Matrix metalloproteinase inhibitors prevent sepsis-induced refractoriness to vasoconstrictors in the cecal ligation and puncture model in rats

European Journal of Pharmacology

Volumn 765, Issue , 2015, Pages 164-170

  De Souza, Priscila ^a   Schulz, Richard ^b   Da Silva Santos, José Eduardo ^c  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^b UNIVERSITY OF ALBERTA   (Canada)

^c FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Calponin 1; Matrix metalloproteinase 2; Septic shock; Vasoplegia

Indexed keywords

5 ETHOXYMETHOXY N HYDROXY 2 METHYL 4 (4 PHENOXYBENZAMIDO)PENTANAMIDE; ANGIOTENSIN II; CALPONIN; CALPONIN 1; DOXYCYCLINE; GELATINASE A; NITRATE; NITRITE; PHENYLEPHRINE; POTASSIUM CHLORIDE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; UNCLASSIFIED DRUG; DIPHENYL ETHER DERIVATIVE; MATRIX METALLOPROTEINASE INHIBITOR; N-HYDROXY-5-ETHOXYMETHYLOXY-2-METHYL-4-(4-PHENOXYBENZOYL)AMINOPENTANAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL REACTIVITY; CECAL LIGATION AND PUNCTURE-INDUCED SEPSIS; CONTROLLED STUDY; ENZYME ACTIVITY; HEMATOLOGICAL PARAMETERS; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; RAT; VASCULAR RING; ANIMAL; CECUM; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; LIGATION; ORAL DRUG ADMINISTRATION; PATHOLOGY; PATHOPHYSIOLOGY; PUNCTURE; SEPSIS; SURGERY; VASOCONSTRICTION; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; CECUM; DISEASE MODELS, ANIMAL; DOXYCYCLINE; LIGATION; MALE; MATRIX METALLOPROTEINASE INHIBITORS; PHENYL ETHERS; PUNCTURES; RATS, WISTAR; SEPSIS; VASOCONSTRICTION;

EID: 84940514536     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.08.030     Document Type: Article

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