Estrogenic Effect of Yam Ingestion in Healthy Postmenopausal Women

Journal of the American College of Nutrition

Volumn 24, Issue 4, 2005, Pages 235-243

  Wu, Wen Huey ^a   Chung, Cheng Jih ^a   Liu, Li Yun ^b   Jou, Hei Jen ^c   Wang, Tzong An ^d  

^a NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

^b SHIH CHIEN UNIVERSITY   (Taiwan)

^c TAIWAN ADVENTIST HOSPITAL   (Taiwan)

^d Section of Infectious Diseases   (Taiwan)

Author keywords

Antioxidant; Blood lipids; Dioscorea; Estrogen metabolites; Postmenopausal women; Sex hormone binding globulin; Sex hormones; Yam

Indexed keywords

ANTIOXIDANT; DRUG DERIVATIVE; ESTROGEN; ESTRONE; FOLLITROPIN; LIPID; LUTEINIZING HORMONE; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

AGED; ARTICLE; BLOOD; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; METABOLISM; MIDDLE AGED; PHYSIOLOGY; POSTMENOPAUSE; URINE; YAM;

AGED; ANTIOXIDANTS; DIOSCOREA; ESTROGENS; ESTRONE; FEMALE; FOLLICLE STIMULATING HORMONE; GONADAL STEROID HORMONES; HUMANS; LIPIDS; LUTEINIZING HORMONE; MIDDLE AGED; POSTMENOPAUSE; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE;

EID: 27744467929     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.2005.10719470     Document Type: Article

References (76)

