-
1
-
-
84907865996
-
Thrombosis: A major contributor to the global disease burden
-
ISTH Stpering Committee for World Thrombosis Day. Thrombosis: a major contributor to the global disease burden. J Thromb Haemost. 2014;12:1580–1590.
-
(2014)
J Thromb Haemost
, vol.12
, pp. 1580-1590
-
-
-
2
-
-
70350733276
-
The prevention and treatment of venous thromboembolism with LMWHs and new anticoagulants
-
Blann AD, Khoo CW. The prevention and treatment of venous thromboembolism with LMWHs and new anticoagulants. Vasc Health Risk Manag. 2009;5:693–704.
-
(2009)
Vasc Health Risk Manag
, vol.5
, pp. 693-704
-
-
Blann, A.D.1
Khoo, C.W.2
-
3
-
-
84923924319
-
Pros and cons of vitamin K antagonists and non-vitamin K antagonist oral anticoagulants
-
Riva N, Ageno W. Pros and cons of vitamin K antagonists and non-vitamin K antagonist oral anticoagulants. Semin Thromb Hemost. 2015;41:178–187.
-
(2015)
Semin Thromb Hemost
, vol.41
, pp. 178-187
-
-
Riva, N.1
Ageno, W.2
-
4
-
-
84899729145
-
ESC Working Group on Thrombosis Task Force on anticoagulants in heart disease. Non-vitamin K antagonist oral anticoagulants (NOACs): No longer new or novel
-
Husted S, De Caterina R, Andreotti F, et al. ESC Working Group on Thrombosis Task Force on anticoagulants in heart disease. Non-vitamin K antagonist oral anticoagulants (NOACs): No longer new or novel. Thromb Haemost. 2014;111:781–782.
-
(2014)
Thromb Haemost
, vol.111
, pp. 781-782
-
-
Husted, S.1
De Caterina, R.2
Reotti, F.3
-
5
-
-
34548031359
-
The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
-
Stangier J, Rathgen K, Stahle H, Gansser D, Roth W. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol. 2007;64:292–303.
-
(2007)
Br J Clin Pharmacol
, vol.64
, pp. 292-303
-
-
Stangier, J.1
Rathgen, K.2
Stahle, H.3
Gansser, D.4
Roth, W.5
-
6
-
-
25844525489
-
Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY59-7939, an oral, direct factor Xa inhibitor
-
Kubitza D, Becka M, Voith B, Zuehlsdorf M, Wensing G. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY59-7939, an oral, direct factor Xa inhibitor. Clin Pharmacol Ther. 2005;78: 412–421.
-
(2005)
Clin Pharmacol Ther
, vol.78
, pp. 412-421
-
-
Kubitza, D.1
Becka, M.2
Voith, B.3
Zuehlsdorf, M.4
Wensing, G.5
-
7
-
-
42149172523
-
Apixaban, an oral, direct and highly selective factor Xa inhibitor: In vitro, antithrombotic and antihemostatic studies
-
Wong PC, Crain EJ, Xin B, et al. Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies. J Thromb Haemost. 2008;6:820–829.
-
(2008)
J Thromb Haemost
, vol.6
, pp. 820-829
-
-
Wong, P.C.1
Crain, E.J.2
Xin, B.3
-
8
-
-
77953787643
-
Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxabanin healthy volunteers
-
Ogata K, Mendell-Harary J, Tachibana M, et al. Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxabanin healthy volunteers. J Clin Pharmacol. 2010;50: 743–753.
-
(2010)
J Clin Pharmacol
, vol.50
, pp. 743-753
-
-
Ogata, K.1
Mendell-Harary, J.2
Tachibana, M.3
-
9
-
-
84867628649
-
Development and clinical applications of novel oral anticoagulants. Part II. Drugs under clinical investigation
-
Ahrens I, Peter K, Lip GY, Bode C. Development and clinical applications of novel oral anticoagulants. Part II. Drugs under clinical investigation. Discov Med. 2012;13:445–450.
-
(2012)
Discov Med
, vol.13
, pp. 445-450
-
-
Ahrens, I.1
Peter, K.2
Lip, G.Y.3
Bode, C.4
-
10
-
-
84896544335
-
Risk of drug-induced liver injury with the new oral anticoagulants: Systematic review and meta-analysis
-
Caldeira D, Barra M, Santos AT, et al. Risk of drug-induced liver injury with the new oral anticoagulants: systematic review and meta-analysis. Heart. 2014;100:550–556.
