메뉴 건너뛰기




Volumn 80, Issue 7, 2013, Pages 443-451

Practical management of bleeding due to the anticoagulants dabigatran, rivaroxaban, and apixaban

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; APIXABAN; BENZIMIDAZOLE DERIVATIVE; BETA ALANINE; DABIGATRAN; DRUG DERIVATIVE; MORPHOLINE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRIDONE DERIVATIVE; RIVAROXABAN; THIOPHENE DERIVATIVE;

EID: 84880737167     PISSN: 08911150     EISSN: None     Source Type: Journal    
DOI: 10.3949/ccjm.80a.13025     Document Type: Article
Times cited : (58)

References (48)
  • 5
    • 71649105333 scopus 로고    scopus 로고
    • Increasing prevalence of atrial fibrillation and flutter in the United States
    • Naccarelli GV, Varker H, Lin J, Schulman KL. Increasing prevalence of atrial fibrillation and flutter in the United States. Am J Cardiol 2009; 104:1534-1539.
    • (2009) Am J Cardiol , vol.104 , pp. 1534-1539
    • Naccarelli, G.V.1    Varker, H.2    Lin, J.3    Schulman, K.L.4
  • 6
    • 0025779484 scopus 로고
    • Atrial fibrillation as an independent risk factor for stroke: The Framingham Study
    • Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: The Framingham Study. Stroke 1991; 22:983-988.
    • (1991) Stroke , vol.22 , pp. 983-988
    • Wolf, P.A.1    Abbott, R.D.2    Kannel, W.B.3
  • 7
    • 84880730619 scopus 로고    scopus 로고
    • on behalf of the VTE Impact Assessment Group. Estimated annual number of incident and recurrent
    • non-fatal and fatal venous thromboembolism (VTE) events in the US. Blood (ASH Annual Meeting Abstracts) 2005; 106:abstract 910.
    • Heit JA, Cohen AT, Anderson FA Jr, on behalf of the VTE Impact Assessment Group. Estimated annual number of incident and recurrent, non-fatal and fatal venous thromboembolism (VTE) events in the US. Blood (ASH Annual Meeting Abstracts) 2005; 106:abstract 910.
    • Heit, J.A.1    Cohen, A.T.2    Anderson Jr., F.A.3
  • 8
    • 77952167209 scopus 로고    scopus 로고
    • Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor
    • Stangier J, Clemens A. Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor. Clin Appl Thromb Hemost 2009; 15(suppl 1):9S-16S.
    • (2009) Clin Appl Thromb Hemost , vol.15 , Issue.SUPPL. 1
    • Stangier, J.1    Clemens, A.2
  • 9
    • 34548031359 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    • Stangier J, Rathgen K, Stähle H, Gansser D, Roth W. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects. Br J Clin Pharmacol 2007; 64:292-303.
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 292-303
    • Stangier, J.1    Rathgen, K.2    Stähle, H.3    Gansser, D.4    Roth, W.5
  • 10
    • 29144518504 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939-an oral, direct factor Xa inhibitor-after multiple dosing in healthy male subjects
    • Kubitza D, Becka M, Wensing G, Voith B, Zuehlsdorf M. Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939-an oral, direct factor Xa inhibitor-after multiple dosing in healthy male subjects. Eur J Clin Pharmacol 2005; 61:873-880.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 873-880
    • Kubitza, D.1    Becka, M.2    Wensing, G.3    Voith, B.4    Zuehlsdorf, M.5
  • 11
    • 34250166525 scopus 로고    scopus 로고
    • Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct factor Xa inhibitor-in healthy subjects
    • Mueck W, Becka M, Kubitza D, Voith B, Zuehlsdorf M. Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct factor Xa inhibitor-in healthy subjects. Int J Clin Pharmacol Ther 2007; 45:335-344.
    • (2007) Int J Clin Pharmacol Ther , vol.45 , pp. 335-344
    • Mueck, W.1    Becka, M.2    Kubitza, D.3    Voith, B.4    Zuehlsdorf, M.5
  • 12
    • 84856776395 scopus 로고    scopus 로고
    • American College of Chest Physicians. New antithrombotic drugs: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    • Weitz JI, Eikelboom JW, Samama MM; American College of Chest Physicians. New antithrombotic drugs: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141(suppl 2):e120S- e151S.
