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Volumn 26, Issue 2, 2013, Pages 191-202

Bleeding and antidotes in new oral anticoagulants

Author keywords

apixaban; bleeding reversal; dabigatran; edoxaban; rivaroxaban

Indexed keywords

ACTIVATED CARBON; ACTIVATED PROTHROMBIN COMPLEX; AMINOCAPROIC ACID; ANTICOAGULANT AGENT; ANTIDOTE; APIXABAN; DABIGATRAN; DESMOPRESSIN; EDOXABAN; PROTHROMBIN COMPLEX; PRT 4445; RECOMBINANT BLOOD CLOTTING FACTOR 7A; RIVAROXABAN; TRANEXAMIC ACID; VON WILLEBRAND FACTOR; WARFARIN; XIMELAGATRAN;

EID: 84882247210     PISSN: 15216926     EISSN: 15321924     Source Type: Journal    
DOI: 10.1016/j.beha.2013.07.001     Document Type: Review
Times cited : (95)

References (60)
  • 1
    • 0345414673 scopus 로고    scopus 로고
    • Executive steering committee of the SPORTIF III Investigators. Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): Randomised controlled trial
    • S.B. Olsson Executive steering committee of the SPORTIF III Investigators. Stroke prevention with the oral direct thrombin inhibitor ximelagatran compared with warfarin in patients with non-valvular atrial fibrillation (SPORTIF III): randomised controlled trial Lancet 362 2003 1691 1698
    • (2003) Lancet , vol.362 , pp. 1691-1698
    • Olsson, S.B.1
  • 2
    • 34548031359 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    • J. Stangier, K. Rathgen, and H. Stahle The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects Br J Clin Pharmacol 64 2007 292 303
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 292-303
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3
  • 3
    • 35449007749 scopus 로고    scopus 로고
    • Oral dabigatran etexilate vs subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: The RE-MODEL randomized trial
    • B.I. Eriksson, O.E. Dahl, and N. Rosencher Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial J Thromb Haemost 5 2007 2178 2185
    • (2007) J Thromb Haemost , vol.5 , pp. 2178-2185
    • Eriksson, B.I.1    Dahl, O.E.2    Rosencher, N.3
  • 4
    • 79953836474 scopus 로고    scopus 로고
    • Oral dabigatran versus enoxaparin for thromboprophylaxis after primary total hip arthroplasty (RE-NOVATE II)
    • B. Eriksson, O. Dahl, and M. Huo Oral dabigatran versus enoxaparin for thromboprophylaxis after primary total hip arthroplasty (RE-NOVATE II) Thromb Haemost 105 2011 721 729
    • (2011) Thromb Haemost , vol.105 , pp. 721-729
    • Eriksson, B.1    Dahl, O.2    Huo, M.3
  • 5
    • 34548575058 scopus 로고    scopus 로고
    • Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: A randomised, double-blind, non-inferiority trial
    • B.I. Eriksson, O.E. Dahl, and N. Rosencher Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial Lancet 370 2007 949 956
    • (2007) Lancet , vol.370 , pp. 949-956
    • Eriksson, B.I.1    Dahl, O.E.2    Rosencher, N.3
  • 6
    • 71849117615 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in the treatment of acute venous thromboembolism
    • S. Schulman, C. Kearon, and A.K. Kakkar Dabigatran versus warfarin in the treatment of acute venous thromboembolism N Engl J Med 361 2009 2342 2352
    • (2009) N Engl J Med , vol.361 , pp. 2342-2352
    • Schulman, S.1    Kearon, C.2    Kakkar, A.K.3
  • 7
    • 84874003257 scopus 로고    scopus 로고
    • Extended use of dabigatran, warfarin or placebo in venous thromboembolism
    • S. Schulman, C. Kearon, and A.J. Kakkar Extended use of dabigatran, warfarin or placebo in venous thromboembolism N Engl J Med 368 2013 709 718
    • (2013) N Engl J Med , vol.368 , pp. 709-718
    • Schulman, S.1    Kearon, C.2    Kakkar, A.J.3
  • 8
