메뉴 건너뛰기




Volumn 100, Issue 7, 2014, Pages 550-556

Risk of drug-induced liver injury with the new oral anticoagulants: Systematic review and meta-analysis

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; ANTICOAGULANT AGENT; ANTIVITAMIN K; APIXABAN; BILIRUBIN; DABIGATRAN; DAREXABAN; EDOXABAN; LOW MOLECULAR WEIGHT HEPARIN; RIVAROXABAN;

EID: 84896544335     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/heartjnl-2013-305288     Document Type: Article
Times cited : (94)

References (54)
  • 1
    • 75449112589 scopus 로고    scopus 로고
    • Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events
    • Lammert C, Bjornsson E, Niklasson A, et al. Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events. Hepatology 2010;51:615-20.
    • (2010) Hepatology , vol.51 , pp. 615-620
    • Lammert, C.1    Bjornsson, E.2    Niklasson, A.3
  • 2
    • 84867578409 scopus 로고    scopus 로고
    • Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs
    • Urban TJ, Shen Y, Stolz A, et al. Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs. Pharmacogenet Genomics 2012;22:784-95.
    • (2012) Pharmacogenet Genomics , vol.22 , pp. 784-795
    • Urban, T.J.1    Shen, Y.2    Stolz, A.3
  • 3
    • 77952718055 scopus 로고    scopus 로고
    • Risk factors for idiosyncratic drug-induced liver injury
    • Chalasani N, Björnsson E. Risk factors for idiosyncratic drug-induced liver injury. Gastroenterology 2010;138:2246-59.
    • (2010) Gastroenterology , vol.138 , pp. 2246-2259
    • Chalasani, N.1    Björnsson, E.2
  • 4
    • 79958013087 scopus 로고    scopus 로고
    • brief: FDA warning on dronedarone (Multaq)
    • In brief: FDA warning on dronedarone (Multaq). Med Lett Drugs Ther 2011;53:17.
    • (2011) Med Lett Drugs Ther , vol.53 , pp. 17
  • 5
    • 77949312944 scopus 로고    scopus 로고
    • Drug-induced liver injury in humans: The case of ximelagatran
    • Keisu M, Andersson TB. Drug-induced liver injury in humans: the case of ximelagatran. Handb Exp Pharmacol 2010;196:407-18.
    • (2010) Handb Exp Pharmacol , vol.196 , pp. 407-418
    • Keisu, M.1    Andersson, T.B.2
  • 6
    • 84896547977 scopus 로고    scopus 로고
    • (accessed 31 Oct)
    • Xarelto: Summary of Products Characteristics. http://www.ema.europa.eu/ docs/en-GB/document-library/EPAR-Product-Information/human/000944/WC500057108. pdf (accessed 31 Oct 2013).
    • (2013) Xarelto: Summary of Products Characteristics
  • 7
    • 84860512524 scopus 로고    scopus 로고
    • (accessed 31 Oct)
    • Eliquis: Summary of Products Characteristics. http://www.ema.europa.eu/ docs/en-GB/document-library/EPAR-Product-Information/human/002148/WC500107728. pdf (accessed 31 Oct 2013).
    • (2013) Eliquis: Summary of Products Characteristics
  • 8
    • 84896547575 scopus 로고    scopus 로고
    • (accessed 31 Oct)
    • Pradaxa: Summary of Products Characteristics. http://www.ema.europa.eu/ docs/en-GB/document-library/EPAR-Product-Information/human/000829/WC500041059. pdf (accessed 31 Oct 2013).
    • (2013) Pradaxa: Summary of Products Characteristics
  • 9
    • 84877301336 scopus 로고    scopus 로고
    • European heart rhythm association practical guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation
    • Heidbuchel H, Verhamme P, Alings M, et al. European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation. Europace 2013;15:625-51.
    • (2013) Europace , vol.15 , pp. 625-651
    • Heidbuchel, H.1    Verhamme, P.2    Alings, M.3
  • 10
    • 68549101842 scopus 로고    scopus 로고
    • The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: Explanation and elaboration
    • Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009;339:b2700.