    • (2012) Chest , vol.141 , Issue.SUPPL. 2
    • Weitz, J.I.1    Eikelboom, J.W.2    Samama, M.M.3
  • 13
    • 58149458160 scopus 로고    scopus 로고
    • Apixaban metabolism and pharmacokinetics after oral administration to humans
    • Raghavan N, Frost CE, Yu Z, et al. Apixaban metabolism and pharmacokinetics after oral administration to humans. Drug Metab Dispos 2009; 37:74-81.
    • (2009) Drug Metab Dispos , vol.37 , pp. 74-81
    • Raghavan, N.1    Frost, C.E.2    Yu, Z.3
  • 14
    • 0035140558 scopus 로고    scopus 로고
    • Population modelling of the effect of inogatran, at thrombin inhibitor, on ex vivo coagulation time (APTT) in healthy subjects and patients with coronary artery disease
    • Cullberg M, Eriksson UG, Larsson M, Karlsson MO. Population modelling of the effect of inogatran, at thrombin inhibitor, on ex vivo coagulation time (APTT) in healthy subjects and patients with coronary artery disease. Br J Clin Pharmacol 2001; 51:71-79.
    • (2001) Br J Clin Pharmacol , vol.51 , pp. 71-79
    • Cullberg, M.1    Eriksson, U.G.2    Larsson, M.3    Karlsson, M.O.4
  • 15
    • 9644295774 scopus 로고    scopus 로고
    • A review of the effects of the oral direct thrombin inhibitor ximelagatran on coagulation assays
    • Carlsson SC, Mattsson C, Eriksson UG, et al. A review of the effects of the oral direct thrombin inhibitor ximelagatran on coagulation assays. Thromb Res 2005; 115:9-18.
    • (2005) Thromb Res , vol.115 , pp. 9-18
    • Carlsson, S.C.1    Mattsson, C.2    Eriksson, U.G.3
  • 16
    • 42949123582 scopus 로고    scopus 로고
    • Population pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct factor Xa inhibitor-in patients undergoing major orthopaedic surgery
    • Mueck W, Eriksson BI, Bauer KA, et al. Population pharmacokinetics and pharmacodynamics of rivaroxaban-an oral, direct factor Xa inhibitor-in patients undergoing major orthopaedic surgery. Clin Pharmacokinet 2008; 47:203-216.
    • (2008) Clin Pharmacokinet , vol.47 , pp. 203-216
    • Mueck, W.1    Eriksson, B.I.2    Bauer, K.A.3
  • 17
    • 77952044405 scopus 로고    scopus 로고
    • Assessment of laboratory assays to measure rivaroxaban-an oral, direct factor Xa inhibitor
    • Samama MM, Martinoli JL, LeFlem L, et al. Assessment of laboratory assays to measure rivaroxaban-an oral, direct factor Xa inhibitor. Thromb Haemost 2010; 103:815-825.
    • (2010) Thromb Haemost , vol.103 , pp. 815-825
    • Samama, M.M.1    Martinoli, J.L.2    LeFlem, L.3
  • 18
    • 42149172523 scopus 로고    scopus 로고
    • Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies
    • Wong PC, Crain EJ, Xin B, et al. Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies. J Thromb Haemost 2008; 6:820-829.
    • (2008) J Thromb Haemost , vol.6 , pp. 820-829
    • Wong, P.C.1    Crain, E.J.2    Xin, B.3
  • 19
    • 84856593171 scopus 로고    scopus 로고
    • Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran
    • Stangier J, Feuring M. Using the HEMOCLOT direct thrombin inhibitor assay to determine plasma concentrations of dabigatran. Blood Coagul Fibrinolysis 2012; 23:138-143.
    • (2012) Blood Coagul Fibrinolysis , vol.23 , pp. 138-143
    • Stangier, J.1    Feuring, M.2
  • 20
    • 77953168824 scopus 로고    scopus 로고
    • Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity
    • van Ryn J, Stangier J, Haertter S, et al. Dabigatran etexilate-a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity. Thromb Haemost 2010; 103:1116-1127.
    • (2010) Thromb Haemost , vol.103 , pp. 1116-1127
    • van Ryn, J.1    Stangier, J.2    Haertter S.et, al.3
  • 21
    • 10844233894 scopus 로고    scopus 로고
    • The ecarin clotting time, a universal method to quantify direct thrombin inhibitors
    • Nowak G. The ecarin clotting time, a universal method to quantify direct thrombin inhibitors. Pathophysiol Haemost Thromb 2003-2004; 33:173-183.