1. Writing Group for the Women's Health Initiative Investigators: Risks and benefits of estrogen plus progestin in healthy postmenopausal women. J Am Med Assoc 288: 321-333, 2002.
2. Djerassi C: Steroid research at Syntex: the Pill and cortisone. Steroids 57: 631-641, 1992.
3. Briggs CJ: Herbal medicine: Dioscorea: The yams-A traditional source of food and drugs. Can Pharm J 123: 413-415, 1990.
4. Rosser A: The day of the yam. Nurs Times 81: 47, 1985.
5. Mirkin G: Estrogen in yams. J Am Med Assoc 265: 912, 1991.
6. Dentali S: Clearing up confusion over yams and progesterone. Altern Ther Health M 2: 19-20, 1996.
7. Taffe AM, Cauffield J: –Natural— hormone replacement therapy and dietary supplements used in the treatment of menopausal symptoms. Lippincott's Prim Care Pract 2: 292-302, 1998.
8. Moyad MA: Complementary/alternative therapies for reducing hot flashes in prostate cancer patients: reevaluating the existing indirect data from studies of breast cancer and postmenopausal women. Urology 59: 20-33, 2002.
9. Cayen MN, Ferdinandi ES, Greselin E, Dvornik D: Studies on the disposition of diosgenin in rats, dogs, monkeys and man. Atherosclerosis 33: 71-87, 1979.
10. Aradhana Rao AR, Kale RK: Diosgenin-a growth stimulator of mammary gland of ovariectomized mouse. Indian J Exp Biol 30: 365-370, 1992.
11. Higdon K, Scott A, Tucci M, Benghuzzi H, Tsao A, Puckett A, Cason Z, Hughes J: The use of estrogen, DHEA, and diosgenin in a sustained delivery setting as a novel treatment approach for osteoporosis in the ovariectomized adult rat model. Biomed Sci Instrum 37: 281-286, 2001.
12. Arghiniknam M, Chung S, Nelson-White T, Eskelson C, Watson RR: Antioxidant activity of dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sci 59: PL147-157, 1996.
13. Zava DT, Dollbaum CM, Blen M: Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 217: 369-378, 1998.
14. Komesaroff PA, Black CV, Cable V, Sudhir K: Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women. Climacteric 4: 144-150, 2001.
15. Liu SY, Chang TW, Lin YK: Studies on the varietal characters, production potential, phytochemical properties, and antioxidant effect of Dioscorea spp. J Agri Res (China) 8: 1, 1999.
16. Chen H, Wang C, Chang CT, Wang T: Effects of Taiwanese yam (Dioscorea japonica Thunb var. pseudojaponica Yamamoto) on upper gut function and lipid metabolism in Balb/c mice. Nutrition 19: 646-651, 2003.
17. Chang SJ, Lee YC, Liu SY, Chang TW: Chinese yam (Dioscorea alata cv. Tainung No. 2) feeding exhibited antioxidative effects in hyperhomocysteinemia rats. J Agri Food Chem 52: 1720-1725, 2004.
18. Association of Official Analytical Chemists: –Official Methods of Analysis,— 14th ed. Washington, DC: AOAC, 1984.
19. Association of Official Analytical Chemists: Total dietary fiber in foods, enzymatic-gravimetric methods. In –Official Methods of Analysis,— 16th ed. Arlington, VA: AOAC, Sec.985.26, Ch 45, pp 70-71, 1995.
20. Yang DJ, Lu TJ, Hwang LS: Isolation and identification of steroidal saponins in Taiwanese yam cultivar (Dioscorea pseudojaponica Yamamoto). J Agri Food Chem 51: 6438-6444, 2003.
21. Department of Health: –Taiwan Nutrient Databases.— Taipei, Taiwan: Department of Health, Executive Yuan, 1998.
22. Marlett JA, Cheung TF: Database and quick methods of assessing typical dietary fiber intakes using data for 228 commonly consumed foods. J Am Diet Assoc 97: 1139-1151, 1997.
23. Havel RJ, Eder HA, Bragdon JH: The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 34: 1345-1353, 1955.
24. Lu SC, Wu WH, Lee CA, Chou HF, Lee HR, Huang PC: LDL of Taiwanese vegetarians are less oxidizable than those of omnivores. J Nutr 130: 1591-1596, 2000.
25. Klug TL, Bradlow HL, Sepkovic DW: Monoclonal antibody-based enzyme immunoassay for simultaneous quantitation of 2-and 16 alpha-hydroxyestrone in urine. Steroids 59: 648-655, 1994.
26. Norton SA: Useful plants of dermatology. III. Corticosteroids, Strophanthus, and Dioscorea. J Am Acad Dermatol 38: 256-259, 1998.
27. Pugeat M, Crave JC, Tourniaire J, Forest MG: Clinical utility of sex hormone-binding globulin measurement. Horm Res 45: 148-155, 1996.
28. Selby C: Sex hormone binding globulin: origin, function and clinical significance. Ann Clin Biochem 27: 532-541, 1990.
29. Cauley JA, Gutai JP, Sandler RB, LaPorte RE, Kuller LH, Sashin D: The relationship of endogenous estrogen to bone density and bone area in normal postmenopausal women. Am J Epidemiol 124: 752-761, 1986.
30. Yu H, Shu XO, Shi R, Dai Q, Jin F, Gao YT, Li BD, Zheng W: Plasma sex steroid hormones and breast cancer risk in Chinese women. Int J Cancer. 105: 92-97, 2003.