    • (2009) BMJ , vol.339
    • Liberati, A.1    Altman, D.G.2    Tetzlaff, J.3
  • 11
    • 84876727681 scopus 로고    scopus 로고
    • Meta-analysis of incidence of rare events
    • Lane PW. Meta-analysis of incidence of rare events. Stat Methods Med Res 2013;22:117-32.
    • (2013) Stat Methods Med Res , vol.22 , pp. 117-132
    • Lane, P.W.1
  • 12
    • 84875424429 scopus 로고    scopus 로고
    • The impact of study size on meta-analyses: Examination of underpowered studies in Cochrane reviews
    • Turner RM, Bird SM, Higgins JP. The impact of study size on meta-analyses: examination of underpowered studies in Cochrane reviews. PLoS ONE 2013;8: e59202.
    • (2013) PLoS ONE , vol.8
    • Turner, R.M.1    Bird, S.M.2    Higgins, J.P.3
  • 13
    • 0035808035 scopus 로고    scopus 로고
    • Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses
    • Kjaergard LL, Villumsen J, Gluud C. Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses. Ann Intern Med 2001;135:982-9. (Pubitemid 33131619)
    • (2001) Annals of Internal Medicine , vol.135 , Issue.11 , pp. 982-989
    • Kjaergard, L.L.1    Villumsen, J.2    Gluud, C.3
  • 14
    • 84872018928 scopus 로고    scopus 로고
    • Small studies may overestimate the effect sizes in critical care meta-analyses: A meta-epidemiological study
    • Zhang Z, Xu X, Ni H. Small studies may overestimate the effect sizes in critical care meta-analyses: a meta-epidemiological study. Crit Care 2013;17:R2.
    • (2013) Crit Care , vol.17
    • Zhang, Z.1    Xu, X.2    Ni, H.3
  • 16
    • 70049099036 scopus 로고    scopus 로고
    • Chapter 8: Assessing risk of bias in included studies
    • Higgins JPT, Green S. eds. (updated March 2011). The Cochrane Collaboration
    • Altman DG, Sterne JAC. Chapter 8: assessing risk of bias in included studies. In: Higgins JPT, Green S. eds. Cochrane handbook for systematic reviews of interventions version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. http://www.cochrane-handbook.org
    • (2011) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0
    • Altman, D.G.1    Sterne, J.A.C.2
  • 17
    • 0037098201 scopus 로고    scopus 로고
    • Issues in the selection of a summary statistic for meta-analysis of clinical trials with binary outcomes
    • DOI 10.1002/sim.1188
    • Deeks JJ. Issues in the selection of a summary statistic for meta-analysis of clinical trials with binary outcomes. Stat Med 2002;21:1575-600. (Pubitemid 34746064)
    • (2002) Statistics in Medicine , vol.21 , Issue.11 , pp. 1575-1600
    • Deeks, J.J.1
  • 18
    • 84890783342 scopus 로고    scopus 로고
    • Chapter 9: Analysing data and undertaking meta-analyses
    • Higgins JPT, Green S. eds. (updated March 2011). The Cochrane Collaboration
    • Deeks JJ, Altman DG. Chapter 9: analysing data and undertaking meta-analyses. In: Higgins JPT, Green S. eds. Cochrane handbook for systematic reviews of interventions version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. http://www.cochrane-handbook.org
    • (2011) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0
    • Deeks, J.J.1    Altman, D.G.2
  • 19
    • 33846260745 scopus 로고    scopus 로고
    • Much ado about nothing: A comparison of the performance of meta-analytical methods with rare events
    • DOI 10.1002/sim.2528
    • Bradburn MJ, Deeks JJ, Berlin JA, et al. Much ado about nothing: a comparison of the performance of meta-analytical methods with rare events. Stat Med 2007;26:53-77. (Pubitemid 46099417)
    • (2007) Statistics in Medicine , vol.26 , Issue.1 , pp. 53-77
    • Bradburn, M.J.1    Deeks, J.J.2    Berlin, J.A.3    Localio, A.R.4
  • 20
    • 77449161636 scopus 로고    scopus 로고
    • Enhancing the utility of alanine aminotransferase as a reference standard biomarker for drug-induced liver injury
    • Ozer JS, Chetty R, Kenna G, et al. Enhancing the utility of alanine aminotransferase as a reference standard biomarker for drug-induced liver injury. Regul Toxicol Pharmacol 2010;56:237-46.
