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Volumn 28, Issue 3, 2015, Pages 159-173

Apathy in Neurodegenerative Diseases: Recommendations on the Design of Clinical Trials

Author keywords

Alzheimer disease; apathy; Parkinson disease; trial design

Indexed keywords

ANTIDEPRESSANT AGENT;

EID: 84940207542     PISSN: 08919887     EISSN: 15525708     Source Type: Journal    
DOI: 10.1177/0891988715573534     Document Type: Article
Times cited : (53)

References (135)
  • 1
    • 79751533753 scopus 로고    scopus 로고
    • Apathy in neuropsychiatric disease: Diagnosis, pathophysiology, and treatment
    • Chase TN,. Apathy in neuropsychiatric disease: diagnosis, pathophysiology, and treatment. Neurotox Res. 2011; 19 (2): 266-278.
    • (2011) Neurotox Res , vol.19 , Issue.2 , pp. 266-278
    • Chase, T.N.1
  • 4
    • 85081882878 scopus 로고    scopus 로고
    • Parkinsons Disease Foundation; Statistics on Parkinsons. Web site. Accessed February 17, 2015
    • Parkinsons Disease Foundation; Statistics on Parkinsons 2013. Web site. http://www.pdf.org/en/parkinson-statistics. Accessed February 17, 2015.
    • (2013)
  • 5
    • 33846016934 scopus 로고    scopus 로고
    • Neuropsychiatric symptoms in patients with Parkinsons disease and dementia: Frequency, profile and associated care giver stress
    • Aarsland D, Bronnick K, Ehrt U,. Neuropsychiatric symptoms in patients with Parkinsons disease and dementia: frequency, profile and associated care giver stress. J Neurol Neurosurg Psychiatry. 2007; 78 (1): 36-42.
    • (2007) J Neurol Neurosurg Psychiatry , vol.78 , Issue.1 , pp. 36-42
    • Aarsland, D.1    Bronnick, K.2    Ehrt, U.3
  • 6
    • 34249040495 scopus 로고    scopus 로고
    • Characteristics of apathy in Parkinsons disease
    • Dujardin K, Sockeel P, Devos D,. Characteristics of apathy in Parkinsons disease. Mov Disord. 2007; 22 (6): 778-784.
    • (2007) Mov Disord , vol.22 , Issue.6 , pp. 778-784
    • Dujardin, K.1    Sockeel, P.2    Devos, D.3
  • 10
    • 84866433778 scopus 로고    scopus 로고
    • Apathy in Parkinsons disease: Clinical features, mechanisms and assessment
    • Dujardin K, Defebvre L,. Apathy in Parkinsons disease: clinical features, mechanisms and assessment. Rev Neurol (Paris). 2012; 168 (8-9): 598-604.
    • (2012) Rev Neurol (Paris) , vol.168 , Issue.8-9 , pp. 598-604
    • Dujardin, K.1    Defebvre, L.2
  • 11
    • 84871899096 scopus 로고    scopus 로고
    • Apathy: A separate syndrome from depression in dementia? A critical review
    • Mortby ME, Maercker A, Forstmeier S,. Apathy: a separate syndrome from depression in dementia? A critical review. Aging Clin Exp Res. 2012; 24 (4): 305-316.
    • (2012) Aging Clin Exp Res , vol.24 , Issue.4 , pp. 305-316
    • Mortby, M.E.1    Maercker, A.2    Forstmeier, S.3
  • 14
    • 61849134801 scopus 로고    scopus 로고
    • A longitudinal study of apathy in patients with Alzheimers disease
    • Turro-Garriga O, Lopez-Pousa S, Vilalta-Franch J,. A longitudinal study of apathy in patients with Alzheimers disease. Rev Neurol. 2009; 48 (1): 7-13.
    • (2009) Rev Neurol , vol.48 , Issue.1 , pp. 7-13
    • Turro-Garriga, O.1    Lopez-Pousa, S.2    Vilalta-Franch, J.3
  • 15
    • 42449136645 scopus 로고    scopus 로고
    • Apathy and depression in Alzheimers disease are associated with functional deficit and psychotropic prescription
    • Benoit M, Andrieu S, Lechowski L, Gillette-Guyonnet S, Robert PH, Vellas B,. Apathy and depression in Alzheimers disease are associated with functional deficit and psychotropic prescription. Int J Geriatr Psychiatry. 2008; 23 (4): 409-414.
    • (2008) Int J Geriatr Psychiatry , vol.23 , Issue.4 , pp. 409-414
    • Benoit, M.1    Andrieu, S.2    Lechowski, L.3    Gillette-Guyonnet, S.4    Robert, P.H.5    Vellas, B.6
  • 16
    • 0031941259 scopus 로고    scopus 로고
    • Assessing the impact of neuropsychiatric symptoms in Alzheimers disease: The Neuropsychiatric Inventory Caregiver Distress Scale
    • Kaufer DI, Cummings JL, Christine D,. Assessing the impact of neuropsychiatric symptoms in Alzheimers disease: the Neuropsychiatric Inventory Caregiver Distress Scale. J Am Geriatr Soc. 1998; 46 (2): 210-215.
    • (1998) J Am Geriatr Soc , vol.46 , Issue.2 , pp. 210-215
    • Kaufer, D.I.1    Cummings, J.L.2    Christine, D.3
  • 17
    • 84880141783 scopus 로고    scopus 로고
    • Designing a trial to evaluate potential treatments for apathy in dementia: The apathy in dementia methylphenidate trial (ADMET)
    • Drye LT, Scherer RW, Lanctot KL,. Designing a trial to evaluate potential treatments for apathy in dementia: the apathy in dementia methylphenidate trial (ADMET). Am J Geriatr Psychiatry. 2013; 21 (6): 549-559.
    • (2013) Am J Geriatr Psychiatry , vol.21 , Issue.6 , pp. 549-559
    • Drye, L.T.1    Scherer, R.W.2    Lanctot, K.L.3
  • 18
    • 0036063168 scopus 로고    scopus 로고
    • The efficacy of cholinesterase inhibitors in treating the behavioural symptoms of dementia
    • Rosler M,. The efficacy of cholinesterase inhibitors in treating the behavioural symptoms of dementia. Int J Clin Pract Suppl. 2002;(127): 20-36.
    • (2002) Int J Clin Pract Suppl , Issue.127 , pp. 20-36
    • Rosler, M.1
  • 20
    • 80053184623 scopus 로고    scopus 로고
    • The role of dopamine in symptoms and treatment of apathy in Alzheimers disease
    • Mitchell RA, Herrmann N, Lanctot KL,. The role of dopamine in symptoms and treatment of apathy in Alzheimers disease. CNS Neurosci Ther. 2011; 17 (5): 411-427.
    • (2011) CNS Neurosci Ther , vol.17 , Issue.5 , pp. 411-427
    • Mitchell, R.A.1    Herrmann, N.2    Lanctot, K.L.3
  • 21
    • 77956399340 scopus 로고    scopus 로고
    • Review: Apathy diagnosis, assessment, and treatment in Alzheimers disease
    • Robert PH, Mulin E, Mallea P, David R,. Review: apathy diagnosis, assessment, and treatment in Alzheimers disease. CNS Neurosci Ther. 2010; 16 (5): 263-271.
    • (2010) CNS Neurosci Ther , vol.16 , Issue.5 , pp. 263-271
    • Robert, P.H.1    Mulin, E.2    Mallea, P.3    David, R.4
  • 22
    • 84887041363 scopus 로고    scopus 로고
    • Apathy in Parkinsons disease: Diagnosis, neuropsychological correlates, pathophysiology and treatment
    • Santangelo G, Trojano L, Barone P, Errico D, Grossi D, Vitale C,. Apathy in Parkinsons disease: diagnosis, neuropsychological correlates, pathophysiology and treatment. Behav Neurol. 2012; 27 (4): 501-513.
