Liver injury in acute hepatitis A is associated with decreased frequency of regulatory T cells caused by Fas-mediated apoptosis

Gut

Volumn 64, Issue 8, 2015, Pages 1303-1313

  Choi, Yoon Seok ^a,b   Lee, Jeewon ^a   Lee, Hyun Woong ^c   Chang, Dong Yeop ^a   Sung, Pil Soo ^a   Jung, Min Kyung ^a   Park, Jun Yong ^d   Kim, Ja Kyung ^d   Lee, Jung Il ^d   Park, Hana ^e   Cheong, Jae Youn ^f   Suh, Kyung Suk ^g   Kim, Hyung Joon ^c   Lee, June Sung ^h   Kim, Kyung Ah ^h   Shin, Eui Cheol ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Chungnam National University   (South Korea)

^c Chung Ang University   (South Korea)

^d Yonsei University College of Medicine   (South Korea)

^e CHA University   (South Korea)

^f Ajou University School of Medicine   (South Korea)

^g Seoul National University   (South Korea)

^h Inje University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; CD45RA ANTIGEN; FAS ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; TRANSCRIPTION FACTOR FOXP3; ANTIVIRUS AGENT;

ACUTE HEPATITIS A; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; APOPTOSIS; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LIVER INJURY; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; ACUTE DISEASE; CELLULAR IMMUNITY; DRUG-INDUCED LIVER INJURY; FLOW CYTOMETRY; HEPATITIS A; IMMUNOLOGY; PATHOLOGY;

ACUTE DISEASE; ADULT; ANTIVIRAL AGENTS; APOPTOSIS; DRUG-INDUCED LIVER INJURY; FEMALE; FLOW CYTOMETRY; HEPATITIS A; HUMANS; IMMUNITY, CELLULAR; MALE; T-LYMPHOCYTES, REGULATORY;

EID: 84940461585     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2013-306213     Document Type: Article

References (43)