    • (2010) Regul Toxicol Pharmacol , vol.56 , pp. 237-246
    • Ozer, J.S.1    Chetty, R.2    Kenna, G.3
  • 21
    • 2942695870 scopus 로고    scopus 로고
    • Controlling the risk of spurious findings from meta-regression
    • DOI 10.1002/sim.1752
    • Higgins JPT, Thompson SG. Controlling the risk of spurious findings from meta-regression. Stat Med 2004;23:1663-82. (Pubitemid 38765338)
    • (2004) Statistics in Medicine , vol.23 , Issue.11 , pp. 1663-1682
    • Higgins, J.P.T.1    Thompson, S.G.2
  • 22
  • 24
    • 68249158084 scopus 로고    scopus 로고
    • Apixaban or enoxaparin for thromboprophylaxis after knee replacement
    • Lassen MR, Raskob GE, Gallus A, et al. Apixaban or enoxaparin for thromboprophylaxis after knee replacement. N Engl J Med 2009;361:594-604.
    • (2009) N Engl J Med , vol.361 , pp. 594-604
    • Lassen, M.R.1    Raskob, G.E.2    Gallus, A.3
  • 25
    • 77649113258 scopus 로고    scopus 로고
    • Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): A randomised double-blind trial
    • Lassen MR, Raskob GE, Gallus A, et al. Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial. Lancet 2010;375:807-15.
    • (2010) Lancet , vol.375 , pp. 807-815
    • Lassen, M.R.1    Raskob, G.E.2    Gallus, A.3
  • 26
    • 78650587760 scopus 로고    scopus 로고
    • Apixaban versus enoxaparin for thromboprophylaxis after hip replacement
    • Lassen MR, Gallus A, Raskob GE, et al. Apixaban versus enoxaparin for thromboprophylaxis after hip replacement. N Engl J Med 2010;363:2487-98.
    • (2010) N Engl J Med , vol.363 , pp. 2487-2498
    • Lassen, M.R.1    Gallus, A.2    Raskob, G.E.3
  • 27
    • 80052162121 scopus 로고    scopus 로고
    • Apixaban with antiplatelet therapy after acute coronary syndrome
    • Alexander JH, Lopes RD, James S, et al. Apixaban with antiplatelet therapy after acute coronary syndrome. N Engl J Med 2011;365:699-708.
    • (2011) N Engl J Med , vol.365 , pp. 699-708
    • Alexander, J.H.1    Lopes, R.D.2    James, S.3
  • 28
    • 79952301326 scopus 로고    scopus 로고
    • Apixaban in patients with atrial fibrillation
    • Connolly SJ, Eikelboom J, Joyner C, et al. Apixaban in patients with atrial fibrillation. N Engl J Med 2011;364:806-17.
    • (2011) N Engl J Med , vol.364 , pp. 806-817
    • Connolly, S.J.1    Eikelboom, J.2    Joyner, C.3
  • 29
    • 80052825103 scopus 로고    scopus 로고
    • Apixaban versus warfarin in patients with atrial fibrillation
    • Granger CB, Alexander JH, McMurray JJ, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011;365:981-92.
    • (2011) N Engl J Med , vol.365 , pp. 981-992
    • Granger, C.B.1    Alexander, J.H.2    McMurray, J.J.3
  • 30
    • 84880327613 scopus 로고    scopus 로고
    • Oral apixaban for the treatment of acute venous thromboembolism
    • Agnelli G, Buller HR, Cohen A, et al. Oral apixaban for the treatment of acute venous thromboembolism. N Engl J Med 2013;369:799-808.
    • (2013) N Engl J Med , vol.369 , pp. 799-808
    • Agnelli, G.1    Buller, H.R.2    Cohen, A.3
  • 31
    • 84873596181 scopus 로고    scopus 로고
    • PLIFY-EXT Investigators. Apixaban for extended treatment of venous thromboembolism
    • Agnelli G, Buller HR, Cohen A, et al. PLIFY-EXT Investigators. Apixaban for extended treatment of venous thromboembolism. N Engl J Med 2013;368:699-708.
