Crinum latifolium leave extracts suppress immune activation cascades in peripheral blood mononuclear cells and proliferation of prostate tumor cells

Scientia Pharmaceutica

Volumn 79, Issue 2, 2011, Pages 323-335

  Jenny, Marcel ^a   Wondrak, Angela ^a   Zvetkova, Elissaveta ^b   Tram, Nguyen Thi Ngoc ^c   Phi, Phan Thi Phi ^d   Schennach, Harald ^e   Culig, Zoran ^a   Ueberall, Florian ^a   Fuchs, Dietmar ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b BULGARIAN ACADEMY OF SCIENCES   (Bulgaria)

^c Thien Duoc Company Ltd   (Viet Nam)

^d HANOI MEDICAL UNIVERSITY   (Viet Nam)

^e UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

Author keywords

Crinum latifolium (L.); Indoleamine 2,3 dioxygenase; Peripheral blood mononuclear cells; Proliferation; Prostate cells

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; CRINUM LATIFOLIUM EXTRACT; INDOLEAMINE 2,3 DIOXYGENASE; KYNURENINE; NEOPTERIN; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL PROLIFERATION; CELL STIMULATION; CRINUM; CRINUM LATIFOLIUM; HUMAN; HUMAN CELL; IC 50; IMMUNE RESPONSE; IN VITRO STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PLANT LEAF; PROSTATE ADENOCARCINOMA; PROSTATE CARCINOMA; PROSTATE HYPERTROPHY;

EID: 79959302764     PISSN: 00368709     EISSN: 22180532     Source Type: Journal    
DOI: 10.3797/scipharm.1011-13     Document Type: Article

References (41)

