoids from Asteraceae species. J Ethnopharmacol 42: 25-29, 1994.
47. He W, Han H, Wang W and Gao B: Anti-influenza virus effect of aqueous extracts from dandelion. Virol J 8: 538, 2011.
48. Han H, He W, Wang W and Gao B: Inhibitory effect of aqueous Dandelion extract on HIV-1 replication and reverse transcriptase activity. BMC Complement Altern Med 11: 112, 2011.
49. Lakshminarayanan V, Beno DW, Costa RH and Roebuck KA: Differential regulation of interleukin-8 and intercellular adhesion molecule-1 by H2O2 and tumor necrosis factor-alpha in endothelial and epithelial cells. J Biol Chem 272: 32910-32918, 1997.
50. McCoy KD and Le Gros G: The role of CTLA-4 in the regulation of T cell immune responses. Immunol Cell Biol 77: 1-10, 1999.
51. Kadono T, Venturi GM, Steeber DA and Tedder TF: Leukocyterolling velocities and migration are optimized by cooperative L-selectin and intercellular adhesion molecule-1 functions. J Immunol 169: 4542-4550, 2002.