Modulation of TLR3/TLR4 inflammatory signaling by the GABAB receptor agonist baclofen in glia and immune cells: Relevance to therapeutic effects in multiple sclerosis

Frontiers in Cellular Neuroscience

Volumn 9, Issue JULY, 2015, Pages

  Crowley, Tadhg ^a   Fitzpatrick, John Mark ^a   Kuijper, Teun ^a   Cryan, John F ^a,b   O’Toole, Orna ^c   O’Leary, Olivia F ^a,b   Downer, Eric J ^a,d  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c MERCY UNIVERSITY HOSPITAL   (Ireland)

^d TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Baclofen; GABA; Glia; Inflammation; Innate immunity; Multiple sclerosis; TLR

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; BACLOFEN; CHEMOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MESSENGER RNA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GLIA CELL; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOCYTOCHEMISTRY; IMMUNOMODULATION; LYMPHOCYTE; MOUSE; MULTIPLE SCLEROSIS; MUSCLE CRAMP; MUSCLE TIGHTNESS; NERVOUS SYSTEM INFLAMMATION; NEUROMODULATION; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPASTICITY;

EID: 84940177760     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2015.00284     Document Type: Article

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