    • (2003) Pathophysiol Haemost Thromb , vol.33 , pp. 173-183
    • Nowak, G.1
  • 22
    • 10844269522 scopus 로고    scopus 로고
    • Ecarin chromogenic assay- a new method for quantitative determination of direct thrombin inhibitors like hirudin
    • Lange U, Nowak G, Bucha E. Ecarin chromogenic assay- a new method for quantitative determination of direct thrombin inhibitors like hirudin. Pathophysiol Haemost Thromb 2003-2004; 33:184-191.
    • (2003) Pathophysiol Haemost Thromb , vol.33 , pp. 184-191
    • Lange, U.1    Nowak, G.2    Bucha, E.3
  • 23
    • 84856632988 scopus 로고    scopus 로고
    • Rivaroxaban Anti-Factor Xa Chromogenic Assay Field Trial Laboratories. Evaluation of the anti-factor Xa chromogenic assay for the measurement of rivaroxaban plasma concentrations using calibrators and controls
    • Samama MM, Contant G, Spiro TE, et al; Rivaroxaban Anti-Factor Xa Chromogenic Assay Field Trial Laboratories. Evaluation of the anti-factor Xa chromogenic assay for the measurement of rivaroxaban plasma concentrations using calibrators and controls. Thromb Haemost 2012; 107:379-387.
    • (2012) Thromb Haemost , vol.107 , pp. 379-387
    • Samama, M.M.1    Contant, G.2    Spiro, T.E.3
  • 24
    • 84865977200 scopus 로고    scopus 로고
    • Newer oral anticoagulants: a review of laboratory monitoring options and reversal agents in the hemorrhagic patient
    • Miyares MA, Davis K. Newer oral anticoagulants: a review of laboratory monitoring options and reversal agents in the hemorrhagic patient. Am J Health Syst Pharm 2012; 69:1473-1484.
    • (2012) Am J Health Syst Pharm , vol.69 , pp. 1473-1484
    • Miyares, M.A.1    Davis, K.2
  • 25
    • 78649736882 scopus 로고    scopus 로고
    • Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay
    • Barrett YC, Wang Z, Frost C, Shenker A. Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay. Thromb Haemost 2010; 104:1263-1271.
    • (2010) Thromb Haemost , vol.104 , pp. 1263-1271
    • Barrett, Y.C.1    Wang, Z.2    Frost, C.3    Shenker, A.4
  • 26
    • 33747599590 scopus 로고    scopus 로고
    • Adverse impact of bleeding on prognosis in patients with acute coronary syndromes
    • Eikelboom JW, Mehta SR, Anand SS, Xie C, Fox KA, Yusuf S. Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation 2006; 114:774-782.
    • (2006) Circulation , vol.114 , pp. 774-782
    • Eikelboom, J.W.1    Mehta, S.R.2    Anand, S.S.3    Xie, C.4    Fox, K.A.5    Yusuf, S.6
  • 27
    • 33947575142 scopus 로고    scopus 로고
    • Impact of major bleeding on 30-day mortality and clinical outcomes in patients with acute coronary syndromes: an analysis from the ACUITY Trial
    • Manoukian SV, Feit F, Mehran R, et al. Impact of major bleeding on 30-day mortality and clinical outcomes in patients with acute coronary syndromes: an analysis from the ACUITY Trial. J Am Coll Cardiol 2007; 49:1362-1368.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1362-1368
    • Manoukian, S.V.1    Feit, F.2    Mehran, R.3
  • 28
    • 22844442726 scopus 로고    scopus 로고
    • In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939-an oral, direct factor Xa inhibitor
    • Perzborn E, Strassburger J, Wilmen A, et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939-an oral, direct factor Xa inhibitor. J Thromb Haemost 2005; 3:514-521.
    • (2005) J Thromb Haemost , vol.3 , pp. 514-521
    • Perzborn, E.1    Strassburger, J.2    Wilmen, A.3
  • 32
    • 77949421739 scopus 로고    scopus 로고
    • Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study
    • Stangier J, Rathgen K, Stähle H, Mazur D. Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study. Clin Pharmacokinet 2010; 49:259-268.