1. Fennell CW, van Staden J. Crinum species in traditional and modern medicine. Ethnopharmacol. 2001; 78: 15-26. doi:10.1016/S0378-8741(01)00305-1.
2. Tram NTN, Titorenkova TV, St Bankova V, Handjieva NV, Popov SS. Crinum L. (Amaryllidaceae). Fitoterapia. 2002; 73: 183-208. doi:10.1016/S0367-326X(02)00068-0.
3. Beckstrom-Sternberg SM, Duke JA, Wain KK. The ethnobotany database. Genome Informatics Group, National Agricultural Library. U.S. Department of Agriculture, Beltsville, MD, 1994.
4. Usher G. A Dictionary of Plants Used by Man. Constable and Company Ltd., London, 1974.
5. Crinum latifolium, a promising and highly effective treatment for BPH, health and life. The Journal of Health Ministry of Vietnam, 2002, N 207.
6. Doan TN. Crinum latifolium in treatment of Benign Hypertrophy of prostate and cancers. Journal of Health and Life of Vietnamese Health Ministry, 2002, N 148.
7. Tram NTN, Yanchev I, Zvetkova E, Dineva J, Katzarova E, Kostov G, Svilenov D, Ilieva I, Shalamanov P. Retarded growth of chemically induced with 20-methylcholanthrene tumours in rats under the action of cold-hot aqueous extracts (decoctions) from Vietnamese plant Crinum latifolium (L.). Exp Pathol Parasitol. 2001; 4: 9-12.
8. Tram NTN, Zvetkova E, Nikolova E, Katzarova E, Kostov G, Yanchev I, Baicheva O. A novel in vitro and in vivo T-lymphocyte activating factor in Crinum latifolium (L.) aqueous extracts. Exp Pathol Parasitol. 1999; 3: 21-26.
9. Zvetkova E, Wirleitner B, Tram NTN, Schennach H, Fuchs D. Aqueous extracts of Crinum latifolium (L.) and Camellia sinensis show immunomodulatory properties in human peripheral blood mononuclear cells. Int Immunopharmacol. 2001; 1: 2143-2150. doi:10.1016/S1567-5769(01)00140-0.
10. Nathan CF. Peroxide and pteridine: a hypothesis on the regulation of macrophage antimicrobial activity by interferon gamma. Interferon. 1986; 7: 125-143. PMid:3102389.
11. Wirleitner B, Neurauter G, Schroecksnadel K, Frick B, Fuchs D. Interferon-γ-induced conversion of tryptophan: immunologic and neuropsychiatric aspects. Curr Med Chem. 2003; 10: 1581-1591. PMid:12871129.
12. Fuchs D, Hausen A, Reibnegger G, Werner ER, Dierich MP, Wachter H. Neopterin as a marker for activated cell-mediated immunity: application in HIV infection. Immunol Today. 1988; 9: 150-155. PMid:3076770.
13. Pfefferkorn ER, Eckel M, Rebhun S. Interferon-gamma suppresses the growth of Toxoplasma gondii in human fibroblasts through starvation for tryptophan. Mol Biochem Parasitol. 1986; 20: 215-224. PMid:3093859.
14. Ozaki Y, Edelstein MP, Duch DS. Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon-gamma. Proc Natl Acad Sci U S A. 1988; 85: 1242-1246. PMid:3124115.
15. Munn DH, Shafizadeh E, Attwoodn JT, Bondarev I, Pashinem A, Mellor AL. Inhibition of T cell proliferation by macrophage tryptophan catabolism. J Exp Med. 1999; 189: 1363-1372. PMid:10224276.
16. Frumento G, Rotondo R, Tonetti M, Damonte G, Benatti U, Ferrara GB. Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase. J Exp Med. 2002; 196: 459-468. PMid:12186838.
17. Murr C, Widner B, Wirleitner B, Fuchs D. Neopterin as a marker for immune system activation. Curr Drug Metabol. 2002; 3: 175-187. PMid:12003349.
18. Schroecksnadel K, Wirleitner B, Winkler C, Fuchs D. Monitoring tryptophan metabolism in chronic immune activation. Clin Chim Acta. 2006; 364: 82-90. doi:10.1016/j.cca.2005.06.013.
19. Schroecksnadel K, Winkler C, Duftner C, Wirleitner B, Schirmer M, Fuchs D. Tryptophan degradation increases with stage in patients with rheumatoid arthritis. Clin Rheumatol. 2006; 25: 334-337. doi:10.1007/s10067-005-0056-6.
20. Murray MF. Tryptophan depletion and HIV infection: a metabolic link to pathogenesis. Lancet Infect Dis. 2003; 3: 644-652. doi:10.1016/S1473-3099(03)00773-4.
21. Weiss G, Murr C, Zoller H, Haun M, Widner B, Ludescher C, Fuchs D. Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cells. Clin Exp Immunol. 1999; 116: 435-440. doi:10.1046/j.1365-2249.1999.00910.x
22. Liao H, Banbury LK, Leach DN. Antioxidant activity of 45 Chinese herbs and the relationship with their TCM characteristics. Evid Based Complement Alternat Med. 2008; 4: 429-434. doi:10.1093/ecam/nem054.
23. Winkler C, Schroecksnadel K, Schennach H, Fuchs D. Vitamin C and E suppress mitogen-stimulated peripheral blood mononuclear cells in vitro. Int Arch Allergy Immunol. 2007; 142: 127-132. doi:10.1159/000096438.
24. Tan PH, Sagoo P, Chan C, Yates JB, Campbell J, Beutelspacher SC, Foxwell BM, Lombardi G, George AJ. Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells. J Immunol. 2005; 174: 7633-7644. PMid:15944264.
25. Schroecksnadel K, Winkler C, Fischer B, Schennach H, Weiss G, Fuchs D. Antioxidants suppress Th1-type immune response in vitro. Drug Metab Lett. 2007; 1: 166-171. PMid:19356038.
26. Wirleitner, B., Schroecksnadel, K., Winkler, C., Schennach, H, Fuchs, D. Resveratrol suppresses interferon-gamma-induced biochemical pathways in human peripheral blood mononuclear cells in vitro. Immunol Lett. 2005; 100: 159-163. doi:10.1016/j.imlet.2005.03.008.
27. Jenny M, Santer E, Klein A, Ledochowski M, Schennach H, Ueberall F, Fuchs D. Cacao extracts suppress tryptophan degradation of mitogen-stimulated peripheral blood mononuclear cells. J Ethnopharmacol. 2009; 122: 261-267. doi:10.1016/j.jep.2009.01.011.
28. Lewis JR. Amaryllidaceae and Sceletium alkaloids. Nat Prod Rep. 1994; 11: 329-332. doi:10.1039/NP9941100329.
29. Tram NT, Mitova M, Bankova V, Handjieva N, Popov SS. GC-MS of Crinum latifolium L. alkaloids. Z Naturforsch C. 2002; 57: 239-242. PMid:12064720.
30. Griffin C, Sharda N, Sood D, Nair J, McNulty J, Pandey S. Selective cytotoxicity of pancratistatin-related natural Amaryllidaceae alkaloids: evaluation of the activity of two new compounds. Cancer Cell Int. 2007; 7: 10. doi:10.1186/1475-2867-7-10.
31. McNulty J, Nair JJ, Codina C, Bastida J, Pandey S, Gerasimoff J, Griffin C. Selective apoptosis-inducing activity of crinum-type Amaryllidaceae alkaloids. Phytochemistry. 2007; 68: 1068-1074. doi:10.1016/j.phytochem.2007.01.006.
32. Werner ER, Werner-Felmayer G, Fuchs D, Hausen A, Reibnegger G, Wachter H. Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma. Biochem J. 1989; 262; 861-866. PMid:2511835.
33. Uyttenhove C, Pilotte L, Théate I, Stroobant V, Colau D, Parmentier N, Boon T, Van den Eynde BJ. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med. 2003; 9: 1269-1274. doi:10.1038/nm934.
34. Katz JB, Muller AJ, Prendergast GC. Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape. Immunol Rev. 2008; 222: 206-221. doi:10.1111/j.1600-065X.2008.00610.x
35. Friberg M, Jennings R, Alsarraj M, Dessureault S, Cantor A, Extermann M, Mellor AL, Munn DH, Antonia SJ. Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection. Int J Cancer. 2002; 101: 151-155. doi:10.1002/ijc.10645.
36. Muller AJ, DuHadaway JB, Donover PS, Sutanto-Ward E, Prendergast GC. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nat Med. 2005; 11: 312-319. doi:10.1038/nm1196.
37. Gaspari P, Banerjee T, Malachowski WP, Muller AJ, Prendergast GC, DuHadaway J, Bennett S, Donovan AM. Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2006; 49: 684-692. doi:10.1021/jm0508888.
38. Banerjee T, Duhadaway JB, Gaspari P, Sutanto-Ward E, Munn DH, Mellor AL, Malachowski WP, Prendergast GC, Muller AJ. A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase. Oncogene. 2008; 27: 2851-2857. doi:10.1038/sj.onc.1210939.
39. Jenny M, Klieber M, Zaknun D, Schroecksnadel S, Kurz K, Ledochowski M, Schennach H, Fuchs D. In vitro testing for anti-inflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors. Inflamm Res. 2011; 60: 127-35 doi:10.1007/s00011-010-0244-y
40. Ou B, Hampsh-Woodill M, Prior R. Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe. J Agric Food Chem. 2001; 49: 4619-4626. doi:10.1021/jf010586o
41. Widner B, Werner ER, Schennach H, Wachter H, Fuchs D. Simultaneous measurement of serum tryptophan and kynurenine by HPLC. Clin Chem. 1997; 43: 2424-2426. PMid:9439467.