31. Jones LA, Ota DM, Jackson GA, Jackson PM, Kemp K, Anderson DE, McCamant SK, Bauman DH: Bioavailability of estradiol as a marker for breast cancer risk assessment. Cancer Res 47: 5224-5229, 1987.
32. Campagnoli C, Biglia N, Belforte P, Botta D, Pedrini E, Sismondi P: Post-menopausal breast cancer risk: oral estrogen treatment and abdominal obesity induce opposite changes in possibly important biological variables. Eur J Gynaecol Oncol 13: 139-154, 1992.
33. Lipworth L, Adami HO, Trichopoulos D, Carlstrom K, Mantzoros C: Serum steroid hormone levels, sex hormone-binding globulin, and body mass index in the etiology of postmenopausal breast cancer. Epidemiology 7: 96-100, 1996.
34. Levitz M, Banerjee S, Raju U, Toniolo PG, Shore RE, Nachtigall LE: Sex hormone-binding globulin in estrogen-dependent cancer and estrogen replacement therapy. Ann NY Acad Sci 828: 358-365, 1997.
35. Berrino F, Muti P, Micheli A, Bolelli G, Krogh V, Sciajno R, Pisani P, Panico S, Secreto G: Serum sex hormone levels after menopause and subsequent breast cancer. J Natl Cancer Inst 88: 291-296, 1996.
36. Phillips GB, Pinkernell BH, Jing TY: Relationship between serum sex hormones and coronary artery disease in postmenopausal women. Arterioscler Thromb Vasc Biol 17: 695-701, 1997.
37. Lindstedt G, Lundberg PA, Lapidus L, Lundgren H, Bengtsson C, Bjorntorp P: Low sex-hormone-binding globulin concentration as independent risk factor for development of NIDDM. 12-yr follow-up of population study of women in Gothenburg, Sweden. Diabetes 40: 123-128, 1991.
38. Reinecke H, Bogdanski J, Woltering A, Breithardt G, Assmann G, Kerber S, von Eckardstein A: Relation of serum levels of sex hormone binding globulin to coronary heart disease in postmenopausal women. Am J Cardiol 90: 364-368, 2002.
39. Andersson AM, Carlsen E, Petersen JH, Skakkebaek NE: Variation in levels of serum inhibin B, testosterone, estradiol, luteinizing hormone, follicle-stimulating hormone, and sex hormone-binding globulin in monthly samples from healthy men during a 17-month period: possible effects of seasons. J Clin Endocrin Metab 88: 932-937, 2003.
40. Wu AH, Stanczyk FZ, Seow A, Lee HP, Yu MC: Soy intake and other lifestyle determinants of serum estrogen levels among postmenopausal Chinese women in Singapore. Cancer Epidemiol Biomark Prev 11: 844-851, 2002.
41. McKinlay SM: The normal menopause transition: an overview. Maturitas 23: 137-145, 1996.
42. Rinaldi S, Déchaud H, Biessy C, Morin-Raverot V, Toniolo P, Zeleniuch-Jacquotte A, Akhmedkhanov A, Shore RE, Secreto G, Ciampi A, Riboli E, Kaaks R: Reliability and Validity of Commercially Available, Direct Radioimmunoassays for Measurement of Blood Androgens and Estrogens in Postmenopausal Women. Cancer Epidemiol Biomark Prev 10: 757-765, 2001.
43. Service RF: New role for estrogen in cancer? Science 279: 1631-1633, 1998.
44. Kabat GC, Chang CJ, Sparano JA, Sepkovie DW, Hu XP, Khalil A, Rosenblatt R, Bradlow HL: Urinary estrogen metabolites and breast cancer: a case-control study. Cancer Epidemiol Biomark Prev 6: 505-509, 1997.
45. Ho GH, Luo XW, Ji CY, Foo SC, Ng EH: Urinary 2/16 alphahydroxyestrone ratio: correlation with serum insulin-like growth factor binding protein-3 and a potential biomarker of breast cancer risk. Ann Acad Med Singap 27: 294-299, 1998.
46. Meilahn EN, De Stavola B, Allen DS, Fentiman I, Bradlow HL, Sepkovic DW, Kuller LH: Do urinary oestrogen metabolites predict breast cancer? Guernsey III cohort follow-up. Br J Cancer 78: 1250-1255, 1998.
47. Muti P, Bradlow HL, Micheli A, Krogh V, Freudenheim JL, Schünemann HJ, Stanulla M, Yang J, Sepkovic DW, Trevisan M, Berrino F: Estrogen metabolism and risk of breast cancer: a prospective study of the 2: 16alpha-hydroxyestrone ratio in premenopausal and postmenopausal women. Epidemiology 11: 635-640, 2000.
48. Ursin G, London S, Stanczyk FZ, Gentzschein E, Paganini-Hill A, Ross RK, Pike MC: Urinary 2-hydroxestrone/16 alpha-hydroxyestrone ratio and risk breast cancer in postmenopausal woman. J Natl Cancer Inst 91: 1067-1072, 1999.
49. Ursin G, Wilson M, Henderson BE, Kolonel LN, Monroe K, Lee HP, Seow A, Yu MC, Stanczyk FZ, Gentzschein E: Do urinary estrogen metabolites reflect the differences in breast cancer risk between Singapore Chinese and United States African-American and white women?. Cancer Res 61: 3326-3329, 2001.
50. Cauley JA, Zmuda JM, Danielson ME, Ljung BM, Bauer DC, Cummings SR, Kuller LH: Estrogen metabolites and the risk of breast cancer in older women. Epidemiology 14: 740-744, 2003.
51. Morrow JD, Roberts LJ: The isoprostanes. Current knowledge and directions for future research [Review]. Biochem Pharmacol 51: 1-9, 1996.
52. Knight DC, Howes JB, Eden JA, Howes LG: Effects on menopausal symptoms and acceptability of isoflavone-containing soy powder dietary supplementation. Climacteric 4: 13-18, 2001.
