Exploring the possible metabolism mediated interaction of Glycyrrhiza glabra extract with CYP3A4 and CYP2D6

Phytotherapy Research

Volumn 25, Issue 10, 2011, Pages 1429-1434

  Pandit, Subrata ^a   Ponnusankar, Sivasankaran ^a   Bandyopadhyay, Arun ^b   Ota, Sarda ^c   Mukherjee, Pulok K ^a  

^a JADAVPUR UNIVERSITY   (India)

^b INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^c GOVERNMENT OF INDIA   (India)

Author keywords

Ayurveda; CYP2D6; CYP3A4; cytochrome P450 inhibition; Glycyrrhiza glabra; herb drug interaction; Traditional Chinese Medicine

Indexed keywords

CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; GLYCYRRHIZA GLABRA EXTRACT; GLYCYRRHIZIC ACID; KETOCONAZOLE; QUINIDINE;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG SCREENING; ENZYME INHIBITION; ENZYME KINETICS; FLUOROMETRY; IC 50; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; ENZYME INHIBITORS; GLYCYRRHIZA; GLYCYRRHIZIC ACID; HERB-DRUG INTERACTIONS; INHIBITORY CONCENTRATION 50; KETOCONAZOLE; MALE; PLANT EXTRACTS; QUINIDINE; RATS, WISTAR; RHIZOME;

GLYCYRRHIZA; GLYCYRRHIZA GLABRA;

EID: 80053342161     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3426     Document Type: Article

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