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • S.J. Connolly, M.D. Ezekowitz, and S. Yusuf Dabigatran versus warfarin in patients with atrial fibrillation N Engl J Med 361 2009 1139 1151
    • (2009) N Engl J Med , vol.361 , pp. 1139-1151
    • Connolly, S.J.1    Ezekowitz, M.D.2    Yusuf, S.3
  • 9
    • 45949099359 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty
    • B.I. Eriksson, L.C. Borris, and R.J. Friedman Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty N Engl J Med 358 2008 2765 2775
    • (2008) N Engl J Med , vol.358 , pp. 2765-2775
    • Eriksson, B.I.1    Borris, L.C.2    Friedman, R.J.3
  • 10
    • 45949103416 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty
    • M.R. Lassen, W. Ageno, and L.C. Borris Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty N Engl J Med 358 2008 2776 2786
    • (2008) N Engl J Med , vol.358 , pp. 2776-2786
    • Lassen, M.R.1    Ageno, W.2    Borris, L.C.3
  • 11
    • 80052592404 scopus 로고    scopus 로고
    • Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    • M.R. Patel, K.W. Mahaffey, and J. Garg Rivaroxaban versus warfarin in nonvalvular atrial fibrillation N Engl J Med 365 2011 883 891
    • (2011) N Engl J Med , vol.365 , pp. 883-891
    • Patel, M.R.1    Mahaffey, K.W.2    Garg, J.3
  • 12
    • 78650619315 scopus 로고    scopus 로고
    • Oral rivaroxaban for symptomatic venous thromboembolism
    • R. Bauersachs, S.D. Berkowitz, and B. Brenner Oral rivaroxaban for symptomatic venous thromboembolism N Engl J Med 363 2010 2499 2510
    • (2010) N Engl J Med , vol.363 , pp. 2499-2510
    • Bauersachs, R.1    Berkowitz, S.D.2    Brenner, B.3
  • 13
    • 84859385808 scopus 로고    scopus 로고
    • Oral rivaroxaban for the treatment of symptomatic pulmonary embolism
    • H.R. Buller, M.H. Prins, and A.W. Lensing Oral rivaroxaban for the treatment of symptomatic pulmonary embolism N Engl J Med 2012 1287 1297
    • (2012) N Engl J Med , pp. 1287-1297
    • Buller, H.R.1    Prins, M.H.2    Lensing, A.W.3
  • 14
    • 78650587760 scopus 로고    scopus 로고
    • Apixaban versus enoxaparin for thromboprophylaxis after hip replacement
    • M.R. Lassen, A. Gallus, and G.E. Raskob Apixaban versus enoxaparin for thromboprophylaxis after hip replacement N Engl J Med 363 2010 2487 2498
    • (2010) N Engl J Med , vol.363 , pp. 2487-2498
    • Lassen, M.R.1    Gallus, A.2    Raskob, G.E.3
  • 15
    • 68249158084 scopus 로고    scopus 로고
    • Apixaban or enoxaparin for thromboprophylaxis after knee replacement
    • M.R. Lassen, G.E. Raskob, and A. Gallus Apixaban or enoxaparin for thromboprophylaxis after knee replacement N Engl J Med 361 2009 594 604
    • (2009) N Engl J Med , vol.361 , pp. 594-604
    • Lassen, M.R.1    Raskob, G.E.2    Gallus, A.3
  • 16
    • 80052825103 scopus 로고    scopus 로고
    • Apixaban versus warfarin in patients with atrial fibrillation
    • C.B. Granger, J.H. Alexander, and J.J. McMurray Apixaban versus warfarin in patients with atrial fibrillation N Engl J Med 365 2011 981 992
    • (2011) N Engl J Med , vol.365 , pp. 981-992
    • Granger, C.B.1    Alexander, J.H.2    McMurray, J.J.3
  • 17
    • 84873326583 scopus 로고    scopus 로고
    • Rates of hemorrhage during warfarin therapy for atrial fibrillation
    • T. Gomes, M.M. Mamdani, and A.M. Holbrook Rates of hemorrhage during warfarin therapy for atrial fibrillation CMAJ 185 2013 E121 E127
    • (2013) CMAJ , vol.185
    • Gomes, T.1    Mamdani, M.M.2    Holbrook, A.M.3
  • 18
    • 84875780959 scopus 로고    scopus 로고
    • Dabigatran and postmarketing reports of bleeding
    • M.R. Southworth, M.E. Reichman, and E.F. Unger Dabigatran and postmarketing reports of bleeding N Engl J Med 368 2013 1272 1274
    • (2013) N Engl J Med , vol.368 , pp. 1272-1274
