Memantine for late-life depression and apathy after a disabling medical event: A 12-week, double-blind placebo-controlled pilot study

International Journal of Geriatric Psychiatry

Volumn 27, Issue 9, 2012, Pages 974-980

  Lenze, Eric J ^a   Skidmore, Elizabeth R ^b   Begley, Amy E ^c   Newcomer, John W ^d   Butters, Meryl A ^c   Whyte, Ellen M ^c  

^a WASHINGTON UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

depression; disability; memantine; motivation; older; participation; rehabilitation; treatment

Indexed keywords

MEMANTINE; PLACEBO;

ADULT; AGED; APATHY; ARTICLE; BEDTIME DOSAGE; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; DIARRHEA; DISEASE COURSE; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; HEADACHE; HELPLESSNESS; HUMAN; LATE LIFE DEPRESSION; MAJOR DEPRESSION; MALE; NAUSEA; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; TREATMENT RESPONSE;

AGED; AGED, 80 AND OVER; ANTIDEPRESSIVE AGENTS; APATHY; DEPRESSIVE DISORDER; DOUBLE-BLIND METHOD; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; HUMANS; MALE; MEMANTINE; MIDDLE AGED; PILOT PROJECTS; PSYCHIATRIC STATUS RATING SCALES;

EID: 84864703206     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.2813     Document Type: Article

References (39)

