Efficacy of phytoestrogens for menopausal symptoms: A meta-analysis and systematic review

Climacteric

Volumn 18, Issue 2, 2015, Pages 260-269

  Chen, M N ^a   Lin, C C ^b   Liu, C F ^c  

^a Department of International Business Hsin Sheng   (Taiwan)

^b MEIHO UNIVERSITY   (Taiwan)

^c NATIONAL TAIPEI UNIVERSITY OF NURSING AND HEALTH SCIENCES   (Taiwan)

Author keywords

Climacteric; estrogen; hot flush; isoflavone; lignan; menopause; meta analysis

Indexed keywords

COUMESTROL; ISOFLAVONE DERIVATIVE; PHYTOESTROGEN; PLACEBO;

ASSESSMENT OF HUMANS; DRUG EFFECT; DRUG EFFICACY; FEMALE; HOT FLUSH; HUMAN; KUPPERMAN INDEX; MENOPAUSAL SYNDROME; META ANALYSIS; OUTCOME ASSESSMENT; POSTMENOPAUSE; PRIORITY JOURNAL; PUBLISHING; QUALITY CONTROL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RED CLOVER; REVIEW; SYSTEMATIC REVIEW; UNSPECIFIED SIDE EFFECT; VASOMOTOR DISORDER; HOT FLASHES; MENOPAUSE; MIDDLE AGED; PHYSIOLOGY; PHYTOTHERAPY; TREATMENT OUTCOME;

FEMALE; HOT FLASHES; HUMANS; ISOFLAVONES; MENOPAUSE; MIDDLE AGED; PHYTOESTROGENS; PHYTOTHERAPY; PLACEBOS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 84924666637     PISSN: 13697137     EISSN: 14730804     Source Type: Journal    
DOI: 10.3109/13697137.2014.966241     Document Type: Review

References (42)