    • (2012) Behav Neurol , vol.27 , Issue.4 , pp. 501-513
    • Santangelo, G.1    Trojano, L.2    Barone, P.3    Errico, D.4    Grossi, D.5    Vitale, C.6
  • 24
    • 84883176211 scopus 로고    scopus 로고
    • Safety and efficacy of methylphenidate for apathy in Alzheimers disease: A randomized, placebo-controlled trial
    • Rosenberg PB, Lanctot KL, Drye LT,. Safety and efficacy of methylphenidate for apathy in Alzheimers disease: a randomized, placebo-controlled trial. J Clin Psychiatry. 2013; 74 (8): 810-816.
    • (2013) J Clin Psychiatry , vol.74 , Issue.8 , pp. 810-816
    • Rosenberg, P.B.1    Lanctot, K.L.2    Drye, L.T.3
  • 25
    • 78650564564 scopus 로고    scopus 로고
    • Are the available apathy measures reliable and valid? A review of the psychometric evidence
    • Clarke DE, Ko JY, Kuhl EA, van Reekum R, Salvador R, Marin RS,. Are the available apathy measures reliable and valid? A review of the psychometric evidence. J Psychosom Res. 2011; 70 (1): 73-97.
    • (2011) J Psychosom Res , vol.70 , Issue.1 , pp. 73-97
    • Clarke, D.E.1    Ko, J.Y.2    Kuhl, E.A.3    Van Reekum, R.4    Salvador, R.5    Marin, R.S.6
  • 26
    • 0034284172 scopus 로고    scopus 로고
    • Negative symptoms: The €pathology€ of motivation and goal-directed behaviour
    • Brown RG, Pluck G,. Negative symptoms: the €pathology€ of motivation and goal-directed behaviour. Trends Neurosci. 2000; 23 (9): 412-417.
    • (2000) Trends Neurosci , vol.23 , Issue.9 , pp. 412-417
    • Brown, R.G.1    Pluck, G.2
  • 27
    • 0033425453 scopus 로고    scopus 로고
    • The primate basal ganglia and the voluntary control of behaviour
    • Schultz W,. The primate basal ganglia and the voluntary control of behaviour. J Consc Stud. 1999; 6 (8-9): 31-45.
    • (1999) J Consc Stud , vol.6 , Issue.8-9 , pp. 31-45
    • Schultz, W.1
  • 28
    • 0025899466 scopus 로고
    • Apathy: A neuropsychiatric syndrome
    • Marin RS,. Apathy: a neuropsychiatric syndrome. J Neuropsychiatry Clin Neurosci. 1991; 3 (3): 243-54.
    • (1991) J Neuropsychiatry Clin Neurosci , vol.3 , Issue.3 , pp. 243-254
    • Marin, R.S.1
  • 29
    • 60849137194 scopus 로고    scopus 로고
    • Proposed diagnostic criteria for apathy in Alzheimers disease and other neuropsychiatric disorders
    • Robert P, Onyike CU, Leentjens AF,. Proposed diagnostic criteria for apathy in Alzheimers disease and other neuropsychiatric disorders. Eur Psychiatry. 2009; 24 (2): 98-104.
    • (2009) Eur Psychiatry , vol.24 , Issue.2 , pp. 98-104
    • Robert, P.1    Onyike, C.U.2    Leentjens, A.F.3
  • 30
    • 0027985334 scopus 로고
    • The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
    • Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J,. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994; 44 (12): 2308-2314.
    • (1994) Neurology , vol.44 , Issue.12 , pp. 2308-2314
    • Cummings, J.L.1    Mega, M.2    Gray, K.3    Rosenberg-Thompson, S.4    Carusi, D.A.5    Gornbein, J.6
  • 32
    • 0036904309 scopus 로고    scopus 로고
    • The apathy inventory: Assessment of apathy and awareness in Alzheimers disease, Parkinsons disease and mild cognitive impairment
    • Robert PH, Clairet S, Benoit M,. The apathy inventory: assessment of apathy and awareness in Alzheimers disease, Parkinsons disease and mild cognitive impairment. Int J Geriatr Psychiatry. 2002; 17 (12): 1099-1105.
    • (2002) Int J Geriatr Psychiatry , vol.17 , Issue.12 , pp. 1099-1105
    • Robert, P.H.1    Clairet, S.2    Benoit, M.3
  • 33
    • 33646897697 scopus 로고    scopus 로고
    • The Lille apathy rating scale (LARS), a new instrument for detecting and quantifying apathy: Validation in Parkinsons disease
    • Sockeel P, Dujardin K, Devos D, Deneve C, Destee A, Defebvre L,. The Lille apathy rating scale (LARS), a new instrument for detecting and quantifying apathy: validation in Parkinsons disease. J Neurol Neurosurg Psychiatry. 2006; 77 (5): 579-584.
    • (2006) J Neurol Neurosurg Psychiatry , vol.77 , Issue.5 , pp. 579-584
    • Sockeel, P.1    Dujardin, K.2    Devos, D.3    Deneve, C.4    Destee, A.5    Defebvre, L.6
  • 34
    • 33745595886 scopus 로고    scopus 로고
    • Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cereb
    • Levy R, Dubois B,. Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cereb. Cortex. 2006; 16 (7): 916-928.
    • (2006) Cortex , vol.16 , Issue.7 , pp. 916-928
    • Levy, R.1    Dubois, B.2
  • 35
    • 53149124795 scopus 로고    scopus 로고
    • The nosological position of apathy in clinical practice
    • Starkstein SE, Leentjens AF,. The nosological position of apathy in clinical practice. J Neurosurg Psychiatr. 2008; 79 (10): 1088-1092.
    • (2008) J Neurosurg Psychiatr , vol.79 , Issue.10 , pp. 1088-1092
    • Starkstein, S.E.1    Leentjens, A.F.2
  • 36
    • 78651451156 scopus 로고    scopus 로고
    • Diagnostic criteria for apathy in clinical practice
    • Mulin E, Leone E, Dujardin K,. Diagnostic criteria for apathy in clinical practice. Int J Geriatr Psychiatry. 2011; 26 (2): 158-165.
    • (2011) Int J Geriatr Psychiatry , vol.26 , Issue.2 , pp. 158-165
    • Mulin, E.1    Leone, E.2    Dujardin, K.3
  • 37
    • 0036082191 scopus 로고    scopus 로고
    • Provisional diagnostic criteria for depression of Alzheimer disease
    • Olin JT, Schneider LS, Katz IR,. Provisional diagnostic criteria for depression of Alzheimer disease. Am J Geriatr Psychiatry. 2002; 10 (2): 125-128.
    • (2002) Am J Geriatr Psychiatry , vol.10 , Issue.2 , pp. 125-128
    • Olin, J.T.1    Schneider, L.S.2    Katz, I.R.3
  • 38
    • 72849115874 scopus 로고    scopus 로고
    • Neuropsychiatric symptoms in Parkinsons disease
    • Aarsland D, Marsh L, Schrag A,. Neuropsychiatric symptoms in Parkinsons disease. Mov Disord. 2009; 24 (15): 2175-2186.
    • (2009) Mov Disord , vol.24 , Issue.15 , pp. 2175-2186
    • Aarsland, D.1    Marsh, L.2    Schrag, A.3
  • 39
    • 79960483167 scopus 로고    scopus 로고
    • Is apathy a valid and meaningful symptom or syndrome in Parkinsons disease?
    • Health Psychol
    • Bogart KR,. Is apathy a valid and meaningful symptom or syndrome in Parkinsons disease? A critical review. Health Psychol. 2011; 30 (4): 386-400.