1. Barry LC, Allore HG, Bruce ML, Gill TM,. Dec 2009. Longitudinal association between depressive symptoms and disability burden among older persons. J Gerontol A Biol Sci Med Sci 64 (12): 1325-1332.
2. Berman RM, Cappiello A, Anand A, et al,. Feb 15 2000. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 47 (4): 351-354.
3. Bleich S, Romer K, Wiltfang J, Kornhuber J,. Sep 2003. Glutamate and the glutamate receptor system: a target for drug action. Int J Geriatr Psychiatry 18 (Suppl 1): S33-S40.
4. Brodaty H, Sachdev PS, Withall A, et al,. Dec 2005. Frequency and clinical, neuropsychological and neuroimaging correlates of apathy following stroke-the Sydney Stroke Study. Psychol Med 35 (12): 1707-1716.
5. Bruce ML,. Mar 2010. Subsyndromal depression and services delivery: at a crossroad? Am J Geriatr Psychiatry 18 (3): 189-192.
6. Bryant C,. Jun 2010. Anxiety and depression in old age: challenges in recognition and diagnosis. Int Psychogeriatr 22 (4): 511-513.
7. Chaturvedi HK, Bapna JS, Chandra D,. Apr 2001. Effect of fluvoxamine and N-methyl-D-aspartate receptor antagonists on shock-induced depression in mice. Indian J Physiol Pharmacol 45 (2): 199-207.
8. Evers AW, Kraaimaat FW, van Lankveld W, et al,. Dec 2001. Beyond unfavorable thinking: the illness cognition questionnaire for chronic diseases. J Consult Clin Psychol 69 (6): 1026-1036.
9. First MB, Spitzer RL, Gibbon M, Williams JBW,. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID), Clinician Version: Administration Booklet. Biometrics Research Department, New York State Psychiatric Institute: Washington, DC, 1996.
10. Folstein MF, Folstein SE, McHugh PR,. Nov 1975. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12 (3): 189-198.
11. Gallo JJ, Rebok GW, Tennsted S, Wadley VG, Horgas A,. Nov 2003. Linking depressive symptoms and functional disability in late life. Aging Ment Health 7 (6): 469-480.
12. Hamilton M,. Feb 1960. A rating scale for depression. J Neurol Neurosurg Psychiatry 23: 56-62.
13. Holmes J, House A,. Jul 2000. Psychiatric illness predicts poor outcome after surgery for hip fracture: a prospective cohort study. Psychol Med 30 (4): 921-929.
14. Hunter AM, Balleine BW, Minor TR,. Feb 2003. Helplessness and escape performance: glutamate-adenosine interactions in the frontal cortex. Behav Neurosci 117 (1): 123-135.
15. Jones RW,. Jun 2010. A review comparing the safety and tolerability of memantine with the acetylcholinesterase inhibitors. Int J Geriatr Psychiatry 25 (6): 547-553.
16. Kennedy GJ, Kelman HR, Thomas C,. Apr 1990. The emergence of depressive symptoms in late life: the importance of declining health and increasing disability. J Community Health 15 (2): 93-104.
17. Kos T, Legutko B, Danysz W, Samoriski G, Popik P,. Sep 2006. Enhancement of antidepressant-like effects but not brain-derived neurotrophic factor mRNA expression by the novel N-methyl-D-aspartate receptor antagonist neramexane in mice. J Pharmacol Exp Ther 318 (3): 1128-1136.
18. Lenze EJ, Rogers JC, Martire LM, et al,. Spring 2001. The association of late-life depression and anxiety with physical disability: a review of the literature and prospectus for future research. Am J Geriatr Psychiatry 9 (2): 113-135.
19. Lenze EJ, Munin MC, Dew MA, et al,. May 2004. Adverse effects of depression and cognitive impairment on rehabilitation participation and recovery from hip fracture. Int J Geriatr Psychiatry 19 (5): 472-478.
20. Lenze EJ, Munin MC, Skidmore ER, et al,. Jan 2007. Onset of depression in elderly persons after hip fracture: implications for prevention and early intervention of late-life depression. J Am Geriatr Soc 55 (1): 81-86.
21. Lenze EJ, Munin MC, Dew MA, et al,. Summer 2009. Apathy after hip fracture: a potential target for intervention to improve functional outcomes. J Neuropsychiatry Clin Neurosci 21 (3): 271-278.
22. Linacre JM, Heinemann AW, Wright BD, Granger CV, Hamilton BB,. Feb 1994. The structure and stability of the functional independence measure. Arch Phys Med Rehabil 75 (2): 127-132.
23. Machado-Vieira R, Yuan P, Brutsche N, et al,. Dec 2009. Brain-derived neurotrophic factor and initial antidepressant response to an N-methyl-D-aspartate antagonist. J Clin Psychiatry 70 (12): 1662-1666.
24. Magaziner J, Simonsick EM, Kashner TM, Hebel JR, Kenzora JE,. May 1990. Predictors of functional recovery one year following hospital discharge for hip fracture: a prospective study. J Gerontol 45 (3): M101-M107.
25. Marin RS, Biedrzycki RC, Firinciogullari S,. Aug 1991. Reliability and validity of the Apathy Evaluation Scale. Psychiatry Res 38 (2): 143-162.
26. Miller MD, Paradis CF, Houck PR, et al,. Mar 1992. Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale. Psychiatry Res 41 (3): 237-248.
27. Moryl E, Danysz W, Quack G,. Jun 1993. Potential antidepressive properties of amantadine, memantine and bifemelane. Pharmacol Toxicol 72 (6): 394-397.
28. Mossey JM, Knott K, Craik R,. Sep 1990. The effects of persistent depressive symptoms on hip fracture recovery. J Gerontol 45 (5): M163-M168.
29. Muhonen LH, Lonnqvist J, Juva K, Alho H,. Mar 2008. Double-blind, randomized comparison of memantine and escitalopram for the treatment of major depressive disorder comorbid with alcohol dependence. J Clin Psychiatry 69 (3): 392-399.
30. Ormel J, Rijsdijk FV, Sullivan M, van Sonderen E, Kempen GI,. Jul 2002. Temporal and reciprocal relationship between IADL/ADL disability and depressive symptoms in late life. J Gerontol B Psychol Sci Soc Sci 57 (4): P338-P347.
31. Ossowska G, Klenk-Majewska B, Szymczyk G,. Mar 1997. The effect of NMDA antagonists on footshock-induced fighting behavior in chronically stressed rats. J Physiol Pharmacol 48 (1): 127-135.
32. Preskorn SH, Baker B, Kolluri S, Menniti FS, Krams M, Landen JW,. Dec 2008. An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder. J Clin Psychopharmacol 28 (6): 631-637.
33. Price RB, Nock MK, Charney DS, Mathew SJ,. Sep 1 2009. Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression. Biol Psychiatry 66 (5): 522-526.
34. Remerand F, Le Tendre C, Baud A, et al,. Dec 2009. The early and delayed analgesic effects of ketamine after total hip arthroplasty: a prospective, randomized, controlled, double-blind study. Anesth Analg 109 (6): 1963-1971.
35. Rogoz Z, Skuza G, Maj J, Danysz W,. Jun 2002. Synergistic effect of uncompetitive NMDA receptor antagonists and antidepressant drugs in the forced swimming test in rats. Neuropharmacology 42 (8): 1024-1030.
36. Secretariat of the UN. World Population Prospects: The 2008 Revision, http://esa.un.org/unpp 2008. Accessed January 7, 2011.
37. Whyte EM, Mulsant BH, Vanderbilt J, Dodge HH, Ganguli M,. May 2004. Depression after stroke: a prospective epidemiological study. J Am Geriatr Soc 52 (5): 774-778.
38. Zarate CA, Jr., Singh JB, Carlson PJ, et al,. Aug 2006a. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 63 (8): 856-864.
39. Zarate CA, Jr., Singh JB, Quiroz JA, et al,. Jan 2006b. A double-blind, placebo-controlled study of memantine in the treatment of major depression. Am J Psychiatry 163 (1): 153-155.