1. Avis N E, S tellato R, C rawford S, e t a l. I s there a menopausal syndrome Menopausal status and symptoms across racial/ethnic groups. Soc Sci Med 2001; 52: 345-56
2. Oldenhave A, Jaszmann LJ, Haspels AA, Everaerd WT. Impact of climacteric on well-being. A survey based on 5213 women 39 to 60 years old. Am J Obstet Gynecol 1993; 168: 772-80
3. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefi ts of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women ' s Health Initiative randomized controlled trial. JAMA 2002; 288: 321-33
4. D epypere H T, C omhaire F H. H erbal preparations for the menopause: beyond isofl avones and black cohosh. Maturitas 2014; 77: 191-4
5. Shou C, L i J, L iu Z. C omplementary and alternative medicine in the treatment of menopausal symptoms. Chin J Integr Med 2011; 17: 883-8
6. Ismail R, T aylor-Swanson L, T homas A, e t a l. E ffects of herbal preparations on symptoms clusters during the menopausal transition. Climacteric 2014 Mar 8. Epub ahead of print
7. Bedell S, N achtigal M, N aftolin F. T he pros and cons of plant estrogens for menopause. J Steroid Biochem Mol Biol 2014; 139: 225-36
8. Thompson L U, R obb P, S erraino M, C heung F. M ammalian lignan production from various foods. Nutr Cancer 1991; 16: 43-52
9. Freeman E W, S herif K. P revalence of hot fl ushes and night sweats around the world: a systematic review. Climacteric 2007; 10: 197-214
10. Messina M, N agata C, W u A H. E stimated Asian adult soy protein and isofl avone intakes. Nutr Cancer 2006; 55: 1-12
11. Lewis J E, N ickell L A, T hompson L U, S zalai J P, K iss A, Hilditch JR. A randomized controlled trial of the effect of dietary soy and fl axseed muffi ns on quality of life and hot fl ashes during menopause. Menopause 2006; 13: 631-42
12. Lethaby A, M arjoribanks J, K ronenberg F, R oberts H, Eden J, Brown J. Phytoestrogens for menopausal vasomotor symptoms. Cochrane Database Syst Rev 2013; 12: CD001395
13. Verhagen AP, de Vet HC, de Bie RA, et al. The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus. J Clin Epidemiol 1998; 51: 1235-41
14. Kupperman H S, W etchler B B, B latt M H. C ontemporary therapy of the menopausal syndrome. JAMA 1959; 171: 1627-37
15. Aso T, Uchiyama S, Matsumura Y, et al. A natural S-equol supplement alleviates hot fl ushes and other menopausal symptoms in equol nonproducing postmenopausal Japanese women. J Womens Health (Larchmt ) 2012; 21: 92-100
16. Atkinson C, W arren R M, S ala E, et a l. R ed-clover-derived isofl avones and mammographic breast density: a double-blind, randomized, placebo-controlled trial [ISRCTN42940165]. Breast Cancer Res 2004; 6: R170-9
17. Cancellieri F, De Leo V, Genazzani AD, et al. Effi cacy on menopausal neurovegetative symptoms and some plasma lipids blood levels of an herbal product containing isofl avones and other plant extracts. Maturitas 2007; 56: 249-56
18. del Giorno C, F onseca A M, Bagnoli V R, A ssis J S, Soares JM J r, Baracat EC. Effects of Trifolium pratense on the climacteric and sexual symptoms in postmenopause women. Rev Assoc Med Bras 2010; 56: 558-62
19. Ferrari A. Soy extract phytoestrogens with high dose of isofl avones for menopausal symptoms. J Obstet Gynaecol Res 2009; 35: 1083-90
20. Han KK, Soares J M J r, Haidar M A, d e Lima G R, Baracat EC. Benefi ts of soy isofl avone therapeutic regimen on menopausal symptoms. Obstet Gynecol 2002; 99: 389-94
21. Nahas E A, N ahas-Neto J, O rsatti F L, C arvalho E P, O liveira M L, Dias R. Effi cacy and safety of a soy isofl avone extract in postmenopausal women: a randomized, double-blind, and placebo-controlled study. Maturitas 2007; 58: 249-58
22. Penotti M, F abio E, M odena A B, R inaldi M, O modei U, V iganó P. Effect of soy-derived isofl avones on hot fl ushes, endometrial thickness, and the pulsatility index of the uterine and cerebral arteries. Fertil Steril 2003; 79: 1112-17
23. Petri Nahas E, N ah á s Neto J, D e Luca L, T raiman P, P ontes A, Dalben I. Benefi ts of soy germ isofl avones in postmenopausal women with contraindication for conventional hormone replacement therapy. Maturitas 2004; 48: 372-80
24. Riesco E, C hoquette S, A udet M, T essier D, D ionne I J. Effect of exercise combined with phytoestrogens on quality of life in postmenopausal women. Climacteric 2011; 14: 573-80
25. Sammartino A, T ommaselli G A, G argano V, d i Carlo C, Attianese W, Nappi C. Short-term effects of a combination of isofl avones, lignans and Cimicifuga racemosa on climactericrelated symptoms in postmenopausal women: a double-blind, randomized, placebo-controlled trial. Gynecol Endocrinol 2006; 22: 646-50
26. Tice J A, E ttinger B, E nsrud K, W allace R, B lackwell T, C ummings SR. Phytoestrogen supplements for the treatment of hot fl ashes: the Isofl avone Clover Extract (ICE) Study: a randomized controlled trial. JAMA 2003; 290: 207-14
27. van de Weijer PH, Barentsen R. Isofl avones from red clover (Promensil) signifi cantly reduce menopausal hot fl ush symptoms compared with placebo. Maturitas 2002; 42: 187-93
28. Van Patten CL, Olivotto IA, Chambers GK, et al. Effect of soy phytoestrogens on hot fl ashes in postmenopausal women with breast cancer: a randomized, controlled clinical trial. J Clin Oncol 2002; 20: 1449-55
29. Hozo S P, D julbegovic B, H ozo I. E stimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 2005; 13: 13
30. Jacobs A, Wegewitz U, Sommerfi eld C, Grossklaus R, Lampen A. Effi cacy of isofl avones in relieving vasomotor menopausal symptoms-A systematic review. Mol Nutr Food Res 2009; 53: 1084-97
31. Eden JA. Phytoestrogens for menopausal symptoms: a review. Maturitas 2012; 72: 157-9
32. Villaseca P. N on-estrogen conventional and phytochemical treatments for vasomotor symptoms: what needs to be known for practice. Climacteric 2012; 15: 115-24
33. Bolanos R, Del Castillo A, Francia J. Soy isofl avones versus placebo in the treatment of climacteric vasomotor symptoms: systematic review and metaanalysis. Menopause 2010; 17: 660-6
34. Carmignani L O, P edro A O, C osta-Paiva L H, P into-Neto AM. The effect of dietary soy supplementation compared to estrogen and placebo on menopausal symptoms: a randomized controlled trial. Maturitas 2010; 67: 262-9
35. Crisafulli A, Marini H, Bitto A, et al. Effects of genistein on hot fl ushes in early postmenopausal women: a randomized, doubleblind EPT-and placebo-controlled study. Menopause 2004; 11: 400-4
36. Marini H, Bitto A, Altavilla D, et al. Breast safety and effi cacy of genistein aglycone for postmenopausal bone loss: a follow-up study. J Clin Endocrinol Metab 2008; 93: 4787-96
37. Bitto A, Polito F, Atteritano M, et al. Genistein aglycone does not affect thyroid function: results from a three year, randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab 2010; 95: 3067-72
38. Quaas AM, Kono N, Mack WJ, et al. Effect of isofl avone soy protein supplementation on endometrial thickness, hyperplasia, and endometrial cancer risk in postmenopausal women: a randomized, controlled trial. Menopause 2013; 20: 840-4
39. Simbalista RL, Sauerbronn AV, Aldrighi JM, Ar ê as JA. Consumption of a fl axseed-rich food is not more effective than a placebo in alleviating the climacteric symptoms of postmenopausal women. J Nutr 2010; 140: 293-7
40. Pruthi S, Qin R, Terstreip SA, et al. A phase III, randomized, placebo-controlled, double-blind trial of fl axseed for the treatment of hot fl ashes: North Central Cancer Treatment Group N08C7. Menopause 2012; 19: 48-53
41. D'Adamo CR, Sahin A. Soy foods and supplementation: a review of commonly perceived health benefi ts and risks. Altern Ther Health Med 2014; 20(Suppl 1): 39-51
42. Tempfer C B, F roese G, H einze G, B entz E K, H efl er L A, H uber J C. Side effects of phytoestrogens: a meta-analysis of randomized trials. Am J Med 2009; 122: 939-46