-
(2014)
Heart
, vol.100
, pp. 550-556
-
-
Caldeira, D.1
Barra, M.2
Santos, A.T.3
-
11
-
-
84885772245
-
Evaluation of the oral direct factor Xa inhibitor – betrixaban
-
Palladino M, Merli G, Thomson L. Evaluation of the oral direct factor Xa inhibitor – betrixaban. Expert Opin Investig Drugs. 2013;22: 1465–1472.
-
(2013)
Expert Opin Investig Drugs
, vol.22
, pp. 1465-1472
-
-
Palladino, M.1
Merli, G.2
Thomson, L.3
-
12
-
-
81855164650
-
Biochemical and pharmacological profile of darexaban, an oral direct factor Xa inhibitor
-
Iwatsuki Y, Sato T, Moritani Y, et al. Biochemical and pharmacological profile of darexaban, an oral direct factor Xa inhibitor. Eur J Pharmacol. 2011;673:49–55.
-
(2011)
Eur J Pharmacol
, vol.673
, pp. 49-55
-
-
Iwatsuki, Y.1
Sato, T.2
Moritani, Y.3
-
13
-
-
84877298221
-
Absorption, metabolism and excretion of darexaban (YM150), a new direct factor Xa inhibitor in humans
-
Hashimoto T, Suzuki K, Kihara Y, et al. Absorption, metabolism and excretion of darexaban (YM150), a new direct factor Xa inhibitor in humans. Xenobiotica. 2013;43(6):534–547.
-
(2013)
Xenobiotica
, vol.43
, Issue.6
, pp. 534-547
-
-
Hashimoto, T.1
Suzuki, K.2
Kihara, Y.3
-
14
-
-
84877786724
-
Darexaban: Anticoagulant effects in mice and human plasma in vitro, antithrombotic effects in thrombosis and bleeding models in mice and effects of anti-inhibitor coagulant complex and recombinant factor VIIa
-
Kaku S, Suzuki M, Saitoh M, et al. Darexaban: anticoagulant effects in mice and human plasma in vitro, antithrombotic effects in thrombosis and bleeding models in mice and effects of anti-inhibitor coagulant complex and recombinant factor VIIa. Thromb Res. 2013;131:450–456.
-
(2013)
Thromb Res
, vol.131
, pp. 450-456
-
-
Kaku, S.1
Suzuki, M.2
Saitoh, M.3
-
15
-
-
84897060638
-
Darexaban (YM150), an oral direct factor Xa inhibitor, has no effect on the pharmacokinetics of digoxi
-
Kadokura T, Groenendaal D, Heeringa M, et al. Darexaban (YM150), an oral direct factor Xa inhibitor, has no effect on the pharmacokinetics of digoxin. Eur J Drug Metab Pharmacokinet. 2014;39:1–9.
-
(2014)
Eur J Drug Metab Pharmacokine
, vol.39
-
-
Kadokura, T.1
Groenendaal, D.2
Heeringa, M.3
-
16
-
-
84872252194
-
The pharmacokinetics of darexaban are not affected to a clinically relevant degree by rifampicin, a strong inducer of P-glycoprotein and CYP3A4
-
Groenendaal D, Strabach G, Garcia-Hernandez A, et al. The pharmacokinetics of darexaban are not affected to a clinically relevant degree by rifampicin, a strong inducer of P-glycoprotein and CYP3A4. Br J Clin Pharmacol. 2013;75(2):440–449.
-
(2013)
Br J Clin Pharmacol
, vol.75
, Issue.2
, pp. 440-449
-
-
Groenendaal, D.1
Strabach, G.2
Garcia-Hernandez, A.3
-
17
-
-
84865230257
-
Darexaban (YM150) prevents venous thromboembolism in Japanese patients undergoing major abdominal surgery: Phase III randomized, mechanical prophylaxis-controlled, open-label study
-
Sakon M, Nakamura M. Darexaban (YM150) prevents venous thromboembolism in Japanese patients undergoing major abdominal surgery: phase III randomized, mechanical prophylaxis-controlled, open-label study. Thromb Res. 2012;130:e52–e59.
-
(2012)
Thromb Res
, vol.130
, pp. e52-e59
-
-
Sakon, M.1
Nakamura, M.2
-
18
-
-
84893473811
-
Darexaban for the prevention of venous thromboembolism in Asian patients undergoing orthopedic surgery: Results from 2 randomized, placebo-controlled, double-blind studies
-
Fuji T, Nakamura M, Takeuchi M. Darexaban for the prevention of venous thromboembolism in Asian patients undergoing orthopedic surgery: results from 2 randomized, placebo-controlled, double-blind studies. Clin Appl Thromb Hemost. 2014;20:199–211.