    • (2011) A Critical Review , vol.30 , Issue.4 , pp. 386-400
    • Bogart, K.R.1
  • 40
    • 0026582759 scopus 로고
    • Depression and Parkinsons disease: A review
    • Cummings JL,. Depression and Parkinsons disease: a review. Am J Psychiatry. 1992; 149 (4): 443-454.
    • (1992) Am J Psychiatry , vol.149 , Issue.4 , pp. 443-454
    • Cummings, J.L.1
  • 42
    • 84865605697 scopus 로고    scopus 로고
    • Apathy and depression in mild Alzheimers disease: A cross-sectional study using diagnostic criteria
    • Benoit M, Berrut G, Doussaint J,. Apathy and depression in mild Alzheimers disease: a cross-sectional study using diagnostic criteria. J Alzheimers Dis. 2012; 31 (2): 325-334.
    • (2012) J Alzheimers Dis , vol.31 , Issue.2 , pp. 325-334
    • Benoit, M.1    Berrut, G.2    Doussaint, J.3
  • 46
    • 85081876142 scopus 로고    scopus 로고
    • Association AP. 5th ed, text rev ed. Arlington, VA: American Psychiatric Publishing
    • Association AP. Diagnostic and Statistical Manual of Mental Disorders (DSM). 5th ed,. text rev ed. Arlington, VA: American Psychiatric Publishing; 2013.
    • (2013) Diagnostic and Statistical Manual of Mental Disorders (DSM)
  • 47
    • 36448966462 scopus 로고    scopus 로고
    • Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: Part i
    • Aalten P, Verhey FR, Boziki M,. Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium: part I. Dement Geriatr Cogn Disord. 2007; 24 (6): 457-463.
    • (2007) Dement Geriatr Cogn Disord , vol.24 , Issue.6 , pp. 457-463
    • Aalten, P.1    Verhey, F.R.2    Boziki, M.3
  • 48
    • 62149150921 scopus 로고    scopus 로고
    • Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population
    • Savva GM, Zaccai J, Matthews FE, Davidson JE, McKeith I, Brayne C,. Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population. Br J Psychiatry. 2009; 194 (3): 212-219.
    • (2009) Br J Psychiatry , vol.194 , Issue.3 , pp. 212-219
    • Savva, G.M.1    Zaccai, J.2    Matthews, F.E.3    Davidson, J.E.4    McKeith, I.5    Brayne, C.6
  • 49
    • 84862301127 scopus 로고    scopus 로고
    • Poor dissociation of patient-evaluated apathy and depressive symptoms
    • Njomboro P, Deb S,. Poor dissociation of patient-evaluated apathy and depressive symptoms. Curr Gerontol Geriatr Res. 2012; 2012: 846075.
    • (2012) Curr Gerontol Geriatr Res , vol.2012 , pp. 846075
    • Njomboro, P.1    Deb, S.2
  • 50
    • 0035123522 scopus 로고    scopus 로고
    • Caregivers judgments of the functional abilities of the Alzheimers disease patient: A comparison of proxy reports and objective measures
    • Loewenstein DA, Arguelles S, Bravo M,. Caregivers judgments of the functional abilities of the Alzheimers disease patient: a comparison of proxy reports and objective measures. J Gerontol B Psychol Sci Soc Sci. 2001; 56 (2): P78-P84.
    • (2001) J Gerontol B Psychol Sci Soc Sci , vol.56 , Issue.2 , pp. P78-P84
    • Loewenstein, D.A.1    Arguelles, S.2    Bravo, M.3
  • 51
    • 0030958347 scopus 로고    scopus 로고
    • The Neuropsychiatric Inventory: Assessing psychopathology in dementia patients
    • Cummings JL,. The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology. 1997; 48 (5 suppl 6): S10-S16.
    • (1997) Neurology , vol.48 , Issue.5 , pp. S10-S16
    • Cummings, J.L.1
  • 52
    • 0034028609 scopus 로고    scopus 로고
    • Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory
    • Kaufer DI, Cummings JL, Ketchel P,. Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory. J Neuropsychiatry Clin Neurosci. 2000; 12 (2): 233-239.
    • (2000) J Neuropsychiatry Clin Neurosci , vol.12 , Issue.2 , pp. 233-239
    • Kaufer, D.I.1    Cummings, J.L.2    Ketchel, P.3
  • 53
    • 77957319896 scopus 로고    scopus 로고
    • The Neuropsychiatric Inventory-Clinician rating scale (NPI-C): Reliability and validity of a revised assessment of neuropsychiatric symptoms in dementia
    • de Medeiros K, Robert P, Gauthier S,. The Neuropsychiatric Inventory-Clinician rating scale (NPI-C): reliability and validity of a revised assessment of neuropsychiatric symptoms in dementia. Int Psychogeriatr. 2010; 22 (6): 984-994.
    • (2010) Int Psychogeriatr , vol.22 , Issue.6 , pp. 984-994
    • De Medeiros, K.1    Robert, P.2    Gauthier, S.3
  • 54
    • 0025819733 scopus 로고
    • Reliability and validity of the Apathy Evaluation Scale
    • Marin RS, Biedrzycki RC, Firinciogullari S,. Reliability and validity of the Apathy Evaluation Scale. Psychiatry Res. 1991; 38 (2): 143-162.
    • (1991) Psychiatry Res , vol.38 , Issue.2 , pp. 143-162
    • Marin, R.S.1    Biedrzycki, R.C.2    Firinciogullari, S.3
  • 55
    • 34447119554 scopus 로고    scopus 로고
    • Development of a short version of the Apathy Evaluation Scale specifically adapted for demented nursing home residents
    • Lueken U, Seidl U, Volker L, Schweiger E, Kruse A, Schroder J,. Development of a short version of the Apathy Evaluation Scale specifically adapted for demented nursing home residents. Am J Geriatr Psychiatry. 2007; 15 (5): 376-385.
    • (2007) Am J Geriatr Psychiatry , vol.15 , Issue.5 , pp. 376-385
    • Lueken, U.1    Seidl, U.2    Volker, L.3    Schweiger, E.4    Kruse, A.5    Schroder, J.6
  • 56
    • 84855614148 scopus 로고    scopus 로고
    • Clinical correlates of apathy in patients recently diagnosed with Parkinsons disease: The ANIMO study
    • Cubo E, Benito-Leon J, Coronell C, Armesto D,. Clinical correlates of apathy in patients recently diagnosed with Parkinsons disease: the ANIMO study. Neuroepidemiology. 2012; 38 (1): 48-55.
    • (2012) Neuroepidemiology , vol.38 , Issue.1 , pp. 48-55
    • Cubo, E.1    Benito-Leon, J.2    Coronell, C.3    Armesto, D.4
  • 57
    • 4344577906 scopus 로고    scopus 로고
    • The development and psychometric evaluation of the Motivation and Energy Inventory (MEI)
    • Fehnel SE, Bann CM, Hogue SL, Kwong WJ, Mahajan SS,. The development and psychometric evaluation of the Motivation and Energy Inventory (MEI). Qual Life Res. 2004; 13 (7): 1321-1336.
    • (2004) Qual Life Res , vol.13 , Issue.7 , pp. 1321-1336
    • Fehnel, S.E.1    Bann, C.M.2    Hogue, S.L.3    Kwong, W.J.4    Mahajan, S.S.5
  • 58
    • 21044436616 scopus 로고    scopus 로고
    • The course of neuropsychiatric symptoms in dementia. Part II: Relationships among behavioural sub-syndromes and the influence of clinical variables
    • Aalten P, de Vugt ME, Jaspers N, Jolles J, Verhey FRJ,. The course of neuropsychiatric symptoms in dementia. Part II: relationships among behavioural sub-syndromes and the influence of clinical variables. Int J Ger Psy. 2005; 20 (6): 531-536.
