The pharmacokinetics of darexaban are not affected to a clinically relevant degree by rifampicin, a strong inducer of P-glycoprotein and CYP3A4

British Journal of Clinical Pharmacology

Volumn 75, Issue 2, 2013, Pages 440-449

  Groenendaal, Dorien ^a   Strabach, Gregory ^b   Garcia Hernandez, Alberto ^a   Kadokura, Takeshi ^c   Heeringa, Marten ^a   Mol, Roelof ^a   Eltink, Charlotte ^a   Onkels, Hartmut ^a  

^a Astellas Pharma Global Development   (Netherlands)

^b SGS   (France)

^c ASTELLAS PHARMA INC   (Japan)

Author keywords

Cytochrome P450; Drug drug interactions; Healthy subjects; Pharmacokinetics; Rifampicin; Transporters

Indexed keywords

CYTOCHROME P450 3A4; DAREXABAN; MULTIDRUG RESISTANCE PROTEIN; RIFAMPICIN; UNCLASSIFIED DRUG; YM 222714;

ABDOMINAL PAIN; ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; CLINICAL TRIAL; CONJUNCTIVITIS; DIARRHEA; DRUG BLOOD LEVEL; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; HUMAN; MALE; MOUTH ULCER; PARESTHESIA; PRIORITY JOURNAL; SIDE EFFECT; URINALYSIS; URTICARIA; VITAL SIGN;

ADOLESCENT; ADULT; AREA UNDER CURVE; AZEPINES; BENZAMIDES; CYTOCHROME P-450 CYP3A; DRUG INTERACTIONS; ENZYME INHIBITORS; FACTOR X; HUMANS; MALE; MIDDLE AGED; P-GLYCOPROTEINS; RIFAMPIN; YOUNG ADULT;

EID: 84872252194     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2012.04346.x     Document Type: Article

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