    • Southworth, M.R.1    Reichman, M.E.2    Unger, E.F.3
  • 19
    • 45949098057 scopus 로고    scopus 로고
    • Hemorrhagic complications of anticoagulant and thrombolytic treatment: American College of Chest Physicians evidence-based clinical practice guidelines (8th Edition)
    • S. Schulman, R.J. Beyth, and C. Kearon Hemorrhagic complications of anticoagulant and thrombolytic treatment: American College of Chest Physicians evidence-based clinical practice guidelines (8th Edition) Chest 133 2008 257S 298S
    • (2008) Chest , vol.133
    • Schulman, S.1    Beyth, R.J.2    Kearon, C.3
  • 20
    • 79958126202 scopus 로고    scopus 로고
    • Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: An analysis of the randomized evaluation of long-term anticoagulant therapY (RE-LY) trial
    • J.W. Eikelboom, L. Wallentin, and S.J. Connolly Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapY (RE-LY) trial Circulation 123 2011 2363 2372
    • (2011) Circulation , vol.123 , pp. 2363-2372
    • Eikelboom, J.W.1    Wallentin, L.2    Connolly, S.J.3
  • 21
    • 84873569160 scopus 로고    scopus 로고
    • Concomitant use of antiplatelet therapy with dabigatran or warfarin in the randomized evaluation of long-term anticoagulation therapy (RE-LY) trial
    • A.L. Dans, S.J. Connolly, and L. Wallentin Concomitant use of antiplatelet therapy with dabigatran or warfarin in the randomized evaluation of long-term anticoagulation therapy (RE-LY) trial Circulation 127 2013 634 640
    • (2013) Circulation , vol.127 , pp. 634-640
    • Dans, A.L.1    Connolly, S.J.2    Wallentin, L.3
  • 22
    • 77956899158 scopus 로고    scopus 로고
    • Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation
    • M.L. Hansen, R. Sorensen, and M.T. Clausen Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation Arch Intern Med 170 2010 1433 1441
    • (2010) Arch Intern Med , vol.170 , pp. 1433-1441
    • Hansen, M.L.1    Sorensen, R.2    Clausen, M.T.3
  • 23
    • 84873596181 scopus 로고    scopus 로고
    • Apixaban for extended treatment of venous thromboembolism
    • G. Agnelli, H.R. Buller, and A. Cohen Apixaban for extended treatment of venous thromboembolism N Engl J Med 368 2013 699 708
    • (2013) N Engl J Med , vol.368 , pp. 699-708
    • Agnelli, G.1    Buller, H.R.2    Cohen, A.3
  • 24
    • 80955182268 scopus 로고    scopus 로고
    • Risks for stroke, bleeding, and death in patients with atrial fibrillation receiving dabigatran or warfarin in relation to the CHADS2 score: A subgroup analysis of the RE-LY trial
    • J. Oldgren, M. Alings, and H. Darius Risks for stroke, bleeding, and death in patients with atrial fibrillation receiving dabigatran or warfarin in relation to the CHADS2 score: a subgroup analysis of the RE-LY trial Ann Intern Med 155 2011 660 667
    • (2011) Ann Intern Med , vol.155 , pp. 660-667
    • Oldgren, J.1    Alings, M.2    Darius, H.3
  • 25
    • 84869083231 scopus 로고    scopus 로고
    • Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: A secondary analysis of a randomised controlled trial
    • R.D. Lopes, S.M. Al-Khatib, and L. Wallentin Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: a secondary analysis of a randomised controlled trial Lancet 380 2012 1749 1758
    • (2012) Lancet , vol.380 , pp. 1749-1758
    • Lopes, R.D.1    Al-Khatib, S.M.2    Wallentin, L.3
  • 26
    • 84869838484 scopus 로고    scopus 로고
    • Efficacy and safety of novel oral anticoagulants for treatment of acute venous thromboembolism: Direct and adjusted indirect meta-analysis of randomised controlled trials
    • B.D. Fox, S.R. Kahn, and D. Langleben Efficacy and safety of novel oral anticoagulants for treatment of acute venous thromboembolism: direct and adjusted indirect meta-analysis of randomised controlled trials BMJ 345 2012 e7498