    • (2005) Int J Ger Psy , vol.20 , Issue.6 , pp. 531-536
    • Aalten, P.1    De Vugt, M.E.2    Jaspers, N.3    Jolles, J.4    Verhey, F.R.J.5
  • 59
    • 0042161712 scopus 로고    scopus 로고
    • Psychiatric symptoms vary with the severity of dementia in probably Alzheimers disease
    • Lopez OL, Becker JT, Sweet RA,. Psychiatric symptoms vary with the severity of dementia in probably Alzheimers disease. J Neuropsy Clin Neurosci. 2003; 15 (3): 346-353.
    • (2003) J Neuropsy Clin Neurosci , vol.15 , Issue.3 , pp. 346-353
    • Lopez, O.L.1    Becker, J.T.2    Sweet, R.A.3
  • 60
    • 0031941259 scopus 로고    scopus 로고
    • Assessing the impact of neuropsychiatric symptoms in Alzheimers disease: The Neuropsychiatric Inventory Caregiver Distress Scale
    • Kaufer DI, Cummings JL, Christine D,. Assessing the impact of neuropsychiatric symptoms in Alzheimers disease: the Neuropsychiatric Inventory Caregiver Distress Scale. J Am Geriatr Soc. 1998; 46 (2): 210-215.
    • (1998) J Am Geriatr Soc , vol.46 , Issue.2 , pp. 210-215
    • Kaufer, D.I.1    Cummings, J.L.2    Christine, D.3
  • 61
    • 3242775357 scopus 로고    scopus 로고
    • The efficacy of donepezil in the tretament of neuropsychiatric symptoms in Alzheimer disease
    • Holmes C, Wilkinson D, Dean C,. The efficacy of donepezil in the tretament of neuropsychiatric symptoms in Alzheimer disease. Neurology. 2004; 63 (2): 213.
    • (2004) Neurology , vol.63 , Issue.2 , pp. 213
    • Holmes, C.1    Wilkinson, D.2    Dean, C.3
  • 62
    • 51449084071 scopus 로고    scopus 로고
    • Methylphenidate for the treatment of apathy in Alzheimer Disease. Prediction of response using dextroamphetamine challenge
    • Hermann N, Rothenburg LS, Black SE,. Methylphenidate for the treatment of apathy in Alzheimer Disease. Prediction of response using dextroamphetamine challenge. J Clin Psychopharmacol. 2008; 28 (3): 296-301.
    • (2008) J Clin Psychopharmacol , vol.28 , Issue.3 , pp. 296-301
    • Hermann, N.1    Rothenburg, L.S.2    Black, S.E.3
  • 63
    • 0035661596 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of the efficacy and safety of donepezil in patients with Alzheimers disease in the nursing home setting
    • Tariot PN, Cummings JL, Katz IR,. A randomized, double-blind, placebo-controlled study of the efficacy and safety of donepezil in patients with Alzheimers disease in the nursing home setting. J Am Ger Soc. 2001; 49 (12): 1590-1599.
    • (2001) J Am Ger Soc , vol.49 , Issue.12 , pp. 1590-1599
    • Tariot, P.N.1    Cummings, J.L.2    Katz, I.R.3
  • 64
    • 0034676757 scopus 로고    scopus 로고
    • Efficacy of rivastigmine in dementia with Lewy bodies: A randomised, double-blind, placebo-controlled international study
    • McKeith I, Del Ser T, Spano PF,. Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study. Lancet. 2000; 356 (9247): 2031-2036.
    • (2000) Lancet , vol.356 , Issue.9247 , pp. 2031-2036
    • McKeith, I.1    Del Ser, T.2    Spano, P.F.3
  • 66
    • 84862804207 scopus 로고    scopus 로고
    • Diagnosis and assessment of apathy in Chinese patients with Alzheimers disease
    • Zhao H, Zhao Z, Huang L, Preter M,. Diagnosis and assessment of apathy in Chinese patients with Alzheimers disease. J Psychosom Res. 2012; 72 (5): 405-407.
    • (2012) J Psychosom Res , vol.72 , Issue.5 , pp. 405-407
    • Zhao, H.1    Zhao, Z.2    Huang, L.3    Preter, M.4
  • 68
    • 0003412410 scopus 로고
    • editor. Rockville, MD: US Department of Heath, Education, and Welfare Public Health Service Alcohol, Drug Abuse, and Mental Health Administration
    • Guy W, editor. ECDEU Assessment Manual for Psychopharmacology. Rockville, MD: US Department of Heath, Education, and Welfare Public Health Service Alcohol, Drug Abuse, and Mental Health Administration; 1976.
    • (1976) ECDEU Assessment Manual for Psychopharmacology
    • Guy, W.1
  • 70
    • 0028100503 scopus 로고
    • Assessing patient dependence in Alzheimers disease
    • Stern Y, Albert SM, Sano M,. Assessing patient dependence in Alzheimers disease. J Gerontol. 1994; 49 (5): M216-M222.
    • (1994) J Gerontol , vol.49 , Issue.5 , pp. M216-M222
    • Stern, Y.1    Albert, S.M.2    Sano, M.3
  • 71
    • 0033193134 scopus 로고    scopus 로고
    • Development of a functional measure for persons with Alzheimers disease: The disability assessment for dementia
    • Gelinas I, Gauthier L, McIntyre M,. Development of a functional measure for persons with Alzheimers disease: the disability assessment for dementia. Am J Occup Ther. 1999; 53 (5): 471-481.
    • (1999) Am J Occup Ther , vol.53 , Issue.5 , pp. 471-481
    • Gelinas, I.1    Gauthier, L.2    McIntyre, M.3
  • 72
    • 0028871662 scopus 로고
    • Self-reported functioning and well-being in patients with Parkinsons disease: Comparison of the Short-form Health Survey (SF-36) and the Parkinsons Disease Questionnaire (PDQ-39)
    • Jenkinson C, Peto V, Fitzpatrick R, Greenhall R, Hyman N,. Self-reported functioning and well-being in patients with Parkinsons disease: comparison of the Short-form Health Survey (SF-36) and the Parkinsons Disease Questionnaire (PDQ-39). Age Ageing. 1995; 24 (6): 505-509.
    • (1995) Age Ageing , vol.24 , Issue.6 , pp. 505-509
    • Jenkinson, C.1    Peto, V.2    Fitzpatrick, R.3    Greenhall, R.4    Hyman, N.5
  • 73
    • 0029005131 scopus 로고
    • The development and validation of a short measure of functioning and well being for individuals with Parkinsons disease
    • Peto V, Jenkinson C, Fitzpatrick R, Greenhall R,. The development and validation of a short measure of functioning and well being for individuals with Parkinsons disease. Qual Life Res. 1995; 4 (3); 241-248.
    • (1995) Qual Life Res , vol.4 , Issue.3 , pp. 241-248
    • Peto, V.1    Jenkinson, C.2    Fitzpatrick, R.3    Greenhall, R.4
  • 75
    • 0016823810 scopus 로고
    • €mini-mental State: A practical method for grading the cognitive state of patients for the clinician
    • Folstein MR, Folstein SE, McHugh PR,. €Mini-mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12 (3): 189-198.
    • (1975) J Psychiatr Res , vol.12 , Issue.3 , pp. 189-198
    • Folstein, M.R.1    Folstein, S.E.2    McHugh, P.R.3
  • 76
    • 34548426482 scopus 로고    scopus 로고
    • Validity of the clinical dementia rating scale for the detection and staging of dementia in Brazilian patients
    • Chaves ML, Camozzato AL, Godinho C,. Validity of the clinical dementia rating scale for the detection and staging of dementia in Brazilian patients. Alzheimer Dis Assoc Disord. 2007; 21 (3): 210-217.
