Impaired function of CD4+/CD25+ T regulatory lymphocytes characterizes the self-limited hepatitis A virus infection

Journal of Gastroenterology and Hepatology (Australia)

Volumn 23, Issue 7 PT2, 2008, Pages

  Perrella, Alessandro ^a   Vitiello, Laura ^b,c   Atripaldi, Luigi ^a   Sbreglia, Costanza ^a   Grattacaso, Stella ^a   Bellopede, Pasquale ^a   Patarino, Tommaso ^a   Morelli, Giuseppe ^a   Altamura, Simona ^b   Racioppi, Luigi ^b,c   Perrella, Oreste ^a  

^a AO Dei Colli Hospital for Infectious Diseases D Cotugno   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c IRCCS SAN RAFFAELE PISANA   (Italy)

Author keywords

Anergy; Hepatitis; Hepatitis A virus; Treg

Indexed keywords

ADULT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL FUNCTION; CELL PROLIFERATION; CELL SELECTION; CELLULAR IMMUNITY; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; DONOR; FEMALE; FLOW CYTOMETRY; HELPER CELL; HEPATITIS A; HEPATITIS A VIRUS; HUMAN; IMMUNOLOGY; MALE; PRIORITY JOURNAL; RANK SUM TEST; REGULATORY T LYMPHOCYTE; SEROCONVERSION; STATISTICAL SIGNIFICANCE; VIRUS INFECTION;

EID: 47649105145     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2007.05008.x     Document Type: Article

References (22)

1. Cuthbert JA. Hepatitis A: old and new. Clin. Microbiol. Rev. 2001 14 : 38 58.
2. Sainokami S, Abe K, Ishikawa K, Suzuki K. Influence of load of hepatitis A virus on disease severity and its relationship with clinical manifestations in patients with hepatitis A. J. Gastroenterol. Hepatol. 2005 20 : 1165 75.
3. Romalde JL, Torrado I, Ribao C, Barja JL. Global market: shellfish imports as a source of reemerging food-borne hepatitis A virus infections in Spain. Int. Microbiol. 2001 4 : 223 6.
4. Delia Boccia and Working Group. Osservatorio epidemiologico regione campania community outbreak of hepatitis A in southern Italy - Campania, January-May 2004. Eurosurveillance 2004 8 : 46 7.
5. Belkaid Y, Rouse BT. Natural regulatory T cells in infectious disease. Nat. Immunol. 2005 6 : 353 60.
6. Maier K, Gabriel P, Koscielniak E et al. Human gamma interferon production by cytotoxic T lymphocytes sensitized during hepatitis A virus infection. J. Virol. 1988 62 : 3756 63.
7. Wang CH, Tschen SY, Heinricy U, Weber M, Flehmig B. Immune response to hepatitis A virus capsid proteins after infection. J. Clin. Microbiol. 1996 34 : 707 13.
8. Stoop JN, van der Molen RG, Baan CC et al. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology 2005 41 : 771 8.
9. Cabrera R, Tu Z, Xu Y et al. An immunomodulatory role for CD4 (+) CD25 (+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology 2004 40 : 1062 71.
10. Demirkiran A, Kok A, Kwekkeboom J et al. Low circulating regulatory T-cell levels after acute rejection in liver transplantation. Liver Transpl. 2006 12 : 277 84.
11. Longhi MS, Ma Y, Mitry RR et al. Effect of CD4+ CD25+ regulatory T-cells on CD8 T-cell function in patients with autoimmune hepatitis. J. Autoimmun. 2005 25 : 63 71.
12. Thornton AM, Shevach EM. Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J. Immunol. 2000 164 : 183 90.
13. Doganci A, Eigenbrod T, Krug N et al. The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo. J. Clin. Invest. 2005 115 : 313 25.
14. Raghavan S, Holmgren J. CD4+CD25+ suppressor T cells regulate pathogen induced inflammation and disease. FEMS Immunol. Med. Microbiol. 2005 44 : 121 7.
15. Sakaguchi S. Regulatory T cells: mediating compromises between host and parasite. Nat. Immunol. 2003 4 : 10 11.
16. Wunschmann S, Becker B, Vallbracht A. Hepatitis A virus suppresses monocyte-to-macrophage maturation in vitro. J. Virol. 2002 76 : 4350 56.
17. Pasare C, Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2000 299 : 1033 6.
18. Kubo T, Hatton RD, Oliver J, Liu X, Elson CO, Weaver CT. Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells. J. Immunol. 2004 173 : 7249 58.
19. Fainboim L, Canero Velasco MC, Marcos CY et al. Protracted, but not acute, hepatitis A virus infection is strongly associated with HLA-DRB*1301, a marker for pediatric autoimmune hepatitis. Hepatology 2001 33 : 1512 17.
20. Vento S, Garofano T, Di Perri G, Dolci L, Concia E, Bassetti D. Identification of hepatitis A virus as a trigger for autoimmune chronic hepatitis type 1 in susceptible individuals. Lancet 1991 337 : 1183 7.
21. Longhi MS, Ma Y, Bogdanos DP, Cheeseman P, Mieli-Vergani G, Vergani D. Impairment of CD4 (+) CD25 (+) regulatory T-cells in autoimmune liver disease. J. Hepatol. 2004 41 : 31 7.
22. Perrella A, Atripaldi L, Racioppi L et al. Elevated CD4+/CD25+ regulatory T cell number and function during acute hepatitis C, presage chronic evolution. Gut 2006 55 : 1370 71.