Microbleed Status and 3-Month Outcome after Intravenous Thrombolysis in 717 Patients with Acute Ischemic Stroke

Stroke

Volumn 46, Issue 9, 2015, Pages 2458-2463

  Turc, Guillaume ^a   Sallem, Asmaa ^b   Moulin, Solène ^b   Tisserand, Marie ^a   Machet, Alexandre ^a   Edjlali, Myriam ^b   Baron, Jean Claude ^a   Leclerc, Xavier ^b   Leys, Didier ^b   Mas, Jean Louis ^a   Cordonnier, Charlotte ^b   Oppenheim, Catherine ^a  

^a CENTRE HOSPITALIER SAINTE ANNE   (France)

^b UNIV LILLE   (France)

Author keywords

cerebral hemorrhage; magnetic resonance imaging; stroke

Indexed keywords

ADULT; AGED; ARTICLE; ATRIAL FIBRILLATION; BLOOD CLOT LYSIS; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; COHORT ANALYSIS; DISEASE ASSOCIATION; FEMALE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; NEURORADIOLOGIST; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANKIN SCALE; VASCULAR DISEASE; VERY ELDERLY; CLINICAL TRIAL; FIBRINOLYTIC THERAPY; FOLLOW UP; INCIDENCE; INTRACRANIAL HEMORRHAGES; MIDDLE AGED; MULTICENTER STUDY; PROCEDURES; SINGLE BLIND PROCEDURE; STROKE; TREATMENT OUTCOME;

AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; INTRACRANIAL HEMORRHAGES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; SINGLE-BLIND METHOD; STROKE; THROMBOLYTIC THERAPY; TREATMENT OUTCOME;

EID: 84940367256     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.115.009290     Document Type: Article

References (32)