    • (2007) Alzheimer Dis Assoc Disord , vol.21 , Issue.3 , pp. 210-217
    • Chaves, M.L.1    Camozzato, A.L.2    Godinho, C.3
  • 77
    • 0024420189 scopus 로고
    • The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus
    • Krupp LB, LaRocca NG, Muir-Nash J, Steinbery AD,. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989; 46 (10): 1121-1123.
    • (1989) Arch Neurol , vol.46 , Issue.10 , pp. 1121-1123
    • Krupp, L.B.1    LaRocca, N.G.2    Muir-Nash, J.3    Steinbery, A.D.4
  • 78
    • 0029006141 scopus 로고
    • The Multidimensional Fatigue Inventory (MFI); Psychometric qualities of an instrument to assess fatigue
    • Smets EM, Garssen B, Bonke B, De Haes JC,. The Multidimensional Fatigue Inventory (MFI); psychometric qualities of an instrument to assess fatigue. J Psychosom Res. 1995; 39 (3): 315-325.
    • (1995) J Psychosom Res , vol.39 , Issue.3 , pp. 315-325
    • Smets, E.M.1    Garssen, B.2    Bonke, B.3    De Haes, J.C.4
  • 79
    • 0026333617 scopus 로고
    • A new method for measuring daytime sleepiness: The Epworth Sleepiness Scale
    • Johns MW,. A new method for measuring daytime sleepiness: the Epworth Sleepiness Scale. Sleep. 1991; 14 (6): 540-545.
    • (1991) Sleep , vol.14 , Issue.6 , pp. 540-545
    • Johns, M.W.1
  • 80
    • 0020527558 scopus 로고
    • €the hospital anxiety and depression scale€
    • Zigmond AS, Snaith RP,. €The hospital anxiety and depression scale€. Acta Psychiatrica Scandinavica. 1983; 67 (6): 361-370.
    • (1983) Acta Psychiatrica Scandinavica , vol.67 , Issue.6 , pp. 361-370
    • Zigmond, A.S.1    Snaith, R.P.2
  • 81
    • 77957301533 scopus 로고    scopus 로고
    • Generalized anxiety disorder and the Hamilton Anxiety Rating Scale in Parkinsons disease
    • Kummer A, Cardoso F, Teixeira AL,. Generalized anxiety disorder and the Hamilton Anxiety Rating Scale in Parkinsons disease. Arq Neuropsiquiatr. 2010; 68 (4): 495-501.
    • (2010) Arq Neuropsiquiatr , vol.68 , Issue.4 , pp. 495-501
    • Kummer, A.1    Cardoso, F.2    Teixeira, A.L.3
  • 82
    • 77957319896 scopus 로고    scopus 로고
    • The Neuropsychiatric Inventory-Clinician rating scale (NPI-C): Reliability and validity of a revised assessment of neuropsychiatric symptoms in dementia
    • for the NPI-C Research Group
    • de Medeiros K, Robert P, Gauthier S, for the NPI-C Research Group. The Neuropsychiatric Inventory-Clinician rating scale (NPI-C): reliability and validity of a revised assessment of neuropsychiatric symptoms in dementia. Int Psychoger. 2010; 22 (6): 984-994.
    • (2010) Int Psychoger , vol.22 , Issue.6 , pp. 984-994
    • De Medeiros, K.1    Robert, P.2    Gauthier, S.3
  • 83
    • 84864881933 scopus 로고    scopus 로고
    • Double-blind placebo-controlled randomized efficacy and safety trial of add-on treatment of dimebon plus risperidone in schizophrenic patients during transition from acute psychotic episode to remission
    • Morozova MA, Beniashvili AG, Lepilkina TA, Rupchev GE,. Double-blind placebo-controlled randomized efficacy and safety trial of add-on treatment of dimebon plus risperidone in schizophrenic patients during transition from acute psychotic episode to remission. Psychiatr Danub. 2012; 24 (2): 159-166.
    • (2012) Psychiatr Danub , vol.24 , Issue.2 , pp. 159-166
    • Morozova, M.A.1    Beniashvili, A.G.2    Lepilkina, T.A.3    Rupchev, G.E.4
  • 84
    • 84873710953 scopus 로고    scopus 로고
    • Lurasidone in the treatment of schizophrenia: A 6-week, placebo-controlled study
    • Ogasa M, Kimura T, Nakamura M, Guarino J,. Lurasidone in the treatment of schizophrenia: a 6-week, placebo-controlled study. Psychopharmacology (Berl). 2013; 225 (3): 519-530.
    • (2013) Psychopharmacology (Berl) , vol.225 , Issue.3 , pp. 519-530
    • Ogasa, M.1    Kimura, T.2    Nakamura, M.3    Guarino, J.4
  • 85
    • 84872132150 scopus 로고    scopus 로고
    • Effectiveness and cost-effectiveness of body psychotherapy in the treatment of negative symptoms of schizophrenia - A multi-centre randomised controlled trial
    • Priebe S, Savill M, Reininghaus U,. Effectiveness and cost-effectiveness of body psychotherapy in the treatment of negative symptoms of schizophrenia-a multi-centre randomised controlled trial. BMC Psychiatry. 2013; 13: 26.
    • (2013) BMC Psychiatry , vol.13 , pp. 26
    • Priebe, S.1    Savill, M.2    Reininghaus, U.3
  • 86
    • 34447118866 scopus 로고    scopus 로고
    • Epidemiology of apathy in older adults: The Cache County Study
    • Onyike CU, Sheppard JM, Tschanz JT,. Epidemiology of apathy in older adults: the Cache County Study. Am J Geriatr Psychiatry. 2007; 15 (5): 365-375.
    • (2007) Am J Geriatr Psychiatry , vol.15 , Issue.5 , pp. 365-375
    • Onyike, C.U.1    Sheppard, J.M.2    Tschanz, J.T.3
  • 87
    • 84870302137 scopus 로고    scopus 로고
    • Prevalence of neuropsychiatric symptoms in young-onset compared to late-onset Alzheimers disease - Part 1: Findings of the two-year longitudinal NeedYD-study
    • van Vliet D, de Vugt ME, Aalten P,. Prevalence of neuropsychiatric symptoms in young-onset compared to late-onset Alzheimers disease-part 1: findings of the two-year longitudinal NeedYD-study. Dement Geriatr Cogn Disord. 2012; 34 (5-6): 319-327.
    • (2012) Dement Geriatr Cogn Disord , vol.34 , Issue.5-6 , pp. 319-327
    • Van Vliet, D.1    De Vugt, M.E.2    Aalten, P.3
  • 88
    • 84872433384 scopus 로고    scopus 로고
    • Apathy syndrome in Alzheimers disease epidemiology: Prevalence, incidence, persistence, and risk and mortality factors
    • Vilalta-Franch J, Calvo-Perxas L, Garre-Olmo J, Turro-Garriga O, Lopez-Pousa S,. Apathy syndrome in Alzheimers disease epidemiology: prevalence, incidence, persistence, and risk and mortality factors. J Alzheimers Dis. 2013; 33 (2): 535-543.
    • (2013) J Alzheimers Dis , vol.33 , Issue.2 , pp. 535-543
    • Vilalta-Franch, J.1    Calvo-Perxas, L.2    Garre-Olmo, J.3    Turro-Garriga, O.4    Lopez-Pousa, S.5
  • 89
    • 78651464885 scopus 로고    scopus 로고
    • Effect of donepezil on emergence of apathy in mild to moderate Alzheimers disease
    • Waldemar G, Gauthier S, Jones R,. Effect of donepezil on emergence of apathy in mild to moderate Alzheimers disease. Int J Geriatr Psychiatry. 2011; 26 (2): 150-157.
