Mechanisms of palmitate-induced lipotoxicity in human osteoblasts

Endocrinology

Volumn 155, Issue 1, 2014, Pages 108-116

  Gunaratnam, Krishanthi ^a   Vidal, Christopher ^a   Gimble, Jeffrey M ^b   Duque, Gustavo ^a  

^a NEPEAN HOSPITAL   (Australia)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BONE MORPHOGENETIC PROTEIN 2; PALMITIC ACID; SMAD4 PROTEIN; SMAD5 PROTEIN; TRANSCRIPTION FACTOR RUNX2;

ADULT; ARTICLE; BONE DEVELOPMENT; BONE MINERALIZATION; CELL DIFFERENTIATION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; LIPOTOXICITY; OSTEOBLAST; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84891381427     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-1712     Document Type: Article

References (28)

1. Nguyen ND, Eisman JA, Center JR, Nguyen TV. Risk factors for fracture in nonosteoporotic men and women. J Clin Endocrinol Metab. 2007;92:955-962.
2. Khosla S, Westendorf JJ, Oursler MJ. Building bone to reverse osteoporosis and repair fractures. J Clin Invest. 2008;118:421-428.
3. Gimble JM, Nuttall ME. The relationship between adipose tissue and bone metabolism. Clin Biochem. 2012;45(12):874-879.
4. Duque G. Bone and fat connection in aging bone. Curr Opin Rheumatol. 2008;20:429-434.
5. Verma S, Rajaratnam JH, Denton J, Hoyland JA, Byers RJ. Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol. 2002;55:693-698.
6. Rosen CJ, Bouxsein ML. Mechanisms of disease: is osteoporosis the obesity of bone Nat Clin Pract Rheumatol. 2006;2:35-43.
7. Ng A, Duque G. Osteoporosis as a lipotoxic disease. Bonekey Rep. 2010;7:108-123.
8. Elbaz A, Wu X, Rivas D, Gimble JM, Duque G. Inhibition of fatty acid biosynthesis prevents adipocyte lipotoxicity on human osteoblasts in vitro. J Cell Mol Med. 2010;14:982-991.
9. Unger RH. Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology. 2003;144:5159-5165.
10. Unger RH. Lipotoxic diseases. Annu Rev Med. 2002;53:319-336.
11. Kusminski CM, Shetty S, Orci L, Unger RH, Scherer PE. Diabetes and apoptosis: lipotoxicity. Apoptosis. 2009;14:1484-1495.
12. Gasparrini M, Rivas D, Elbaz A, Duque G. Differential expression of cytokines in subcutaneous and marrow fat of aging C57BL/6J mice. Exp Gerontology. 2009;44:613-618.
13. Sepe A, Tchkonia T, Thomou T, Zamboni M, Kirkland JL. Aging and regional differences in fat cell progenitors -A mini-review. Gerontology. 2011;57:66-75.
14. Maurin AC, Chavassieux PM, Frappart L, Delmas PD, Serre CM, Meunier PJ. Influence of mature adipocytes on osteoblast proliferation in human primary cocultures. Bone. 2000;26:485-489.
15. Kim JE, AhnMW,Baek SH, et al.AMPKactivator, AICAR, inhibits palmitate-induced apoptosis in osteoblast. Bone. 2008;43:394-404.
16. Xiao Y, Cui J, Li YX, et al. Dyslipidemic high-fat diet affects adversely bone metabolism in mice associated with impaired antioxidant capacity. Nutrition. 2011;27:214-220.
17. Lecka-Czernik B, Moerman EJ, Grant DF, Lehmann JM, Manolagas SC, Jilka RL. Divergent effects of selective peroxisome proliferator-Activated receptor-α 2 ligands on adipocyte versus osteoblast differentiation. Endocrinology. 2002;143:2376-2384.
18. Farina EK, Kiel DP, Roubenoff R, Schaefer EJ, Cupples LA, Tucker KL. Dietary intakes of arachidonic acid and -linolenic acid are associated with reduced risk of hip fracture in older adults. J Nutr. 2011;141:1146-1153.
19. Aicart-Ramos C, Valero RA, Rodriguez-Crespo I. Protein palmitoylation and subcellular trafficking. Biochim Biophys Acta. 2011; 1808:2981-2994.
20. Long F. Building strong bones: molecular regulation of the osteoblast lineage. Nat Rev Mol Cell Biol. 2011;13:27-38.
21. Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 2002;30:e36.
22. Comeau JW, Costantino S, Wiseman PW. A guide to accurate fluorescence microscopy colocalization measurements. Biophys J. 2006;91:4611-4622.
23. Leong WF, Zhou T, Lim GL, Li B. Protein palmitoylation regulates osteoblast differentiation through BMP-induced osterix expression. PloS One. 2009;4:e4135.
24. Griffith JF, Yeung DK, Ahuja AT, et al.Astudy of bone marrow and subcutaneous fatty acid composition in subjects of varying bone mineral density. Bone. 2009;44:1092-1096.
25. Bain G, Müller T, Wang X, Papkoff J. Activated -catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction. Biochem Biophys Res Commun. 2003;31:84-91.
26. McCarthy TL, Centrella M. Novel links among Wnt and TGF-α signaling and Runx2. Mol Endocrinol. 2010;24:587-597.
27. Lian JB, Stein GS, Javed A, et al. Networks and hubs for the transcriptional control of osteoblastogenesis. Rev Endocr Metab Disord. 2006;7:1-16.
28. Giacca A, Xiao C, Oprescu AI, Carpentier AC, Lewis GF. Lipidinduced pancreatic-cell dysfunction: focus on in vivo studies.AmJ Physiol Endocrinol Metab. 2011;300:E255-E262.