1. Roncador G, Brown PJ, Maestre L, et al Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur J Immunol 2005; 35:1681-91.
2. Sakaguchi S, Yamaguchi T, Nomura T., et al. Regulatory T cells and immune tolerance. Cell 2008; 133:775-87.
3. Sakaguchi S, Miyara M, Costantino C.M., et al. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 2010; 10:490-500.
4. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299:1057-61.
5. Yagi H, Nomura T, Nakamura K., et al. Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int Immunol 2004; 16:1643-56.
6. Viglietta V, Baecher-Allan C, Weiner H.L., et al. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 2004; 199:971-9.
7. Miyara M, Amoura Z, Parizot C., et al. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 2005; 175:8392-400.
8. Bonelli M, Savitskaya A, von Dalwigk K, et al. Quantitative and qualitative deficiencies of regulatory T cells in patients with systemic lupus erythematosus (SLE). Int Immunol 2008; 20:861-8.
9. Flores-Borja F., Jury EC, Mauri C, et al Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis. Proc Natl Acad Sci USA 2008; 105:19396-401.
10. Rouse BT, Sarangi PP, Suvas S. Regulatory T cells in virus infections. Immunol Rev 2006; 212:272-86.
11. Belkaid Y. Regulatory T cells and infection: a dangerous necessity. Nat Rev Immunol 2007; 7:875-88.
12. ∗). Annu Rev Immunol 2009; 27:551-89.
13. Suvas S, Kumaraguru U, Pack C.D., et al. CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses. J Exp Med 2003; 198:889-901.
14. Dittmer U, He H, Messer R.J., et al. Functional impairment of CD8(+) T cells by regulatory T cells during persistent retroviral infection. Immunity 2004; 20: 293-303.
15. + regulatory T cells limit pulmonary immunopathology by modulating the CD8T cell response during respiratory syncytial virus infection. J Immunol 2010; 185:2382-92.
16. Suvas S, Azkur AK, Kim B.S., et al. CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions. J Immunol 2004; 172:4123-32.
17. Sarangi PP, Sehrawat S, Suvas S., et al. IL-10 and natural regulatory T cells: two independent anti-inflammatory mechanisms in herpes simplex virus-induced ocular immunopathology. J Immunol 2008; 180:6297-306.
18. Xu D, Fu J, Jin L., et al. Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J Immunol 2006; 177:739-47.
19. Yang G, Liu A, Xie Q., et al. Association of CD4+CD25+Foxp3+ regulatory T cells with chronic activity and viral clearance in patients with hepatitis B. Int Immunol 2007; 19:133-40.
20. Sugimoto K, Ikeda F, Stadanlick J., et al. Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection. Hepatology 2003; 38:1437-48.
21. Ward SM, Fox BC, Brown P.J., et al. Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection. J Hepatol 2007; 47:316-24.
22. Cabrera R, Tu Z, Xu Y., et al. An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology 2004; 40:1062-71.
23. Franzese O, Kennedy PT, Gehring A.J., et al. Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with hepatitis B virus infection. J Virol 2005; 79:3322-8.
24. Boettler T, Spangenberg HC, Neumann-Haefelin C, et al. T cells with a CD4+CD25 + regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection. J Virol 2005; 79:7860-7.
25. Franco E, Meleleo C, Serino L., et al. Hepatitis A: Epidemiology and prevention in developing countries. World J Hepatol 2012; 4:68-73.
26. Koff RS. Hepatitis A. Lancet 1998; 351:1643-9.
27. Rezende G, Roque-Afonso AM, Samuel D., et al. Viral and clinical factors associated with the fulminant course of hepatitis A infection. Hepatology 2003; 38:613-18.
28. Siegl G, Weitz M. Pathogenesis of hepatitis A: persistent viral infection as basis of an acute disease? Microb Pathog 1993; 14:1-8.
29. Karayiannis P, Jowett T, Enticott M., et al. Hepatitis A virus replication in tamarins and host immune response in relation to pathogenesis of liver cell damage. J Med Virol 1986; 18:261-76.
30. Manigold T, Shin EC, Mizukoshi E, et al Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C. Blood 2006; 107:4424-32.
31. Miyara M, Yoshioka Y, Kitoh A., et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 2009; 30:899-911.
32. Manangeeswaran M, Jacques J, Tami C., et al. Binding of hepatitis A virus to its cellular receptor 1 inhibits T-regulatory cell functions in humans. Gastroenterology 2012; 142:1516-25 e3.
33. Rushbrook SM, Ward SM, Unitt E, et al Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection. J Virol 2005; 79:7852-9.
34. Smyk-Pearson S., Golden-Mason L, Klarquist J., et al. Functional suppression by FoxP3+CD4+CD25(high) regulatory T cells during acute hepatitis C virus infection. J Infect Dis 2008; 197:46-57.
35. Perrella A, Vitiello L, Atripaldi L., et al. Impaired function of CD4+/CD25+ T regulatory lymphocytes characterizes the self-limited hepatitis A virus infection. J Gastroenterol Hepatol 2008; 23:e105-10.
36. Wang J, Ioan-Facsinay A, van der Voort EI, et al. Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells. Eur J Immunol 2007; 37:129-38.
37. Seddiki N, Santner-Nanan B, Martinson J., et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006; 203:1693-700.
38. Liu W, Putnam AL, Xu-Yu Z, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006; 203:1701-11.
39. Lanteri MC, O'Brien KM, Purtha WE, et al Tregs control the development of symptomatic West Nile virus infection in humans and mice. J Clin Invest 2009; 119:3266-77.
40. Fritzsching B, Oberle N, Eberhardt N., et al. In contrast to effector T cells, CD4+CD25+FoxP3+ regulatory T cells are highly susceptible to CD95 ligand-but not to TCR-mediated cell death. J Immunol 2005; 175:32-6.
41. Reardon C, Wang A, McKay DM Transient local depletion of Foxp3+ regulatory T cells during recovery from colitis via Fas/Fas ligand-induced death. J Immunol 2008; 180:8316-26.
42. Schulte I, Hitziger T, Giugliano S., et al. Characterization of CD8+ T-cell response in acute and resolved hepatitis A virus infection. J Hepatol 2011; 54:201-8.
43. Zhou Y, Callendret B, Xu D., et al. Dominance of the CD4+ T helper cell response during acute resolving hepatitis A virus infection. J Exp Med 2012; 209:1481-92.