    • (2011) Int J Geriatr Psychiatry , vol.26 , Issue.2 , pp. 150-157
    • Waldemar, G.1    Gauthier, S.2    Jones, R.3
  • 90
    • 84876347675 scopus 로고    scopus 로고
    • Prevalence of neuropsychiatric symptoms across the declining memory continuum: An observational study in a memory clinic setting
    • Zhang M, Wang H, Li T, Yu X,. Prevalence of neuropsychiatric symptoms across the declining memory continuum: an observational study in a memory clinic setting. Dement Geriatr Cogn Dis Extra. 2012; 2: 200-208.
    • (2012) Dement Geriatr Cogn Dis Extra , vol.2 , pp. 200-208
    • Zhang, M.1    Wang, H.2    Li, T.3    Yu, X.4
  • 92
  • 94
    • 38949152690 scopus 로고    scopus 로고
    • Assessing apathy: The use of the Apathy Evaluation Scale in first episode psychosis
    • Faerden A, Nesvag R, Barrett EA,. Assessing apathy: the use of the Apathy Evaluation Scale in first episode psychosis. Eur Psychiatry. 2008; 23 (1): 33-39.
    • (2008) Eur Psychiatry , vol.23 , Issue.1 , pp. 33-39
    • Faerden, A.1    Nesvag, R.2    Barrett, E.A.3
  • 95
    • 84864703206 scopus 로고    scopus 로고
    • Memantine for late-life depression and apathy after a disabling medical event: A 12-week, double-blind placebo-controlled pilot study
    • Lenze EJ, Skidmore ER, Begley AE, Newcomer JW, Butters MA, Whyte EM,. Memantine for late-life depression and apathy after a disabling medical event: a 12-week, double-blind placebo-controlled pilot study. Int J Geriatr Psychiatry. 2012; 27 (9): 974-980.
    • (2012) Int J Geriatr Psychiatry , vol.27 , Issue.9 , pp. 974-980
    • Lenze, E.J.1    Skidmore, E.R.2    Begley, A.E.3    Newcomer, J.W.4    Butters, M.A.5    Whyte, E.M.6
  • 96
    • 0036247179 scopus 로고    scopus 로고
    • Olanzapine in the treatment of apathy in previously depressed participants maintained with selective serotonin reuptake inhibitors: An open-label, flexible-dose study
    • Marangell LB, Johnson CR, Kertz B, Zboyan HA, Martinez JM,. Olanzapine in the treatment of apathy in previously depressed participants maintained with selective serotonin reuptake inhibitors: an open-label, flexible-dose study. J Clin Psychiatry. 2002; 63 (5): 391-395.
    • (2002) J Clin Psychiatry , vol.63 , Issue.5 , pp. 391-395
    • Marangell, L.B.1    Johnson, C.R.2    Kertz, B.3    Zboyan, H.A.4    Martinez, J.M.5
  • 97
    • 84859872874 scopus 로고    scopus 로고
    • Apathy in currently nondepressed patients treated with a SSRI for a major depressive episode: Outcomes following randomized switch to either duloxetine or escitalopram
    • Raskin J, George T, Granger RE, Hussain N, Zhao GW, Marangell LB,. Apathy in currently nondepressed patients treated with a SSRI for a major depressive episode: outcomes following randomized switch to either duloxetine or escitalopram. J Psychiatr Res. 2012; 46 (5): 667-674.
    • (2012) J Psychiatr Res , vol.46 , Issue.5 , pp. 667-674
    • Raskin, J.1    George, T.2    Granger, R.E.3    Hussain, N.4    Zhao, G.W.5    Marangell, L.B.6
  • 98
    • 79952794222 scopus 로고    scopus 로고
    • Apathy, but not depression, reflects inefficient cognitive strategies in Parkinsons disease
    • Varanese S, Perfetti B, Ghilardi MF, Di Rocco A,. Apathy, but not depression, reflects inefficient cognitive strategies in Parkinsons disease. PLoS One. 2011; 6 (3): e17846.
    • (2011) PLoS One , vol.6 , Issue.3 , pp. e17846
    • Varanese, S.1    Perfetti, B.2    Ghilardi, M.F.3    Di Rocco, A.4
  • 99
    • 0028827547 scopus 로고
    • Residual symptoms after partial remission: An important outcome in depression
    • Paykel ES, Ramana R, Cooper Z, Hayhurst H, Kerr J, Barocka A,. Residual symptoms after partial remission: an important outcome in depression. Psychol Med. 1995; 25 (6): 1171-1180.
    • (1995) Psychol Med , vol.25 , Issue.6 , pp. 1171-1180
    • Paykel, E.S.1    Ramana, R.2    Cooper, Z.3    Hayhurst, H.4    Kerr, J.5    Barocka, A.6
  • 100
    • 79952449206 scopus 로고    scopus 로고
    • Residual symptoms in depressed outpatients who respond by 50% but do not remit to antidepressant medication
    • McClintock SM, Husain MM, Wisniewski SR,. Residual symptoms in depressed outpatients who respond by 50% but do not remit to antidepressant medication. J Clin Psychopharmacol. 2011; 31 (2): 180-186.
    • (2011) J Clin Psychopharmacol , vol.31 , Issue.2 , pp. 180-186
    • McClintock, S.M.1    Husain, M.M.2    Wisniewski, S.R.3
  • 101
    • 33845617627 scopus 로고    scopus 로고
    • A cross-sectional study of the prevalence of cognitive and physical symptoms during long-term antidepressant treatment
    • Fava M, Graves LM, Benazzi F,. A cross-sectional study of the prevalence of cognitive and physical symptoms during long-term antidepressant treatment. J Clin Psychiatry. 2006; 67 (11): 1754-1759.
    • (2006) J Clin Psychiatry , vol.67 , Issue.11 , pp. 1754-1759
    • Fava, M.1    Graves, L.M.2    Benazzi, F.3
  • 102
    • 28844456067 scopus 로고    scopus 로고
    • Residual symptoms in depressed patients after treatment with fluoxetine or reboxetine
    • Nelson JC, Portera L, Leon AC,. Residual symptoms in depressed patients after treatment with fluoxetine or reboxetine. J Clin Psychiatry. 2005; 66 (11): 1409-1414.
    • (2005) J Clin Psychiatry , vol.66 , Issue.11 , pp. 1409-1414
    • Nelson, J.C.1    Portera, L.2    Leon, A.C.3
  • 103
    • 56249147792 scopus 로고    scopus 로고
    • Efficacy and safety of galantamine (reminyl) for dementia in patients with Parkinsons disease (an open controlled trial)
    • Litvinenko IV, Odinak MM, Mogilnaya VI, Emelin AY,. Efficacy and safety of galantamine (reminyl) for dementia in patients with Parkinsons disease (an open controlled trial). Neurosci Behav Physiol. 2008; 38 (9): 937-945.
    • (2008) Neurosci Behav Physiol , vol.38 , Issue.9 , pp. 937-945
    • Litvinenko, I.V.1    Odinak, M.M.2    Mogilnaya, V.I.3    Emelin, A.Y.4
  • 104
    • 72249102382 scopus 로고    scopus 로고
    • Occurrence and risk factors for apathy in Parkinson disease: A 4-year prospective longitudinal study
    • Pedersen KF, Alves G, Aarsland D, Larsen JP,. Occurrence and risk factors for apathy in Parkinson disease: a 4-year prospective longitudinal study. J Neurol Neruosurg Psychiatry. 2009: 80 (11): 1279-1282.