    • (2010) Clin Pharmacokinet , vol.49 , pp. 259-268
    • Stangier, J.1    Rathgen, K.2    Stähle, H.3    Mazur, D.4
  • 33
    • 84880727455 scopus 로고    scopus 로고
    • US Food and Drug Administration (FDA). Medication Guide: Pradaxa (dabigatran etexilate mesylate) capsules, Accessed June 5
    • US Food and Drug Administration (FDA). Medication Guide: Pradaxa (dabigatran etexilate mesylate) capsules. http://www.fda.gov/downloads/Drugs/DrugSafety/UCM231720.pdf. Accessed June 5, 2013.
    • (2013)
  • 34
    • 84859178003 scopus 로고    scopus 로고
    • How I treat with anticoagulants in 2012: new and old anticoagulants, and when and how to switch
    • Schulman S, Crowther MA. How I treat with anticoagulants in 2012: new and old anticoagulants, and when and how to switch. Blood 2012; 119:3016-3023.
    • (2012) Blood , vol.119 , pp. 3016-3023
    • Schulman, S.1    Crowther, M.A.2
  • 35
    • 79952445042 scopus 로고    scopus 로고
    • 2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (update on dabigatran): a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines
    • Wann LS, Curtis AB, Ellenbogen KA, et al. 2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (update on dabigatran): a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. J Am Coll Cardiol 2011; 57:1330-1337.
    • (2011) J Am Coll Cardiol , vol.57 , pp. 1330-1337
    • Wann, L.S.1    Curtis, A.B.2    Ellenbogen, K.A.3
  • 36
    • 67849126841 scopus 로고    scopus 로고
    • Managing bleeding in anticoagulated patients with a focus on novel therapeutic agents
    • Crowther MA, Warkentin TE. Managing bleeding in anticoagulated patients with a focus on novel therapeutic agents. J Thromb Haemost 2009; 7(suppl 1):107-110.
    • (2009) J Thromb Haemost , vol.7 , Issue.SUPPL. 1 , pp. 107-110
    • Crowther, M.A.1    Warkentin, T.E.2
  • 37
    • 84864370719 scopus 로고    scopus 로고
    • Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers
    • Marlu R, Hodaj E, Paris A, Albaladejo P, Cracowski JL, Pernod G. Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers. Thromb Haemost 2012; 108:217-224.
    • (2012) Thromb Haemost , vol.108 , pp. 217-224
    • Marlu, R.1    Hodaj, E.2    Paris, A.3    Albaladejo, P.4    Cracowski, J.L.5    Pernod, G.6
  • 38
    • 67849124919 scopus 로고    scopus 로고
    • Reversibility of the anticoagulant effect of high doses of the direct thrombin inhibitor dabigatran, by recombinant factor VIIa or activated prothrombin complex concentrate. 13th Congress of the European Hematology Association, June 12-15, 2008
    • Abs.0370
    • van Ryn J, Ruehl D, Priepke H, Hauel N, Wienen W. Reversibility of the anticoagulant effect of high doses of the direct thrombin inhibitor dabigatran, by recombinant factor VIIa or activated prothrombin complex concentrate. 13th Congress of the European Hematology Association, June 12-15, 2008. Hematologica 2008; 93(s1):148 Abs.0370.
    • (2008) Hematologica , vol.93 , Issue.S1 , pp. 148
    • van Ryn, J.1    Ruehl, D.2    Priepke, H.3    Hauel, N.4    Wienen, W.5
  • 39
    • 80053571188 scopus 로고    scopus 로고
    • Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects
    • Eerenberg ES, Kamphuisen PW, Sijpkens MK, Meijers JC, Buller HR, Levi M. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation 2011; 124:1573-1579.
    • (2011) Circulation , vol.124 , pp. 1573-1579
    • Eerenberg, E.S.1    Kamphuisen, P.W.2    Sijpkens, M.K.3    Meijers, J.C.4    Buller, H.R.5    Levi, M.6
  • 40
    • 66549108216 scopus 로고    scopus 로고
    • Suboptimal effect of a three-factor prothrombin complex concentrate (Profilnine-SD) in correcting supratherapeutic international normalized ratio due to warfarin overdose
    • Holland L, Warkentin TE, Refaai M, Crowther MA, Johnston MA, Sarode R. Suboptimal effect of a three-factor prothrombin complex concentrate (Profilnine-SD) in correcting supratherapeutic international normalized ratio due to warfarin overdose. Transfusion 2009; 49:1171-1177.
