CYP-mediated clozapine interactions: How predictable are they?

Current Drug Metabolism

Volumn 8, Issue 4, 2007, Pages 307-313

  Chetty, Manoranjenni ^a   Murray, Michael ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Clozapine interactions; CYP1A2 inducers; CYP1A2 inhibitors; CYP2D6 interactions; CYP3A4 interactions; Predictable interactions

Indexed keywords

CAFFEINE; CARBAMAZEPINE; CIGARETTE SMOKE; CIPROFLOXACIN; CITALOPRAM; CLOZAPINE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 INHIBITOR; DRUG METABOLITE; ERYTHROMYCIN; FLUOXETINE; FLUVOXAMINE; ISONIAZID; MOOD STABILIZER; NORCLOZAPINE; OMEPRAZOLE; PANTOPRAZOLE; PAROXETINE; PROTON PUMP INHIBITOR; PSYCHOTROPIC AGENT; RIFAMPICIN; RISPERIDONE; SERTRALINE; UNINDEXED DRUG; VALPROIC ACID;

AGRANULOCYTOSIS; AKATHISIA; BIOTRANSFORMATION; CARDIOMYOPATHY; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONFUSION; CONSTIPATION; DROWSINESS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENTIATION; DRUG RESPONSE; DRUG WITHDRAWAL; ENZYME INHIBITION; EOSINOPHILIA; GASTROINTESTINAL SYMPTOM; HUMAN; HYPERSALIVATION; HYPOTENSION; IN VITRO STUDY; IN VIVO STUDY; LIVER TOXICITY; MYOCARDITIS; NAUSEA; PHARMACODYNAMICS; PREDICTION; PSYCHOSIS; REVIEW; SEDATION; SEIZURE; SIDE EFFECT; TONIC CLONIC SEIZURE; WEIGHT GAIN;

ANIMALS; ANTIPSYCHOTIC AGENTS; BIOTRANSFORMATION; CLOZAPINE; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INDUCTION; ENZYME INHIBITORS; HUMANS;

EID: 34249084393     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920007780655469     Document Type: Review

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