-
(2014)
Clin Appl Thromb Hemost
, vol.20
, pp. 199-211
-
-
Fuji, T.1
Nakamura, M.2
Takeuchi, M.3
-
19
-
-
84893177071
-
Darexaban (YM150) versus enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: A randomised phase IIb dose confirmation study (ONYX-3)
-
Eriksson BI, Agnelli G, Gallus AS, et al. Darexaban (YM150) versus enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a randomised phase IIb dose confirmation study (ONYX-3). Thromb Haemost. 2014;111:213–225.
-
(2014)
Thromb Haemost
, vol.111
, pp. 213-225
-
-
Eriksson, B.I.1
Agnelli, G.2
Gallus, A.S.3
-
20
-
-
80054733922
-
RUBY-1 investigators. RUBY-1: A randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome
-
Steg PG, Mehta SR, Jukema JW, et al. RUBY-1 investigators. RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome. Eur Heart J. 2011;32:2541–2554.
-
(2011)
Eur Heart J
, vol.32
, pp. 2541-2554
-
-
Steg, P.G.1
Mehta, S.R.2
Jukema, J.W.3
-
21
-
-
84862907587
-
ATLAS ACS 2–TIMI 51 Investigators. Rivaroxaban in patients with a recent acute coronary syndrome
-
Mega JL, Braunwald E, Wiviott SD, et al; ATLAS ACS 2–TIMI 51 Investigators. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med. 2012;366:9–19.
-
(2012)
N Engl J Med
, vol.366
, pp. 9-19
-
-
Mega, J.L.1
Braunwald, E.2
Wiviott, S.D.3
-
22
-
-
84902176240
-
Role of novel and emerging oral anticoagulants for secondary prevention of acute coronary syndromes
-
Ganetsky VS, Hadley DE, Thomas TF. Role of novel and emerging oral anticoagulants for secondary prevention of acute coronary syndromes. Pharmacotherapy. 2014;34:590–604.
-
(2014)
Pharmacotherapy
, vol.34
, pp. 590-604
-
-
Ganetsky, V.S.1
Hadley, D.E.2
Thomas, T.F.3
-
23
-
-
84936761917
-
Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism
-
Chan NC, Bhagirath V, Eikelboom JW. Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism. Vasc Health Risk Manag. 2015;11:343–351.
-
(2015)
Vasc Health Risk Manag
, vol.11
, pp. 343-351
-
-
Chan, N.C.1
Bhagirath, V.2
Eikelboom, J.W.3
-
24
-
-
84931291673
-
Reversal of anticoagulants: An overview of current developments
-
Greinacher A, Thiele T, Selleng K. Reversal of anticoagulants: an overview of current developments. Thromb Haemost. 2015;113:931–942.
-
(2015)
Thromb Haemost
, vol.113
, pp. 931-942
-
-
Greinacher, A.1
Thiele, T.2
Selleng, K.3
-
25
-
-
84930965307
-
A randomised study in healthy volunteers to investigate the safety, tolerability and pharmacokinetics of idarucizumab, a specific antidote to dabigatran
-
Glund S, Moschetti V, Norris S, et al. A randomised study in healthy volunteers to investigate the safety, tolerability and pharmacokinetics of idarucizumab, a specific antidote to dabigatran. Thromb Haemost. 2015;113:943–951.
-
(2015)
Thromb Haemost
, vol.113
, pp. 943-951
-
-
Glund, S.1
Moschetti, V.2
Norris, S.3
-
26
-
-
84934759814
-
Design and rationale for RE-VERSE AD: A phase 3 study of idarucizumab, a specific reversal agent for dabigatran
-
Pollack CV Jr, Reilly PA, Bernstein R, et al. Design and rationale for RE-VERSE AD: a phase 3 study of idarucizumab, a specific reversal agent for dabigatran. Thromb Haemost. 2015;114(1):198–205.
-
(2015)
Thromb Haemost
, vol.114
, Issue.1
, pp. 198-205
-
-
Pollack, C.V.1
Reilly, P.A.2
Bernstein, R.3
-
27
-
-
84878460192
-
A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa
-
Lu G, DeGuzman FR, Hollenbach SJ, et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa. Nat Med. 2013;19:446–451.
-
(2013)
Nat Med
, vol.19
, pp. 446-451
-
-
Lu, G.1
Deguzman, F.R.2
Hollenbach, S.J.3
-
28
-
-
84880737167
-
Practical management of bleeding due to the anticoagulants dabigatran, rivaroxaban, and apixaban
-
Fawole A, Daw HA, Crowther MA. Practical management of bleeding due to the anticoagulants dabigatran, rivaroxaban, and apixaban. Cleve Clin J Med. 2013;80:443–451.