    • (2009) Transfusion , vol.49 , pp. 1171-1177
    • Holland, L.1    Warkentin, T.E.2    Refaai, M.3    Crowther, M.A.4    Johnston, M.A.5    Sarode, R.6
  • 41
    • 84857759555 scopus 로고    scopus 로고
    • Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding
    • Warkentin TE, Margetts P, Connolly SJ, Lamy A, Ricci C, Eikelboom JW. Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding. Blood 2012; 119:2172-2174.
    • (2012) Blood , vol.119 , pp. 2172-2174
    • Warkentin, T.E.1    Margetts, P.2    Connolly, S.J.3    Lamy, A.4    Ricci, C.5    Eikelboom, J.W.6
  • 42
    • 84858337925 scopus 로고    scopus 로고
    • Prothrombin complex concentrate (PCC, Octaplex) in patients requiring immediate reversal of vitamin K antagonist anticoagulation
    • Song MM, Warne CP, Crowther MA. Prothrombin complex concentrate (PCC, Octaplex) in patients requiring immediate reversal of vitamin K antagonist anticoagulation. Thromb Res 2012; 129:526-529.
    • (2012) Thromb Res , vol.129 , pp. 526-529
    • Song, M.M.1    Warne, C.P.2    Crowther, M.A.3
  • 43
    • 84880712152 scopus 로고    scopus 로고
    • Adsorption of dabigatran etexilate in water or dabigatran in pooled human plasma by activated charcoal in vitro. 51st ASH Annual Meeting and Exposition
    • Abstract no. 1065 Accessed June 5, 2013
    • van Ryn J, Sieger P, Kink-Eiband M, Gansser D, Clemens A. Adsorption of dabigatran etexilate in water or dabigatran in pooled human plasma by activated charcoal in vitro. 51st ASH Annual Meeting and Exposition. Abstract no. 1065. http://ash.confex.com/ash/2009/webprogram/Paper21383. html. Accessed June 5, 2013.
    • van Ryn, J.1    Sieger, P.2    Kink-Eiband, M.3    Gansser, D.4    Clemens, A.5
  • 44
    • 0026434005 scopus 로고
    • Heparin
    • Hirsh J. Heparin. N Engl J Med 1991; 324:1565-1574.
    • (1991) N Engl J Med , vol.324 , pp. 1565-1574
    • Hirsh, J.1
  • 45
    • 0003940062 scopus 로고    scopus 로고
    • Guidelines for thromboplastins and plasmas used to control for oral anticoagulant therapy
    • van den Besselaar AMHP
    • van den Besselaar AMHP, Poller L, Tripodi A. Guidelines for thromboplastins and plasmas used to control for oral anticoagulant therapy. WHO Technical Report Series 1999; 889:64-93.
    • (1999) WHO Technical Report Series , vol.889 , pp. 64-93
    • Poller, L.1    Tripodi, A.2
  • 46
    • 78650943861 scopus 로고    scopus 로고
    • The international normalized ratio calibrated for rivaroxaban has the potential to normalize prothrombin time results for rivaroxaban-treated patients: Results of an in vitro study
    • Tripodi A, Chantarangkul V, Guinet C, Samama MM. The international normalized ratio calibrated for rivaroxaban has the potential to normalize prothrombin time results for rivaroxaban-treated patients: Results of an in vitro study. J Thromb Haemost 2011; 9:226-228.
    • (2011) J Thromb Haemost , vol.9 , pp. 226-228
    • Tripodi, A.1    Chantarangkul, V.2    Guinet, C.3    Samama, M.M.4
  • 48
    • 0036489638 scopus 로고    scopus 로고
    • Safety of factor VIII inhibitor bypass activity (FEIBA): 10-year compilation of thrombotic adverse events
    • Ehrlich HJ, Henzl MJ, Gomperts ED. Safety of factor VIII inhibitor bypass activity (FEIBA): 10-year compilation of thrombotic adverse events. Haemophilia 2002; 8:83-90.
    • (2002) Haemophilia , vol.8 , pp. 83-90
    • Ehrlich, H.J.1    Henzl, M.J.2    Gomperts, E.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.