    • (2009) J Neurol Neruosurg Psychiatry , vol.80 , Issue.11 , pp. 1279-1282
    • Pedersen, K.F.1    Alves, G.2    Aarsland, D.3    Larsen, J.P.4
  • 106
    • 57049121696 scopus 로고    scopus 로고
    • Prevalence and correlates of neuropsychiatric symptoms in Parkinsons disease without dementia
    • Kulisevsky J, Pagonabarraga J, Pascual-Sedano B, Garcia-Sanchez C, Gironell A,. Prevalence and correlates of neuropsychiatric symptoms in Parkinsons disease without dementia. Mov Disord. 2008; 21 (13): 1889-1896.
    • (2008) Mov Disord , vol.21 , Issue.13 , pp. 1889-1896
    • Kulisevsky, J.1    Pagonabarraga, J.2    Pascual-Sedano, B.3    Garcia-Sanchez, C.4    Gironell, A.5
  • 107
    • 69949153066 scopus 로고    scopus 로고
    • The Priamo study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinsons disease
    • on behalf of the PRIAMO study group
    • Barone P, Antonini A, Colosimo C, on behalf of the PRIAMO study group. The Priamo study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinsons disease. Mov Disord. 2009; 24 (11): 1641-1649.
    • (2009) Mov Disord , vol.24 , Issue.11 , pp. 1641-1649
    • Barone, P.1    Antonini, A.2    Colosimo, C.3
  • 108
    • 61449165975 scopus 로고    scopus 로고
    • Movement Disorder Society-sponsored revision of the Unified Parkinsons Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results
    • on behalf of the Movement Disorder Society UPDRS Revision Task Force
    • Goetz CG, Tilley BC, Shaftman SR, on behalf of the Movement Disorder Society UPDRS Revision Task Force. Movement Disorder Society-sponsored revision of the Unified Parkinsons Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Move Disord. 2008; 23 (15): 2129-2179.
    • (2008) Move Disord , vol.23 , Issue.15 , pp. 2129-2179
    • Goetz, C.G.1    Tilley, B.C.2    Shaftman, S.R.3
  • 109
    • 84855926742 scopus 로고    scopus 로고
    • Validation of the MDS-UPDRS part 1 for nonmotor symptoms in Parkinsons disease
    • Gallagher DA, Goetz CG, Stebbins G, Lees AJ, Schrag A,. Validation of the MDS-UPDRS part 1 for nonmotor symptoms in Parkinsons disease. Mov Disord. 2012: 27 (1): 79-83.
    • (2012) Mov Disord , vol.27 , Issue.1 , pp. 79-83
    • Gallagher, D.A.1    Goetz, C.G.2    Stebbins, G.3    Lees, A.J.4    Schrag, A.5
  • 110
    • 57049117070 scopus 로고    scopus 로고
    • Apathy and anhedonia rating scales in Parkinsons disease: Critique and recommendations
    • Leentjens AFG, Dujardin K, Marsh L,. Apathy and anhedonia rating scales in Parkinsons disease: critique and recommendations. Mov Disord. 2008; 23 (14): 2004-2014.
    • (2008) Mov Disord , vol.23 , Issue.14 , pp. 2004-2014
    • Leentjens, A.F.G.1    Dujardin, K.2    Marsh, L.3
  • 111
    • 84856950829 scopus 로고    scopus 로고
    • Apathy in Parkinsons disease: Diagnostic and etiological dilemmas
    • Starkstein S,. Apathy in Parkinsons disease: diagnostic and etiological dilemmas. Mov Disord. 2012: 27 (2): 174-178.
    • (2012) Mov Disord , vol.27 , Issue.2 , pp. 174-178
    • Starkstein, S.1
  • 112
    • 38049080654 scopus 로고    scopus 로고
    • The Unified Parkinsons Disease Rating Scale: Validation study of the mentation, behavior, and mood section
    • Starkstein SE, Merello M,. The Unified Parkinsons Disease Rating Scale: validation study of the mentation, behavior, and mood section. Mov Disord. 2007; 22 (15): 2156-2161.
    • (2007) Mov Disord , vol.22 , Issue.15 , pp. 2156-2161
    • Starkstein, S.E.1    Merello, M.2
  • 113
    • 41449113936 scopus 로고    scopus 로고
    • Validation of the Unified Parkinsons Disease Rating Scale (UPDRS) section i as a screening and diagnositc instrument for apathy in patients with Parkinsons disease
    • Pedersen KF, Larsen JP, Aarsland D,. Validation of the Unified Parkinsons Disease Rating Scale (UPDRS) section I as a screening and diagnositc instrument for apathy in patients with Parkinsons disease. Parkinsonism Relat Disord. 2008; 14 (3): 183-186.
    • (2008) Parkinsonism Relat Disord , vol.14 , Issue.3 , pp. 183-186
    • Pedersen, K.F.1    Larsen, J.P.2    Aarsland, D.3
  • 114
    • 67651174512 scopus 로고    scopus 로고
    • How cautious should we be when assessing apathy with the Unified Parkinsons Disease Rating Scale?
    • Kirsch-Darrow L, Zahodne LB,. How cautious should we be when assessing apathy with the Unified Parkinsons Disease Rating Scale? Mov Disord. 2009: 24 (5): 684-688.
    • (2009) Mov Disord , vol.24 , Issue.5 , pp. 684-688
    • Kirsch-Darrow, L.1    Zahodne, L.B.2
  • 116
    • 51449084071 scopus 로고    scopus 로고
    • Methylphenidate for the treatment of apathy in Alzheimer disease: Prediction of response using dextroamphetamine challenge
    • Herrmann N, Rothenburg LS, Black SE, Ryan M, Liu BA, Busto UE, Lanctôt KL., Methylphenidate for the treatment of apathy in Alzheimer disease: prediction of response using dextroamphetamine challenge. J Clin Psychopharmacol. 2008; 28 (3): 296-301.
    • (2008) J Clin Psychopharmacol , vol.28 , Issue.3 , pp. 296-301
    • Herrmann, N.1    Rothenburg, L.S.2    Black, S.E.3    Ryan, M.4    Liu, B.A.5    Busto, U.E.6    Lanctôt, K.L.7
  • 117
    • 84906853884 scopus 로고    scopus 로고
    • Effect of methylphenidate on attention in apathetic AD patients in a randomized, placebo-controlled trial
    • Lanctot KL, Chau SA, Herrmann N,. Effect of methylphenidate on attention in apathetic AD patients in a randomized, placebo-controlled trial. Int Psychogeriatr. 2013; 29 (2): 1-8.
    • (2013) Int Psychogeriatr , vol.29 , Issue.2 , pp. 1-8
    • Lanctot, K.L.1    Chau, S.A.2    Herrmann, N.3
  • 118
    • 77949502907 scopus 로고    scopus 로고
    • Methylphenidate for apathy and functional status in dementia of the Alzheimer type
    • Padala PR, Burke WJ, Shostrom VK,. Methylphenidate for apathy and functional status in dementia of the Alzheimer type. Am J Geriatr Psychiatry. 2010; 18 (4): 371-374.
    • (2010) Am J Geriatr Psychiatry , vol.18 , Issue.4 , pp. 371-374
    • Padala, P.R.1    Burke, W.J.2    Shostrom, V.K.3
  • 120
    • 33745824631 scopus 로고    scopus 로고
    • Effects of donepezil on neuropsychiatric symptoms in patients with dementia and severe behavioral disorders
    • Cummings JL, McRae T, Zhang R,. Effects of donepezil on neuropsychiatric symptoms in patients with dementia and severe behavioral disorders. Am J Geriatr Psychiatry. 2006; 14 (7): 605-612.