1. Fazekas F, Kleinert R, Roob G, Kleinert G, Kapeller P, Schmidt R, et al. Histopathologic analysis of foci of signal loss on gradient-echo T2∗-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. AJNR Am J Neuroradiol. 1999;20:637-642.
2. Cordonnier C, Al-Shahi Salman R, Wardlaw J. Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain. 2007;130(pt 8):1988-2003. doi: 10.1093/brain/awl387.
3. Fiehler J, Albers GW, Boulanger JM, Derex L, Gass A, Hjort N, et al; MR STROKE Group. Bleeding risk analysis in stroke imaging before thromboLysis (BRASIL): pooled analysis of T2∗-weighted magnetic resonance imaging data from 570 patients. Stroke. 2007;38:2738-2744. doi: 10.1161/STROKEAHA.106.480848.
4. Gratz PP, El-Koussy M, Hsieh K, von Arx S, Mono ML, Heldner MR, et al. Preexisting cerebral microbleeds on susceptibility-weighted magnetic resonance imaging and post-thrombolysis bleeding risk in 392 patients. Stroke. 2014;45:1684-1688. doi: 10.1161/STROKEAHA.114.004796.
5. Dannenberg S, Scheitz JF, Rozanski M, Erdur H, Brunecker P, Werring DJ, et al. Number of cerebral microbleeds and risk of intracerebral hemorrhage after intravenous thrombolysis. Stroke. 2014;45:2900-2905. doi: 10.1161/STROKEAHA.114.006448.
6. Charidimou A, Fox Z, Werring DJ. Do cerebral microbleeds increase the risk of intracerebral hemorrhage after thrombolysis for acute ischemic stroke? Int J Stroke. 2013;8:E1-E2. doi: 10.1111/ijs.12048.
7. Jauch EC, Saver JL, Adams HP Jr, Bruno A, Connors JJ, Demaerschalk BM, et al; American Heart Association Stroke Council; Council on Cardiovascular Nursing; Council on Peripheral Vascular Disease; Council on Clinical Cardiology. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44:870-947. doi: 10.1161/STR.0b013e318284056a.
8. Charidimou A, Kakar P, Fox Z, Werring DJ. Cerebral microbleeds and the risk of intracerebral haemorrhage after thrombolysis for acute ischaemic stroke: systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2013;84:277-280. doi: 10.1136/jnnp-2012-303379.
9. Shoamanesh A, Kwok CS, Lim PA, Benavente OR. Postthrombolysis intracranial hemorrhage risk of cerebral microbleeds in acute stroke patients: a systematic review and meta-analysis. Int J Stroke. 2013;8:348-356. doi: 10.1111/j.1747-4949.2012.00869.x.
10. Charidimou A, Werring DJ. Cerebral microbleeds as a predictor of macrobleeds: what is the evidence? Int J Stroke. 2014;9:457-459. doi: 10.1111/ijs.12280.
11. Yan S, Jin X, Zhang X, Zhang S, Liebeskind DS, Lou M. Extensive cerebral microbleeds predict parenchymal haemorrhage and poor outcome after intravenous thrombolysis [published online ahead of print January 28, 2015]. J Neurol Neurosurg Psychiatry. http://jnnp.bmj.com/content/early/2015/01/28/jnnp-2014-309857.long. Accessed May 14, 2015.
12. Thomalla G, Cheng B, Ebinger M, Hao Q, Tourdias T, Wu O, et al; STIR and VISTA Imaging Investigators. DWI-FLAIR mismatch for the identification of patients with acute ischaemic stroke within 4.5 h of symptom onset (PRE-FLAIR): a multicentre observational study. Lancet Neurol. 2011;10:978-986. doi: 10.1016/S1474-4422(11)70192-2.
13. Petkova M, Rodrigo S, Lamy C, Oppenheim G, Touzé E, Mas JL, et al. MR imaging helps predict time from symptom onset in patients with acute stroke: implications for patients with unknown onset time. Radiology. 2010;257:782-792. doi: 10.1148/radiol.10100461.
14. Gregoire SM, Chaudhary UJ, Brown MM, Yousry TA, Kallis C, Jäger HR, et al. The Microbleed Anatomical Rating Scale (MARS): reliability of a tool to map brain microbleeds. Neurology. 2009;73:1759-1766. doi: 10.1212/WNL.0b013e3181c34a7d.
15. Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, et al; STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1). Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol. 2013;12:822-838. doi: 10.1016/S1474-4422(13)70124-8.
16. Greenberg SM, Vernooij MW, Cordonnier C, Viswanathan A, Al-Shahi Salman R, Warach S, et al; Microbleed Study Group. Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol. 2009;8:165-174. doi: 10.1016/S1474-4422(09)70013-4.
17. Knudsen KA, Rosand J, Karluk D, Greenberg SM. Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria. Neurology. 2001;56:537-539.
18. Trouillas P, von Kummer R. Classification and pathogenesis of cerebral hemorrhages after thrombolysis in ischemic stroke. Stroke. 2006;37:556-561. doi: 10.1161/01.STR.0000196942.84707.71.
19. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581-1587.
20. Hacke W, Kaste M, Fieschi C, von Kummer R, Davalos A, Meier D, et al. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators. Lancet. 1998;352:1245-1251.
21. Hacke W, Kaste M, Bluhmki E, Brozman M, Dávalos A, Guidetti D, et al; ECASS Investigators. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359:1317-1329. doi: 10.1056/NEJMoa0804656.
22. Wahlgren N, Ahmed N, Dávalos A, Ford GA, Grond M, Hacke W, et al; SITS-MOST Investigators. Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet. 2007;369:275-282. doi: 10.1016/S0140-6736(07)60149-4.
23. Saver JL, Gornbein J. Treatment effects for which shift or binary analyses are advantageous in acute stroke trials. Neurology. 2009;72:1310-1315. doi: 10.1212/01.wnl.0000341308.73506.b7.
24. Ananth CV, Kleinbaum DG. Regression models for ordinal responses: a review of methods and applications. Int J Epidemiol. 1997;26:1323-1333.
25. Turc G, Apoil M, Naggara O, Calvet D, Lamy C, Tataru AM, et al. Magnetic Resonance Imaging-DRAGON score: 3-month outcome prediction after intravenous thrombolysis for anterior circulation stroke. Stroke. 2013;44:1323-1328. doi: 10.1161/STROKEAHA.111.000127.
26. Strbian D, Sairanen T, Meretoja A, Pitkäniemi J, Putaala J, Salonen O, et al; Helsinki Stroke Thrombolysis Registry Group. Patient outcomes from symptomatic intracerebral hemorrhage after stroke thrombolysis. Neurology. 2011;77:341-348. doi: 10.1212/WNL. 0b013e3182267b8c.
27. Charidimou A, Kakar P, Fox Z, Werring DJ. Cerebral microbleeds and recurrent stroke risk: systematic review and meta-analysis of prospective ischemic stroke and transient ischemic attack cohorts. Stroke. 2013;44:995-1001. doi: 10.1161/STROKEAHA.111.000038.
28. Kakuda W, Thijs VN, Lansberg MG, Bammer R, Wechsler L, Kemp S, et al; DEFUSE Investigators. Clinical importance of microbleeds in patients receiving IV thrombolysis. Neurology. 2005;65:1175-1178. doi: 10.1212/01.wnl.0000180519.27680.0f.
29. Turc G, Tisserand M, Seners P, Oppenheim C, Baron JC. Letter by Turc et al regarding article, "Defining clinically relevant cerebral hemorrhage after thrombolytic therapy for stroke: analysis of the national institute of neurological disorders and stroke tissue-type plasminogen activator trials." Stroke. 2015;46:e43-e44. doi: 10.1161/STROKEAHA.114.007747.
30. Rao NM, Levine SR, Saver JL. Response to letter regarding article, "Defining clinically relevant cerebral hemorrhage after thrombolytic therapy for stroke: analysis of the national institute of neurological disorders and stroke tissue-type plasminogen activator trials." Stroke. 2015;46:e45. doi: 10.1161/STROKEAHA.114.007860.
31. Kim HS, Lee DH, Ryu CW, Lee JH, Choi CG, Kim SJ, et al. Multiple cerebral microbleeds in hyperacute ischemic stroke: impact on prevalence and severity of early hemorrhagic transformation after thrombolytic treatment. AJR Am J Roentgenol. 2006;186:1443-1449. doi: 10.2214/AJR.04.1933.
32. Cheng AL, Batool S, McCreary CR, Lauzon ML, Frayne R, Goyal M, et al. Susceptibility-weighted imaging is more reliable than T2∗-weighted gradient-recalled echo MRI for detecting microbleeds. Stroke. 2013;44:2782-2786. doi: 10.1161/STROKEAHA.113.002267.