Biological pacemaker created by minimally invasive somatic reprogramming in pigs with complete heart block

Science Translational Medicine

Volumn 6, Issue 245, 2014, Pages

  Hu, Yu Feng ^a,b   Dawkins, James Frederick ^a   Cho, Hee Cheol ^a   Marbán, Eduardo ^a   Cingolani, Eugenio ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; GREEN FLUORESCENT PROTEIN; ISOPRENALINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR T BOX 18; UNCLASSIFIED DRUG; T BOX TRANSCRIPTION FACTOR; TBX18 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOREGULATION; CIRCADIAN RHYTHM; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG SAFETY; FEASIBILITY STUDY; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; GFP GENE; HEART ARRHYTHMIA; HEART ATRIUM PACEMAKER; HEART BEAT; HEART BLOCK; HEART RATE; HEART RATE VARIABILITY; HEART SIZE; HEMODYNAMICS; METABOLISM; MINIMALLY INVASIVE PROCEDURE; MUSCLE CELL; NONHUMAN; NUCLEAR REPROGRAMMING; PHENOTYPE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SINUS NODE; SWINE; TBX18 GENE; VIRAL GENE DELIVERY SYSTEM; ANIMAL; BIOLOGICAL RHYTHM; CARDIAC MUSCLE CELL; GENETICS; HUMAN; MOTOR ACTIVITY; PATHOLOGY; PIG; TISSUE DISTRIBUTION; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ARRHYTHMIAS, CARDIAC; BIOLOGICAL CLOCKS; CELLULAR REPROGRAMMING; GREEN FLUORESCENT PROTEINS; HEART BLOCK; HUMANS; MOTOR ACTIVITY; MYOCYTES, CARDIAC; SUS SCROFA; T-BOX DOMAIN PROTEINS; TISSUE DISTRIBUTION; TRANSDUCTION, GENETIC;

EID: 84940285961     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3008681     Document Type: Article

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