    • (2012) BMJ , vol.345 , pp. 7498
    • Fox, B.D.1    Kahn, S.R.2    Langleben, D.3
  • 27
    • 84865138532 scopus 로고    scopus 로고
    • Indirect comparisons of new oral anticoagulant drugs for efficacy and safety when used for stroke prevention in atrial fibrillation
    • G.Y. Lip, T.B. Larsen, and F. Skjoth Indirect comparisons of new oral anticoagulant drugs for efficacy and safety when used for stroke prevention in atrial fibrillation J Am Coll Cardiol 60 2012 738 746
    • (2012) J Am Coll Cardiol , vol.60 , pp. 738-746
    • Lip, G.Y.1    Larsen, T.B.2    Skjoth, F.3
  • 28
    • 84870047587 scopus 로고    scopus 로고
    • Is the network meta-analysis (NETMA) bringing us closer to the truth? Insights from recent antithrombotic drug data
    • S. Schulman Is the network meta-analysis (NETMA) bringing us closer to the truth? insights from recent antithrombotic drug data Thromb Haemost 108 2012 872 875
    • (2012) Thromb Haemost , vol.108 , pp. 872-875
    • Schulman, S.1
  • 29
    • 84869236631 scopus 로고    scopus 로고
    • Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: A systematic review and meta-analysis of the literature
    • F. Dentali, N. Riva, and M. Crowther Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature Circulation 126 2012 2381 2391
    • (2012) Circulation , vol.126 , pp. 2381-2391
    • Dentali, F.1    Riva, N.2    Crowther, M.3
  • 30
    • 77954717667 scopus 로고    scopus 로고
    • Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial
    • H. Shakur, I. Roberts, and R. Bautista Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial Lancet 376 2010 23 32
    • (2010) Lancet , vol.376 , pp. 23-32
    • Shakur, H.1    Roberts, I.2    Bautista, R.3
  • 31
    • 60449090703 scopus 로고    scopus 로고
    • Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: A systematic review of randomized trials
    • Y.K. Kagoma, M.A. Crowther, and J. Douketis Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trials Thromb Res 123 2009 687 696
    • (2009) Thromb Res , vol.123 , pp. 687-696
    • Kagoma, Y.K.1    Crowther, M.A.2    Douketis, J.3
  • 32
    • 79952270874 scopus 로고    scopus 로고
    • Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion
    • D.A. Henry, P.A. Carless, and A.J. Moxey Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion Cochrane Database Syst Rev 2011 CD001886
    • (2011) Cochrane Database Syst Rev , pp. 001886
    • Henry, D.A.1    Carless, P.A.2    Moxey, A.J.3
  • 33
    • 3042712107 scopus 로고    scopus 로고
    • Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant
    • D.F. O'Shaughnessy, C. Atterbury, and P. Bolton Maggs Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant Br J Haematol 126 2004 11 28
    • (2004) Br J Haematol , vol.126 , pp. 11-28
    • O'Shaughnessy, D.F.1    Atterbury, C.2    Bolton Maggs, P.3
  • 34
    • 31044439272 scopus 로고    scopus 로고
    • Plasma and plasma products in the treatment of massive haemorrhage
    • W.N. Erber, and D.J. Perry Plasma and plasma products in the treatment of massive haemorrhage Best Pract Res Clin Haematol 19 2006 97 112
    • (2006) Best Pract Res Clin Haematol , vol.19 , pp. 97-112
    • Erber, W.N.1    Perry, D.J.2
  • 35
    • 84879551507 scopus 로고    scopus 로고
    • Management and outcomes of major bleeding on dabigatran or warfarin
    • Abstr 19
    • A. Majeed, H.-G. Hwang, and M. Brueckmann Management and outcomes of major bleeding on dabigatran or warfarin Blood 120 2012 Abstr 19
    • (2012) Blood , vol.120
    • Majeed, A.1    Hwang, H.-G.2    Brueckmann, M.3
  • 36
    • 77953168824 scopus 로고    scopus 로고
    • Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: Interpretation of coagulation assays and reversal of anticoagulant activity
    • J. van Ryn, J. Stangier, and S. Haertter Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity Thromb Haemost 103 2010 1116 1127
    • (2010) Thromb Haemost , vol.103 , pp. 1116-1127
    • Van Ryn, J.1    Stangier, J.2    Haertter, S.3
  • 37
    • 0025981535 scopus 로고
    • The influence of infusions of 1-desamino-8-D-arginine vasopressin (DDAVP) in vivo on the anticoagulant effect of recombinant hirudin (CGP39393) in vitro
    • S.H. Ibbotson, P.J. Grant, and R. Kerry The influence of infusions of 1-desamino-8-D-arginine vasopressin (DDAVP) in vivo on the anticoagulant effect of recombinant hirudin (CGP39393) in vitro Thromb Haemost 65 1991 64 66
    • (1991) Thromb Haemost , vol.65 , pp. 64-66
    • Ibbotson, S.H.1    Grant, P.J.2    Kerry, R.3
  • 38
    • 0035251820 scopus 로고    scopus 로고
    • Effects of activated prothrombin complex concentrate or recombinant factor VIIa on bleeding time and thrombus formation during anticoagulation with a direct thrombin inhibitor
    • M. Elg, S. Carlsson, and D. Gustafsson Effects of activated prothrombin complex concentrate or recombinant factor VIIa on bleeding time and thrombus formation during anticoagulation with a direct thrombin inhibitor Thromb Res 101 2001 145 157
    • (2001) Thromb Res , vol.101 , pp. 145-157
    • Elg, M.1    Carlsson, S.2    Gustafsson, D.3
  • 39
    • 0029043170 scopus 로고
    • Investigation of activated prothrombin complex concentrate as potential hirudin antidote in animal models
    • K.H. Diehl, J. Romisch, and B. Hein Investigation of activated prothrombin complex concentrate as potential hirudin antidote in animal models Haemostasis 25 1995 182 192
    • (1995) Haemostasis , vol.25 , pp. 182-192
    • Diehl, K.H.1    Romisch, J.2    Hein, B.3
  • 40
    • 84864370719 scopus 로고    scopus 로고
    • Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban. A randomised crossover ex vivo study in healthy volunteers
    • R. Marlu, E. Hodaj, and A. Paris Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban. A randomised crossover ex vivo study in healthy volunteers Thromb Haemost 108 2012 217 224
    • (2012) Thromb Haemost , vol.108 , pp. 217-224
    • Marlu, R.1    Hodaj, E.2    Paris, A.3
  • 41
    • 84875053456 scopus 로고    scopus 로고
    • ®) in the correction of coagulation abnormalities induced by dabigatran
    • ®) in the correction of coagulation abnormalities induced by dabigatran Int J Lab Hematol 35 2013 222 224
    • (2013) Int J Lab Hematol , vol.35 , pp. 222-224
    • Khoo, T.L.1    Weatherburn, C.2    Kershaw, G.3
  • 42
    • 84865856473 scopus 로고    scopus 로고
    • Reversing dabigatran with FEIBA in a patient with a transseptal perforation during cardiac ablation
    • W. Dager, and A. Roberts Reversing dabigatran with FEIBA in a patient with a transseptal perforation during cardiac ablation Crit Care Med 39 Suppl. 2011 243
    • (2011) Crit Care Med , vol.39 , Issue.SUPPL. , pp. 243
    • Dager, W.1    Roberts, A.2
  • 43
    • 0036489638 scopus 로고    scopus 로고
    • Safety of factor VIII inhibitor bypass activity (FEIBA): 10-year compilation of thrombotic adverse events
    • H.J. Ehrlich, M.J. Henzl, and E.D. Gomperts Safety of factor VIII inhibitor bypass activity (FEIBA): 10-year compilation of thrombotic adverse events Haemophilia 8 2002 83 90
    • (2002) Haemophilia , vol.8 , pp. 83-90
    • Ehrlich, H.J.1    Henzl, M.J.2    Gomperts, E.D.3
  • 44
    • 84856214360 scopus 로고    scopus 로고
    • Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran
    • W. Zhou, S. Schwarting, and S. Illanes Hemostatic therapy in experimental intracerebral hemorrhage associated with the direct thrombin inhibitor dabigatran Stroke 42 2011 3594 3599
    • (2011) Stroke , vol.42 , pp. 3594-3599
    • Zhou, W.1    Schwarting, S.2    Illanes, S.3
  • 45
    • 84865773023 scopus 로고    scopus 로고
    • Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model
    • I. Pragst, S.H. Zeitler, and B. Doerr Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model J Thromb Haemost 10 2012 1841 1848
    • (2012) J Thromb Haemost , vol.10 , pp. 1841-1848
    • Pragst, I.1    Zeitler, S.H.2    Doerr, B.3
  • 46
    • 80053571188 scopus 로고    scopus 로고
    • Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: A randomized, placebo-controlled, crossover study in healthy subjects
    • E.S. Eerenberg, P.W. Kamphuisen, and M.K. Sijpkens Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects Circulation 124 2011 1573 1579
    • (2011) Circulation , vol.124 , pp. 1573-1579
    • Eerenberg, E.S.1    Kamphuisen, P.W.2    Sijpkens, M.K.3
  • 47
    • 84865815830 scopus 로고    scopus 로고
    • Life-threatening bleeding in four patients with an unusual excessive response to dabigatran: Implications for emergency surgery and resuscitation
    • A. Lillo-Le Louet, M. Wolf, and L. Soufir Life-threatening bleeding in four patients with an unusual excessive response to dabigatran: implications for emergency surgery and resuscitation Thromb Haemost 108 2012 583 585
    • (2012) Thromb Haemost , vol.108 , pp. 583-585
    • Lillo-Le Louet, A.1    Wolf, M.2    Soufir, L.3
  • 48
    • 3042531845 scopus 로고    scopus 로고
    • Effect of recombinant factor VIIa on melagatran-induced inhibition of thrombin generation and platelet activation in healthy volunteers
    • M. Wolzt, M. Levi, and T.C. Sarich Effect of recombinant factor VIIa on melagatran-induced inhibition of thrombin generation and platelet activation in healthy volunteers Thromb Haemost 91 2004 1090 1096
    • (2004) Thromb Haemost , vol.91 , pp. 1090-1096
    • Wolzt, M.1    Levi, M.2    Sarich, T.C.3
  • 49
    • 1642499296 scopus 로고    scopus 로고
    • Argatroban as anticoagulant in cardiopulmonary bypass in an infant and attempted reversal with recombinant activated factor VII
    • S. Malherbe, B.C. Tsui, and K. Stobart Argatroban as anticoagulant in cardiopulmonary bypass in an infant and attempted reversal with recombinant activated factor VII Anesthesiology 100 2004 443 445
    • (2004) Anesthesiology , vol.100 , pp. 443-445
    • Malherbe, S.1    Tsui, B.C.2    Stobart, K.3
  • 50
    • 84857759555 scopus 로고    scopus 로고
    • Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding
    • T.E. Warkentin, P. Margetts, and S. Connolly Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding Blood 119 2012 2172 2174
    • (2012) Blood , vol.119 , pp. 2172-2174
    • Warkentin, T.E.1    Margetts, P.2    Connolly, S.3
  • 51
    • 77949421739 scopus 로고    scopus 로고
    • Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: An open-label, parallel-group, single-centre study
    • J. Stangier, K. Rathgen, and H. Stahle Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study Clin Pharmacokinet 49 2010 259 268
    • (2010) Clin Pharmacokinet , vol.49 , pp. 259-268
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3
  • 52
    • 84865851374 scopus 로고    scopus 로고
    • Safe use of hemodialysis for dabigatran removal before cardiac surgery
    • M.R. Wanek, E.T. Horn, and S. Elapavaluru Safe use of hemodialysis for dabigatran removal before cardiac surgery Ann Pharmacother 46 2012 e21
    • (2012) Ann Pharmacother , vol.46 , pp. 21
    • Wanek, M.R.1    Horn, E.T.2    Elapavaluru, S.3
  • 53
    • 84859703006 scopus 로고    scopus 로고
    • Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment
    • M.K. Wychowski, and P.A. Kouides Dabigatran-induced gastrointestinal bleeding in an elderly patient with moderate renal impairment Ann Pharmacother 46 2012 e10
    • (2012) Ann Pharmacother , vol.46 , pp. 10
    • Wychowski, M.K.1    Kouides, P.A.2
  • 54
    • 84879548455 scopus 로고    scopus 로고
    • A specific antidote for dabigatran: Functional and structural characterization
    • F. Schiele, J. van Ryn, and K. Canada A specific antidote for dabigatran: functional and structural characterization Blood 121 2013 3554 3562
    • (2013) Blood , vol.121 , pp. 3554-3562
    • Schiele, F.1    Van Ryn, J.2    Canada, K.3
  • 55
    • 84875844889 scopus 로고    scopus 로고
    • Investigating the enteroenteric recirculation of apixaban, a factor Xa inhibitor: Administration of activated charcoal to bile duct-cannulated rats and dogs receiving an intravenous dose and use of drug transporter knockout rats
    • D. Zhang, C.E. Frost, and K. He Investigating the enteroenteric recirculation of apixaban, a factor Xa inhibitor: administration of activated charcoal to bile duct-cannulated rats and dogs receiving an intravenous dose and use of drug transporter knockout rats Drug Metab Dispos 41 2013 906 915
    • (2013) Drug Metab Dispos , vol.41 , pp. 906-915
    • Zhang, D.1    Frost, C.E.2    He, K.3
  • 56
    • 84876288671 scopus 로고    scopus 로고
    • Hemostatic therapy in experimental intracerebral hemorrhage associated with rivaroxaban
    • W. Zhou, M. Zorn, and P. Nawroth Hemostatic therapy in experimental intracerebral hemorrhage associated with rivaroxaban Stroke 44 2013 771 778
    • (2013) Stroke , vol.44 , pp. 771-778
    • Zhou, W.1    Zorn, M.2    Nawroth, P.3
  • 57
    • 84655176578 scopus 로고    scopus 로고
    • Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model
    • A. Godier, A. Miclot, and B. Le Bonniec Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model Anesthesiology 116 2012 94 102
    • (2012) Anesthesiology , vol.116 , pp. 94-102
    • Godier, A.1    Miclot, A.2    Le Bonniec, B.3
  • 58
    • 84879555279 scopus 로고    scopus 로고
    • Evaluation of recombinant activated factor vii, prothrombin complex concentrate and fibrinogen concentrate to reverse apixaban in a rabbit model
    • [Abstr 904-8]
    • A.C. Martin, B. Le Bonniec, and T. Lecompte Evaluation of recombinant activated factor vii, prothrombin complex concentrate and fibrinogen concentrate to reverse apixaban in a rabbit model J Am Coll Cardiol 59 2012 E573 [Abstr 904-8]
    • (2012) J Am Coll Cardiol , vol.59 , pp. 573
    • Martin, A.C.1    Le Bonniec, B.2    Lecompte, T.3
  • 59
    • 84856631805 scopus 로고    scopus 로고
    • Reversal of anticoagulant effects of edoxaban, an oral, direct factor xa inhibitor, with haemostatic agents
    • T. Fukuda, Y. Honda, and C. Kamisato Reversal of anticoagulant effects of edoxaban, an oral, direct factor xa inhibitor, with haemostatic agents Thromb Haemost 107 2012 253 259
    • (2012) Thromb Haemost , vol.107 , pp. 253-259
    • Fukuda, T.1    Honda, Y.2    Kamisato, C.3
  • 60
    • 84871157786 scopus 로고    scopus 로고
    • Reversal of the antihaemostatic effects of rivaroxaban by activated factor vii and activated prothrombin complex in primates
    • [Abstr 449]
    • A. Gruber, U.M. Marzec, and U. Buetehorn Reversal of the antihaemostatic effects of rivaroxaban by activated factor vii and activated prothrombin complex in primates Haematologica 94 Suppl. 2 2009 181 [Abstr 449]
    • (2009) Haematologica , vol.94 , Issue.SUPPL. 2 , pp. 181
    • Gruber, A.1    Marzec, U.M.2    Buetehorn, U.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.