-
(2013)
Cleve Clin J Med
, vol.80
, pp. 443-451
-
-
Fawole, A.1
Daw, H.A.2
Crowther, M.A.3
-
29
-
-
84879151748
-
On the treatment of new oral anticoagulant-associated gastrointestinal haemorrhage
-
Holster IL, Hunfield NGM, Kuipers EJ, Kruip MJHA, Tjwa ETTL. On the treatment of new oral anticoagulant-associated gastrointestinal haemorrhage. J Gastrointestin Liver Dis. 2013;22:229–231.
-
(2013)
J Gastrointestin Liver Dis
, vol.22
, pp. 229-231
-
-
Holster, I.L.1
Hunfield, N.2
Kuipers, E.J.3
Kruip, M.4
Tjwa, E.T.T.L.5
-
30
-
-
84882247210
-
Bleeding and antidotes in new oral anticoagulants
-
Majeed A, Schulman S. Bleeding and antidotes in new oral anticoagulants. Best Pract Res Clin Haematol. 2013;26:191–202.
-
(2013)
Best Pract Res Clin Haematol
, vol.26
, pp. 191-202
-
-
Majeed, A.1
Schulman, S.2
-
31
-
-
84878260361
-
Recommendations for the emergency management of complications associated with the new direct oral anticoagulants (DOACs) apixaban, dabigatran and rivaroxaban
-
Steiner T, Bohm M, Dichgans M, et al. Recommendations for the emergency management of complications associated with the new direct oral anticoagulants (DOACs) apixaban, dabigatran and rivaroxaban. Clin Res Cardiol. 2013;102:399–412.
-
(2013)
Clin Res Cardiol
, vol.102
, pp. 399-412
-
-
Steiner, T.1
Bohm, M.2
Dichgans, M.3
-
33
-
-
84908109518
-
Global coagulation tests: Their applicability for measuring direct factor Xa- and thrombin inhibition and reversal of anticoagulation by prothrombin complex concentrate
-
Dinkelaar J, Patiwael S, Harenberg J, Leyte A, Brinkman HJ. Global coagulation tests: their applicability for measuring direct factor Xa- and thrombin inhibition and reversal of anticoagulation by prothrombin complex concentrate. Clin Chem Lab Med. 2014;52:1615–1623.
-
(2014)
Clin Chem Lab Med
, vol.52
, pp. 1615-1623
-
-
Dinkelaar, J.1
Patiwael, S.2
Harenberg, J.3
Leyte, A.4
Brinkman, H.J.5
-
34
-
-
84925224400
-
Non-vitamin K antagonist oral anticoagulants (NOACs): A view from the laboratory
-
Blann AD. Non-vitamin K antagonist oral anticoagulants (NOACs): a view from the laboratory. Br J Biomed Sci. 2014;71:158–167.
-
(2014)
Br J Biomed Sci
, vol.71
, pp. 158-167
-
-
Blann, A.D.1
-
35
-
-
84876192857
-
Measuring oral direct inhibitors (ODIs) of thrombin and factor Xa: A recommendation from the Subcommittee on Control of Anticoagulation of the Scientific and Standardisation Committee of the ISTH
-
Baglin T, Hillarp A, Tripodi A, Elalamy I, Buller H, Ageno W. Measuring oral direct inhibitors (ODIs) of thrombin and factor Xa: a recommendation from the Subcommittee on Control of Anticoagulation of the Scientific and Standardisation Committee of the ISTH. J Thromb Haemost. 2013;11:756–760.
-
(2013)
J Thromb Haemost
, vol.11
, pp. 756-760
-
-
Baglin, T.1
Hillarp, A.2
Tripodi, A.3
Elalamy, I.4
Buller, H.5
Ageno, W.6
-
36
-
-
84907597644
-
Measurement of non-coumarin anticoagulants and their effects on tests of haemostasis: Guidance from the British Committee for standards in haematology
-
Kitchen S, Gray E, Mackie I, Baglin T, Makris M. Measurement of non-coumarin anticoagulants and their effects on tests of haemostasis: guidance from the British Committee for standards in haematology. Br J Haematol. 2014;166:830–841.
-
(2014)
Br J Haematol
, vol.166
, pp. 830-841
-
-
Kitchen, S.1
Gray, E.2
Mackie, I.3
Baglin, T.4
Makris, M.5
|