    • (2013) N Engl J Med , vol.368 , pp. 699-708
    • Agnelli, G.1    Buller, H.R.2    Cohen, A.3
  • 34
    • 57649123692 scopus 로고    scopus 로고
    • RE-MOBILIZE writing committee. Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery
    • Ginsberg JS, Davidson BL, Comp PC, et al. RE-MOBILIZE Writing Committee. Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery. J Arthroplasty 2009;24:1-9.
    • (2009) J Arthroplasty , vol.24 , pp. 1-9
    • Ginsberg, J.S.1    Davidson, B.L.2    Comp, P.C.3
  • 35
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • Connolly SJ, Ezekowitz MD, Yusuf S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009;361:1139-51.
    • (2009) N Engl J Med , vol.361 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 36
    • 71849117615 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in the treatment of acute venous thromboembolism
    • Schulman S, Kearon C, Kakkar AK, et al. Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med 2009;361:2342-52.
    • (2009) N Engl J Med , vol.361 , pp. 2342-2352
    • Schulman, S.1    Kearon, C.2    Kakkar, A.K.3
  • 37
    • 79953836474 scopus 로고    scopus 로고
    • Oral dabigatran versus enoxaparin for thromboprophylaxis after primary total hip arthroplasty (RE-NOVATE II*). A randomised, double-blind, non-inferiority trial
    • Eriksson BI, Dahl OE, Huo MH, et al. Oral dabigatran versus enoxaparin for thromboprophylaxis after primary total hip arthroplasty (RE-NOVATE II*). A randomised, double-blind, non-inferiority trial. Thromb Haemost 2011;105:721-9.
    • (2011) Thromb Haemost , vol.105 , pp. 721-729
    • Eriksson, B.I.1    Dahl, O.E.2    Huo, M.H.3
  • 38
    • 84874003257 scopus 로고    scopus 로고
    • Extended use of dabigatran, warfarin, or placebo in venous thromboembolism
    • Schulman S, Kearon C, Kakkar AK, et al. Extended use of dabigatran, warfarin, or placebo in venous thromboembolism. N Engl J Med 2013;368:709-18.
    • (2013) N Engl J Med , vol.368 , pp. 709-718
    • Schulman, S.1    Kearon, C.2    Kakkar, A.K.3
  • 39
    • 84865230257 scopus 로고    scopus 로고
    • Darexaban (YM150) prevents venous thromboembolism in Japanese patients undergoing major abdominal surgery: Phase III randomized, mechanical prophylaxis-controlled, open-label study
    • Sakon M, Nakamura M. Darexaban (YM150) prevents venous thromboembolism in Japanese patients undergoing major abdominal surgery: phase III randomized, mechanical prophylaxis-controlled, open-label study. Thromb Res 2012;130:e52-9.
    • (2012) Thromb Res , vol.130
    • Sakon, M.1    Nakamura, M.2
  • 40
    • 84885618705 scopus 로고    scopus 로고
    • Hokusai-VTE Investigators. Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism
    • Büller HR, Décousus H, Grosso MA, et al. Hokusai-VTE Investigators. Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med 2013;369:1406-15.
    • (2013) N Engl J Med , vol.369 , pp. 1406-1415
    • Büller, H.R.1    Décousus, H.2    Grosso, M.A.3
  • 42
    • 46049106502 scopus 로고    scopus 로고
    • Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: A double-blind, randomised controlled trial
    • Kakkar AK, Brenner B, Dahl OE, et al. Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial. Lancet 2008;372:31-9.
    • (2008) Lancet , vol.372 , pp. 31-39
    • Kakkar, A.K.1    Brenner, B.2    Dahl, O.E.3
  • 44
    • 65549169515 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): A randomised trial
    • Turpie AG, Lassen MR, Davidson BL, et al. Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial. Lancet 2009;373:1673-80.
    • (2009) Lancet , vol.373 , pp. 1673-1680
    • Turpie, A.G.1    Lassen, M.R.2    Davidson, B.L.3
  • 45
    • 78650619315 scopus 로고    scopus 로고
    • EINSTEIN Investigators. Oral rivaroxaban for symptomatic venous thromboembolism
    • Bauersachs R, Berkowitz SD, Brenner B, et al. EINSTEIN Investigators. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 2010;363:2499-510.