53. Baird DD, Umbach DM, Lansdell L, Hughes CL, Setchell KD, Weinberg CR, Haney AF, Wilcox AJ, Mclachlan JA: Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women. J Clin Endocrin Metab 80: 1685-1690, 1995.
54. Pino AM, Valladares LE, Palma MA, Mancilla AM, Yanez M, Albala C: Dietary isoflavones affect sex hormone-binding globulin levels in postmenopausal women. J Clin Endocrin Metab 85: 2797-2800, 2000.
55. Duncan AM, Merz BE, Xu X, Nagel, TC, Phipps WR, Kurzer MS: Soy isoflavones exert modest hormonal effects in premenopausal women. J Clin Endocrinol Metab 84: 192-197, 1999.
56. Xu X, Duncan AM, Merz BE, Kurzer, MS: Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women. Cancer Epidemiol Biomak Prev 7: 1101-1108, 1998.
57. Wangen KE, Duncan AM, Xu X, Kurzer MS: Soy isoflavones improve plasma lipids in normocholesterolemic and mildly hypercholesterolemic postmenopausal women. Am J Clin Nutr 73: 225-231, 2001.
58. Gardner CD, Newell KA, Cherin R, Haskell WL: The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women. Am J Clin Nutr 73: 728-735, 2001.
59. Uesugi T, Fukui Y, Yamori Y: Beneficial effects of soybean isoflavone supplementation on bone metabolism and serum lipids in postmenopausal Japanese women: a four-week study. J Am Coll Nutr 21: 97-102, 2002.
60. Wiseman H, O'Reilly JD, Aldercreutz H, Mallet AI, Bowey EA, Rowland IR, Sanders TAB: Isoflavone phytoestrogens consumed in soy decrease F2-isoprostane concentration and increase resistance of low-density lipoprotein to oxidation in humans. Am J Clin Nutr 72: 395-400, 2000.
61. Tikkanen MJ, Wahala K, Ojala S, Vihma V, Adlercreutz H: Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance. Proc Natl Acad Sci USA 95: 3106-3110, 1998.
62. Michnovicz JJ, Adlercreutz H, Bradlow, HL: Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans. J Natl Cancer Inst 89: 718-723, 1997.
63. Haggans CJ, Hutchins AM, Olson BA, Thomas W, Martini MC, Slavin JL: Effect of flaxseed consumption on urinary estrogen metabolites in postmenopausal women. Nutr Cancer 33: 188-195, 1999.
64. Lu LJW, Cree M, Josyula S, Nagamani M, Grady JJ, Anderson KE: Increased urinary excretion of 2-hydroxyestrone but not 16-hydroxyestrone in premenopausal women during a soya diet containing isoflavones. Cancer Res 60: 1299-1305, 2000.
65. Fowke JH, Longcope C, Hebert JR: Macronutrient intake and estrogen metabolism in healthy postmenopausal women. Breast Cancer Res Treat 65: 1-10, 2001.
66. Goldin BR, Woods MN, Spiegelman DL, Longcope C, Morrill-LaBrode A, Dwyer JT, Gualtieri LJ, Hertzmark E, Gorbach SL: The effect of dietary fat and fiber on serum estrogen concentrations in premenopausal women under controlled dietary conditions. Cancer 74: 1125-1131, 1994.
67. Longcope C, Feldman HA, McKinlay JB, Araujo AB: Diet and sex hormone-binding globulin. J Clin Endocrin Metab 85: 293-296, 2000.
68. Estour B, Pugeat M, Lang F, Dechaud H, Pellet J, Rousset H: Sex hormone binding globulin in women with anorexia nervosa. Clin Endocrin 24: 571-576, 1986.
69. Kiddy DS, Hamilton-Fairley D, Seppala M, Koistinen R, James VH, Reed MJ, Franks S: Diet-induced changes in sex hormone binding globulin and free testosterone in women with normal or polycystic ovaries: correlation with serum insulin and insulin-like growth factor-I. Clin Endocrin 31: 757-763, 1989.
70. Reed MJ, Cheng RW, Simmonds M, Richmond W, James VH: Dietary lipids: an additional regulator of plasma levels of sex hormone binding globulin. J Clin Endocrin Metab 64: 1083-1085, 1987.
71. Preziosi P, Barrett-Connor E, Papoz L, Roger M, Saint-Paul M, Nahoul K, Simon D: Interrelation between plasma sex hormonebinding globulin and plasma insulin in healthy adult women: the telecom study. J Clin Endocrin Metab 76: 283-7, 1993.
72. Plymate SR, Jones RE, Matej LA, Friedl KE: Regulation of sex hormone binding globulin (SHBG) production in Hep G2 cells by insulin. Steroids 52: 339-340, 1988.
73. Foster-Powell K, Holt SHA, Brand-Miller JC: International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr 76: 5-56, 2002.
74. Gates JR, Parpia B, Campbell TC, Junshi C: Association of dietary factors and selected plasma variables with sex hormone-binding globulin in rural Chinese women. Am J Clin Nutr 63: 22-31, 1996.
75. Plymate SR, Namkung PC, Metej LA, Petra PH: Direct effect of plasma sex hormone binding globulin (SHBG) on the metabolic clearance rate of 17 beta-estradiol in the primate. J Steroid Biochem 36: 311-317, 1990.
76. Kasim-Karakas SE, Almario RU, Gregory L, Todd H, Wong R, Lasley BL: Effects of prune consumption on the ratio of 2-hydroxyestrone to 16alpha-hydroxyestrone. Am J Clin Nutr 76: 1422-1427, 2002.