Nephron toxicity profiling via untargeted metabolome analysis employing a high performance liquid chromatography-mass spectrometry-based experimental and computational pipeline

Journal of Biological Chemistry

Volumn 290, Issue 31, 2015, Pages 19121-19132

  Ranninger, Christina ^a   Rurik, Marc ^b   Limonciel, Alice ^c   Ruzek, Silke ^a   Reischl, Roland ^a   Wilmes, Anja ^c   Jennings, Paul ^c   Hewitt, Philip ^d   Dekant, Wolfgang ^e   Kohlbacher, Oliver ^b   Huber, Christian G ^a  

^a UNIVERSITY OF SALZBURG   (Austria)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^d Merck Serono GmbH   (Germany)

^e UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; RISK ASSESSMENT; TOXICITY;

ANIMAL MODEL; CHLOROACETALDEHYDE; DRUG DEVELOPMENT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRIES; IN-VITRO ASSAYS; METABOLIC CHANGES; METABOLOME ANALYSIS; TOXICITY TESTING;

LIQUID CHROMATOGRAPHY;

CHLOROACETALDEHYDE; GLUTATHIONE; ACETALDEHYDE; ANTINEOPLASTIC AGENT;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IONIZATION; KIDNEY CELL; KIDNEY TUBULE CELL; MASS SPECTROMETRY; METABOLITE; METABOLOME; METABOLOMICS; MICROARRAY ANALYSIS; NEPHROTOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEOMICS; RPTEC CELL LINE; TERT1 CELL LINE; TRANSCRIPTOMICS; ANALOGS AND DERIVATIVES; CELL LINE; COMPUTER PROGRAM; DRUG EFFECTS; METABOLISM; NEPHRON; TANDEM MASS SPECTROMETRY;

ACETALDEHYDE; ANTINEOPLASTIC AGENTS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; METABOLOME; NEPHRONS; SOFTWARE; TANDEM MASS SPECTROMETRY;

EID: 84940504861     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.644146     Document Type: Article

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