Postthrombolysis intracranial hemorrhage risk of cerebral microbleeds in acute stroke patients: A systematic review and meta-analysis

International Journal of Stroke

Volumn 8, Issue 5, 2013, Pages 348-356

  Shoamanesh, Ashkan ^a   Kwok, Chun Shing ^b   Lim, Patricia Annabelle ^c   Benavente, Oscar R ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Complications; Hemorrhage; Microbleeds; Microhemorrhages; Thrombolysis; TPA; Urokinase

Indexed keywords

ARTICLE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; FIBRINOLYTIC THERAPY; HUMAN; META ANALYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; STROKE PATIENT; SYSTEMATIC REVIEW;

BIAS (EPIDEMIOLOGY); HUMANS; INTRACRANIAL HEMORRHAGES; OBSERVATIONAL STUDY AS TOPIC; RANDOMIZED CONTROLLED TRIALS AS TOPIC; STROKE; THROMBOLYTIC THERAPY;

EID: 84879497684     PISSN: 17474930     EISSN: 17474949     Source Type: Journal    
DOI: 10.1111/j.1747-4949.2012.00869.x     Document Type: Article

References (30)

1. Shoamanesh A, Kwok CS, Benavente O. Cerebral microbleeds: histopathological correlation of neuroimaging. Cerebrovasc Dis 2011; 32:528-534.
2. Greenberg SM, Finklestein SP, Schaefer PW. Petechial hemorrhages accompanying lobar hemorrhage: detection by gradient-echo MRI. Neurology 1996; 46:1751-1754.
3. Scharf J, Brauherr E, Forsting M, Sartor K. Significance of haemorrhagic lacunes on MRI in patients with hypertensive cerebrovascular disease and intracerebral haemorrhage. Neuroradiology 1994; 36:504-508.
4. Offenbacher H, Fazekas F, Schmidt R, Koch M, Fazekas G, Kapeller P. MR of cerebral abnormalities concomitant with primary intracerebral hematomas. AJNR Am J Neuroradiol 1996; 17:573-578.
5. Lovelock CE, Cordonnier C, Naka H etal. Antithrombotic drug use, cerebral microbleeds, and intracerebral hemorrhage: a systematic review of published and unpublished studies. Stroke 2010; 41:1222-1228.
6. Hjort N, Butcher K, Davis SM etal. Magnetic resonance imaging criteria for thrombolysis in acute cerebral infarct. Stroke 2005; 36:388-397.
7. Schellinger PD, Fiebach JB, Hacke W. Imaging-based decision making in thrombolytic therapy for ischemic stroke: present status. Stroke 2003; 34:575-583.
8. Chalela JA, Kang DW, Warach S. Multiple cerebral microbleeds: MRI marker of a diffuse hemorrhage-prone state. J Neuroimaging 2004; 14:54-57.
9. Vernooij MW, van der Lugt A, Breteler MM. Risk of thrombolysis-related hemorrhage associated with microbleed presence. Stroke 2008; 39:e115; author reply e116.
10. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement. BMJ 2009; 339:332-336.
11. Sanderson S, Tatt ID, Higgins JP. Tools for assessing quality and susceptibility to bias in observational studies in epidemiology: a systematic review and annotated bibliography. Int J Epidemiol 2007; 36:666-676.
12. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003; 327:557-560.
13. Kim HS, Lee DH, Ryu CW etal. Multiple cerebral microbleeds in hyperacute ischemic stroke: impact on prevalence and severity of early hemorrhagic transformation after thrombolytic treatment. AJR Am J Roentgenol 2006; 186:1443-1449.
14. Derex L, Nighoghossian N, Hermier M etal. Thrombolysis for ischemic stroke in patients with old microbleeds on pretreatment MRI. Cerebrovasc Dis 2004; 17:238-241.
15. Fiehler J, Albers GW, Boulanger JM etal. Bleeding risk analysis in stroke imaging before thrombolysis (BRASIL): pooled analysis of T2-weighted magnetic resonance imaging data from 570 patients. Stroke 2007; 38:2738-2744.
16. Kakuda W, Thijs VN, Lansberg MG etal. Clinical importance of microbleeds in patients receiving IV thrombolysis. Neurology 2005; 65:1175-1178.
17. Kidwell CS, Saver JL, Villablanca JP etal. Magnetic resonance imaging detection of microbleeds before thrombolysis: an emerging application. Stroke 2002; 33:95-98.
18. Berger C, Fiorelli M, Steiner T etal. Hemorrhagic transformation of ischemic brain tissue: asymptomatic or symptomatic? Stroke 2001; 32:1330-1335.
19. Neumann-Haefelin T, Hoelig S, Berkefeld J etal. Leukoaraiosis is a risk factor for symptomatic intracerebral hemorrhage after thrombolysis for acute stroke. Stroke 2006; 37:2463-2466.
20. Soo YO, Yang SR, Lam WW etal. Risk vs benefit of anti-thrombotic therapy in ischaemic stroke patients with cerebral microbleeds. J Neurol 2008; 255:1679-1686.
21. von Kummer R. Brain hemorrhage after thrombolysis: good or bad? Stroke 2002; 33:1446-1447.
22. Graham GD. Tissue plasminogen activator for acute ischemic stroke in clinical practice: a meta-analysis of safety data. Stroke 2003; 34:2847-2850.
23. Cordonnier C, Al-Shahi Salman R, Wardlaw J. Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain 2007; 130:1988-2003.
24. Hsia AW, Sachdev HS, Tomlinson J, Hamilton SA, Tong DC. Efficacy of IV tissue plasminogen activator in acute stroke: does stroke subtype really matter? Neurology 2003; 61:71-75.
25. Cordonnier C, Potter GM, Jackson CA etal. Improving interrater agreement about brain microbleeds: development of the Brain Observer MicroBleed Scale (BOMBS). Stroke 2009; 40:94-99.
26. Gregoire SM, Chaudhary UJ, Brown MM etal. The Microbleed Anatomical Rating Scale (MARS): reliability of a tool to map brain microbleeds. Neurology 2009; 73:1759-1766.
27. Knudsen KA, Rosand J, Karluk D, Greenberg SM. Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria. Neurology 2001; 56:537-539.
28. Winkler DT, Biedermann L, Tolnay M etal. Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy. Ann Neurol 2002; 51:790-793.
29. McCarron MO, Nicoll JA. Cerebral amyloid angiopathy and thrombolysis-related intracerebral haemorrhage. Lancet Neurol 2004; 3:484-492.
30. Wahlgren N, Ahmed N, Eriksson N etal. Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials: Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST). Stroke 2008; 39:3316-3322.