    • (2010) N Engl J Med , vol.363 , pp. 2499-2510
    • Bauersachs, R.1    Berkowitz, S.D.2    Brenner, B.3
  • 46
    • 80052592404 scopus 로고    scopus 로고
    • Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    • Patel MR, Mahaffey KW, Garg J, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011;365:883-91.
    • (2011) N Engl J Med , vol.365 , pp. 883-891
    • Patel, M.R.1    Mahaffey, K.W.2    Garg, J.3
  • 47
    • 84862907587 scopus 로고    scopus 로고
    • Rivaroxaban in patients with a recent acute coronary syndrome
    • Mega JL, Braunwald E, Wiviott SD, et al. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med 2012;366:9-19.
    • (2012) N Engl J Med , vol.366 , pp. 9-19
    • Mega, J.L.1    Braunwald, E.2    Wiviott, S.D.3
  • 48
    • 84859385808 scopus 로고    scopus 로고
    • EINSTEIN-PE Investigators. Oral rivaroxaban for the treatment of symptomatic pulmonary embolism
    • Büller HR, Prins MH, Lensin AW, et al. EINSTEIN-PE Investigators. Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med 2012;366: 1287-97.
    • (2012) N Engl J Med , vol.366 , pp. 1287-1297
    • Büller, H.R.1    Prins, M.H.2    Lensin, A.W.3
  • 49
    • 84873514413 scopus 로고    scopus 로고
    • Rivaroxaban for thromboprophylaxis in acutely ill medical patients
    • Cohen AT, Spiro TE, Büller HR, et al. Rivaroxaban for thromboprophylaxis in acutely ill medical patients. N Engl J Med 2013;368:513-23.
    • (2013) N Engl J Med , vol.368 , pp. 513-523
    • Cohen, A.T.1    Spiro, T.E.2    Büller, H.R.3
  • 50
    • 84864379749 scopus 로고    scopus 로고
    • Rivaroxaban vs. Warfarin in Japanese patients with atrial fibrillation-The J-ROCKET AF study
    • Hori M, Matsumoto M, Tanahashi N, et al. Rivaroxaban vs. warfarin in Japanese patients with atrial fibrillation-the J-ROCKET AF study. Circ J 2012;76:2104-11.
    • (2012) Circ J , vol.76 , pp. 2104-2111
    • Hori, M.1    Matsumoto, M.2    Tanahashi, N.3
  • 51
    • 40949113623 scopus 로고    scopus 로고
    • Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: Meta-epidemiological study
    • DOI 10.1136/bmj.39465.451748.AD
    • Wood L, Egger M, Gluud LL, et al. Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study. BMJ 2008;336:601-5. (Pubitemid 351439518)
    • (2008) BMJ , vol.336 , Issue.7644 , pp. 601-605
    • Wood, L.1    Egger, M.2    Gluud, L.L.3    Schulz, K.F.4    Juni, P.5    Altman, D.G.6    Gluud, C.7    Martin, R.M.8    Wood, A.J.G.9    Sterne, J.A.C.10
  • 52
    • 84896546512 scopus 로고    scopus 로고
    • PS2-42: Assessment of drug induced liver injury using an automated causality assessment tool
    • Cheetham TC, Shin J, Murray R, et al. PS2-42: assessment of drug induced liver injury using an automated causality assessment tool. Clin Med Res 2013;11:156.
    • (2013) Clin Med Res , vol.11 , pp. 156
    • Cheetham, T.C.1    Shin, J.2    Murray, R.3
  • 54
    • 0035168307 scopus 로고    scopus 로고
    • Elevation of hepatic transaminases after enoxaparin use: Case report and review of unfractionated and low-molecular-weight heparin-induced hepatotoxicity
    • DOI 10.1592/phco.21.1.108.34436
    • Carlson MK, Gleason PP, Sen S. Elevation of hepatic transaminases after enoxaparin use: case report and review of unfractionated and low-molecular-weight heparin-induced hepatotoxicity. Pharmacotherapy 2001;21:108-13. (Pubitemid 32047579)
    • (2001) Pharmacotherapy , vol.21 , Issue.1 , pp. 108-113
    • Carlson, M.K.1    Gleason, P.P.2    Sen, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.