    • (2006) Am J Geriatr Psychiatry , vol.14 , Issue.7 , pp. 605-612
    • Cummings, J.L.1    McRae, T.2    Zhang, R.3
  • 121
    • 0034965634 scopus 로고    scopus 로고
    • Efficacy of metrifonate in improving the psychiatric and behavioral disturbances of patients with Alzheimers disease
    • Cummings JL, Nadel A, Masterman D, Cyrus PA,. Efficacy of metrifonate in improving the psychiatric and behavioral disturbances of patients with Alzheimers disease. J Geriatr Psychiatry Neurol. 2001; 14 (2): 101-108.
    • (2001) J Geriatr Psychiatry Neurol , vol.14 , Issue.2 , pp. 101-108
    • Cummings, J.L.1    Nadel, A.2    Masterman, D.3    Cyrus, P.A.4
  • 122
    • 0032709113 scopus 로고    scopus 로고
    • The spectrum of behavioral responses to cholinesterase inhibitor therapy in Alzheimer disease
    • Mega MS, Masterman DM, OConnor SM, Barclay TR, Cummings JL,. The spectrum of behavioral responses to cholinesterase inhibitor therapy in Alzheimer disease. Arch Neurol. 1999; 56 (11): 1388-1393.
    • (1999) Arch Neurol , vol.56 , Issue.11 , pp. 1388-1393
    • Mega, M.S.1    Masterman, D.M.2    OConnor, S.M.3    Barclay, T.R.4    Cummings, J.L.5
  • 123
    • 84880087198 scopus 로고    scopus 로고
    • Phenotyping apathy in individuals with Alzheimer disease using functional principal component analysis
    • Zeitzer JM, David R, Friedman L,. Phenotyping apathy in individuals with Alzheimer disease using functional principal component analysis. Am J Geriatr Psychiatry. 2013; 21 (4): 391-397.
    • (2013) Am J Geriatr Psychiatry , vol.21 , Issue.4 , pp. 391-397
    • Zeitzer, J.M.1    David, R.2    Friedman, L.3
  • 124
    • 47749146154 scopus 로고    scopus 로고
    • Antipsychotics for the treatment of behavioral and psychological symptoms of dementia (BPSD)
    • Liperoti R, Pedone C, Corsonello A,. Antipsychotics for the treatment of behavioral and psychological symptoms of dementia (BPSD). Curr Neuropharmacol. 2008; 6 (2): 117-1124.
    • (2008) Curr Neuropharmacol , vol.6 , Issue.2 , pp. 117-1124
    • Liperoti, R.1    Pedone, C.2    Corsonello, A.3
  • 125
    • 84871484560 scopus 로고    scopus 로고
    • Pharmacological treatments for neuropsychiatric symptoms of dementia in long-term care: A systematic review
    • Seitz DP, Gill SS, Herrmann N,. Pharmacological treatments for neuropsychiatric symptoms of dementia in long-term care: a systematic review. Int Psychogeriatr. 2013; 25 (2): 185-203.
    • (2013) Int Psychogeriatr , vol.25 , Issue.2 , pp. 185-203
    • Seitz, D.P.1    Gill, S.S.2    Herrmann, N.3
  • 126
    • 12844274439 scopus 로고    scopus 로고
    • Pharmacological treatment of neuropsychiatric symptoms of dementia: A review of the evidence
    • Sink KM, Holden KF, Yaffe K,. Pharmacological treatment of neuropsychiatric symptoms of dementia: a review of the evidence. JAMA. 2005; 293 (5): 596-608.
    • (2005) JAMA , vol.293 , Issue.5 , pp. 596-608
    • Sink, K.M.1    Holden, K.F.2    Yaffe, K.3
  • 127
    • 84863548826 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of modafinil for the treatment of apathy in individuals with mild-to-moderate Alzheimers disease
    • Frakey LL, Salloway S, Buelow M, Malloy P,. A randomized, double-blind, placebo-controlled trial of modafinil for the treatment of apathy in individuals with mild-to-moderate Alzheimers disease. J Clin Psychiatry. 2012; 73 (6): 796-801.
    • (2012) J Clin Psychiatry , vol.73 , Issue.6 , pp. 796-801
    • Frakey, L.L.1    Salloway, S.2    Buelow, M.3    Malloy, P.4
  • 128
    • 0036727209 scopus 로고    scopus 로고
    • Behavioral change in persons with dementia: Relationships with mental and physical health of caregivers
    • Hooker K, Bowman SR, Coehlo DP,. Behavioral change in persons with dementia: relationships with mental and physical health of caregivers. J Gerontol B Psychol Sci Soc Sci. 2002; 57 (5): P453-P460.
    • (2002) J Gerontol B Psychol Sci Soc Sci , vol.57 , Issue.5 , pp. P453-P460
    • Hooker, K.1    Bowman, S.R.2    Coehlo, D.P.3
  • 129
    • 79952116183 scopus 로고    scopus 로고
    • Prevalence of psychiatric disorders among older adults in long-term care homes: A systematic review
    • Seitz D, Purandare N, Conn D,. Prevalence of psychiatric disorders among older adults in long-term care homes: a systematic review. Int Psychogeriatr. 2010; 22 (7): 1025-1039.
    • (2010) Int Psychogeriatr , vol.22 , Issue.7 , pp. 1025-1039
    • Seitz, D.1    Purandare, N.2    Conn, D.3
  • 130
    • 33846905932 scopus 로고    scopus 로고
    • Prevalence and predictors of neuropsychiatric symptoms in cognitively impaired nursing home patients
    • Zuidema S, Koopmans R, Verhey F,. Prevalence and predictors of neuropsychiatric symptoms in cognitively impaired nursing home patients. J Geriatr Psychiatry Neurol. 2007; 20 (1): 41-49.
    • (2007) J Geriatr Psychiatry Neurol , vol.20 , Issue.1 , pp. 41-49
    • Zuidema, S.1    Koopmans, R.2    Verhey, F.3
  • 132
    • 27944444563 scopus 로고    scopus 로고
    • Frequency and clinical, neuropsychological and neuroimaging correlates of apathy following stroke - the Sydney Stroke Study
    • Brodaty H, Sachdev PS, Withall A, Altendorf A, Valenzuela MJ, Lorentz L,. Frequency and clinical, neuropsychological and neuroimaging correlates of apathy following stroke-the Sydney Stroke Study. Psychol Med. 2005; 12 (12): 1707-1716.
    • (2005) Psychol Med , vol.12 , Issue.12 , pp. 1707-1716
    • Brodaty, H.1    Sachdev, P.S.2    Withall, A.3    Altendorf, A.4    Valenzuela, M.J.5    Lorentz, L.6
  • 133
    • 84884596581 scopus 로고    scopus 로고
    • Incident apathy during the first year after stroke and its effect on physical and cognitive recovery
    • Mikarni K, Jorge RE, Moser DJ, Jany M, Robinson RG,. Incident apathy during the first year after stroke and its effect on physical and cognitive recovery. Am J Ger Psych. 2013; 21 (9): 848-854.
    • (2013) Am J Ger Psych , vol.21 , Issue.9 , pp. 848-854
    • Mikarni, K.1    Jorge, R.E.2    Moser, D.J.3    Jany, M.4    Robinson, R.G.5
  • 135
    • 80054045613 scopus 로고    scopus 로고
    • The Patient-Centered Outcomes Research Institute - Promoting better information, decisions, and health
    • Washington AE, Lipstein SH,. The Patient-Centered Outcomes Research Institute-promoting better information, decisions, and health. New Eng J Med. 2011; 365 (15): e31.
    • (2011) New Eng J Med , vol.365 , Issue.15 , pp. e31
    • Washington, A.E.1    Lipstein, S.H.2


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