Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress

Journal of Proteomics

Volumn 79, Issue , 2013, Pages 180-194

  Wilmes, Anja ^a   Limonciel, Alice ^a   Aschauer, Lydia ^a   Moenks, Konrad ^b   Bielow, Chris ^c   Leonard, Martin O ^d   Hamon, Jeremy ^e,m   Carpi, Donatella ^f   Ruzek, Silke ^g   Handler, Andreas ^g   Schmal, Olga ^h   Herrgen, Karin ^h   Bellwon, Patricia ^h   Burek, Christof ^h   Truisi, Germaine L ^i,l   Hewitt, Philip ⁱ   Di Consiglio, Emma ^j   Testai, Emanuela ^j   Blaauboer, Bas J ^k   Guillou, Claude ^f   Huber, Christian G ^g   Lukas, Arno ^b   Pfaller, Walter ^a   Mueller, Stefan O ^i,l   Bois, Frederic Y ^e,m   Dekant, Wolfgang ^h   Jennings, Paul ^a   more..

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b Emergentec Biodevelopment GmbH   (Austria)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

^e DRC/VIVA/METO   (France)

^f UNIVERSITÉ DE TECHNOLOGIE DE COMPIÈGNE   (France)

^g JOINT RESEARCH CENTRE   (Italy)

^h UNIVERSITY OF SALZBURG   (Austria)

ⁱ UNIVERSITY OF WÜRZBURG   (Germany)

^j Merck Serono GmbH   (Germany)

^k Istituto Superiore   (Italy)

^l UTRECHT UNIVERSITY   (Netherlands)

^m KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

more..

Author keywords

ATF4; Cyclophilin; Cyclosporine A; Integrated omics; Nrf2; Unfolded protein response

Indexed keywords

CYCLOSPORIN A; TRANSCRIPTION FACTOR NRF2;

ARTICLE; CELL STRESS; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG SCREENING; DRUG UPTAKE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; KINETICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLOMICS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEOMICS; TRANSCRIPTOMICS;

CYCLOPHILINS; CYCLOSPORINE; EPITHELIAL CELLS; HUMANS; KIDNEY TUBULES, PROXIMAL; METABOLOMICS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROTEOMICS; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; TOXICOLOGY;

EID: 84872649832     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2012.11.022     Document Type: Article

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